Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 10, 2009, Pages 4917-4925

  Maeda, Tadao ^a   Maeda, Akiko ^a   Matosky, Melissa ^a   Okano, Kiichiro ^a   Roos, Satsumi ^a   Tang, Johnny ^a,b   Palczewski, Krzysztof ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 CIS RETINYL ACETATE; ABC TRANSPORTER; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; ATP BINDING CASSETTE TRANSPORTER 4; BUTYLCRESOL; IMMUNOSUPPRESSIVE AGENT; MANGANESE TETRAKIS (4 BENZOIC ACID) PORPHYRIN; RAPAMYCIN; RETINOL DEHYDROGENASE; RETINOL DEHYDROGENASE 8; RETINYLAMINE; THIOCTIC ACID; UNCLASSIFIED DRUG; A2E COMPOUND; ABCA4 PROTEIN, MOUSE; ALCOHOL DEHYDROGENASE; DITERPENE; DRUG DERIVATIVE; PYRIDINIUM DERIVATIVE; RDH8 PROTEIN, MOUSE; RETINOID; RETINOL; RETINOL ACETATE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DRUG EFFICACY; ELECTRORETINOGRAM; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINA CONE; RETINA DEGENERATION; RETINA MACULA AGE RELATED DEGENERATION; RETINA ROD; SUBRETINAL NEOVASCULARIZATION; TREATMENT DURATION; TREATMENT RESPONSE; ANIMAL; BAGG ALBINO MOUSE; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; DARK ADAPTATION; ELECTRORETINOGRAPHY; FLUORESCENCE ANGIOGRAPHY; GENETICS; LIGHT; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RETINA; RETINA MACULA DEGENERATION;

ALCOHOL OXIDOREDUCTASES; ANIMALS; ANTIOXIDANTS; ATP-BINDING CASSETTE TRANSPORTERS; DARK ADAPTATION; DITERPENES; ELECTRORETINOGRAPHY; FEMALE; FLUORESCEIN ANGIOGRAPHY; IMMUNOSUPPRESSIVE AGENTS; LIGHT; MACULAR DEGENERATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; PYRIDINIUM COMPOUNDS; RADIATION INJURIES, EXPERIMENTAL; RETINA; RETINOIDS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VITAMIN A;

EID: 70349567390     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3581     Document Type: Article

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