Fasting, lactate, and insulin improve ischemia tolerance in rat heart: A comparison with ischemic preconditioning

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 5 39-5, 1996, Pages

  Doenst, Torsten ^b   Guthrie, Patrick H ^b   Chemnitius, Jörg Michael ^b   Zech, Ronald ^b   Taegtmeyer, Heinrich ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

2 deoxy 2 18F fluoroglucose; cardiac work; glycogen; isolated working rat heart; reperfusion; subsarcolemmal and interfibrillar mitochondria

Indexed keywords

INSULIN; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; GLUCOSE METABOLISM; HEART INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 0029931432     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.5.h1607     Document Type: Article

References (40)

1. Asimakis, G. K., K. Inners-McBride, G. Medellin, and V. R. Conti. Ischemic preconditioning attenuates acidosis and postischemic dysfunction in isolated rat hearts. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H887-H894, 1992.
2. Auchampach, J. A., G. J. Grover, and G. J. Gross. Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate. Cardiovasc. Res. 26: 1054-1062, 1992.
3. 1-adrenergic mechanism. Circ. Res. 73: 656-670, 1993.
4. Basuk, W. L., K. A. Reimer, and R. B. Jennings. Effect of repetitive brief episodes of ischemia on cell volume, electrolytes and ultrastructure. J. Am. Coll. Cardiol. 8: 33A-41A, 1986.
5. Bergmeyer, H. U. Methods of Enzymatic Analysis (3rd ed.). Deerfield Beach, FL: Verlag-Chemie International, 1974.
6. Cave, A. C., G. L. Horrowitz, and C. S. Apstein. Can ischemic preconditioning protect against hypoxia induced damage ? Studies of contractile function in isolated perfused rat hearts. J. Mol. Cell. Cardiol. 26: 1471-1486, 1994.
7. Chemnitius, J. M., K. H. Haselmeyer, T. Manglitz, P. Schwartz, H. Kreuzer, and R. Zech. Differential injury of mitochondrial subpopulations during myocardial ischemia. J. Appl. Cardiol. 4: 441-453, 1989.
8. Depré, C., and L. Hue. Improvement of postischemic functional recovery by increasing glycogen content in the isolated working rat heart (Abstract). J. Am. Coll. Cardiol. Special Issue Suppl.: 263A, 1994.
9. Divecha, N., and R. F. Irvine. Phospholipid signaling. Cell 80: 269-278, 1995.
10. Evans, G. The glycogen content of the rat heart. J. Physiol. Lond. 82: 468-480, 1934.
11. Fralix, T. A., C. Steenbergen, R. E. London, and E. Murphy. Metabolic substrates can alter postischemic recovery in preconditioned ischemic heart. Am. J. Physiol. 263 (Cell Physiol. 32): C17-C23, 1992.
12. Gevers, W. Generation of protons by metabolic processes in heart cells. J. Mol. Cell. Cardiol. 9: 867-874, 1977.
13. Goodwin, G. W., and H. Taegtmeyer. Metabolic recovery of the isolated working rat heart after brief global ischemia. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H462-H470, 1994.
14. 18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nueleophilic substitution. J. Nucl. Med. 27: 235-238, 1986.
15. 18F]2-deoxy-2-fluoro-D-glucose for assessing myocardial glucose uptake. Circulation 91: 2435-2444, 1995.
16. Illes, R. W., J. K. Wright, K. Inners-McBride, C. J. Yang, and A. Tristan. Ischemic preconditioning improves preservation with crystalloid cardioplegia. Ann. Thorax. Surg 58: 1481-1485, 1994.
17. Janier, M. F., J.-L. J. Vanoverschelde, and S. R. Bergmann. Ischemic preconditioning stimulates anaerobic glycolysis in the isolated rabbit heart. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1353-H1360, 1994.
18. Jeremy, R. W., G. Ambrosio, M. M. Pike, W. E. Jacobus, and L. W. Becker. The functional recovery of postischemic myocardium requires glycolysis during early reperfusion. J. Mol. Cell. Cardiol. 25: 261-276, 1993.
19. Kloner, R. A., K. Przyklenk, P. Whittaker, and S. Hale. Preconditioning stimuli and inadvertent preconditioning. J. Mol. Cell. Cardiol. 27: 743-747, 1995.
20. Lagerstrom, C. F., W. E. Walker, and H. Taegtmeyer. Failure of glycogen depletion to improve left ventricular function of the rabbit heart after hypothermic ischemic arrest. Circ. Res. 63: 81-86, 1988.
21. Lawson, C. S., and J. M. Downey. Preconditioning: state of the art myocardial protection. Cardiovasc. Res. 27: 542-550, 1993.
22. Liu, Y., and J. M. Downey. Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein. Cardiovasc. Res. 27: 608-611, 1993.
23. Murry, C. E., R. B. Jennings, and K. A. Reimer. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124-1136, 1986.
24. Murry, C. E., V. J. Richard, K. A. Reimer, and R. B. Jennings. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ. Res. 66: 913-931, 1990.
25. Neely, J. R., and L. W. Grotyohann. Role of glycolytic products in damage to myocardium: dissociation of adenosine triphosphate levels and recovery of function of reperfused canine myocardium. Circ. Res. 55: 816-824, 1984.
26. Neer, E. J. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80: 249-257, 1995.
27. 18F-2-deoxy-2-fluoro-D-glueose. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1022-H1031, 1990.
28. Patlak, C. S., and R. G. Blasberg. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J. Cereb. Blood Flow Metab. 5: 584-590, 1985,
29. Russell, R. R., V. T. B. Nguyêñ, J. M. Mrus, and H. Taegtmeyer. Fasting and lactate unmask insulin responsiveness in the isolated working rat heart. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E556-E561, 1992.
30. Russell, R. R., and H. Taegtmeyer. Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidizing acetoacetate. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H756-H762, 1991.
31. Schneider, C. A., V. T. B. Nguyêñ, and H. Taegtmeyer. Feeding and fasting determine postisehemic glucose utilization in isolated working rat hearts. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H542-H548, 1991.
32. Schneider, C. A., and H. Taegtmeyer. Fasting in vivo delays myocardial cell damage after brief periods of ischemia in the isolated working rat heart. Circ. Res. 68: 1045-1050, 1991.
33. Srere, P. A. Citrate synthase. Methods Enzymol. 13: 3-11, 1969.
34. Taegtmeyer, H., R. Hems, and H. A. Krebs. Utilization of energy providing substrates in the isolated working rat heart. Biochem. J. 186: 701-711, 1980.
35. Taegtmeyer, H., A. F. C. Roberts, and A. E. G. Rayne. Energy metabolism in reperfused rat heart: return of function before normalization of ATP content. J. Am. Coll. Cardiol. 6: 864-870, 1985.
36. Volovsek, A., R. Subramanian, and D. Reboussin. Effects of duration of ischemia during preconditioning on mechanical function, enzyme release and energy production in the isolated working rat heart. J. Mol. Cell. Cardiol. 24: 1011-1019, 1992.
37. Walaas, O., and E. Walaas. Effect of epinephrine on rat diaphragm. J. Biol. Chem. 187: 769-776, 1950.
38. Wolfe, C. L., R. E. Sievers, F. L. J. Visseren, and T. J. Donnelly. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation 87: 881-892, 1993.
39. Ytrehus, K., Y. Liu, and J. M. Downey. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1145-H1152, 1994.
40. Zar, J. H. Biostatistical Analysis (2nd ed.). Englewood Cliffs, NJ: Prentice-Hall, 1984.