Role of Cybr, a cytohesin binder and regulator, in CD4+ T-cell function and host immunity

Molecular Immunology

Volumn 46, Issue 16, 2009, Pages 3218-3223

  Chang, Shu Lin ^a   Chang, C Lee Tian ^b   Huang, Pei Ing ^a   Tao, Mi Hua ^c   Yang, Wen Chin ^a  

^a AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Cybr; IFN ; MAP kinase; T cells; T bet; Transgenic mice

Indexed keywords

GAMMA INTERFERON; PROTEIN CYBR; REGULATOR PROTEIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOREGULATION; LISTERIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE;

ANIMALS; CARRIER PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; INTERFERON-GAMMA; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; MEMBRANE PROTEINS; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; T-BOX DOMAIN PROTEINS;

BACTERIA (MICROORGANISMS); LISTERIA; MUS; MUS MUSCULUS;

EID: 70349462800     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.08.014     Document Type: Article

References (31)

1. Boehm T., Hofer S., Winklehner P., Kellersch B., Geiger C., Trockenbacher A., Neyer S., Fiegl H., Ebner S., Ivarsson L., Schneider R., Kremmer E., Heufler C., and Kolanus W. Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. EMBO J. 22 (2003) 1014-1024
2. Chang C.L., Kuo H.K., Chang S.L., Chiang Y.M., Lee T.H., Wu W.M., Shyur L.F., and Yang W.C. The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice. J. Biomed. Sci. 12 (2005) 79-89
3. Chen Q., Coffey A., Bourgoin S.G., and Gadina M. Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells. AP-1 activation through regulation of the JNK pathway. J. Biol. Chem. 281 (2006) 19985-19994
4. Chen S.L., Chang Y.J., Wu Y.H., and Lin K.H. Mitogen-activated protein kinases potentiate thyroid hormone receptor transcriptional activity by stabilizing its protein. Endocrinology 144 (2003) 1407-1419
5. Coppola V., Barrick C.A., Bobisse S., Rodriguez-Galan M.C., Pivetta M., Reynolds D., Howard O.M., Palko M.E., Esteban P.F., Young H.A., Rosato A., and Tessarollo L. The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo. Mol. Cell. Biol. 26 (2006) 5249-5258
6. Dixon B., Sahely B., Liu L., and Pohajdak B. Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein. Biochim. Biophys. Acta 1216 (1993) 321-324
7. Dorman S.E., and Holland S.M. Interferon-gamma and interleukin-12 pathway defects and human disease. Cytokine Growth Factor Rev. 11 (2000) 321-333
8. Fukushima N., Nishiura Y., Nakamura T., Yamada Y., Kohno S., and Eguchi K. Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. J. Neuroimmunol. 159 (2005) 196-202
9. Halloran P.F. T- cell activation pathways: a transplantation perspective. Transplant. Proc. 31 (1999) 769-771
10. Hofer S., Pfeil K., Niederegger H., Ebner S., Nguyen V.A., Kremmer E., Auffinger M., Neyer S., Furhapter C., and Heufler C. Dendritic cells regulate T-cell deattachment through the integrin-interacting protein CYTIP. Blood 107 (2006) 1003-1009
11. Ji H.B., Gupta A., Okamoto S., Blum M.D., Tan L., Goldring M.B., Lacy E., Roy A.L., and Terhorst C. T cell-specific expression of the murine CD3delta promoter. J. Biol. Chem. 277 (2002) 47898-47906
12. Jones D.C., Ding X., Zhang T.Y., and Daynes R.A. Peroxisome proliferator-activated receptor alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation. J. Immunol. 171 (2003) 196-203
13. Kaufmann S.H. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11 (1993) 129-163
14. Kim H.S. Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11. 2 by radiation hybrid mapping. Cytogenet. Cell. Genet. 84 (1999) 95
15. Koch A., Raidl M., Lux M., Muller K., Buning H., Humme S., and Erdmann E. IL- 12-induced T-bet expression and IFNgamma release in lymphocytes from asthmatics-role of MAPkinases ERK-1/-2, p38(MAPK) and effect of dexamethasone. Respir. Med. 101 (2007) 1321-1330
16. Kolanus W. Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transduction. Immunol. Rev. 218 (2007) 102-113
17. Kondadasula S.V., Roda J.M., Parihar R., Yu J., Lehman A., Caligiuri M.A., Tridandapani S., Burry R.W., and Carson III W.E. Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. Blood 111 (2008) 4173-4183
18. Li H., Wojciechowski W., Dell'Agnola C., Lopez N.E., and Espinoza-Delgado I. IFN- gamma and T-bet expression in human dendritic cells from normal donors and cancer patients is controlled through mechanisms involving ERK-1/2-dependent and IL-12-independent pathways. J. Immunol. 177 (2006) 3554-3563
19. Lighvani A.A., Frucht D.M., Jankovic D., Yamane H., Aliberti J., Hissong B.D., Nguyen B.V., Gadina M., Sher A., Paul W.E., and O'Shea J.J. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 15137-15142
20. MacNeil A.J., Mansour M., and Pohajdak B. Sorting nexin 27 interacts with the cytohesin associated scaffolding protein (CASP) in lymphocytes. Biochem. Biophys. Res. Commun. 359 (2007) 848-853
21. Mansour M., Lee S.Y., and Pohajdak B. The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP. J. Biol. Chem. 277 (2002) 32302-32309
22. Owaki T., Asakawa M., Fukai F., Mizuguchi J., and Yoshimoto T. IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways. J. Immunol. 177 (2006) 7579-7587
23. Rincon M. MAP-kinase signaling pathways in T cells. Curr. Opin. Immunol. 13 (2001) 339-345
24. Rincon M., Enslen H., Raingeaud J., Recht M., Zapton T., Su M.S., Penix L.A., Davis R.J., and Flavell R.A. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17 (1998) 2817-2829
25. Rogge L., Bianchi E., Biffi M., Bono E., Chang S.Y., Alexander H., Santini C., Ferrari G., Sinigaglia L., Seiler M., Neeb M., Mous J., Sinigaglia F., and Certa U. Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat. Genet. 25 (2000) 96-101
26. Szabo S.J., Sullivan B.M., Stemmann C., Satoskar A.R., Sleckman B.P., and Glimcher L.H. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295 (2002) 338-342
27. Tang P., Cheng T.P., Agnello D., Wu C.Y., Hissong B.D., Watford W.T., Ahn H.J., Galon J., Moss J., Vaughan M., O'Shea J.J., and Gadina M. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 2625-2629
28. Usui T., Preiss J.C., Kanno Y., Yao Z.J., Bream J.H., O'Shea J.J., and Strober W. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J. Exp. Med. 203 (2006) 755-766
29. Watford W.T., Li D., Agnello D., Durant L., Yamaoka K., Yao Z.J., Ahn H.J., Cheng T.P., Hofmann S.R., Cogliati T., Chen A., Hissong B.D., Husa M.R., Schwartzberg P., O'Shea J.J., and Gadina M. Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation. Mol. Cell. Biol. 26 (2006) 6623-6632
30. Yang W.C., Ching K.A., Tsoukas C.D., and Berg L.J. Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain. J. Immunol. 166 (2001) 387-395
31. Zhang J., Salojin K.V., Gao J.X., Cameron M.J., Bergerot I., and Delovitch T.L. p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells. J. Immunol. 162 (1999) 3819-3829