STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemokine ligands and B clade serine protease inhibitors in macrophage

Parasitology Research

Volumn 105, Issue 5, 2009, Pages 1445-1453

  Ahn, Hye Jin ^a   Kim, Ji Yeon ^a   Ryu, Kyung Ju ^a   Nam, Ho Woo ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CASPASE; CCL1 CHEMOKINE; CD23 ANTIGEN; CD40 LIGAND; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR4; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; JANUS KINASE 3 INHIBITOR; LIGAND; MACROPHAGE DERIVED CHEMOKINE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 4; SERINE PROTEINASE INHIBITOR; SMALL INTERFERING RNA; STAT6 PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DAMAGE; CLADISTICS; CLUSTER ANALYSIS; ENZYME INHIBITION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYSOSOME; MACROPHAGE; MICROARRAY ANALYSIS; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TACHYZOITE; TH2 CELL; TOXOPLASMOSIS; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; CHEMOKINES, CC; HUMANS; MACROPHAGES; MONOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; SERPINS; STAT6 TRANSCRIPTION FACTOR; TH2 CELLS; TOXOPLASMA; TOXOPLASMOSIS;

TOXOPLASMA GONDII;

EID: 70349593634     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-009-1577-8     Document Type: Article

References (36)

1. HJ Ahn KJ Song ES Son JC Shin HW Nam 2001 Protease activity and host cell binding of the 42-kDa rhoptry protein from Toxoplasma gondii after secretion Biochem Biophys Res Commun 287 630 635 11563841 10.1006/bbrc.2001.5637 1:CAS:528:DC%2BD3MXmvV2jsLs%3D (Pubitemid 32912760)
2. HJ Ahn JY Kim HW Nam 2009 IL-4 independent nuclear translocalization of STAT6 in HeLa cells by entry of Toxoplasma gondii Korean J Parasitol 47 117 124 19488417 10.3347/kjp.2009.47.2.117 1:CAS:528:DC%2BD1MXosVeksro%3D
3. SK Bliss AJ Marshall Y Zhang EY Denkers 1999 Human polymorphonuclear leukocytes produce IL-12, TNF-α, and the chemokines macrophage- inflammatory protein-1a and 1b in response to Toxoplasma gondii antigens J Immunol 162 7369 7375 10358188 1:CAS:528:DyaK1MXktF2htLw%3D
4. BA Butcher L Kim PF Johnson EY Denkers 2001 Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NFkB J Immunol 167 2193 2201 11490005 1:CAS:528:DC%2BD3MXlvFequ7k%3D
5. BA Butcher L Kim AD Panopoulos SS Watowich PJ Murray EY Denkers 2005 Cutting edge: IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-α in host macrophages J Immunol 174 3148 3152 15749841 1:CAS:528:DC%2BD2MXitVeiurc%3D
6. D Buzoni-Gatel JF Dubremetz C Werts 2008 Manipulation du systeme immunitaire par le parasite Toxoplasma gondii Medicine/Sciences 24 191 196
7. V Calo M Migliavacca V Bazan M Macaluso M Buscemi N Gebbia A Russo 2003 STAT proteins: from normal control of cellular events to tumorigenesis J Cell Physiol 197 157 168 14502555 10.1002/jcp.10364 1:CAS:528:DC%2BD3sXntlKkt7k%3D (Pubitemid 37485244)
8. ACL Chaves IP Ceravolo JAS Gomes CL Zani AJ Romanha RT Gazzinelli 2001 IL-4 and IL-13 regulate the induction of indoleamine 2,3-dioxygenase activity and the control of Toxoplasma gondii replication in human fibroblasts activated with IFN-γ Eur J Immunol 31 333 344 11180096 10.1002/1521-4141(200102)31: 2<333::AID-IMMU333>3.0.CO;2-X 1:CAS:528:DC%2BD3MXhs1Kksrk%3D (Pubitemid 32166586)
9. CM Collazo GS Yap GD Sempowski KC Lusby L Tessarollo GF Vande Woude A Sher GA Taylor 2001 Inactivation of LRG-47 and IRG-47 reveals a family of interferon-γ-inducible genes with essential, pathogen-specific roles in resistance to infection J Exp Med 194 181 187 11457893 10.1084/jem.194.2.181 1:CAS:528:DC%2BD3MXlsVCksbY%3D (Pubitemid 32673351)
10. CM Collazo GS Yap S Hieny P Caspar CG Feng GA Taylor A Sher 2002 The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is STAT1 dependent and requires expression in both hematopoietic and non-hematopoietic cellular compartments Infect Immun 70 6933 6939 12438372 10.1128/IAI.70.12.6933-6939.2002 1:CAS:528: DC%2BD38XptVyhsr0%3D (Pubitemid 35387928)
11. EY Denker 2003 From cells to signaling cascades: manipulation of innate immunity by Toxoplasma gondii FEMS Immunol Med Microbiol 39 193 203 10.1016/S0928-8244(03)00279-7 (Pubitemid 37456834)
12. F Durand MP Brenier-Pinchart F Berger PN Marche R Grillot H Pelloux 2004 Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC chemokine ligand-2 (CCL-2) by human astrocytes during infection with Toxoplasma gondii Parasite Immunol 26 419 422 15752119 10.1111/j.0141-9838.2004.00722.x 1:CAS:528:DC%2BD2MXjtFWhsbw%3D (Pubitemid 40364837)
13. RT Gazzinelli S Hieny T Wynn S Wolf A Sher 1993 IL-12 is required for the T-cell independent induction of IFN-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts Proc Natl Acad Sci U S A 90 6115 6119 8100999 10.1073/pnas.90.13.6115 1:CAS:528:DyaK3sXkvFent7w%3D
14. S Goebel U Gross CGK Luder 2001 Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alteration of poly(ADP-ribose) polymerase expression J Cell Sci 114 3495 3505 11682609 1:CAS:528:DC%2BD3MXotVSqtLg%3D
15. C Guiter I Dusanter-Fourt C Copie-Bergman ML Boulland S Gouvello P Gaulard K Leroy F Castellano 2004 Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma Blood 104 543 549 15044251 10.1182/blood-2003-10-3545 1:CAS:528:DC%2BD2cXlvFSmsrg%3D (Pubitemid 38900039)
16. D Jin M Takamoto T Hu S Taki K Sugane 2009 STAT6 signaling is important in CD8+ T-cell activation and defence against Toxoplasma gondii infection in the brain Immunology 127 187 195 18795973 10.1111/j.1365-2567.2008.02935.x 1:CAS:528:DC%2BD1MXmsFSqu7c%3D
17. S Koenen-Waisman JC Howard 2007 Cell-autonomous immunity to Toxoplasma gondii in mouse and man Microbes Infect 9 1652 1661 10.1016/j.micinf.2007.09.005 1:CAS:528:DC%2BD2sXhsVCjt7nO (Pubitemid 350217084)
18. N Kozma M Halsz B Polgar TG Poehlmann UR Markert T Palkovics M Keszei M Par K Kiss J Szeberenyi L Grama J Szekeres-Bartho 2006 Progesterone-induced blocking factor activates STAT6 via binding to a novel IL-4 receptor J Immunol 176 819 826 16393965 1:CAS:528:DC%2BD28Xht1Cqug%3D%3D
19. J Laliberte VB Carruthers 2008 Host cell manipulation by the human pathogen Toxoplasma gondii Cell Mol Life Sci 65 1900 1915 18327664 10.1007/s00018-008-7556-x 1:CAS:528:DC%2BD1cXnsVSntL0%3D
20. AA Lighvani DM Frucht D Jankovie H Yamane J Aliberti BD Hissong BV Nguyen M Gadina A Sher WE Paul JJ O'Shea 2001 T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells Proc Natl Acad Sci U S A 98 15137 15142 11752460 10.1073/pnas.261570598 1:CAS:528:DC%2BD38XpsVWl (Pubitemid 34013982)
21. Z Liu G Kharmate E Patterson MM Khan 2006 Role of H1 receptors in histamine-mediated up-regulation of STAT4 phosphorylation Int Immunopharmacol 6 485 493 16428084 10.1016/j.intimp.2005.09.014 1:CAS:528:DC%2BD28Xls1Wmug%3D%3D (Pubitemid 43120463)
22. CGK Luder M Algner C Lang N Bleicher U Gross 2003 Reduced expression of the inducible nitric oxide synthase after infection with Toxoplasma gondii facilitates parasite replication in activated murine macrophages Int J Parasitol 33 833 844 12865083 10.1016/S0020-7519(03)00092-4 1:CAS:528: DC%2BD3sXlsVWks7g%3D (Pubitemid 36831007)
23. JD MacMicking 2004 IFN-inducible GTPases and immunity to intracellular pathogens Trends Immunol 25 601 609 15489189 10.1016/j.it.2004.08.010 1:CAS:528:DC%2BD2cXos1aqtLw%3D (Pubitemid 39369737)
24. S Martens I Parvanova J Zerrahn G Griffiths G Schell G Reichmann JC Howard 2005 Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases PLoS Pathog 1 187 201 10.1371/journal.ppat.0010024 1:CAS:528:DC%2BD2MXht1Kqs73K
25. AF McGettrick RC Barnes DM Worrall 2001 SCCA2 inhibits TNF-mediated apoptosis in transfected HeLa cells. The reactive centre loop sequence is essential for this function and TNF-induced cathepsin G is a candidate target Eur J Biochem 268 5868 5875 11722574 10.1046/j.0014-2956.2001.02535.x 1:CAS:528:DC%2BD3MXosFymsLg%3D (Pubitemid 33079322)
26. R Ray M Choi Z Zhang GA Silverman D Askew AB Mukherjee 2005 Uteroglobin suppresses SCCA gene expression associated with allergic asthma J Biol Chem 280 9761 9764 15677460 10.1074/jbc.C400581200 1:CAS:528:DC%2BD2MXit1ertLY%3D (Pubitemid 40395819)
27. S Romagnani 2002 Cytokines and chemoattractants in allergic inflammation Mol Immunol 38 881 885 12009564 10.1016/S0161-5890(02)00013-5 1:CAS:528:DC%2BD38XjsFClt7g%3D (Pubitemid 34496945)
28. R Rutschman R Lang M Hesse JN Ihle TA Wynn PJ Murray 2001 Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production J Immunol 166 2173 2177 11160269 1:CAS:528:DC%2BD3MXht1Gitrs%3D
29. JP Saeij S Coller JP Boyle ME Jerome MW White JC Boothroyd 2007 Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue Nature 445 324 327 17183270 10.1038/nature05395 1:CAS:528: DC%2BD2sXmt1Kisw%3D%3D (Pubitemid 46122820)
30. CW Schindler 2002 JAK-STAT signaling in human disease J Clin Invest 109 1133 1137 11994400 1:CAS:528:DC%2BD38XjsFalsL4%3D
31. NM Silva CV Rodrigues MM Santoro LF Reis JI Alvarez-Leite RT Gazzinelli 2002 Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1 Infect Immun 70 859 868 11796621 10.1128/IAI.70.2.859-868.2002 1:CAS:528:DC%2BD38XoslyitA%3D%3D (Pubitemid 34083850)
32. GA Silverman JC Whisstock DJ Askew SC Pak CJ Luke S Cataltepe JA Irving PI Bird 2004 Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis Cell Mol Life Sci 61 301 325 14770295 10.1007/s00018-003-3240-3 1:CAS:528:DC%2BD2cXjt1yhtb4%3D (Pubitemid 38228416)
33. WM Sohn HW Nam 1999 Western blot analysis of stray cat sera against Toxoplasma gondii and the diagnostic availability of monoclonal antibodies in sandwich-ELISA Korean J Parasitol 37 249 256 10634041 10.3347/kjp.1999.37.4.249 1:STN:280:DC%2BD3c%2FpvFymug%3D%3D
34. Y Suminami S Nagashima NL Vuyanovic K Hirabayashi H Kato TL Whiteside 2000 Inhibition of apoptosis in human tumor cells by the tumor-associated serpin, SCC antigen-1 Br J Cancer 82 981 989 10732775 10.1054/bjoc.1999.1028 1:CAS:528:DC%2BD3cXhs1yhtbk%3D
35. T Welss J Sun JA Irving R Blum AI Smith JC Whisstock RN Pike A von Mikecz T Ruzicka PI Bird HF Abts 2003 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis Biochemistry 42 7381 7389 12809493 10.1021/bi027307q 1:CAS:528: DC%2BD3sXkt1Clt7s%3D (Pubitemid 36735816)
36. AL Wurster DJ Whiters T Uchida MF White MJ Grusby 2002 Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis Mol Cell Biol 22 117 126 11739727 10.1128/MCB.22.1.117-126.2002 1:CAS:528:DC%2BD3MXptlOitbs%3D (Pubitemid 33144261)