Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain

Human Molecular Genetics

Volumn 18, Issue 20, 2009, Pages 3894-3905

  Zhang, Yi ^a,b   Chen, Di ^a,b   Wang, Zhaohui ^a  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; DECAPENTAPLEGIC PROTEIN; LONG CHAIN FATTY ACID COENZYME A LIGASE; LONG CHAIN FATTY ACID COENZYME A LIGASE 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN DAMAGE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CONSERVATION; GLIA CELL; HUMAN; LARVAL STAGE; LETHALITY; LIPID STORAGE; MALE; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NEUROPATHOLOGY; NONHUMAN; OPTIC LOBE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; VISUAL CORTEX; WILD TYPE; X LINKED MENTAL RETARDATION;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; COENZYME A LIGASES; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; MENTAL RETARDATION, X-LINKED; MOLECULAR SEQUENCE DATA; OPTIC LOBE, NONMAMMALIAN; SEQUENCE ALIGNMENT; VISUAL PERCEPTION;

EID: 70349575757     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp332     Document Type: Article

References (50)

1. Soupene, E. and Kuypers, F.A. (2008) Mammalian long-chain acyl-CoA synthetases. Exp. Biol. Med. (Maywood), 233, 507-521.
2. Black, P.N., Zhang, Q., Weimar, J.D. and DiRusso, C.C. (1997) Mutational analysis of a fatty acyl-coenzyme A synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. J. Biol. Chem., 272, 4896-4903.
3. Coleman, R.A., Lewin, T.M., Van Horn, C.G. and Gonzalez-Baro, M.R. (2002) Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways? J. Nutr., 132, 2123-2126.
4. Longo, I., Frints, S.G., Fryns, J.P., Meloni, I., Pescucci, C., Ariani, F., Borghgraef, M., Raynaud, M., Marynen, P., Schwartz, C. et al. (2003) A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: Proposal of a rapid enzymatic assay for screening mentally retarded patients. J. Med. Genet., 40, 11-17.
5. Meloni, I., Muscettola, M., Raynaud, M., Longo, I., Bruttini, M., Moizard, M.P., Gomot, M., Chelly, J., des Portes, V., Fryns, J.P. et al. (2002) FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Nat. Genet., 30, 436-440.
6. Piccini, M., Vitelli, F., Bruttini, M., Pober, B.R., Jonsson, J.J., Villanova, M., Zollo, M., Borsani, G., Ballabio, A. and Renieri, A. (1998) FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation. Genomics, 47, 350-358.
7. Renieri, A., Pescucci, C., Longo, I., Ariani, F., Mari, F. and Meloni, I. (2005) Non-syndromic X-linked mental retardation: From a molecular to a clinical point of view. J. Cell Physiol., 204, 8-20.
8. Meloni, I., Parri, V., De Filippis, R., Ariani, F., Artuso, R., Bruttini, M., Katzaki, E., Longo, I., Mari, F., Bellan, C. et al. (2009) The XLMR gene ACSL4 plays a role in dendritic spine architecture. Neuroscience, 159, 657-669.
9. Cao, Y., Traer, E., Zimmerman, G.A., McIntyre, T.M. and Prescott, S.M. (1998) Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4). Genomics, 49, 327-330.
10. Cao, Y., Murphy, K.J., McIntyre, T.M., Zimmerman, G.A. and Prescott, S.M. (2000) Expression of fatty acid-CoA ligase 4 during development and in brain. FEBS Lett., 467, 263-267.
11. Bilen, J. and Bonini, N.M. (2005) Drosophila as a model for human neurodegenerative disease. Annu. Rev. Genet., 39, 153-171.
12. Cauchi, R.J. and van den Heuvel, M. (2006) The fly as a model for neurodegenerative diseases: Is it worth the jump? Neurodegener. Dis. 3, 338-356.
13. Lu, B. and Vogel, H. (2009) Drosophila models of neurodegenerative diseases. Annu. Rev. Pathol., 4, 315-342.
14. Broadie, K. and Pan, L. (2005) Translational complexity of the fragile X mental retardation protein: Insights from the fly. Mol. Cell, 17, 757-759.
15. Reeve, S.P., Bassetto, L., Genova, G.K., Kleyner, Y., Leyssen, M., Jackson, F.R. and Hassan, B.A. (2005) The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr. Biol., 15, 1156-1163.
16. Zarnescu, D.C., Shan, G., Warren, S.T. and Jin, P. (2005) Come FLY with us: Toward understanding fragile X syndrome. Genes. Brain. Behav., 4, 385-392.
17. Jin, P., Duan, R., Qurashi, A., Qin, Y., Tian, D., Rosser, T.C., Liu, H., Feng, Y. and Warren, S.T. (2007) Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome. Neuron, 55, 556-564.
18. Sofola, O.A., Jin, P., Qin, Y., Duan, R., Liu, H., de Haro, M., Nelson, D.L. and Botas, J. (2007) RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS. Neuron, 55, 565-571.
19. Chang, S., Bray, S.M., Li, Z., Zarnescu, D.C., He, C., Jin, P. and Warren, S.T. (2008) Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat. Chem. Biol., 4, 256-263.
20. Tessier, C.R. and Broadie, K. (2008) Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development, 135, 1547-1557.
21. Gutierrez, E., Wiggins, D., Fielding, B. and Gould, A.P. (2007) Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature, 445, 275-280.
22. Yoshida, S., Soustelle, L., Giangrande, A., Umetsu, D., Murakami, S., Yasugi, T., Awasaki, T., Ito, K., Sato, M. and Tabata, T. (2005) DPP signaling controls development of the lamina glia required for retinal axon targeting in the visual system of Drosophila. Development, 132, 4587-4598.
23. Poeck, B., Fischer, S., Gunning, D., Zipursky, S.L. and Salecker, I. (2001) Glial cells mediate target layer selection of retinal axons in the developing visual system of Drosophila. Neuron, 29, 99-113.
24. Suh, G.S., Poeck, B., Chouard, T., Oron, E., Segal, D., Chamovitz, D.A. and Zipursky, S.L. (2002) Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells. Neuron, 33, 35-46.
25. Dearborn, R. Jr and Kunes, S. (2004) An axon scaffold induced by retinal axons directs glia to destinations in the Drosophila optic lobe. Development, 131, 2291-2303.
26. Chotard, C. and Salecker, I. (2007) Glial cell development and function in the Drosophila visual system. Neuron. Glia. Biol., 3 17-25.
27. Kaphingst, K. and Kunes, S. (1994) Pattern formation in the visual centers of the Drosophila brain: Wingless acts via decapentaplegic to specify the dorsoventral axis. Cell, 78, 437-448.
28. Chu, T., Chiu, M., Zhang, E. and Kunes, S. (2006) A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain. Dev. Cell, 10, 635-646.
29. Huang, Z. and Kunes, S. (1998) Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly. Development, 125, 3753-3764.
30. Kunes, S. (2000) Axonal signals in the assembly of neural circuitry. Curr. Opin. Neurobiol., 10, 58-62.
31. Franch-Marro, X., Wendler, F., Griffith, J., Maurice, M.M. and Vincent, J.P. (2008) In vivo role of lipid adducts on wingless. J. Cell Sci., 121, 1587-1592.
32. Zhai, L., Chaturvedi, D. and Cumberledge, S. (2004) Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine. J. Biol. Chem., 279 33220-33227.
33. Hausmann, G., Banziger, C. and Basler, K. (2007) Helping Wingless take flight: How WNT proteins are secreted. Nat. Rev. Mol. Cell Biol., 8, 331-336.
34. Panakova, D., Sprong, H., Marois, E., Thiele, C. and Eaton, S. (2005) Lipoprotein particles are required for Hedgehog and wingless signalling. Nature, 435, 58-65.
35. Charron, F. and Tessier-Lavigne, M. (2005) Novel brain wiring functions for classical morphogens: A role as graded positional cues in axon guidance. Development, 132, 2251-2262.
36. Galceran, J., Miyashita-Lin, E.M., Devaney, E., Rubenstein, J.L. and Grosschedl, R. (2000) Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development, 127, 469-482.
37. Lee, S.M., Tole, S., Grove, E. and McMahon, A.P. (2000) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development, 127, 457-467.
38. Shimogori, T., Banuchi, V., Ng, H.Y., Strauss, J.B. and Grove, E.A. (2004) Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex. Development, 131, 5639-5647.
39. Zhao, C., Aviles, C., Abel, R.A., Almli, C.R., McQuillen, P. and Pleasure, S.J. (2005) Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Development, 132, 2917-2927.
40. Song, Y., Chung, S. and Kunes, S. (2000) Combgap relays wingless signal reception to the determination of cortical cell fate in the Drosophila visual system. Mol. Cell, 6, 1143-1154.
41. Carrel, L. and Willard, H.F. (2005) X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434, 400-404.
42. Franco, B. and Ballabio, A. (2006) X-inactivation and human disease: X-linked dominant male-lethal disorders. Curr. Opin. Genet. Dev., 16, 254-259.
43. Min, K.T. and Benzer, S. (1999) Preventing neurodegeneration in the Drosophila mutant bubblegum. Science, 284, 1985-1988.
44. Blackman, R.K., Sanicola, M., Raftery, L.A., Gillevet, T. and Gelbart, W.M. (1991) An extensive 3′ cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-beta family in Drosophila. Development, 111, 657-666.
45. Dietzl, G., Chen, D., Schnorrer, F., Su, K.C., Barinova, Y., Fellner, M., Gasser, B., Kinsey, K., Oppel, S., Scheiblauer, S. et al. (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature, 448, 151-156.
46. Lee, Y.S. and Carthew, R.W. (2003) Making a better RNAi vector for Drosophila: Use of intron spacers. Methods, 30, 322-329.
47. Tautz, D. and Pfeifle, C. (1989) A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma, 98, 81-85.
48. Li, C.Y., Guo, Z. and Wang, Z. (2007) TGFbeta receptor saxophone non-autonomously regulates germline proliferation in a Smox/ dSmad2-dependent manner in Drosophila testis. Dev. Biol., 309, 70-77.
49. Gronke, S., Beller, M., Fellert, S., Ramakrishnan, H., Jackle, H. and Kuhnlein, R.P. (2003) Control of fat storage by a Drosophila PAT domain protein. Curr. Biol., 13, 603-606.
50. Mourikis, P., Hurlbut, G.D. and Artavanis-Tsakonas, S. (2006) Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila. Proc. Natl Acad. Sci. USA, 103, 1307-1312.