Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry

Analytical Chemistry

Volumn 78, Issue 24, 2006, Pages 8421-8429

  Castiglioni, Sara ^a,b   Zuccato, Ettore ^a   Crisci, Elisabetta ^a   Chiabrando, Chiara ^a   Fanelli, Roberte ^a   Bagnati, Renzo ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; WASTEWATER TREATMENT;

MORPHINE; MULTIPLE REACTION MONITORING; SOLID-PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

DRUG DOSAGE;

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; AMPHETAMINE; BENZOYLECGONINE; CANNABINOID; COCAINE; DEUTERIUM; ILLICIT DRUG; METHADONE; MORPHINE; MORPHINE 6 ACETATE; PYRROLIDINE DERIVATIVE; TETRAHYDROCANNABINOLIC ACID;

ANALYTIC METHOD; ARTICLE; COMPOSITE MATERIAL; CONTROLLED STUDY; DRUG ABUSE; DRUG IDENTIFICATION; DRUG USE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ITALY; MEASUREMENT; METABOLITE; POPULATION RISK; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SOCIOLOGY; SOLID PHASE EXTRACTION; SWITZERLAND; TANDEM MASS SPECTROMETRY; URBAN AREA; WASTE WATER; WASTE WATER MANAGEMENT; WATER ANALYSIS;

CHROMATOGRAPHY, LIQUID; CITIES; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEWAGE; STREET DRUGS; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

EID: 33845528593     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac061095b     Document Type: Article

References (37)

1. Cone, E. J. Forensic Sci. Int. 2001, 121, 7-15.
2. Brettell, T. A.; Butler, J. M.; Saferstein, R. Anal. Chem. 2005, 77, 3839-3860.
3. Wolff, K.; Farrell, M.; Marsden, J.; Monteiro, M. G.; Ali, R.; Welch, S.; Strang, J. Addiction 1999, 94, 1279-1298.
4. Soriano, T.; Jurado, C.; Menendez, M.; Repetto, M. J. Anal. Toxicol. 2001, 25, 137-143.
5. Lachenmeier, D. W.; Kroener, L.; Musshoff, F.; Madea, B. Rapid Commun. Mass Spectrom. 2003, 17, 472-478.
6. Preston, K. L.; Huestis, M. A.; Wong, C. J.; Umbricht, A.; Goldberger, B. A.; Cone, E. J. J. Anal. Toxicol. 1999, 23, 313-322.
7. Moeller, M. R.; Steinmeyer, S.; Kraemer, T. J. Chromatogr., B 1998, 773, 91-109.
8. Toennes, S. W.; Steinmeyer, S.; Maurer, H. J.; Moeller, M. R.; Kauert, G. F. J. Anal. Toxicol. 2005, 29, 22-27.
9. Wylie, F. M.; Torrance, H.; Anderson, R. A.; Oliver, J. S. Forensic Sci. Int. 2005, 150, 191-198.
10. Welch, M. J.; Sniegoski, L. T.; Tai, S. Anal. Bioanal. Chem. 2003, 376, 1205-1211.
11. Maurer, H. H. J. Chromatogr. 1992, 580, 3-41.
12. Maurer, H. H. J. Chromatogr., B 1998, 713, 3-25.
13. Strano-Rossi, S.; Molaioni, F.; Rossi, F.; Botre, F. Rapid Commun. Mass Spectrom. 2005, 19, 1529-1535.
14. Bourland, J. A.; Hayes, E. F.; Kelly, R. C.; Sweeney, S. A.; Hatab, M. M. J. Anal. Toxicol. 2000, 24, 489-595.
15. Gunnar, T.; Ariniemi, K.; Lillsunde, P. J. Mass Spectrom. 2005, 40, 739-753.
16. Vorce, S. P.; Sklerov, J. H.; Kalasinsky, K. S. J. Anal. Toxicol. 2000, 24, 595-601.
17. Bogusz, M. J.; Kruger, K. D.; Maier, R. D. J. Anal. Toxicol. 2000, 24, 77-84.
18. Nordgren, H. K.; Beck, O. Ther. Drug Monit. 2004, 26, 90-97.
19. Dams, R.; Murphy, C. M.; Choo, R. E.; Lambert, W. E.; De Leenheer, A. P.; Huestis, M. A. Anal. Chem. 2003, 75, 798-804.
20. Dams, R.; Murphy, C. M.; Lambert, W. E.; Huestis, M. A. Rapid Commun. Mass Spectrom. 2003, 77, 1665-1670.
21. Ministero del Lavoro e delle Politiche Sociali; Italy Drug Situation 2001; Report to the EMCDDA by the Reitox National Focal Point; www.emcdda.eu.int/index.cfm?fuseaction=public.AttachmentDownload&nNodeID= 1240&slanguageISO=EN, accessed April 2005.
22. European Monitoring Centre for Drugs and Drug Addiction; The state of the Drug Problem in the European Union and Norway, Annual Report 2003; Lisbon: EMCDDA, 2004; http://annualreport.emcdda.eu.int/en/home-en.html, accessed April 2005.
23. Zuccato, E.; Chiabrando, C.; Castiglioni, S.; Calamari, D.; Bagnati, R.; Schiarea, S.; Fanelli, R. Environ. Health 2005, 4, 14.
24. Khamsi, R. news@nature.com, 2005; http://www.nature.com/news/2005/ 050801/full/050801-12.html, accessed August 2005.
25. Ross, K. Anal. Chem. 2006, 78, 13.
26. Calamari, D.; Zuccato, E.; Castiglioni, S.; Bagnati, R.; Fanelli, R. Environ. Sci. Technol. 2003, 37, 1241-1248.
27. Castiglioni, S.; Bagnati, R.; Fanelli, R.; Calamari, D.; Zuccato, E. J. Chromatogr., A 2005, 1092, 206-215.
28. Jones-Leep, T. L.; Alvarez, D. A.; Petty, J. D.; Huckins, J. N. Arch. Environ. Contam. Toxicol. 2004, 47, 427-439.
29. Daughton, C. G. In Pharmaceuticals and Personal Care Products in the Environment: Scientific and Regulatory Issue; Daughton, C. G., Jones-Lepp, T., Eds; American Chemical Society: Washington, DC, 2001, pp 348-364; http://epa.gov/nerlesd1/chemistry/phanna/book-conclude.htm, accessed September 2004.
30. Raith, K.; Neubert, R.; Poeaknapo, C.; Boettcher, C.; Zenk, M. H.; Schmidt, J. J. Am. Soc. Mass Spectrom. 2003, 14, 1262-1269.
31. Poeaknapo, C.; Fisinger, U.; Zenk, M. H.; Schmidt, J. Phytochemistry 2004, 65, 1413-1420.
32. D'Ascenzo, G.; Di Corcia, A.; Gentili, A.; Mancini, R.; Mastropasqua, R.; Nazzari, M.; Samperi, R. Sci. Total Environ. 2003, 302, 199-209.
33. Heberer, T. Toxicol Lett. 2002, 131, 5-17.
34. Ternes, T. A. Wat. Res. 1998, 32, 3245-3260.
35. Castiglioni, S.; Bagnati, R.; Fanelli, R.; Pomati, F.; Calamari, D.; Zuccato, E. Environ. Sci. Technol. 2006, 40, 357-363.
36. Hirsch, R.; Ternes, T.; Haberer, K.; Kratz, K-L. Sci. Total Environ. 1999, 225, 109-118.
37. Metcalfe, C. D.; Koenig, B. G.; Bennie, D. T.; Servos, M.; Ternes, T. A.; Hirsch, R. Environ. Toxicol Chem. 2003, 22, 2872-2880.