메뉴 건너뛰기




Volumn 34, Issue 4, 2004, Pages 427-436

Pentoxifylline inhibits endotoxin-induced NF-kappa B activation and associated production of proinflammatory cytokines

Author keywords

Interleukin 10; Interleukin 6; NF B; Pentoxifylline; TNF

Indexed keywords

CYTOKINE; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

EID: 11144300239     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (61)

References (48)
  • 1
    • 0033035861 scopus 로고    scopus 로고
    • Gram-positive sepsis: Mechanism and differences from gram-negative sepsis
    • Sriskandan S, Cohen J. Gram-positive sepsis: Mechanism and differences from gram-negative sepsis. Infect Dis Clin North Am 1999;13:397-412.
    • (1999) Infect Dis Clin North Am , vol.13 , pp. 397-412
    • Sriskandan, S.1    Cohen, J.2
  • 3
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-150.
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 4
    • 0035723078 scopus 로고    scopus 로고
    • Pathogenesis of septic shock: Implications for prevention and treatment
    • Calandra T. Pathogenesis of septic shock: implications for prevention and treatment. J Chemother 2001;13(Spec No 1):173-180.
    • (2001) J Chemother , vol.13 , Issue.SPEC. NO. 1 , pp. 173-180
    • Calandra, T.1
  • 6
    • 0030584901 scopus 로고    scopus 로고
    • Platelet activating factor and endotoxin increase the enzyme activity and gene expression of type II phospholipase A2 in the rat intestine. Role of polymorphonuclear leukocytes
    • Tan XD, Wang H, Gonzalez-Crussi FX, Chang H, Gonzalez-Crussi F, Hsueh W. Platelet activating factor and endotoxin increase the enzyme activity and gene expression of type II phospholipase A2 in the rat intestine. Role of polymorphonuclear leukocytes. J Immunol 1996;156:2985-2990.
    • (1996) J Immunol , vol.156 , pp. 2985-2990
    • Tan, X.D.1    Wang, H.2    Gonzalez-Crussi, F.X.3    Chang, H.4    Gonzalez-Crussi, F.5    Hsueh, W.6
  • 7
    • 0031879121 scopus 로고    scopus 로고
    • Endotoxemia and IL-1 beta stimulate mucosal IL-6 production in different parts of the gastrointestinal tract
    • Wang Q, Wang JJ, Boyce S, Fischer JE, Hasseigren PO. Endotoxemia and IL-1 beta stimulate mucosal IL-6 production in different parts of the gastrointestinal tract. J Surg Res 1998;76:27-31.
    • (1998) J Surg Res , vol.76 , pp. 27-31
    • Wang, Q.1    Wang, J.J.2    Boyce, S.3    Fischer, J.E.4    Hasseigren, P.O.5
  • 8
    • 0031255051 scopus 로고    scopus 로고
    • Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells
    • Parikh AA, Salzman AL, Fischer JE, Szabo C, Hasselgren PO. Interleukin-1 beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells. Shock 1997;8:249-255.
    • (1997) Shock , vol.8 , pp. 249-255
    • Parikh, A.A.1    Salzman, A.L.2    Fischer, J.E.3    Szabo, C.4    Hasselgren, P.O.5
  • 9
    • 0020315001 scopus 로고
    • Pentoxifylline efficacy in the treatment of intermittent claudication: Multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients
    • Porter JM, Cutler BS, Lee BY, Reich T, Reichle FA, Scogin JT, Strandness E. Pentoxifylline efficacy in the treatment of intermittent claudication: Multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients. Am Heart J 1982;104:66-72.
    • (1982) Am Heart J , vol.104 , pp. 66-72
    • Porter, J.M.1    Cutler, B.S.2    Lee, B.Y.3    Reich, T.4    Reichle, F.A.5    Scogin, J.T.6    Strandness, E.7
  • 12
    • 0026642365 scopus 로고
    • Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) by monocytes and T cells
    • Schandene L, Vandenbussche P, Crusiaux A, Alegre ML, Abramowicz D, Dupont E, Content J, Goldman M. Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) by monocytes and T cells. Immunology 1992;76:30-34.
    • (1992) Immunology , vol.76 , pp. 30-34
    • Schandene, L.1    Vandenbussche, P.2    Crusiaux, A.3    Alegre, M.L.4    Abramowicz, D.5    Dupont, E.6    Content, J.7    Goldman, M.8
  • 13
    • 0026987554 scopus 로고
    • Study of pentoxifylline of TNF-α and interleukin-6 secretion in healthy and septic patients by the use of an ex-vivo model on whole blood
    • Bienvenu J, Coulon L, Barbier Y, Doche C, Lepape A, Guenounou M. Study of pentoxifylline of TNF-α and interleukin-6 secretion in healthy and septic patients by the use of an ex-vivo model on whole blood. Nouv Rev Fr Hematol 1992;34:65-67.
    • (1992) Nouv Rev Fr Hematol , vol.34 , pp. 65-67
    • Bienvenu, J.1    Coulon, L.2    Barbier, Y.3    Doche, C.4    Lepape, A.5    Guenounou, M.6
  • 14
    • 0030433858 scopus 로고    scopus 로고
    • Differential regulations of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline
    • D'Hellencourt CL, Diaw L, Cornillet P, Guenounou M. Differential regulations of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline. Int J Immunopharm 1996;18:739-748.
    • (1996) Int J Immunopharm , vol.18 , pp. 739-748
    • D'Hellencourt, C.L.1    Diaw, L.2    Cornillet, P.3    Guenounou, M.4
  • 18
    • 0032200423 scopus 로고    scopus 로고
    • Mucosal production of complement C3 and serum amyloid A is differentially regulated in different parts of the gastrointestinal tract during endotoxemia in mice
    • Wang Q, Wang JJ, Fischer JE, Hasselgren PO. Mucosal production of complement C3 and serum amyloid A is differentially regulated in different parts of the gastrointestinal tract during endotoxemia in mice. J Gastrointest Surg 1998;2:537-546.
    • (1998) J Gastrointest Surg , vol.2 , pp. 537-546
    • Wang, Q.1    Wang, J.J.2    Fischer, J.E.3    Hasselgren, P.O.4
  • 20
    • 0032471452 scopus 로고    scopus 로고
    • Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock
    • Magnotti, LJ, Upperman, JS, Xu D-Z, Lu Q; Deitch, EA. Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg 1998;228:518-527.
    • (1998) Ann Surg , vol.228 , pp. 518-527
    • Magnotti, L.J.1    Upperman, J.S.2    Xu, D.-Z.3    Lu, Q.4    Deitch, E.A.5
  • 21
    • 0034280578 scopus 로고    scopus 로고
    • Mesenteric lymph duct ligation provides long term protection against hemorrhagic shock-induced lung injury
    • Sambol JT Xu DZ, Adams CA, Magnotti LJ, Deitch EA. Mesenteric lymph duct ligation provides long term protection against hemorrhagic shock-induced lung injury. Shock 2000;14:416-419.
    • (2000) Shock , vol.14 , pp. 416-419
    • Sambol, J.T.1    Xu, D.Z.2    Adams, C.A.3    Magnotti, L.J.4    Deitch, E.A.5
  • 22
    • 0035003391 scopus 로고    scopus 로고
    • Role of the gut lymphatic system in multiple organ failure
    • Deitch EA. Role of the gut lymphatic system in multiple organ failure. Curr Opin Crit Care 2001;7:92-98.
    • (2001) Curr Opin Crit Care , vol.7 , pp. 92-98
    • Deitch, E.A.1
  • 24
    • 0002024075 scopus 로고    scopus 로고
    • The significance of intestinal cytokines
    • (Schein M, Wise L, Eds), Landes, Austin, TX
    • Hasselgren PO. The significance of intestinal cytokines. In Cytokines and the Abdominal Surgeon (Schein M, Wise L, Eds), Landes, Austin, TX, 1998; pp 197-213.
    • (1998) Cytokines and the Abdominal Surgeon , pp. 197-213
    • Hasselgren, P.O.1
  • 25
    • 0029981734 scopus 로고    scopus 로고
    • Ingredients of organ dysfunction or failure
    • Gullo A, Berlot G. Ingredients of organ dysfunction or failure. World J Surg 1996;20:430-436.
    • (1996) World J Surg , vol.20 , pp. 430-436
    • Gullo, A.1    Berlot, G.2
  • 27
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB IκB proteins: New discoveries and insights
    • Baldwin AS Jr. The NF-κB and IκB proteins: new discoveries and insights. Ann Rev Immunol 1996;14:649-683.
    • (1996) Ann Rev Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 28
    • 0030434274 scopus 로고    scopus 로고
    • Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methyl-xanthine action in murine models of endotoxic shock
    • Jilg S, Barsig J, Leist M, Kusters S, Volk HD, Wendel A. Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methyl-xanthine action in murine models of endotoxic shock. J Pharmacol Exp Ther 1996;278:421-431.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 421-431
    • Jilg, S.1    Barsig, J.2    Leist, M.3    Kusters, S.4    Volk, H.D.5    Wendel, A.6
  • 29
    • 0030848073 scopus 로고    scopus 로고
    • Differential regulation of IFN-gamma, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway
    • Benbernou N, Esnault S, Shin HC, Fekkar H, Guenounou M. Differential regulation of IFN-gamma, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Immunology 1997;91:361-368.
    • (1997) Immunology , vol.91 , pp. 361-368
    • Benbernou, N.1    Esnault, S.2    Shin, H.C.3    Fekkar, H.4    Guenounou, M.5
  • 30
    • 0032825029 scopus 로고    scopus 로고
    • Polaprezine downregulates proinflammatory cytokine-induced nuclear factor-κB activation and interleukin-8 expression in gastric epithelial cells
    • Shimada T, Watanaba N, Ohtsuka Y, Endoh M, Kojima K, Hiraishi H, Terano A. Polaprezine downregulates proinflammatory cytokine-induced nuclear factor-κB activation and interleukin-8 expression in gastric epithelial cells. J Pharmacol Exp Ther 1999;291:345-352.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 345-352
    • Shimada, T.1    Watanaba, N.2    Ohtsuka, Y.3    Endoh, M.4    Kojima, K.5    Hiraishi, H.6    Terano, A.7
  • 31
    • 2542440848 scopus 로고    scopus 로고
    • Effect of ketamine on NF-kappa B activity andTNF-alpha production in endotoxin-treated rats
    • Sun J, Li F, Chen J, Xu J. Effect of ketamine on NF-kappa B activity andTNF-alpha production in endotoxin-treated rats. Ann Clin Lab Sci 2004;34:181-186.
    • (2004) Ann Clin Lab Sci , vol.34 , pp. 181-186
    • Sun, J.1    Li, F.2    Chen, J.3    Xu, J.4
  • 32
    • 0032234267 scopus 로고    scopus 로고
    • Endogenous mediators in sepsis and septic shock
    • Beishuizen A, Vermes I, Haanen C. Endogenous mediators in sepsis and septic shock. Adv Clin Chem 1998;33:55-131
    • (1998) Adv Clin Chem , vol.33 , pp. 55-131
    • Beishuizen, A.1    Vermes, I.2    Haanen, C.3
  • 33
    • 0023944339 scopus 로고
    • Tumor necrosis, cachexia, shock, and inflammation: A common mediator
    • Beutler B, Cerami A. Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu Rev Biochem 1988;57:505-518.
    • (1988) Annu Rev Biochem , vol.57 , pp. 505-518
    • Beutler, B.1    Cerami, A.2
  • 34
    • 0023658648 scopus 로고
    • Tumor necrosis factor: Another chapter in the long history of endotoxin
    • Old LJ. Tumor necrosis factor: another chapter in the long history of endotoxin. Nature 1987;330:602-603.
    • (1987) Nature , vol.330 , pp. 602-603
    • Old, L.J.1
  • 35
    • 0022485610 scopus 로고
    • Cachectin and tumour necrosis factor as two sides of the same biological coin
    • Beutler B, Cerami A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 1986;320:584-588.
    • (1986) Nature , vol.320 , pp. 584-588
    • Beutler, B.1    Cerami, A.2
  • 37
    • 0031032016 scopus 로고    scopus 로고
    • Treatment of endotoxemic mice with anti-interleukin-6 antibody paradoxically increases interleukin-6 levels and stimulates musosal protein synthesis
    • Wang Q, Fischer JE, Hasseigren PO. Treatment of endotoxemic mice with anti-interleukin-6 antibody paradoxically increases interleukin-6 levels and stimulates musosal protein synthesis. Arch Surg 1997;132:82-88.
    • (1997) Arch Surg , vol.132 , pp. 82-88
    • Wang, Q.1    Fischer, J.E.2    Hasseigren, P.O.3
  • 39
    • 0026557009 scopus 로고
    • Interleukin-6 as a new indicator of inflammatory status: Detection of serum levels of interleukin-6 and C-reactive protein after surgery
    • Ohzato H, Yoshizaki K, Nishimoto N, Ogata A, Tagoh H, Monden M, Gotoh M, Kishimoto T, Mori T. Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery. Surgery 1992;111:201-209.
    • (1992) Surgery , vol.111 , pp. 201-209
    • Ohzato, H.1    Yoshizaki, K.2    Nishimoto, N.3    Ogata, A.4    Tagoh, H.5    Monden, M.6    Gotoh, M.7    Kishimoto, T.8    Mori, T.9
  • 40
    • 0027207242 scopus 로고
    • Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: A mechanism for NF-kappa B activation
    • Beg AA, Finco PV, Nantermet TS, Baldwin AS Jr. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol Cell Biol 1993;13:3301-3310.
    • (1993) Mol Cell Biol , vol.13 , pp. 3301-3310
    • Beg, A.A.1    Finco, P.V.2    Nantermet, T.S.3    Baldwin Jr., A.S.4
  • 41
    • 0030271387 scopus 로고    scopus 로고
    • Nf-kappa B: Ten years after
    • Baeuerle PA, Baltimore D. NF-kappa B: ten years after. Cell 1996;87:13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 42
    • 0031183766 scopus 로고    scopus 로고
    • The role of nuclear factor kappa B in cytokine gene regulation
    • Blackwell TS, Christman JW. The role of nuclear factor kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 1997;17:3-9.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 3-9
    • Blackwell, T.S.1    Christman, J.W.2
  • 43
    • 0025279239 scopus 로고
    • Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic- decontaminated rats
    • Deitch EA, Morrison J, Berg R, Specian RD. Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic-decontaminated rats. Crit Care Med 1990;18:529-536.
    • (1990) Crit Care Med , vol.18 , pp. 529-536
    • Deitch, E.A.1    Morrison, J.2    Berg, R.3    Specian, R.D.4
  • 44
    • 0028382313 scopus 로고
    • Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock
    • Deitch EA, Xu D, Franko L, Ayala A, Chaudry IH. Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock. Shock 1994;1:141-146.
    • (1994) Shock , vol.1 , pp. 141-146
    • Deitch, E.A.1    Xu, D.2    Franko, L.3    Ayala, A.4    Chaudry, I.H.5
  • 45
    • 0026094306 scopus 로고
    • Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • DeWaal MR, Abrams J, Bennett B, Figdor CG, deVries JE. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209-1220.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • DeWaal, M.R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    DeVries, J.E.5
  • 46
    • 0024408824 scopus 로고
    • Two types of mouse T-helper cell IV Th2 clones secrete a factor that inhibits cytokine production by ThI clones
    • Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T-helper cell IV Th2 clones secrete a factor that inhibits cytokine production by ThI clones. J Exp Med 1989;170:2081-2095.
    • (1989) J Exp Med , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 47
    • 0026510903 scopus 로고
    • Biological properties of interleukin-10
    • Howard M, O'Garra A. Biological properties of interleukin-10. Immunol Today 1992;13:198-200.
    • (1992) Immunol Today , vol.13 , pp. 198-200
    • Howard, M.1    O'Garra, A.2
  • 48
    • 0033592288 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes
    • Liu SF, Ye X, Malik AB. Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes. Circulation 1999;100:1330-1307.
    • (1999) Circulation , vol.100 , pp. 1330-1307
    • Liu, S.F.1    Ye, X.2    Malik, A.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.