Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the ebro river basin (northeast Spain)

Environmental Toxicology and Chemistry

Volumn 26, Issue 8, 2007, Pages 1553-1562

  Gros, Meritxell ^a   Petrović, Mira ^b   Barceló, Damià ^a  

^a DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^b INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Multiresidue analytical method; Pharmaceutical removal; Pharmaceuticals; Surface wastewater analysis

Indexed keywords

ANTIBIOTICS; LIPIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; WASTEWATER TREATMENT; WATER TREATMENT PLANTS;

ANTIINFLAMMATORIES; LIPID REGULATORS; MULTIRESIDUE ANALYTICAL METHOD; PHARMACEUTICAL REMOVAL; SURFACE/WASTEWATER ANALYSIS;

WATER POLLUTION;

ATENOLOL; AZITHROMYCIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BEZAFIBRATE; CARBAMAZEPINE; CLOFIBRIC ACID; COMPACTIN; DICLOFENAC; ERYTHROMYCIN; FAMOTIDINE; FLUOXETINE; GEMFIBROZIL; IBUPROFEN; INDOMETACIN; KETOPROFEN; LANSOPRAZOLE; LORATADINE; MACROLIDE; MEFENAMIC ACID; NAPROXEN; OFLOXACIN; PAROXETINE; PRAVASTATIN; PROPYPHENAZONE; RANITIDINE; SOTALOL; SULFAMETHOXAZOLE; TRIMETHOPRIM;

DRUG; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POLLUTANT REMOVAL; RIVER WATER; WASTE TREATMENT; WASTEWATER;

AQUATIC ENVIRONMENT; ARTICLE; HOSPITAL WASTE; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; WASTE WATER TREATMENT PLANT; WATER CONTAMINATION;

ENVIRONMENTAL MONITORING; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INDUSTRIAL WASTE; PHARMACEUTICAL PREPARATIONS; RISK ASSESSMENT; RIVERS; SEWAGE; SPAIN; WATER POLLUTANTS, CHEMICAL;

EBRO BASIN; EURASIA; EUROPE; SOUTHERN EUROPE; SPAIN;

EID: 34547945842     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/06-495R.1     Document Type: Article

References (33)

1. Daughton CG, Ternes TA. 1999. Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environ Health Perspect 107:907-938.
2. Petrovic M, Hernando MD, Díaz-Cruz MS, Barceló D. 2005. Liquid chromatography-tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: A review. J Chromatogr A 1067:1-14.
3. Kolpin D, Skopec M, Meyer M, Furlong ET, Zaugg S. 2004. Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions. Sci Total Environ 328:119-130.
4. Wiegel S, Aulinger A, Brockmeyer R, Harms H, Löffler J, Reincke H, Schmidt R, Stachel B, Tv W, Wanke A. 2004. Pharmaceuticals in the river Elbe and its tributaries. Chemosphere 57:107-126.
5. Bendz D, Paxéus NA, Ginn T, Loge FJ. 2005. Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Höje River in Sweden. J Hazard Mater 122:195-204.
6. Castiglioni S, Bagnati R, Calamari D, Fanelli R, Zucatto F, Zucatto E. 2005. A multiresidue analytical method using solid-phase extraction and high-pressure liquid chromatography tandem mass spectrometry to measure pharmaceuticals of different therapeutic classes in urban wastewaters. J Chromatogr A 1092:206-215.
7. Hao C, Lissemore L, Nguyen B, Kleywegt S, Yang P, Solomon K. 2006. Determination of pharmaceuticals in environmental waters by liquid chromatography/electrospray ionization/tandem mass spectrometry. Anal Bioanal Chem 384:505-513.
8. Brown KD, Kulis J, Thomson B, Chapman TH, Mawhinney DB. 2005. Occurrence of antibiotics in hospital, residential and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. Sci Total Environ 366:772-783.
9. Ternes T, Stumpf M, Mueller J, Haberer K, Wilken R, Servos M. 1999. Behavior and occurrence of estrogens in municipal sewage treatment plants I. Investigations in Germany, Canada, and Brazil. Sci Total Environ 225:81-90.
10. Heberer T. 2002. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: A review of recent research data. Toxicol Lett 131:5-17.
11. Lindqvist N, Tuhkanen T, Kronberg L. 2005. Occurrence of acidic pharmaceuticals in raw and treated sewages and in receiving waters. Water Res 39:2219-2228.
12. Carballa M, Omil F, Lema JM, Llompart M, Garcia-Jares C, Rodriguez I, Gomez M, Ternes T. 2004. Behaviour of pharmaceuticals, cosmetics, and hormones in sewage treatment plant. Water Res 38:2918-2926.
13. Thomas PM, Foster GD. 2004. Determination of nonsteroidal anti-inflammatory drugs, caffeine, and triclosan in wastewater by gas chromatography-mass spectrometry. J Environ Sci Health Part A 39:1969-1978.
14. Larsen TA, Lienert J, Joss A, Siegrist H. 2004. How to avoid pharmaceuticals in the aquatic environment. J Biotechnol 113:295-304.
15. Fent K, Weston AA, Caminada D. 2006. Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122-159.
16. Buser HR, Poiger T, Müller MD. 1998. Occurrence and fate of the pharmaceutical drug diclofenac in surface waters: Rapid photodegradation in a lake. Environ Sci Technol 32:3449-3456.
17. Winkler M, Lawrence JR, Neu TR. 2001. Selective degradation of ibuprofen and clofibric acid in two model river biofilm systems. Water Res 35:3197-3205.
18. Tixier C, Singer HP, Oellers S, Müller SR. 2003. Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters. Environ Sci Technol 37:1061-1068.
19. Packer JL, Werner JL, Latch DE, McNeill K, Arnold WA. 2003. Photochemical fate of pharmaceuticals in the environment: Naproxen, diclofenac, clofibric acid, and ibuprofen. Aquat Sci 65:342-351.
20. Lam MW, Mabury SA. 2005. Photodegradation of the pharmaceuticals atorvastatin, carbamazepine, levofloxacin, and sulfamethoxazole in natural waters. Aquat Sci 67:177-188.
21. Official Journal of the European Communities. 2002. Implementing council directive (96/23/EC) concerning the performance of analytical methods and the interpretation of results OJOT. Commission Decision (2002/657/EC). Brussels, Belgium.
22. Gros M, Petrovic M, Barceló D. 2006. Development of a multiresidue analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 70:678-690.
23. Ferrari B, Mons R, Vollat B, Paxeus N, Lo Giudice R, Pollio A, Garric J. 2004. Environmental risk assessment of six human pharmaceuticals: Are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment? Environ Toxicol Chem 23:1344-1354.
24. Hugget D, Brook B, Peterson B, Foran CM, Schlenk D. 2002. Toxicity of selected β-adrenergic receptor-blocking pharmaceuticals (B-blockers) on aquatic organisms. Arch Environ Contam Toxicol 43:229-235.
25. Isidori M, Lavorgna M, Nardelli A, Pascarella L, Parella A. 2005. Toxic and genotoxic evaluation of six antibiotics on nontarget organisms. Sci Total Environ 346:87-98.
26. Flaherty B, Paxeus N, Lo Giudice R, Pollio A, Garric J. 2003. Ecotoxicological impact of pharmaceuticals found in treated wastewaters: Study of carbamazepine, clofibric acid, and diclofenac. Ecotoxicol Environ Saf 55:359-370.
27. Thaker PD. 2005. Pharmaceutical data elude researchers. Environ Sci Technol 139:193A-194A.
28. Cleuvers M. 2003. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett 142:185-194.
29. Cleuvers M. 2004. Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid. Ecotoxicol Environ Saf 59:309-315.
30. Boyd GR, Reemtsma T, Grimm DA, Mitra S. 2003. Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA, and Ontario, Canada. Sci Total Environ 311:135-149.
31. Calamari D, Zucatto E, Castiglioni S, Bagnati R, Fanelli R. 2003. Strategic survey of therapeutic drugs in the Rivers Po and Lambro in Northern Italy. Environ Sci Technol 37:1241-1248.
32. Thomas PM, Foster GD. 2004. Determination of nonsteroidal anti-inflammatory drugs, caffeine, and triclosan in wastewater by gas chromatography-mass spectrometry. J Environ Sci Health Part A 39:1969-1978.
33. Quintana JB, Weiss S, Reemtsma T. 2005. Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. Water Res 39:2654-2664.