Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 367, Issue 1904, 2009, Pages 3979-4003

  Petrovic, Mira ^a,b   De Alda, Maria Jose Lopez ^a   Diaz Cruz, Silvia ^a   Postigo, Cristina ^a   Radjenovic, Jelena ^a   Gros, Meritxell ^a   Barcelo, Damià ^a,c  

^a INSTITUTE OF ENVIRONMENTAL ASSESSMENT AND WATER RESEARCH   (Spain)

^b INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^c CATALAN INSTITUTE FOR WATER RESEARCH ICRA   (Spain)

Author keywords

Conventional activated sludge treatment; Drugs of abuse; Membrane bioreactor; Pharmaceutically active compounds; River bank filtration

Indexed keywords

ACTIVATED SLUDGE PROCESS; AQUIFERS; BANKS (BODIES OF WATER); BIOACTIVITY; BIOCONVERSION; BIOLOGICAL WATER TREATMENT; BIOREACTORS; DRUG PRODUCTS; GROUNDWATER POLLUTION; GROUNDWATER RESOURCES; HYDROGEOLOGY; MICROFILTRATION; POROUS MATERIALS; RECHARGING (UNDERGROUND WATERS); WASTEWATER; WASTEWATER RECLAMATION; WATER TREATMENT PLANTS;

CONVENTIONAL ACTIVATED SLUDGE TREATMENT; DRUGS OF ABUSE; MEMBRANE BIOREACTOR; PHARMACEUTICALLY ACTIVE COMPOUNDS; RIVER BANK FILTRATION;

WASTEWATER TREATMENT;

DRUG; STREET DRUG;

BIOREACTOR; BIOREMEDIATION; ENVIRONMENTAL MONITORING; ENVIRONMENTAL PROTECTION; FILTRATION; INDUSTRIAL WASTE; ISOLATION AND PURIFICATION; METHODOLOGY; REVIEW; RIVER; SEWAGE; WATER MANAGEMENT; WATER POLLUTANT; WATER SUPPLY;

BIODEGRADATION, ENVIRONMENTAL; BIOREACTORS; CONSERVATION OF NATURAL RESOURCES; ENVIRONMENTAL MONITORING; FILTRATION; INDUSTRIAL WASTE; PHARMACEUTICAL PREPARATIONS; RIVERS; SEWAGE; STREET DRUGS; WASTE DISPOSAL, FLUID; WATER POLLUTANTS, CHEMICAL; WATER PURIFICATION; WATER SUPPLY;

EID: 70349658086     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2009.0105     Document Type: Review

References (83)

1. Batt, A. L., Kim, S. & Aga, D. S. 2006 Enhanced biodegradation of lopromide and trimethoprim in nitrifying activated sludge. Environ. Sci. Technol. 40, 7367-7373. (doi:10.1021/es060835v) (Pubitemid 44871849)
2. Boleda, M. R., Galcerán, M. T. & Ventura, F. 2007 Trace determination of cannabinoids and opiates in wastewater and surface waters by ultra-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1175, 38-48. (doi:10.1016/j.chroma.2007.10.029) (Pubitemid 350123625)
3. Bound, P. J. & Voulvoulis, N. 2006 Predicted and measured concentrations for selected pharmaceuticals in UK rivers: implications for risk assessment. Water Res. 40, 2885-2892. (doi:10.1016/j.watres.2006.05.036) (Pubitemid 44148737)
4. Bones, J., Thomas, K. V. & Paull, B. 2007 Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals. J. Environ. Monit. 9, 701-707. (doi:10.1039/b702799k) (Pubitemid 47025268)
5. Brauch, H. J., Sacher, F., Denecke, E. & Tacke, T. 2000 Efficiency of bank filtration for the removal of hydrophilic organic micropollutants. Wasser Abwasser 14, 226-234.
6. Carballa, M., Omil, F., Lema, J. M., Llompart, M., García-Jares, C., Rodríguez, I., Gómez, M. & Ternes, T. 2004 Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Res. 38, 2918-2926. (doi:10.1016/j.watres.2004.03.029) (Pubitemid 38829583)
7. Castiglioni, S., Bagnati, R., Fanelli, R., Pomati, F., Calamari, D. & Zuccato, E. 2006a Removal of pharmaceuticals in sewage treatment plants in Italy. Environ. Sci. Technol. 40, 357-363. (doi:10.1021/es050991m) (Pubitemid 43069923)
8. Castiglioni, S., Zuccato, E., Crisci, E., Chiabrando, C., Fanelly, R. & Bagnati, R. 2006b Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry. Anal. Chem. 78, 8421-8429. (doi:10.1021/ac061095b) (Pubitemid 44927619)
9. Clara, M., Strenn, N. & Kreuzinger, N. 2004a Carbamazepine as a possible anthropogenic marker in the aquatic environment: investigations on the behaviour of carbamazepine in wastewater treatment and during groundwater infiltration. Water Res. 38, 947-954. (doi:10.1016/j.watres.2003.10.058) (Pubitemid 38177461)
10. Clara, M., Strenn, B., Kreuzinger, N. & Ausserleitner, M. 2004b Comparison of the behaviour of selected micropollutants in a membrane bioreactor and a conventional wastewater treatment plant. Water Sci. Technol. 50, 29-36.
11. Clara, M., Strenn, B., Gans, O., Martinez, E., Kreuzinger, N. & Kroiss, H. 2005 Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. Water Res. 39, 4797-4807. (doi:10.1016/j.watres.2005.09.015) (Pubitemid 41608518)
12. Daughton, C. G. 2001 Illicit drugs in municipal sewage in pharmaceuticals and personal care products in the environment: scientific and regulatory issues. In ACS Symposium Series 791 (eds C. G. Daughton & T. L. Jones-Lepp), pp. 116-139. Washington, DC: The American Chemical Society.
13. Díaz-Cruz, M. S. & Barceló, D. 2008 Trace organic chemicals contamination in ground water recharge. Chemosphere 72, 333-342. (doi:10.1016/j.chemosphere.2008.02.031)
14. EMEA. 2005 Note for guidance on environmental risk assessment of medicinal products for human use. CPMP/SWP/4447/00 draft corr. See http://www.emea.europa.eu/pdfs/human/swp/444700en.pdf (accessed January 2009). London, UK: European Agency for the Evaluation of Medicinal Products.
15. Gheorghe, A., Van Nuijs, A., Pecceu, B., Bervoets, L., Jorens, P. G., Blust, R., Neels, H. & Covaci, A. 2008 Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography-ion trap tandem mass spectrometry. Anal. Bioanal. Chem. 391, 1309-1319. (doi:10.1007/s00216-007-1754-5)
16. Göbel, A., McArdell, C. S., Suter, M. J. F. & Giger, W. 2004 Trace determination of macrolide and sulfonamide antimicrobials, a human sulfonamide metabolite, and trimethoprim in wastewater using liquid chromatography coupled to electrospray tandem mass spectrometry. Anal. Chem. 76, 4756-4764. (doi:10.1021/ac0496603) (Pubitemid 39079473)
17. Göbel, A., McArdell, C. S., Joss, A., Siegrist, H. & Giger, W. 2007 Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies. Sci. Total Environ. 372, 361-371. (doi:10.1016/j. scitotenv. 2006.07.039)
18. Gómez, M. J., Martínez Bueno, M. J., Lacorte, S., Fernández-Alba, A. R. & Agúera, A. 2007 Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. Chemosphere 66, 993-1002. (doi:10.1016/j.chemosphere.2006.07.051) (Pubitemid 44792220)
19. González, S., Muller, J., Petroviæ, M., Barceló, D. & Knepper, T. P. 2006 Biodegradation studies of selected priority acidic pesticides and diclofenac in different bioreactors. Environ. Pollut. 144, 926-932. (doi:10.1016/j.envpol.2006.02.021) (Pubitemid 44344907)
20. Greskowiak, J., Prommer, H., Massmann, G. & Nützmann, G. 2006 Modelling seasonal redox dynamics and the corresponding fate of the pharmaceutical residue phenazone during artificial recharge of ground water. J. Hydrol. 40, 6615-6621.
21. Gros, M., Petrović, M. & Barceló, D. 2006 Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 70, 678-690. (doi:10.1016/j.talanta.2006.05.024) (Pubitemid 44442374)
22. Gros, M., Petrović, M. & Barceló, D. 2007 Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the Ebro river basin (northeast Spain). Environ. Toxicol. Chem. 26, 1553-1562. (doi:10.1897/06-495R.1) (Pubitemid 47265495)
23. Grünheid, S., Amy, G. & Jekel, M. 2005 Removal of bulk dissolved organic carbon (DOC) and trace organic compounds by bank filtration and artificial recharge. Water Res. 39, 3219-3228. (doi:10.1016/j.watres.2005.05. 030) (Pubitemid 41138826)
24. Heberer, T. 2002 Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 131, 5-17. (doi:10.1016/S0378-4274 (02) 00041-3) (Pubitemid 34461906)
25. Heberer, T., Dünnbier, U., Reilich, Ch. & Stan, H. J. 1997 Detection of drugs and drug metabolites in ground water samples of a drinking water treatment plant. Fresen. Environ. Bull. 6, 438-443.
26. Heberer, T., Verstraeten, I. M., Meyer, M. T., Mechlinski, A. & Reddersen, K. 2001 Occurrence and fate of pharmaceuticals during bank filtration: preliminary results from investigations in Germany and the United States. Water Resour. Update 120, 4-17.
27. Heberer, T., Mechlinski, A., Franck, B., Knappe, A., Massmann, G. & Fritz, B. 2004 Field studies on the fate and transport of pharmaceutical residues in bank filtration. Ground Water Monit. Remediat. 24, 70-77. (doi:10.1111/j.1745-6592.2004.tb00714.x)
28. Heberer, T., Massmann, G., Frank, B., Taute, T. & Dünnbier, U. 2008 Behavior and redox sensitivity of antimicrobial residues during bank filtration. Chemosphere 73, 451-460. (doi:10.1016/S0378-4274 (02) 00041-3)
29. Hiemstra, P., Kolpa, R. J., van Eekhout, J. M., van Kessel A. L., Adamse, E. D. & van Paassen, J. A. M. 2003 Natural recharge of ground water: bank filtration in The Netherlands. J. Water Supply. Res. Technol. 52, 37-47. See http://www.unodc.org/pdf/research/wdr07/WDR 2007.pdf.
30. Huerta-Fontela, M., Galcerán, M. T. & Ventura, F. 2007 Ultraperformance liquid chromatographytandem mass spectrometry analysis of stimulatory drugs of abuse in wastewater and surface waters. Anal. Chem. 79, 3821-3829. (doi:10.1021/ac062370x) (Pubitemid 46799079)
31. Huerta-Fontela, M., Galceran, M. T., Martin-Alonso, J. & Ventura, F. 2008 Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain. Sci. Total Environ. 397, 31-40. (doi:10.1016/j.scitotenv. 2008.02.057)
32. Hummel, D., Löffler, D., Fink, G. & Ternes, T. A. 2006 Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry. Environ. Sci. Technol. 40, 7321-7328. (doi:10.1021/es061740w) (Pubitemid 44871843)
33. Jones-Lepp, T. L., Alvarez, D. A., Petty, J. D. & Huckins, J. N. 2004 Polar organic chemical integrative sampling and liquid chromatography- electrospray/ion-trap mass spectrometry for assessing selected prescription and illicit drugs in treated sewage effluents. Arch. Environ. Contam. Toxicol. 47, 427-439. (doi:10.1007/s00244-004-3146-6) (Pubitemid 39506602)
34. Joss, A., Keller, E., Alder, A. C., Göbel, A., McArdell, C. S., Ternes, T. & Siegrist, H. 2005 Removal of pharmaceuticals and fragrances in biological wastewater treatment. Water Res. 39, 3139-3152. (doi:10.1016/j. watres.2005.05.031) (Pubitemid 41138819)
35. Joss, A., Zabczynski, S., Göbel, A., Hoffmann, B., Löffler, D., McArdell, C. S., Ternes, T. A., Thomsen, A. & Siegrist, H. 2006 Biological degradation of pharmaceuticals in municipal wastewater treatment: proposing a classification scheme. Water Res. 40, 1686-1696. (doi:10.1016/j.watres.2006.02. 014)
36. Kasprzyk-Hordern, B., Dinsdale, R. M. & Guwy, A. J. 2007 Multi-residue method for the determination of basic/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry. J. Chromatogr. A 1161, 132-145. (doi:10.1016/j.chroma.2007.05.074) (Pubitemid 47088504)
37. Kasprzyk-Hordern, B., Dinsdale, R. M. & Guwy, A. J. 2008 Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry. Anal. Bioanal. Chem. 391, 1-16. (doi:10.1007/S00216-008-1854-x)
38. Kimura, K., Hara, H. & Watanabe, Y. 2005 Removal of pharmaceutical compounds by submerged membrane bioreactors (MBRs). Desalination 178, 135-140. (doi:10.1016/j.desal.2004.11.033) (Pubitemid 41574183)
39. Kimura, K., Hara, H. & Watanabe, Y. 2007 Elimination of selected acidic pharmaceuticals from municipal wastewater by an activated sludge system and membrane bioreactors. Environ. Sci. Technol. 41, 3708-3714. (doi:10.1021/es061684z) (Pubitemid 350067217)
40. Lesjean, B., Gnirrs, R., Buisson, H., Keller, S., Tazi-Pain, A. & Luck, F. 2005 Outcome of a 2-year investigation on enhanced biological nutrients removal and trace organics elimination in membrane bioreactor (MBR). Water Sci. Technol. 52, 453-460.
41. Lindqvist, N., Tuhkanen, T. & Kronberg, L. 2005 Occurrence of acidic pharmaceuticals in raw and treated sewages and in receiving waters. Water Res. 39, 2219-2228. (doi:10.1016/j.watres.2005.04.003) (Pubitemid 40840674)
42. Lishman, L., Smyth, S. A., Sarafin, K., Kleywegt, S., Toito, J., Peart, T., Lee, B., Servos Beland, M. & Seto, P. 2006 Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada. Sci. Total Environ. 367, 544-558. (doi:10.1016/j.scitotenv. 2006.03.021)
43. MacLeod, S. L., Sudhir, P. & Wong, C. S. 2007 Stereoisomer analysis of wastewaterderived β-blockers, selective serotonin re-uptake inhibitors, and salbutamol by highperformance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1170, 23-33. (doi:10.1016/j.chroma.2007.09.010) (Pubitemid 47539466)
44. Mansell, J. & Drewes, J. E. 2004 Fate of steroidal hormones during soil aquifer treatment. Ground Water Monit. Rem. 24, 91-101. (doi:10.1111/j.1745-6592.2004.tb00717.x)
45. Massmann, G., Dünnbier, U., Heberer, T. & Taute, T. 2008a. Behavior and redox sensitivity of pharmaceutical residues during bank filtration - investigation of residues of phenazone-type analgesics. Chemosphere 71, 1476-1485. (doi:10.1016/j.chemosphere.2007.12.017)
46. Massmann, G., Sültenfus, J., Dünnbier, U., Knappe, A., Taute, T. & Pekdeger, A. 2008b Investigation of groundwater residence times during bank filtration in Berlin: a multi-tracer approach. Hydrol. Process. 22, 788-801. (doi:10.1002/hyp. 6649)
47. Mersmann, P., Scheytt, T. J. & Heberer, Th. 2002 Column experiments on the transport behavior of pharmaceutically active compounds in the saturated zone. Acta Hydrochim. Hydrobiol. 30, 275-284. (doi:10.1002/aheh.200390009)
48. Metcalfe, C. D., Koenig, B. G., Bennie, D. T., Servos, M., Ternes, T. A. & Hirsch, R. 2003 Occurrence of neutral and acidic drugs in the effluents of Canadian sewage treatment plants. Environ. Toxicol. Chem. 22, 2872-2880. (doi:10.1897/02-469) (Pubitemid 37485216)
49. Miao, X. S., Bishay, F., Chen, M. & Metcalfe, C. D. 2004 Occurrence of antimicrobials in the final effluents of wastewater treatment plants in Canada. Environ. Sci. Technol. 38, 3533-3541. (doi:10.1021/es030653q) (Pubitemid 38879891)
50. Montforts, M. H. M. M. 2001 In Pharmaceuticals in the environment (ed. K. Kümmerer), p. 159. Berlin, Germany: Springer.
51. Nakada, N., Tanishima, T., Shinohara, H., Kiri, K. & Takada, H. 2006 Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Res. 40, 3297-3303. (doi:10.1016/j.watres.2006. 06.039)
52. Nikolai, L. N., McClure, E. L., MacLeod, S. L. & Wong, C. S. 2006 Stereoisomer quantification of the β-blocker drugs atenolol, metoprolol, and propranolol in wastewaters by chiral highperformance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1131, 103-109. (doi:10.1016/j.chroma.2006.07.033) (Pubitemid 44485666)
53. Oleksy-Frenzel, J., Wischnack, S. & Jekel, M. 2000 Application of ion-chromatography for the determination of the organic-group parameters AOCl, AOBr and AOI in water. Fresenius J. Anal. Chem. 366, 89-94. (doi:10.1007/ s002160050016)
54. Postigo, C., Lopez De Alda, M. J. & Barcelo, D. 2008a Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solidphase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Anal. Chem. 80, 3123-3134. (doi:10.1021/ac702060j) (Pubitemid 351620696)
55. 2: A non-intrusive tool for drug abuse estimation at the community level. Trends Anal. Chem. 27, 1053-1069. (doi:10.1016/j.trac.2008.10.002)
56. Preuss, G., Willme, U. & Zullei-Seibert, N. 2002 Behavior of some pharmaceuticals during artificial ground water recharge. Elimination and effects on microbiology. Acta Hydrochem. Hydrobiol. 29, 269-277.
57. Prommer, H. & Stuyfzand, P. J. 2005 Identification of temperature-dependent water quality changes during a deep well injection experiment in a pyretic aquifer. Environ. Sci. Technol. 39, 2200-2209. (doi:10.1021/es0486768) (Pubitemid 40490308)
58. Putschew, A., Wischnack, S. & Jekel, M. 2000 Occurrence of triiodinated X-ray contrast agents in the aquatic environment. Sci. Total Environ. 255, 129-134. (doi:10.1016/S0048-9697 (00) 00461-7)
59. Quintana, J. B., Weiss, S. & Reemtsma, T. 2005 Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. Water Res. 39, 2654-2664. (doi:10.1016/j.watres.2005.04.068) (Pubitemid 40943299)
60. Radjenovic, J., Petrović, M. & Barceló, D. 2007 Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Anal. Bioanal. Chem. 387, 1365-1377. (doi:10.1007/s00216-006-0883-6) (Pubitemid 46220419)
61. Radjenovic, J., Petrović, M. & Barceló, D. Submitted Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment.
62. Reif, R., Suárez, S., Omil, F. & Lema, J. M. 2008 Fate of pharmaceuticals and cosmetic ingredients during the operation of a MBR treating sewage. Desalination 221, 511-517. (doi:10.1016/j.desal.2007.01.111)
63. Roberts, P. V. & Valocchi, A. J. 1981 Principles of organic contaminant behavior during artificial recharge. Sci. Total Environ. 21, 161-172. (doi:10.1016/0048-9697 (81) 90149-2)
64. Sacher, F. & Brauch, H. J. 2000 Experiences on the fate of organic micropollutants during river bank filtration. In Understanding contaminant biogeochemistry and pathogen removal (ed. C. Ray), pp. 135-151. Dordrecht, Boston, London: Kluwer Academic Publishers.
65. Santos, J. L., Aparicio, I. & Alonso, E. 2007 Occurrence and risk assessment of pharmaceutically active compounds in wastewater treatment plants. A case study: Seville city (Spain). Environ. Int. 33, 596-601. (doi:10.1016/j.envint.2006.09.014) (Pubitemid 46507611)
66. Scheytt, T. J., Grams, S., Rejman-Rasinski, E., Heberer, Th. & Stan, H. J. 2001 Pharmaceuticals in groundwater: chlofibric acid beneath sewage farms south of Berlin, Germany. In Pharmaceuticals and personal care products in the environment. Scientific and regulatory issues (eds C. G. Daughton & T. L. Jones-Lepp). ACS Symposium Series 791. Oxford, UK: Oxford University Press.
67. Scheytt, T. J., Mersmann, P., Rejman-Rasinski, E. & These, A. 2007 Tracing pharmaceuticals in the unsaturated zone. J. Soils Sediments 7, 75-84. (doi:10.1065/jss2006.12.200) (Pubitemid 46647447)
68. Singer, A. C., Nunn, M. A., Gould, E. A. & Johnson A. C. 2007 Potential risks associated with the proposed widespread use of Tamiflu. Environ. Health Perspect. 115, 102-106.
69. Singer, A. C. et al. 2008 Meeting report: risk assessment of Tamiflu use under pandemic conditions. Environ. Health Perspect. 116, 1563-1567. (doi:10.1289/ehp. 11310)
70. Suárez, S., Carballa, M., Omil, F. & Lema, J. M. 2008 How are pharmaceutical and personal care products (PPCPs) removed from urban wastewaters? Rev. Environ. Sci. Biotechnol. 7, 125-138. (doi:10.1007/S11157-008- 9130-2)
71. Tauxe-Wuersch, A., De Alencastro, L. F., Grandjean, D. & Tarradellas, J. 2005 Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment. Water Res. 39, 1761-1772. (doi:10.1016/j. watres.2005.03.003) (Pubitemid 40719682)
72. Ternes, T. A. 1998 Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32, 3245-3260. (doi:10.1016/S0043-1354 (98) 00099-2)
73. Ternes, T. A. & Hirsch, R. 2000 Occurrence and behavior of X-ray contrast media in sewage facilities and the aquatic environment. Environ. Sci. Technol. 34, 2741-2748. (doi:10.1021/es991118m) (Pubitemid 30436978)
74. Ternes, T. A., Bonerz, M., Hermann, N., Teiser, B. & Andersen, H. R. 2007 Irrigation of treated wastewater in Braunschweig, Germany: an option to remove pharmaceuticals and musk fragrances. Chemosphere 66, 894-904. (doi:10.1016/j.chemosphere.2006.06.035) (Pubitemid 44803057)
75. Terzic, S. et al. 2008 Occurrence and fate of emerging wastewater contaminants in Western Balkan Region. Sci. Total Environ. 399, 66-77.
76. Thomas, P. M. & Foster, G. D. 2005 Tracking acidic pharmaceuticals, caffeine, and triclosan through THE wastewater treatment process. Environ. Toxicol. Chem. 24, 25-30. (doi:10.1897/04-144R.1) (Pubitemid 39658139)
77. UNODC. 2007 World Drug Report. See http://www.unodc.org/pdf/research/ wdr07/WDR-2007.pdf.
78. Verstraeten, I. M., Heberer, T. & Scheytt, T. 2002 Occurrence, characteristics and transport and fate of pesticides, pharmaceutical active compounds, and industrial and personal care products at bank-filtration sites. In Riverbank filtration improving source water quality (eds C. Ray, G. Melin & R. B. Linsky). Dordrecht, The Netherlands: Kluwer Academic Publisher.
79. Vieno, N. M., Tuhkanen, T. & Kronberg, L. 2005 Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water. Environ. Sci. Technol. 39, 8220-8226. (doi:10.1021/es051124k) (Pubitemid 41572406)
80. Vieno, N. M., Tuhkanen, T. & Kronberg, L. 2006 Analysis of neutral and basic pharmaceuticals in sewage treatment plants and in recipient rivers using solid phase extraction and liquid chromatography-tandem mass spectrometry detection. J. Chromatogr. A 1134, 101-111. (doi:10.1016/j.chroma.2006.08.077) (Pubitemid 44633934)
81. Watkinson, A. J., Murby, E. J. & Costanzo, S. D. 2007 Removal of antibiotics in conventional and advanced wastewater treatment: implications for environmental discharge and wastewater recycling. Water Res. 41, 4164-4176. (doi:10.1016/j.watres.2007.04.005) (Pubitemid 47418938)
82. Zuccato, E., Chiabrando, C., Castiglioni, S., Calamari, D., Bagnati, R., Schiarea, S. & Fanelli, R. 2005 Cocaine in surface water: a new evidence-based tool to monitor community drug abuse. Environ. Health 4, 1-7. (doi:10.1186/1476-069X-4-14) (Pubitemid 41215901)
83. Zuccato, E., Castiglioni, S., Bagnati, R., Chiabrando, C., Grassi, P. & Fanelli, R. 2008 Illicit drugs, a novel group of environmental contaminants. Water Res. 42, 961-968. (doi:10.1016/j.watres.2007.09.010) (Pubitemid 351231961)