Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC chemokine ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii

Parasite Immunology

Volumn 26, Issue 10, 2004, Pages 419-422

  Durand, François ^a   Brenier Pinchart, Marie Pierre ^a   Berger, Francois ^b   Marche, Patrice N ^c   Grillot, Renée ^a   Pelloux, Hervé ^a  

^a UNIV GRENOBLE ALPES   (France)

^b INSERM   (France)

^c CEA GRENOBLE   (France)

Author keywords

CCL 2; Human astrocytes; IFN ; Phosphatidylcholine specific phospholipase C; Toxoplasma gondii

Indexed keywords

GAMMA INTERFERON; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHOLIPASE C; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE;

ARTICLE; ASTROCYTE; ASTROCYTOMA; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RIBONUCLEASE PROTECTION ASSAY; TOXOPLASMA GONDII; TOXOPLASMOSIS;

TOXOPLASMA GONDII;

EID: 14944348959     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0141-9838.2004.00722.x     Document Type: Article

References (16)

1. Ambroise-Thomas P. Parasitic diseases and immunodeficiencies. Parasitology 2001; 122: 65-71.
2. Frenkel JK, Nelson BM & Arias-Stella B. Immunosuppression and toxoplasmic encephalitis: clinical and experimental aspects. Hum Pathol 1975; 6: 97-111.
3. Hunter CA & Remington JS. Immunopathogenesis of toxoplasmic encephalitis. J Infect Dis 1994; 170: 1057-1067.
4. Porter SB & Sande M. Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome. N Engl J Med 1992; 327: 1643-1648.
5. Suzuki Y. Host resistance in the brain against Toxoplasma gondii. J Infect Dis 2002; 185: 58-65.
6. Halonen SK, Lyman WD & Chiu FC. Growth and development of Toxoplasma gondii in human neurons and astrocytes. J Neuropathol Exp Neurol 1996; 55: 1150-1156.
7. Fagard R, Van Tan H, Creuzet C & Pelloux H. Differential development of Toxoplasma gondii in neural cells. Parasitol Today 1999; 15: 504-507.
8. Schlüter D, Deckert M, Hof H & Frei K. Toxoplasma gondii infection of neurons induces neuronal cytokine and chemokine production, but gamma interferon- and tumor necrosis factor-stimulated neurons fail to inhibit the invasion and growth of Toxoplasma gondii. Infect Immun 2001; 69: 7889-7893.
9. Strack A, Asensio VC, Campbell IL, Schlüter D & Deckert M. Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-γ. Acta Neuropathol 2002; 103: 458-468.
10. Brenier-Pinchart MP, Blanc-Gonnet E, Marche PN, et al. Infection of human astrocytes and glioblastoma cells with Toxoplasma gondii: monocyte chemotactic protein-1 secretion and chemokine expression in vitro. Acta Neuropathol 2004; 107: 245-249.
11. Amtmann E. The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drug Exp Clin Res 1996; 22: 287-294.
12. Goebeler M, Gillitzer R, Kilian K, et al. Multiple signaling pathways regulate NF-kB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells. Blood 2001; 97: 46-55.
13. Ricard J, Pelloux H, Gross U, Meunier A & Ambroise-Thomas P. Induction of Toxoplasma gondii cystogenesis and multiplication arrest by treatments with a phosphatidylcholine-specific phospholipase C inhibitor. J Parasitol 1999; 85: 583-585.
14. Ricard J, Pelloux H, Favier AL, Gross U, Brambilla E & Ambroise-Thomas P. Toxoplasma gondii: role of the phosphatidylcholine-specific phospholipase C during cell invasion and intracellular development. Exp Parasitol 1999; 91: 231-237.
15. Denney CF, Eckmann L & Reed SL. Chemokine secretion of human cells in response to Toxoplasma gondii infection. Infect Immun 1999; 67: 1547-1552.
16. Mennechet FJ, Kasper LH, Rachinel N, Wen L, Vandewalle A & Buzoni-Gatel D. Lamina propria CD4+ T lymphocytes synergize with murine intestinal epithelial cells to enhance proinflammatory response against an intracellular pathogen. J Immunol 2002; 168: 2988-2996.