The effects of NMDA receptor antagonists over intestinal ischemia/reperfusion injury in rats

European Journal of Pharmacology

Volumn 621, Issue 1-3, 2009, Pages 78-85

  Cámara Lemarroy, Carlos Rodrigo ^a   Guzmán de la Garza, Francisco Javier ^a   Alarcón Galván, Gabriela ^b   Cordero Pérez, Paula ^c   Fernández Garza, Nancy Esthela ^a  

^a Medicina UANL   (Mexico)

^b HOSPITAL UNIVERSITARIO DR JOSÉ ELEUTERIO GONZÁLEZ   (Mexico)

^c UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

Author keywords

Intestine; Ischemia reperfusion; Ketamine; Memantine; NMDA (N methyl d aspartate)

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTITHROMBIN III; ASPARTATE AMINOTRANSFERASE; KETAMINE; LACTATE DEHYDROGENASE; MALONALDEHYDE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; DEFECATION; HISTOPATHOLOGY; INJURY SEVERITY; INTESTINE INJURY; INTESTINE ISCHEMIA; INTESTINE MOTILITY; INTESTINE TRANSIT TIME; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 70349487037     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.08.038     Document Type: Article

References (71)

1. Albrecht-Goepfert E., Schempp H., and Elstner E.F. Modulation of the production of reactive oxygen species by pre-activated neutrophils by aminoadamantane derivatives. Biochem. Pharmacol. 56 (1998) 141-152
2. Arumugam T.V., Arnold N., Proctor L.M., Newman M., Reid R.C., Hansford K.A., Fairlie D.P., Shiels I.A., and Taylor S.M. Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. Br. J. Pharmacol. 140 (2003) 71-80
3. Atkinson P.M., Taylor D.I., and Chetty N. Inhibition of platelet aggregation by ketamine hydrochloride. Thromb. Res. 40 (1985) 227-234
4. Bakiri Y., Hamilton N.B., Káradóttir R., and Attwell D. Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter. Glia 56 (2008) 233-240
5. Ballabeni V., Barocelli E., Bertoni S., and Impicciatore M. Alterations of intestinal motor responsiveness in a model of mild mesenteric ischemia/reperfusion in rats. Life Sci. 71 (2002) 2025-2035
6. Beilin B., Rusabrov Y., Shapira Y., Roytblat L., Greemberg L., Yardeni I.Z., and Bessler H. Low-dose ketamine affects immune responses in humans during the early postoperative period. Br. J. Anaesth. 99 (2007) 522-527
7. Ben-Abraham R., Guttman M., Flaishon R., Marouani N., Niv D., and Weinbroum A.A. Mesenteric artery clamping/unclamping-induced acute lung injury is attenuated by N-methyl-d-aspartate antagonist dextromethorphan. Lung 184 (2006) 309-317
8. Bolton C., and Paul C. Glutamate receptors in neuroinflammatory demyelinating disease. Mediat. Inflamm. (2006) 1-12
9. Caǧlayan F., Caǧlayan O., Gunel E., Elcuman Y., and Cakmak M. Intestinal ischemia-reperfusion and plasma enzyme levels. Pediatr. Surg. Int. 18 (2002) 255-257
10. Calcina F., Barocelli E., Bertoni S., Furukawa O., Kaunitz J., Impicciatore M., and Sternini C. Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia/reperfusion in rats. Neuroscience 134 (2005) 39-49
11. Camara C.R., Guzman F.J., Barrera E.A., Cabello A.J., Garcia A., Fernandez N.E., Caballero E., and Ancer J. Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats. World J. Gastroenterol. 14 (2008) 5192-5196
12. Carter Y.M., Gelman A.E., and Kreisel D. Pathogenesis, management, and consequences of primary graft dysfunction. Semin. Thorac. Cardiovasc. Surg. 20 (2008) 165-172
13. Chang Y., Chen T.L., Wu G.J., Hsiao G., Shen M.Y., Lin K.H., Chou D.S., Lin C.H., and Sheu J.R. Mechanisms involved in the antiplatelet activity of ketamine in human platelets. J. Biomed. Sci. 11 (2004) 764-772
14. Chang J.X., Chen S., Ma L.P., Jiang L.Y., Chen J.W., Chang R.M., Wen L.Q., Wu W., Jiang Z.P., and Huang Z.T. Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock. World J. Gastroenterol. 11 (2005) 5485-5491
15. Chang R.W., Chang J.B., and Longo W.E. Update in management of mesenteric ischemia. World J. Gastroenterol. 12 (2006) 3243-3247
16. Chang Y.C., Kim H.W., Rapoport S.I., and Rao J.S. Chronic NMDA administration increases neuroinflammatory markers in rat frontal cortex: cross-talk between excitotoxicity and neuroinflammation. Neurochem. Res. 33 (2008) 2318-2323
17. Chiu C.J., McArdle A.H., Brown R., Scott H.J., and Gurd F.N. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch. Surg. 101 (1970) 478-483
18. Davis J.M., Gute D.C., Jones S., Krsmanovic A., and Korthuis R.J. Ischemic preconditioning prevents postischemic p-selectin expression in the rat small intestine. Am. J. Physiol. 277 (1999) 2476-2481
19. Dogan A., Eras M.A., Rao V.L., and Dempsey R.J. Protective effects of memantine against ischemia-reperfusion injury in spontaneously hypertensive rats. Acta Neurochir. (Wien) 141 (1999) 1107-1113
20. Fábrega E., Casafont F., Merino J., de la Peña J., Crespo J., Amado J.A., and Pons-Romero F. Value of plasma p-selectin for vascular complications in liver transplantation. Clin. Transplant. 10 (1996) 261-265
21. Görgülü A., Kinş T., Cobanoglu S., Unal F., Izgi N.I., Yanik B., and Küçük M. Reduction of edema and infarction by memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat. Acta Neurochir. (Wien) 142 (2000) 1287-1292
22. Grotz M.R., Deitch E.A., Ding J., Xu D., Huang Q., and Regel G. Intestinal cytokine response after gut ischemia: role of gut barrier failure. Ann. Surg. 229 (1999) 478-486
23. Haglund U., Bulkley G.B., and Granger D.N. On the pathophysiology of intestinal ischemic injury. Clinical review. Acta Chir. Scand. 153 (1987) 321-324
24. Hayward R., and Lefer A.M. Acute mesenteric ischemia and reperfusion: protective effects of recombinant soluble p-selectin glycoprotein ligand-1. Shock 12 (1999) 201-207
25. Himmelseher S., and Durieux M.E. Revising a dogma: ketamine for patients with neurological injury?. Anesth. Analg. 101 (2005) 524-553
26. Ji Q., Zhang L., Jia H., and Xu J. Pentoxifylline inhibits endotoxin-induced NF-kappa B activation and associated production of proinflammatory cytokines. Ann. Clin. Lab. Sci. 34 (2004) 427-436
27. Kato R., and Foëx P. Myocardial protection by anesthetic agents against ischemia-reperfusion injury: an update for anesthesiologists. Can. J. Anaesth. 49 (2002) 777-791
28. Kawasaki T., Ogata M., Kawasaki C., Ogata J., Inoue Y., and Shigematsu A. Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth. Analg. 89 (1999) 665-669
29. Kirchgessner A.L., Liu M.T., and Alcantara F. Excitotoxicity in the enteric nervous system. J. Neurosci. 17 (1997) 8804-8816
30. Krizbai I.A., Deli M.A., Pestenácz A., Siklós L., Szabó C.A., András I., and Joó F. Expression of glutamate receptors on cultured cerebral endothelial cells. J. Neurosci. Res. 54 (1998) 814-819
31. Kubes P. The role of adhesion molecules and nitric oxide in intestinal and hepatic ischemia/reperfusion. Hepatogastroenterology 46 (1999) 1458-1463
32. Lee H.T., Ota-Setlik A., Fu Y., Nasr S.H., and Emala C.W. Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo. Anesthesiology 101 (2004) 1313-1324
33. Linhares G.K., Martins J.L., Fontanezzi F., Patrício F.dosR., and Montero E.F. Do lesions of the enteric nervous system occur following intestinal ischemia/reperfusion?. Acta Cir. Bras. 22 (2007) 120-124
34. Liu M.T., Rothstein J.D., Gershon M.D., and Kirchgessner A.L. Glutamatergic enteric neurons. J. Neurosci. 17 (1997) 4764-4784
35. Lupp A., Kerst S., Karge E., Quack G., and Klinger W. Investigation on possible antioxidative properties of the NMDA-receptor antagonists ketamine, memantine, and amantadine in comparison to nicanartine in vitro. Exp. Toxicol. Pathol. 50 (1998) 501-506
36. Lupp A., Kerst S., and Karge E. Evaluation of possible pro- or antioxidative properties and of the interaction capacity with the microsomal cytochrome P450 system of different NMDA-receptor ligands and of taurine in vitro. Exp. Toxicol. Pathol. 54 (2003) 441-448
37. Lush C.W., Cepinskas G., and Kvietys P.R. Regulation of intestinal nuclear factor-kappaB activity and E-selectin expression during sepsis: a role for peroxynitrite. Gastroenterology 124 (2003) 118-128
38. McRoberts J.A., Coutinho S.V., Marvizón J.C., Grady E.F., Tognetto M., Sengupta J.N., Ennes H.S., Chaban V.V., Amadesi S., Creminon C., Lanthorn T., Geppetti P., Bunnett N.W., and Mayer E.A. Role of peripheral N-methyl-d-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 120 (2001) 1737-1748
39. Nakagawa T., Hirakata H., Sato M., Nakamura K., Hatano Y., Nakamura T., and Fukuda K. Ketamine suppresses platelet aggregation possibly by suppressed inositol triphosphate formation and subsequent suppression of cytosolic calcium increase. Anesthesiology 96 (2002) 1147-1152
40. Nishina K., Akamatsu H., Mikawa K., Shiga M., Maekawa N., Obara H., and Niwa Y. The inhibitory effects of thiopental, midazolam, and ketamine on human neutrophil functions. Anesth. Analg. 86 (1998) 159-165
41. Olivar T., and Laird J.M. Differential effects of N-methyl-d-aspartate receptor blockade on nociceptive somatic and visceral reflexes. Pain 79 (1999) 67-73
42. Osborne N.N. Memantine reduces alterations to the mammalian retina, in situ, induced by ischemia. Vis. Neurosci. 16 (1999) 45-52
43. Ostrovsky L., Woodman R.C., Payne D., Teoh D., and Kubes P. Antithrombin III prevents and rapidly reverses leukocyte recruitment in ischemia/reperfusion. Circulation 96 (1997) 2302-2310
44. Ozden A., Tetik C., Bilgihan A., Calli N., Bostanci B., Yis O., and Düzcan E. Antithrombin III prevents 60 min warm intestinal ischemia reperfusion injury in rats. Res. Exp. Med. (Berl) 198 (1999) 237-246
45. Pellegrini J.W., and Lipton S.A. Delayed administration of memantine prevents N-methyl-d-aspartate receptor-mediated neurotoxicity. Ann. Neurol. 33 (1993) 403-407
46. Petrović M., Horák M., Sedlácek M., and Vyklický Jr. L. Physiology and pathology of NMDA receptors. Prague Med. Rep. 106 (2005) 113-136
47. Pirat A., Zeyneloglu P., Aldemir D., Yücel M., Ozen O., Candan S., and Arslan G. Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats. Anesth. Analg. 102 (2006) 225-232
48. Pritts T.A., Moon R., Fischer J.E., Salzman A.L., and Hasselgren P.O. Nuclear factor-kappaB is activated in intestinal mucosa during endotoxemia. Arch. Surg. 133 (1998) 1311-1315
49. Rosi S., Vazdarjanova A., Ramirez-Amaya V., Worley P.F., Barnes C.A., and Wenk G.L. Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience 142 (2006) 1303-1315
50. Said S.I., Berisha H.I., and Pakbaz H. N-methyl-d-aspartate receptors outside the central nervous system: activation causes acute lung injury that is mediated by nitric oxide synthesis and prevented by vasoactive intestinal peptide. Neuroscience 65 (1995) 943-946
51. Sakai T., Ichiyama T., Whitten C.W., Giesecke A.H., and Lipton J.M. Ketamine suppresses endotoxin-induced NF-kappaB expression. Can. J. Anaesth. 47 (2000) 1019-1024
52. Salman A.E., Dal D., Salman M.A., Iskit A.B., and Aypar U. The effect of ketamine on acute muscular ischaemia reperfusion in rats. Eur. J. Anaesthesiol. 22 (2005) 712-716
53. Schmidt H., Ebeling D., Bauer H., Bach A., Bohrer H., Gebhard M.M., and Martin E. Ketamine attenuates endotoxin-induced leukocyte adherence in rat mesenteric venules. Crit. Care Med. 23 (1995) 2008-2014
54. Schoots I.G., Levi M., van Vliet A.K., Maas A.M., Roossink E.H., and van Gulik T.M. Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats. Crit. Care Med. 32 (2004) 1375-1383
55. Shafton A.D., Bogeski G., Kitchener P.D., Sanger G.J., Furness J.B., and Shimizu Y. Effects of NMDA receptor antagonists on visceromotor reflexes and on intestinal motility, in vivo. Neurogastroenterol. Motil. 19 (2007) 617-624
56. Sharp C.D., Houghton J., Elrod J.W., Warren A., Jackson IV T.H., Jawahar A., Nanda A., Minagar A., and Alexander J.S. N-methyl-d-aspartate receptor activation in human cerebral endothelium promotes intracellular oxidant stress. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) 1893-1899
57. Silva M.A., de Meirelles L.R., and Bustorff-Silva J.M. Changes in intestinal motility and in the myenteric plexus in a rat model of intestinal ischemia-reperfusion. J. Pediatr. Surg. 42 (2007) 1062-1065
58. Sinner B., and Graf B.M. Ketamine. Handb. Exp. Pharmacol. 182 (2008) 313-333
59. Sun Z., Olanders K., Lasson A., Dib M., Annborn M., Andersson K., Wang X., and Andersson R. Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. J. Surg. Res. 105 (2002) 220-233
60. Sun J., Wang X.D., Liu H., and Xu J.G. Ketamine suppresses intestinal NF-kappa B activation and proinflammatory cytokine in endotoxic rats. World J. Gastroenterol. 10 (2004) 1028-1031
61. Taniguchi T., and Yamamoto K. Anti-inflammatory effects of intravenous anesthetics on endotoxemia. Mini. Rev. Med. Chem. 5 (2005) 241-245
62. Tendler D.A. Acute intestinal ischemia and infarction. Semin. Gastrointest. Dis. 14 (2003) 66-76
63. von Boyen G.B., Steinkamp M., Adler G., and Kirsch J. Glutamate receptor subunit expression in primary enteric glia cultures. J. Recept. Signal Transduct. Res. 26 (2006) 329-336
64. Wang J., Qiao L., Li Y., and Yang G. Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion- induced liver injury by inhibiting NF-kappaB activation. Exp. Mol. Med. 40 (2008) 686-698
65. Weigand M.A., Schmidt H., Zhao Q., Plaschke K., Martin E., and Bardenheuer H.J. Ketamine modulates the stimulated adhesion molecule expression on human neutrophils in vitro. Anesth. Analg. 90 (2000) 206-212
66. Wilson R.F., Farag A., Mammen E.F., and Fujii Y. Sepsis and antithrombin III, prekallikrein, and fibronectin levels in surgical patients. Am. Surg. 55 (1989) 450-456
67. Yao Y., Yu Y., Wu Y., Shi Z., and Sheng Z. The role of gut as a cytokine-generating organ in remote organ dysfunction after intestinal ischemia and reperfusion. Chin. Med. J. 111 (1998) 514-518
68. Yao J.H., Li Y.H., Wang Z.Z., Zhang X.S., Wang Y.Z., Yuan J.C., Zhou Q., Liu K.X., and Tian X.F. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin. Exp. Pharmacol. Physiol. 34 (2007) 1102-1108
69. Yu M., Shao D., Liu J., Zhu J., Zhang Z., and Xu J. Effects of ketamine on levels of cytokines, NF-kappaB and TLRs in rat intestine during CLP-induced sepsis. Int. Immunopharmacol. 7 (2007) 1076-1082
70. Zhang X.Q., Sun J.L., Chen Y.J., Ma R., Fan X.H., and Sun J.Z. Amelioration of ischemia-reperfusion injury of transplanted small intestine by ulinastatin: effects on accumulation and adhesion of neutrophil. Transplant. Proc. 37 (2005) 4464-4466
71. Zhang F., Tong L., Qiao H., Dong X., Qiao G., Jiang H., and Sun X. Taurine attenuates multiple organ injury induced by intestinal ischemia reperfusion in rats. J. Surg. Res. 149 (2008) 101-109