Involvement of p38 MAPK signaling pathway in IFN-γ and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

Journal of Neuroimmunology

Volumn 159, Issue 1-2, 2005, Pages 196-202

  Fukushima, Naomi ^a   Nishiura, Yoshihiro ^a   Nakamura, Tatsufumi ^a   Yamada, Yasuaki ^a   Kohno, Shigeru ^a   Eguchi, Katsumi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

HAM TSP; HTLV I; IFN ; p38 MAPK; Th1

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GAMMA INTERFERON; HUMAN T CELL LEUKEMIA VIRUS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38;

ADULT; AGED; ARTICLE; CELL LINE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; T CELL LEUKEMIA; T LYMPHOCYTE; UPREGULATION; VIRUS LOAD;

ADULT; AGED; ANTIVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; FEMALE; GENE PRODUCTS, GAG; HTLV-I ANTIGENS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; IMIDAZOLES; INTERFERON TYPE II; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARAPARESIS, TROPICAL SPASTIC; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROVIRUSES; PYRIDINES; RETROVIRIDAE PROTEINS, ONCOGENIC; T-LYMPHOCYTES;

EID: 12344317246     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2004.10.007     Document Type: Article

References (24)

1. D.A. Brown, F.B. Nelson, E.L. Reinherz, and D.J. Diamond The human interferon-gamma gene contains an inducible promoter that can be transactivated by tax I and II Eur. J. Immunol. 21 1991 1879 1885
2. A. Cuenda, J. Rouse, Y.N. Doza, R. Meier, P. Cohen, T.F. Gallagher, P.R. Young, and J.C. Lee SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 FEBS Lett. 364 1995 229 233
3. C. Dong, R.J. Davis, and R.A. Flavell MAP kinases in the immune response Annu. Rev. Immunol. 20 2002 55 72
4. A.A. Franklin, M.F. Kubik, M.N. Uittenbogaard, A. Brauweiler, P. Utaisincharoen, M.A. Matthews, W.S. Dynan, J.P. Hoeffler, and J.K. Nyborg Transactivation by the human T-cell leukemia virus tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB) J. Biol. Chem. 268 1993 21225 21231
5. Y. Furukawa, M. Saito, W. Matsumoto, K. Usuku, Y. Tanaka, S. Izumo, and M. Osame Different cytokine production in tax-expressing cells between patients with human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis and asymptomatic HTLV-I carriers J. Infect. Dis. 187 2003 1116 1125
6. Y. Iwasaki Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP) J. Neurol. Sci. 96 1990 103 123
7. S. Jacobson Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease J. Infect. Dis. 186 Suppl. 2 2002 S187 S192
8. K.J. Jeffery, K. Usuku, S.E. Hall, W. Matsumoto, G.P. Taylor, J. Procter, M. Bunce, G.S. Ogg, K.I. Welsh, J.N. Weber, A.L. Lloyd, M.A. Nowak, M. Nagai, D. Kodama, S. Izumo, M. Osame, and C.R. Bangham HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy Proc. Natl. Acad. Sci. U. S. A. 96 1999 3848 3853
9. I. Miyoshi, I. Kubonishi, S. Yoshimoto, T. Akagi, Y. Ohtsuki, Y. Shiraishi, K. Nagata, and Y. Hinuma Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells Nature 294 1981 770 771
10. K.M. Murphy, W. Ouyang, J.D. Farrar, J. Yang, S. Ranganath, H. Asnagli, M. Afkarian, and T.L. Murphy Signaling and transcription in T helper development Annu. Rev. Immunol. 18 2000 451 494
11. T. Nakamura, M. Tsujihata, S. Shirabe, H. Matsuo, Y. Ueki, and S. Nagataki Characterization of HTLV-I in a T-cell line established from a patient with myelopathy Arch. Neurol. 46 1989 35 37
12. T. Nakamura, T. Furuya, Y. Nishiura, K. Ichinose, S. Shirabe, and K. Eguchi Importance of immune deviation toward Th1 in the early immunopathogenesis of human T-lymphotropic virus type I-associated myelopathy Med. Hypotheses 54 2000 777 782
13. M. Osame Review of WHO Kagoshima meeting and diagnostic guidelines for HAM/TSP W.A. Blattner Human Retrovirology: HTLV 1990 Raven Press New York 191 197
14. M. Osame Pathological mechanisms of human T-cell lymphotropic virus type I-associated myelopathy (HAM/TSP) J. Neurovirology 8 2002 359 364
15. M. Osame, K. Usuku, S. Izumo, N. Ijichi, H. Amitani, A. Igata, M. Matsumoto, and M. Tara HTLV-I associated myelopathy, a new clinical entity Lancet i 1986 1031 1032
16. + T cells Immunol. Rev. 192 2003 131 142
17. + T-cells Annu. Rev. Immunol. 12 1994 635 673
18. S.J. Szabo, B.M. Sullivan, S.L. Peng, and L.H. Glimcher Molecular mechanisms regulating TH1 immune responses Annu. Rev. Immunol. 21 2003 713 758
19. Y. Tan, J. Rouse, A. Zhang, S. Cariati, P. Cohen, and M.J. Comb FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 EMBO J. 15 1996 4629 4642
20. X. Xu, S.H. Kang, O. Heidenreich, D.A. Brown, and M. Nerenberg Sequence requirements of ATF-2 and CREB binding to the human T-cell leukemia virus type 1 LTR R region Virology 218 1996 362 371
21. Y. Yamada, Y. Ohmoto, T. Hata, M. Yamamura, K. Murata, K. Tsukasaki, T. Kohno, Y. Chen, S. Kamihira, and M. Tomonaga Features of the cytokines secreted by adult T cell leukemia (ATL) cells Leuk. Lymphoma 21 1996 443 447
22. J. Yang, H. Zhu, T.L. Murphy, W. Ouyang, and K.M. Murphy IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production Nat. Immunol. 2 2001 157 164
23. M. Yoshida Multiple viral strategies of HTLV-1 for dysregulation of cell growth control Annu. Rev. Immunol. 19 2001 475 496
24. S. Zhang, and M. Kaplan The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression J. Immunol. 165 2000 1374 1380