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Volumn 66, Issue 10, 2009, Pages 874-892

Helicobacter pylori activates protein kinase C delta to control Raf in MAP kinase signalling: Role in AGS epithelial cell scattering and elongation

Author keywords

Molecular pathogenesis; Pathogenicity island; Protein kinase C; Silencing RNA; Type IV secretion; Tyrosine phosphorylation; Virulence

Indexed keywords

ACTIN; CAGA PROTEIN; FOCAL ADHESION KINASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PAXILLIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; PROTEIN KINASE C BETA2; PROTEIN KINASE C DELTA; PROTEIN KINASE C IOTA; PROTEIN KINASE C MU; PROTEIN KINASE C THETA; PROTEIN KINASE C ZETA; PROTEIN SERINE THREONINE KINASE; RAF PROTEIN; SERINE; THREONINE; UNCLASSIFIED DRUG;

EID: 70349433677     PISSN: 08861544     EISSN: 10970169     Source Type: Journal    
DOI: 10.1002/cm.20373     Document Type: Conference Paper
Times cited : (23)

References (113)
  • 1
    • 1642396348 scopus 로고    scopus 로고
    • Inhibition of Human p53 Basal Transcription by Down-regulation of Protein Kinase Cdelta
    • DOI 10.1074/jbc.M306979200
    • Abbas T, White D, Hui L, Yoshida K, Foster DA, Bargonetti J. 2004. Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta. J Biol Chem 279:9970-9977. (Pubitemid 38372599)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.11 , pp. 9970-9977
    • Abbas, T.1    White, D.2    Hui, L.3    Yoshida, K.4    Foster, D.A.5    Bargonetti, J.6
  • 2
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494.
    • (1995) J Biol Chem , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 3
    • 0037108571 scopus 로고    scopus 로고
    • Atypical protein kinase C-zeta is essential for delayed phagocytosis of Helicobacter pylori
    • Allen LA, Allgood JA. 2002. Atypical protein kinase C-zeta is essential for delayed phagocytosis of Helicobacter pylori. Curr Biol 12:1762-1766.
    • (2002) Curr Biol , vol.12 , pp. 1762-1766
    • Allen, L.A.1    Allgood, J.A.2
  • 4
    • 33645740999 scopus 로고    scopus 로고
    • The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases
    • Atherton JC. 2006. The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Annu Rev Pathol 1:63-96.
    • (2006) Annu Rev Pathol , vol.1 , pp. 63-96
    • Atherton, J.C.1
  • 5
    • 0036948008 scopus 로고    scopus 로고
    • Helicobacter pylori type IV secretion, host cell signalling and vaccine development
    • Backert S, Churin Y, Meyer TF. 2002. Helicobacter pylori type IV secretion, host cell signalling and vaccine development. Keio J Med 51(Suppl 2):6-14. (Pubitemid 36083612)
    • (2002) Keio Journal of Medicine , vol.51 , Issue.SUPPL. 2 , pp. 6-14
    • Backert, S.1    Churin, Y.2    Meyer, T.F.3
  • 6
    • 33645865541 scopus 로고    scopus 로고
    • Type IV secretion systems and their effectors in bacterial pathogenesis
    • Backert S, Meyer TF. 2006. Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin Microbiol 9:207-217.
    • (2006) Curr Opin Microbiol , vol.9 , pp. 207-217
    • Backert, S.1    Meyer, T.F.2
  • 7
    • 0035162820 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells
    • DOI 10.1046/j.1365-2958.2001.02649.x
    • Backert S, Moese S, Selbach M, Brinkmann V, Meyer TF. 2001a. Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Mol Microbiol 42:631-644. (Pubitemid 33064475)
    • (2001) Molecular Microbiology , vol.42 , Issue.3 , pp. 631-644
    • Backert, S.1    Moese, S.2    Selbach, M.3    Brinkmann, V.4    Meyer, T.F.5
  • 8
    • 0035317836 scopus 로고    scopus 로고
    • Tyrosine phosphorylation patterns and size modification of the Helicobacter pylori CagA protein after translocation into gastric epithelial cells
    • Backert S, Müller EC, Jungblut PR, Meyer TF. 2001b. Tyrosine phosphorylation patterns and size modification of the Helicobacter pylori CagA protein after translocation into gastric epithelial cells. Proteomics 1:608-617. (Pubitemid 33588313)
    • (2001) Proteomics , vol.1 , Issue.4 , pp. 608-617
    • Backert, S.1    Muller, E.-C.2    Jungblut, P.R.3    Meyer, T.F.4
  • 9
    • 10744221155 scopus 로고    scopus 로고
    • Functional Analysis of the cag Pathogenicity Island in Helicobacter pylori Isolates from Patients with Gastritis, Peptic Ulcer, and Gastric Cancer
    • DOI 10.1128/IAI.72.2.1043-1056.2004
    • Backert S, Schwarz T, Miehlke S, Kirsch C, Sommer C, Kwok T, Gerhard M, Goebel UB, Lehn N, Koenig W, Meyer TF. 2004. Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer. Infect Immun 72:1043-1056. (Pubitemid 38166687)
    • (2004) Infection and Immunity , vol.72 , Issue.2 , pp. 1043-1056
    • Backert, S.1    Schwarz, T.2    Miehlke, S.3    Kirsch, C.4    Sommer, C.5    Kwok, T.6    Gerhard, M.7    Goebel, U.B.8    Lehn, N.9    Koenig, W.10    Meyer, T.F.11
  • 10
    • 17044389822 scopus 로고    scopus 로고
    • Subproteomes of soluble and structure-bound Helicobacter pylori proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry
    • DOI 10.1002/pmic.200401019
    • Backert S, Kwok T, Schmid M, Selbach M, Moese S, Peek RM Jr., König W, Meyer TF, Jungblut PR. 2005. Subproteomes of soluble and structure-bound Helicobacter pylori proteins analyzed by two-dimensional gel electrophoresis and mass spectrometry. Proteomics 5:1331-1345. (Pubitemid 40503050)
    • (2005) Proteomics , vol.5 , Issue.5 , pp. 1331-1345
    • Backert, S.1    Kwok, T.2    Schmid, M.3    Seibach, M.4    Moese, S.5    Peek Jr., R.M.6    Konig, W.7    Meyer, T.F.8    Jungblut, P.R.9
  • 11
    • 24944519321 scopus 로고    scopus 로고
    • Tyrosine-phosphorylated bacterial effector proteins: The enemies within
    • DOI 10.1016/j.tim.2005.08.002, PII S0966842X05002015
    • Backert S, Selbach M. 2005. Tyrosine-phosphorylated bacterial effector proteins: the enemies within. Trends Microbiol 13:476-484. (Pubitemid 41317525)
    • (2005) Trends in Microbiology , vol.13 , Issue.10 , pp. 476-484
    • Backert, S.1    Selbach, M.2
  • 12
    • 47549090077 scopus 로고    scopus 로고
    • Role of type IV secretion in Helicobacter pylori pathogenesis
    • DOI 10.1111/j.1462-5822.2008.01156.x
    • Backert S, Selbach M. 2008. Role of type IV secretion in Helicobacter pylori pathogenesis. Cell Microbiol 10:1573-1581. (Pubitemid 352006141)
    • (2008) Cellular Microbiology , vol.10 , Issue.8 , pp. 1573-1581
    • Backert, S.1    Selbach, M.2
  • 13
    • 0034634443 scopus 로고    scopus 로고
    • Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms
    • DOI 10.1016/S0014-5793(00)02162-1, PII S0014579300021621
    • Balendran A, Hare GR, Kieloch A, Williams MR, Alessi DR. 2000. Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms. FEBS Lett 484:217-223. (Pubitemid 30811101)
    • (2000) FEBS Letters , vol.484 , Issue.3 , pp. 217-223
    • Balendran, A.1    Hare, G.R.2    Kieloch, A.3    Williams, M.R.4    Alessi, D.R.5
  • 15
    • 0031194212 scopus 로고    scopus 로고
    • Stimulation of IL-8 production in human gastric epithelial cells by Helicobacter pylori. IL-1beta and TNF-alpha requires tyrosine kinase activity, but not protein kinase C
    • Beales IL, Calam J. 1997. Stimulation of IL-8 production in human gastric epithelial cells by Helicobacter pylori. IL-1beta and TNF-alpha requires tyrosine kinase activity, but not protein kinase C. Cytokine 9:514-520.
    • (1997) Cytokine , vol.9 , pp. 514-520
    • Beales, I.L.1    Calam, J.2
  • 16
    • 0031665731 scopus 로고    scopus 로고
    • 2+](i), activates protein kinase C and stimulates acid secretion in parietal cells
    • DOI 10.1016/S0952-3278(98)90090-4
    • Beil W, Birkholz C, Wagner S, Sewing KF. 1998. Helicobacter pylori fatty acid cis 9, 10-methyleneoctadecanoic acid increases [Ca2+]i, activates protein kinase C and stimulates acid secretion in parietal cells. Prostaglandins Leukot Essent Fatty Acids 59:119-125. (Pubitemid 28432137)
    • (1998) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.59 , Issue.2 , pp. 119-125
    • Beil, W.1    Birkholz, C.2    Wagner, S.3    Sewing, K.-F.4
  • 17
    • 0031749829 scopus 로고    scopus 로고
    • The Helicobacter pylori fatty acid cis-9,10-methyleneoctadecanoic acid stimulates protein kinase C and increases DNA synthesis of gastric HM02 cells
    • Beil W, Obst B, Wagner S, Sewing KF. 1998. The Helicobacter pylori fatty acid cis-9, 10-methyleneoctadecanoic acid stimulates protein kinase C and increases DNA synthesis of gastric HM02 cells. Br J Cancer 77:1852-1856. (Pubitemid 28254623)
    • (1998) British Journal of Cancer , vol.77 , Issue.11 , pp. 1852-1856
    • Beil, W.1    Obst, B.2    Wagner, S.3    Sewing, K.F.4
  • 19
    • 85047691456 scopus 로고    scopus 로고
    • Helicobacter pylori persistence: Biology and disease
    • DOI 10.1172/JCI200420925
    • Blaser MJ, Atherton JC. 2004. Helicobacter pylori persistence: biology and disease. J Clin Invest 113:321-333. (Pubitemid 38544173)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.3 , pp. 321-333
    • Blaser, M.J.1    Atherton, J.C.2
  • 20
    • 0028670129 scopus 로고
    • Regulation of protein kinase C and role in cancer biology
    • Blobe GC, Obeid LM, Hannun YA. 1994. Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev 13:411-431.
    • (1994) Cancer Metastasis Rev , vol.13 , pp. 411-431
    • Blobe, G.C.1    Obeid, L.M.2    Hannun, Y.A.3
  • 21
    • 33847733565 scopus 로고    scopus 로고
    • Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3
    • DOI 10.1128/IAI.01702-06
    • Bourzac KM, Botham CM, Guillemin K. 2007. Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3. Infect Immun 75:1203-1213. (Pubitemid 46385811)
    • (2007) Infection and Immunity , vol.75 , Issue.3 , pp. 1203-1213
    • Bourzac, K.M.1    Botham, C.M.2    Guillemin, K.3
  • 23
    • 34250370846 scopus 로고    scopus 로고
    • Use of a novel coinfection system reveals a role for Rac1. H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements
    • Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, Konig W, Engel J, Backert S. 2007. Use of a novel coinfection system reveals a role for Rac1. H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements. FEMS Immunol Med Microbiol 50:190-205.
    • (2007) FEMS Immunol Med Microbiol , vol.50 , pp. 190-205
    • Brandt, S.1    Shafikhani, S.2    Balachandran, P.3    Jin, S.4    Hartig, R.5    Konig, W.6    Engel, J.7    Backert, S.8
  • 26
    • 0034280331 scopus 로고    scopus 로고
    • Protein kinase C as a drug target: Implications for drug or diet prevention and treatment of cancer
    • Carter CA. 2000. Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer. Curr Drug Targets 1:163-183.
    • (2000) Curr Drug Targets , vol.1 , pp. 163-183
    • Carter, C.A.1
  • 27
    • 0020326790 scopus 로고
    • Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
    • Castagna M, Takai Y, Kaibuchi K, Sano K, Kikkawa U, Nishizuka Y. 1982. Direct activation of calcium-activated, phospholipiddependent protein kinase by tumor-promoting phorbol esters. J Biol Chem 257:7847-7851. (Pubitemid 12043279)
    • (1982) Journal of Biological Chemistry , vol.257 , Issue.13 , pp. 7847-7851
    • Castagna, M.1    Takai, Y.2    Kaibuchi, K.3
  • 28
    • 9444252934 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation
    • DOI 10.1124/mol.104.005199
    • Chang YJ, Wu MS, Lin JT, Sheu BS, Muta T, Inoue H, Chen CC. 2004. Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/ TLR9 and c-Src-dependent nuclear factor-kappaB activation. Mol Pharmacol 66:1465-1477. (Pubitemid 39564773)
    • (2004) Molecular Pharmacology , vol.66 , Issue.6 , pp. 1465-1477
    • Chang, Y.J.1    Wu, M.S.2    Lin, J.T.3    Sheu, B.S.4    Muta, T.5    Inoue, H.6    Chen, C.-C.7
  • 29
    • 28244472296 scopus 로고    scopus 로고
    • The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinerqic regulation of keratinocyte directional migration
    • DOI 10.1074/jbc.M504407200
    • Chernyavsky AI, Arredondo J, Karlsson E, Wessler I, Grando SA. 2005. The Ras/Raf-1/MEK1/ERK signalling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration. J Biol Chem 280:39220-39228. (Pubitemid 41713874)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.47 , pp. 39220-39228
    • Chernyavsky, A.I.1    Arredondo, J.2    Karlsson, E.3    Wessler, I.4    Grando, S.A.5
  • 30
    • 0037732638 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
    • DOI 10.1083/jcb.200208039
    • Churin Y, Al Ghoul L, Kepp O, Meyer TF, Birchmeier W, Naumann M. 2003. Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 161:249-255. (Pubitemid 36529844)
    • (2003) Journal of Cell Biology , vol.161 , Issue.2 , pp. 249-255
    • Churin, Y.1    Al-Ghoul, L.2    Kepp, O.3    Meyer, T.F.4    Birchmeier, W.5    Naumann, M.6
  • 31
    • 0026739795 scopus 로고
    • Purification and characterization of the vacuolating toxin from Helicobacter pylori
    • Cover TL, Blaser MJ. 1992. Purification and characterization of the vacuolating toxin from Helicobacter pylori. J Biol Chem 267:10570-10575.
    • (1992) J Biol Chem , vol.267 , pp. 10570-10575
    • Cover, T.L.1    Blaser, M.J.2
  • 33
    • 0029924152 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta
    • DOI 10.1074/jbc.271.10.5325
    • Denning MF, Dlugosz AA, Threadgill DW, Magnuson T, Yuspa SH. 1996. Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta. J Biol Chem 271:5325-5331. (Pubitemid 26083864)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.10 , pp. 5325-5331
    • Denning, M.F.1    Dlugosz, A.A.2    Threadgill, D.W.3    Magnuson, T.4    Yuspa, S.H.5
  • 34
    • 0037110732 scopus 로고    scopus 로고
    • Nuclear import of PKCdelta is required for apoptosis: Identification of a novel nuclear import sequence
    • DeVries TA, Neville MC, Reyland ME. 2002. Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. EMBO J 21:6050-6060.
    • (2002) EMBO J , vol.21 , pp. 6050-6060
    • Devries, T.A.1    Neville, M.C.2    Reyland, M.E.3
  • 35
    • 34250003172 scopus 로고    scopus 로고
    • In-Cell Western analysis of Helicobacter pylori-induced phosphorylation of extracellular-signal related kinase via the transactivation of the epidermal growth factor receptor
    • DOI 10.1016/j.micinf.2007.03.004, PII S1286457907001050
    • Du Y, Danjo K, Robinson PA, Crabtree JE. 2007. In-cell western analysis of Helicobacter pylori-induced phosphorylation of extracellular-signal related kinase via the transactivation of the epidermal growth factor receptor. Microbes Infect 9:838-846. (Pubitemid 46891853)
    • (2007) Microbes and Infection , vol.9 , Issue.7 , pp. 838-846
    • Du, Y.1    Danjo, K.2    Robinson, P.A.3    Crabtree, J.E.4
  • 36
    • 45849104784 scopus 로고    scopus 로고
    • Targeting protein kinase C (PKC) in physiology and cancer of the gastric cell system
    • DOI 10.2174/092986708784310413
    • Fahrmann M. 2008. Targeting protein kinase C (PKC) in physiology and cancer of the gastric cell system. Curr Med Chem 15: 1175-1191. (Pubitemid 351997806)
    • (2008) Current Medicinal Chemistry , vol.15 , Issue.12 , pp. 1175-1191
    • Fahrmann, M.1
  • 38
    • 0028229299 scopus 로고
    • Tyrosine phosphorylation and stimulation of protein kinase C delta from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C delta
    • Gschwendt M, Kielbassa K, Kittstein W, Marks F. 1994. Tyrosine phosphorylation and stimulation of protein kinase C delta from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C delta. FEBS Lett 347:85-89.
    • (1994) FEBS Lett , vol.347 , pp. 85-89
    • Gschwendt, M.1    Kielbassa, K.2    Kittstein, W.3    Marks, F.4
  • 39
    • 0033082319 scopus 로고    scopus 로고
    • Protein kinase C delta
    • Gschwendt M. 1999. Protein kinase C delta. Eur J Biochem 259:555-564.
    • (1999) Eur J Biochem , vol.259 , pp. 555-564
    • Gschwendt, M.1
  • 40
    • 40849085080 scopus 로고    scopus 로고
    • SagA of CagA in Helicobacter pylori pathogenesis
    • Hatakeyama M. 2008. SagA of CagA in Helicobacter pylori pathogenesis. Curr Opin Microbiol 11:30-37.
    • (2008) Curr Opin Microbiol , vol.11 , pp. 30-37
    • Hatakeyama, M.1
  • 42
    • 0027321737 scopus 로고
    • Chelerythrine, a selective protein kinase C inhibitor, counteracts pyrogen-induced expression of tissue factor without effect on thrombomodulin down-regulation in endothelial cells
    • DOI 10.1016/0049-3848(93)90122-5
    • Herbert JM, Savi P, Laplace MC, Dumas A, Dol F. 1993. Chelerythrine, a selective protein kinase C inhibitor, counteracts pyrogen- induced expression of tissue factor without effect on thrombomodulin down-regulation in endothelial cells. Thromb Res 71:487-493. (Pubitemid 23248669)
    • (1993) Thrombosis Research , vol.71 , Issue.6 , pp. 487-493
    • Herbert, J.-M.1    Savi, P.2    Laplace, M.-C.3    Dumas, A.4    Dol, F.5
  • 44
    • 0027322679 scopus 로고
    • Protein kinase C isoenzymes: Divergence in signal transduction?
    • Hug H, Sarre TF. 1993. Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291(Part 2):329-343.
    • (1993) Biochem J , vol.291 , Issue.PART 2 , pp. 329-343
    • Hug, H.1    Sarre, T.F.2
  • 45
    • 17444373968 scopus 로고    scopus 로고
    • A metalloprotease-disintegrin. MDC9/meltringamma/ ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
    • Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S, Mekada E. 1998. A metalloprotease- disintegrin. MDC9/meltringamma/ ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J 17:7260-7272.
    • (1998) EMBO J , vol.17 , pp. 7260-7272
    • Izumi, Y.1    Hirata, M.2    Hasuwa, H.3    Iwamoto, R.4    Umata, T.5    Miyado, K.6    Tamai, Y.7    Kurisaki, T.8    Sehara-Fujisawa, A.9    Ohno, S.10    Mekada, E.11
  • 47
    • 0033571334 scopus 로고    scopus 로고
    • Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori
    • Keates S, Keates AC, Warny M, Peek RM, Jr., Murray PG, Kelly CP. 1999. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. J Immunol 163:5552-5559.
    • (1999) J Immunol , vol.163 , pp. 5552-5559
    • Keates, S.1    Keates, A.C.2    Warny, M.3    Peek Jr., R.M.4    Murray, P.G.5    Kelly, C.P.6
  • 48
    • 0029615509 scopus 로고
    • Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
    • DOI 10.1016/S0960-9822(95)00277-6
    • Keranen LM, Dutil EM, Newton AC. 1995. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol 5:1394-1403. (Pubitemid 3008935)
    • (1995) Current Biology , vol.5 , Issue.12 , pp. 1394-1403
    • Keranen, L.M.1    Dutil, E.M.2    Newton, A.C.3
  • 50
    • 4143112597 scopus 로고    scopus 로고
    • Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells
    • DOI 10.1158/0008-5472.CAN-03-3511
    • Koivunen J, Aaltonen V, Koskela S, Lehenkari P, Laato M, Peltonen J. 2004. Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells. Cancer Res 64:5693-5701. (Pubitemid 39095567)
    • (2004) Cancer Research , vol.64 , Issue.16 , pp. 5693-5701
    • Koivunen, J.1    Aaltonen, V.2    Koskela, S.3    Lehenkar, P.4    Laato, M.5    Peltonen, J.6
  • 52
    • 33748044620 scopus 로고    scopus 로고
    • Integrin signalling and cell spreading mediated by phorbol 12-myristate 13-acetate treatment
    • Lee MS, Kim YB, Lee SY, Kim JG, Kim SH, Ye SK, Lee JW. 2006. Integrin signalling and cell spreading mediated by phorbol 12-myristate 13-acetate treatment. J Cell Biochem 99:88-95.
    • (2006) J Cell Biochem , vol.99 , pp. 88-95
    • Lee, M.S.1    Kim, Y.B.2    Lee, S.Y.3    Kim, J.G.4    Kim, S.H.5    Ye, S.K.6    Lee, J.W.7
  • 53
    • 0642303674 scopus 로고    scopus 로고
    • Mechanical stress-activated PKCdelta regulates smooth muscle cell migration
    • Li C, Wernig F, Leitges M, Hu Y, Xu Q. 2003. Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. FASEB J 17:2106-2108.
    • (2003) FASEB J , vol.17 , pp. 2106-2108
    • Li, C.1    Wernig, F.2    Leitges, M.3    Hu, Y.4    Xu, Q.5
  • 54
    • 0036061133 scopus 로고    scopus 로고
    • An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen
    • DOI 10.1006/excr.2001.5422
    • Li W, Nadelman C, Gratch NS, Li W, Chen M, Kasahara N, Woodley DT. 2002. An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen. Exp Cell Res 273:219-228. (Pubitemid 34920672)
    • (2002) Experimental Cell Research , vol.273 , Issue.2 , pp. 219-228
    • Li, W.1    Nadelman, C.2    Gratch, N.S.3    Li, W.4    Chen, M.5    Kasahara, N.6    Woodley, D.T.7
  • 55
    • 0031786125 scopus 로고    scopus 로고
    • The sevenfold way of PKC regulation
    • Liu WS, Heckman CA. 1998. The sevenfold way of PKC regulation. Cell Signal 10:529-542.
    • (1998) Cell Signal , vol.10 , pp. 529-542
    • Liu, W.S.1    Heckman, C.A.2
  • 56
    • 34250902930 scopus 로고    scopus 로고
    • Targeting the protein kinase C family: Are we there yet?
    • Mackay HJ, Twelves CJ. 2007. Targeting the protein kinase C family: are we there yet? Nat Rev Cancer 7:554-562.
    • (2007) Nat Rev Cancer , vol.7 , pp. 554-562
    • Mackay, H.J.1    Twelves, C.J.2
  • 58
    • 0037032835 scopus 로고    scopus 로고
    • The protein kinase complement of the human genome
    • DOI 10.1126/science.1075762
    • Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. 2002. The protein kinase complement of the human genome. Science 298:1912-1934. (Pubitemid 35425239)
    • (2002) Science , vol.298 , Issue.5600 , pp. 1912-1934
    • Manning, G.1    Whyte, D.B.2    Martinez, R.3    Hunter, T.4    Sudarsanam, S.5
  • 59
    • 0030581475 scopus 로고    scopus 로고
    • Cell signalling. Raf gets it together
    • Marshall CJ. 1996. Cell signalling. Raf gets it together. Nature 383:127-128.
    • (1996) Nature , vol.383 , pp. 127-128
    • Marshall, C.J.1
  • 60
    • 0036809776 scopus 로고    scopus 로고
    • Grb2 is a key mediator of Helicobacter pylori CagA protein activities
    • DOI 10.1016/S1097-2765(02)00681-0
    • Mimuro H, Suzuki T, Tanaka J, Asahi M, Haas R, Sasakawa C. 2002. Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell 10:745-755. (Pubitemid 35335631)
    • (2002) Molecular Cell , vol.10 , Issue.4 , pp. 745-755
    • Mimuro, H.1    Suzuki, T.2    Tanaka, J.3    Asahi, M.4    Haas, R.5    Sasakawa, C.6
  • 62
    • 0035320135 scopus 로고    scopus 로고
    • Identification of a tyrosine-phosphorylated 35 kDa carboxy-terminal fragment (p35CagA) of the Helicobacter pylori CagA protein in phagocytic cells: Processing or breakage?
    • Moese S, Selbach M, Zimny-Arndt U, Jungblut PR, Meyer TF, Backert S. 2001. Identification of a tyrosine-phosphorylated 35 kDa carboxy-terminal fragment (p35CagA) of the Helicobacter pylori CagA protein in phagocytic cells: processing or breakage? Proteomics 1:618-629.
    • (2001) Proteomics , vol.1 , pp. 618-629
    • Moese, S.1    Selbach, M.2    Zimny-Arndt, U.3    Jungblut, P.R.4    Meyer, T.F.5    Backert, S.6
  • 63
    • 0036076895 scopus 로고    scopus 로고
    • + Helicobacter pylori induces homotypic aggregation of macrophage-like cells by up-regulation and recruitment of intracellular adhesion molecule 1 to the cell surface
    • DOI 10.1128/IAI.70.8.4687-4691.2002
    • Moese S, Selbach M, Meyer TF, Backert S. 2002. cag+ Helicobacter pylori induces homotypic aggregation of macrophage-like cells by up-regulation and recruitment of intracellular adhesion molecule 1 to the cell surface. Infect Immun 70:4687-4691. (Pubitemid 34790984)
    • (2002) Infection and Immunity , vol.70 , Issue.8 , pp. 4687-4691
    • Moese, S.1    Selbach, M.2    Meyer, T.F.3    Backert, S.4
  • 64
    • 2542635813 scopus 로고    scopus 로고
    • Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways
    • DOI 10.1128/IAI.72.6.3646-3649.2004
    • Moese S, Selbach M, Kwok T, Brinkmann V, Konig W, Meyer TF, Backert S. 2004. Helicobacter pylori induces AGS cell motility and elongation via independent signalling pathways. Infect Immun 72:3646-3649. (Pubitemid 38697796)
    • (2004) Infection and Immunity , vol.72 , Issue.6 , pp. 3646-3649
    • Moese, S.1    Selbach, M.2    Kwok, T.3    Brinkmann, V.4    Konig, W.5    Meyer, T.F.6    Backert, S.7
  • 65
    • 34047245107 scopus 로고    scopus 로고
    • The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin
    • DOI 10.1111/j.1462-5822.2006.00856.x
    • Moese S, Selbach M, Brinkmann V, Karlas A, Haimovich B, Backert S, Meyer TF. 2007. The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin. Cell Microbiol 9:1148-1161. (Pubitemid 46547135)
    • (2007) Cellular Microbiology , vol.9 , Issue.5 , pp. 1148-1161
    • Moese, S.1    Selbach, M.2    Brinkmann, V.3    Karlas, A.4    Haimovich, B.5    Backert, S.6    Meyer, T.F.7
  • 66
    • 0035374653 scopus 로고    scopus 로고
    • Living dangerously: How helicobacter pylori survives in the human stomach
    • DOI 10.1038/35073084
    • Montecucco C, Rappuoli R. 2001. Living dangerously: how Helicobacter pylori survives in the human stomach. Nat Rev Mol Cell Biol 2:457-466. (Pubitemid 33680584)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.6 , pp. 457-466
    • Montecucco, C.1    Rappuoli, R.2
  • 67
    • 0034221202 scopus 로고    scopus 로고
    • The role of protein kinase C isoforms in cell proliferation and apoptosis
    • Musashi M, Ota S, Shiroshita N. 2000. The role of protein kinase C isoforms in cell proliferation and apoptosis. Int J Hematol. 72:12-19.
    • (2000) Int J Hematol , vol.72 , pp. 12-19
    • Musashi, M.1    Ota, S.2    Shiroshita, N.3
  • 68
    • 0028811653 scopus 로고
    • Protein kinase C: Structure, function, and regulation
    • Newton AC. 1995. Protein kinase C: structure, function, and regulation. J Biol Chem 270:28495-28498.
    • (1995) J Biol Chem , vol.270 , pp. 28495-28498
    • Newton, A.C.1
  • 69
    • 0030987070 scopus 로고    scopus 로고
    • Regulation of protein kinase C
    • Newton AC. 1997. Regulation of protein kinase C. Curr Opin Cell Biol 9:161-167.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 161-167
    • Newton, A.C.1
  • 70
    • 0035413601 scopus 로고    scopus 로고
    • Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
    • Newton AC. 2001. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 101:2353-2364.
    • (2001) Chem Rev , vol.101 , pp. 2353-2364
    • Newton, A.C.1
  • 71
    • 0021227676 scopus 로고
    • The role of protein kinase C in cell surface signal transduction and tumour promotion
    • Nishizuka Y. 1984. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 308:693-698. (Pubitemid 14127666)
    • (1984) Nature , vol.308 , Issue.5961 , pp. 693-698
    • Nishizuka, Y.1
  • 72
    • 0023814294 scopus 로고
    • The heterogeneity and differential expression of multiple species of the protein kinase C family
    • Nishizuka Y. 1988. The heterogeneity and differential expression of multiple species of the protein kinase C family. Biofactors 1:17-20. (Pubitemid 18179205)
    • (1988) BioFactors , vol.1 , Issue.1 , pp. 17-20
    • Nishizuka, Y.1
  • 73
    • 0027857930 scopus 로고
    • Intracellular signalling by phospholipid hydrolysis and protein kinase C activation
    • Nishizuka Y. 1992. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614. (Pubitemid 24075388)
    • (1993) Biomedical Research , vol.14 , Issue.SUPPL. 2 , pp. 93-98
    • Asaoka, Y.1    Nakamura -i, S.2    Nishizuka, Y.3
  • 74
    • 0035010873 scopus 로고    scopus 로고
    • Chromosomal imbalances in gastric cancer: Correlation with histologic subtypes and tumor progression
    • DOI 10.1309/2Q9E-3EP5-KYPK-VFGQ
    • Noguchi T, Wirtz HC, Michaelis S, Gabbert HE, Mueller W. 2001. Chromosomal imbalances in gastric cancer. Correlation with histologic subtypes and tumor progression. Am J Clin Pathol 115:828-834. (Pubitemid 32476708)
    • (2001) American Journal of Clinical Pathology , vol.115 , Issue.6 , pp. 828-834
    • Noguchi, T.1    Wirtz, H.-C.2    Michaelis, S.3    Gabbert, H.E.4    Mueller, W.5
  • 75
    • 11144358287 scopus 로고    scopus 로고
    • Protein Kinase C Activation by Helicobacter pylori in Human Gastric Epithelial Cells Limits Interleukin-8 Production Through Suppression of Extracellular Signal Regulated Kinase
    • DOI 10.1254/jphs.94.233
    • Nozawa Y, Nishihara K, Akizawa Y, Orimoto N, Nakano M, Uji T, Ajioka H, Kanda A, Matsuura N, Kiniwa M. 2004. Protein kinase C activation by Helicobacter pylori in human gastric epithelial cells limits interleukin-8 production through suppression of extracellular signal-regulated kinase. J Pharmacol Sci 94:233-239. (Pubitemid 38470731)
    • (2004) Journal of Pharmacological Sciences , vol.94 , Issue.3 , pp. 233-239
    • Nozawa, Y.1    Nishihara, K.2    Akizawa, Y.3    Orimoto, N.4    Nakano, M.5    Uji, T.6    Ajioka, H.7    Kanda, A.8    Matsuura, N.9    Kiniwa, M.10
  • 77
    • 0036401022 scopus 로고    scopus 로고
    • Helicobacter pylori-induced apoptosis in gastric epithelial cells is blocked by protein kinase C activation
    • DOI 10.1016/S0882-4010(02)90523-1
    • Obst B, Schutz S, Ledig S, Wagner S, Beil W. 2002. Helicobacter pylori-induced apoptosis in gastric epithelial cells is blocked by protein kinase C activation. Microb Pathog 33:167-175. (Pubitemid 35193462)
    • (2002) Microbial Pathogenesis , vol.33 , Issue.4 , pp. 167-175
    • Obst, B.1    Schutz, S.2    Ledig, S.3    Wagner, S.4    Beil, W.5
  • 81
    • 0035119146 scopus 로고    scopus 로고
    • CD40-mediated signalling in monocytic cells: Up-regulation of tumor necrosis factor receptor- Associated factor mRNAs and activation of mitogenactivated protein kinase signalling pathways
    • Pearson LL, Castle BE, Kehry MR. 2001. CD40-mediated signalling in monocytic cells: up-regulation of tumor necrosis factor receptor- associated factor mRNAs and activation of mitogenactivated protein kinase signalling pathways. Int Immunol 13:273-283.
    • (2001) Int Immunol , vol.13 , pp. 273-283
    • Pearson, L.L.1    Castle, B.E.2    Kehry, M.R.3
  • 82
    • 0036370334 scopus 로고    scopus 로고
    • Helicobacter pylori and gastrointestinal tract adenocarcinomas
    • Peek RM, Jr., Blaser MJ. 2002. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2:28-37. (Pubitemid 37328805)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 28-37
    • Peek Jr., R.M.1    Blaser, M.J.2
  • 83
    • 34249308195 scopus 로고    scopus 로고
    • Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility
    • DOI 10.1038/sj.onc.1210139, PII 1210139
    • Poppe M, Feller SM, Romer G, Wessler S. 2007. Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. Oncogene 26:3462-3472. (Pubitemid 46816757)
    • (2007) Oncogene , vol.26 , Issue.24 , pp. 3462-3472
    • Poppe, M.1    Feller, S.M.2    Romer, G.3    Wessler, S.4
  • 84
    • 51249090123 scopus 로고    scopus 로고
    • The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells
    • Ramos JW. 2008. The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int J Biochem Cell Biol 40:2707-2719.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 2707-2719
    • Ramos, J.W.1
  • 88
    • 16244370694 scopus 로고    scopus 로고
    • Cortactin: An Achilles' heel of the actin cytoskeleton targeted by pathogens
    • DOI 10.1016/j.tim.2005.02.007
    • Selbach M, Backert S. 2005. Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens. Trends Microbiol 13:181-189. (Pubitemid 40463320)
    • (2005) Trends in Microbiology , vol.13 , Issue.4 , pp. 181-189
    • Selbach, M.1    Backert, S.2
  • 89
    • 0036510363 scopus 로고    scopus 로고
    • Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    • DOI 10.1074/jbc.C100754200
    • Selbach M, Moese S, Hauck CR, Meyer TF, Backert S. 2002. Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 277:6775-6778. (Pubitemid 34953058)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.9 , pp. 6775-6778
    • Selbach, M.1    Moese, S.2    Hauck, C.R.3    Meyer, T.F.4    Backert, S.5
  • 90
    • 0037415684 scopus 로고    scopus 로고
    • The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation
    • DOI 10.1093/emboj/cdg050
    • Selbach M, Moese S, Hurwitz R, Hauck CR, Meyer TF, Backert S. 2003. The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J 22:515-528. (Pubitemid 36193596)
    • (2003) EMBO Journal , vol.22 , Issue.3 , pp. 515-528
    • Selbach, M.1    Moese, S.2    Hurwitz, R.3    Hauck, C.R.4    Meyer, T.F.5    Backert, S.6
  • 92
    • 0030907067 scopus 로고    scopus 로고
    • Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D
    • Singer WD, Brown HA, Sternweis PC. 1997. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Annu Rev Biochem 66:475-509.
    • (1997) Annu Rev Biochem , vol.66 , pp. 475-509
    • Singer, W.D.1    Brown, H.A.2    Sternweis, P.C.3
  • 93
    • 0036227053 scopus 로고    scopus 로고
    • C-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
    • DOI 10.1046/j.1365-2958.2002.02781.x
    • Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, Covacci A. 2002. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 43:971-980. (Pubitemid 34415720)
    • (2002) Molecular Microbiology , vol.43 , Issue.4 , pp. 971-980
    • Stein, M.1    Bagnoli, F.2    Halenbeck, R.3    Rappuoli, R.4    Fantl, W.J.5    Covacci, A.6
  • 94
    • 10944238407 scopus 로고    scopus 로고
    • Distinctive activation mechanisms and functions for protein kinase Cdelta
    • Steinberg SF. 2004. Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem J 384:449-459.
    • (2004) Biochem J , vol.384 , pp. 449-459
    • Steinberg, S.F.1
  • 95
    • 0033803074 scopus 로고    scopus 로고
    • Photo-induced inactivation of protein kinase Calpha by dequalinium inhibits motility of murine melanoma cells
    • Sullivan RM, Stone M, Marshall JF, Uberall F, Rotenberg SA. 2000. Photo-induced inactivation of protein kinase calpha by dequalinium inhibits motility of murine melanoma cells. Mol Pharmacol 58:729-737. (Pubitemid 30761287)
    • (2000) Molecular Pharmacology , vol.58 , Issue.4 , pp. 729-737
    • Sullivan, R.M.1    Stone, M.2    Marshall, J.F.3    Uberall, F.4    Rotenberg, S.A.5
  • 96
    • 0018800888 scopus 로고
    • Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids
    • Takai Y, Kishimoto A, Iwasa Y, Kawahara Y, Mori T, Nishizuka Y. 1979. Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem 254:3692-3695.
    • (1979) J Biol Chem , vol.254 , pp. 3692-3695
    • Takai, Y.1    Kishimoto, A.2    Iwasa, Y.3    Kawahara, Y.4    Mori, T.5    Nishizuka, Y.6
  • 97
    • 0022653769 scopus 로고
    • Effects of 12-O-tetradecanoylphorbol-13-acetate on adhesiveness and lung-colonizing ability of Lewis lung carcinoma cells
    • Takenaga K, Takahashi K. 1986. Effects of 12-O-tetradecanoylphorbol- 13-acetate on adhesiveness and lung-colonizing ability of Lewis lung carcinoma cells. Cancer Res 46:375-380. (Pubitemid 16189077)
    • (1986) Cancer Research , vol.46 , Issue.1 , pp. 375-380
    • Takenaga, K.1    Takahashi, K.2
  • 98
    • 34247255905 scopus 로고    scopus 로고
    • Activation of Abl by Helicobacter pylori: A Novel Kinase for CagA and Crucial Mediator of Host Cell Scattering
    • DOI 10.1053/j.gastro.2007.01.050, PII S0016508507001898
    • Tammer I, Brandt S, Hartig R, Konig W, Backert S. 2007. Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology 132:1309-1319. (Pubitemid 46627580)
    • (2007) Gastroenterology , vol.132 , Issue.4 , pp. 1309-1319
    • Tammer, I.1    Brandt, S.2    Hartig, R.3    Konig, W.4    Backert, S.5
  • 99
    • 59849112591 scopus 로고    scopus 로고
    • Importance of EGF receptor. HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: Antagonistic effects of the vacuolating cytotoxin VacA
    • Tegtmeyer N, Zabler D, Schmidt D, Hartig R, Brandt S, Backert S. 2009. Importance of EGF receptor. HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cell Microbiol 11:488-505.
    • (2009) Cell Microbiol , vol.11 , pp. 488-505
    • Tegtmeyer, N.1    Zabler, D.2    Schmidt, D.3    Hartig, R.4    Brandt, S.5    Backert, S.6
  • 100
    • 33645214468 scopus 로고    scopus 로고
    • Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA
    • Tsutsumi R, Takahashi A, Azuma T, Higashi H, Hatakeyama M. 2006. Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol Cell Biol 26:261-276.
    • (2006) Mol Cell Biol , vol.26 , pp. 261-276
    • Tsutsumi, R.1    Takahashi, A.2    Azuma, T.3    Higashi, H.4    Hatakeyama, M.5
  • 101
    • 34548746356 scopus 로고    scopus 로고
    • Interaction of MUC1 with beta-catenin modulates the WNT target gene cyclinD1 in H. pylori-induced gastric cancer
    • DOI 10.1002/mc.20311
    • Udhayakumar G, Jayanthi V, Devaraj N, Devaraj H. 2007. Interaction of MUC1 with beta-catenin modulates the Wnt target gene cyclinD1 in H. pylori-induced gastric cancer. Mol Carcinog 46:807-817. (Pubitemid 47438731)
    • (2007) Molecular Carcinogenesis , vol.46 , Issue.9 , pp. 807-817
    • Udhayakumar, G.1    Jayanthi, V.2    Devaraj, N.3    Devaraj, H.4
  • 102
    • 0029789967 scopus 로고    scopus 로고
    • Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
    • DOI 10.1074/jbc.271.38.23512
    • Ueda Y, Hirai S, Osada S, Suzuki A, Mizuno K, Ohno S. 1996. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J Biol Chem 271:23512-23519. (Pubitemid 26314803)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.38 , pp. 23512-23519
    • Ueda, Y.1    Hirai, S.-I.2    Osada, S.-I.3    Suzuki, A.4    Mizuno, K.5    Ohno, S.6
  • 103
    • 0037780971 scopus 로고    scopus 로고
    • A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C
    • DOI 10.1083/jcb.200302125
    • Violin JD, Zhang J, Tsien RY, Newton AC. 2003. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol 161:899-909. (Pubitemid 36718423)
    • (2003) Journal of Cell Biology , vol.161 , Issue.5 , pp. 899-909
    • Violin, J.D.1    Zhang, J.2    Tsien, R.Y.3    Newton, A.C.4
  • 105
    • 28844470640 scopus 로고    scopus 로고
    • PKCδ-mediated regulation of FLIP expression in human colon cancer cells
    • DOI 10.1002/ijc.21373
    • Wang Q, Wang X, Zhou Y, Evers BM. 2006. PKCδ-mediated regulation of FLIP expression in human colon cancer cells. Int J Cancer 118:326-334. (Pubitemid 41779071)
    • (2006) International Journal of Cancer , vol.118 , Issue.2 , pp. 326-334
    • Wang, Q.1    Wang, X.2    Zhou, Y.3    Evers, B.M.4
  • 107
    • 0031844527 scopus 로고    scopus 로고
    • Insulin receptor regulation of cell surface integrins: A possible mechanism contributing to the development of diabetic complications
    • Wertheimer E, Taylor SI, Tennenbaum T. 1998. Insulin receptor regulation of cell surface integrins: a possible mechanism contributing to the development of diabetic complications. Proc Assoc Am Physicians 110:333-339. (Pubitemid 28345903)
    • (1998) Proceedings of the Association of American Physicians , vol.110 , Issue.4 , pp. 333-339
    • Wertheimer, E.1    Taylor, S.I.2    Tennenbaum, T.3
  • 108
    • 48149105975 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori
    • Wessler S, Backert S. 2008. Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori. Trends Microbiol 16:397-405.
    • (2008) Trends Microbiol , vol.16 , pp. 397-405
    • Wessler, S.1    Backert, S.2
  • 109
    • 34548621770 scopus 로고    scopus 로고
    • CagA-independent disruption of adherence junction complexes involves E-cadherin shedding and implies multiple steps in Helicobacter pylori pathogenicity
    • DOI 10.1016/j.yexcr.2007.07.015, PII S0014482707003424
    • Weydig C, Starzinski-Powitz A, Carra G, Löwer J, Wessler S. 2007. CagA-independent disruption of adherence junction complexes involves E-cadherin shedding and implies multiple steps in Helicobacter pylori pathogenicity. Exp Cell Res 313:3459-3471. (Pubitemid 47404551)
    • (2007) Experimental Cell Research , vol.313 , Issue.16 , pp. 3459-3471
    • Weydig, C.1    Starzinski-Powitz, A.2    Carra, G.3    Lower, J.4    Wessler, S.5
  • 111
    • 0034069093 scopus 로고    scopus 로고
    • Water extract of Helicobacter pylori stimulates interleukin-8 secretion by a human gastric epithelial cell line (JR-St) through protein tyrosine phosphoration
    • DOI 10.1046/j.1440-1746.2000.02130.x
    • Yakabi K, Ro S, Okazaki R, Shiojima J, Tsuda K, Mimura H, Tomono H, Nakamura T. 2000. Water extract of Helicobacter pylori stimulates interleukin-8 secretion by a human gastric epithelial cell line (JR-St) through protein tyrosine phosphorylation. J Gastroenterol Hepatol 15:263-270. (Pubitemid 30190739)
    • (2000) Journal of Gastroenterology and Hepatology , vol.15 , Issue.3 , pp. 263-270
    • Yakabi, K.1    Ro, S.2    Okazaki, R.3    Shiojima, J.4    Tsuda, K.5    Mimura, H.6    Tomono, H.7    Nakamura, T.8
  • 112
    • 0242321186 scopus 로고    scopus 로고
    • Divergence and complexities in DAG signaling: Looking beyond PKC
    • DOI 10.1016/j.tips.2003.09.003
    • Yang C, Kazanietz MG. 2003. Divergence and complexities in DAG signalling: looking beyond PKC. Trends Pharmacol Sci 24:602-608. (Pubitemid 37357145)
    • (2003) Trends in Pharmacological Sciences , vol.24 , Issue.11 , pp. 602-608
    • Yang, C.1    Kazanietz, M.G.2
  • 113
    • 38849168048 scopus 로고    scopus 로고
    • Analysis of detergent-resistant membranes of Helicobacter pylori-infected cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity
    • Zeaiter Z, Cohen D, Müsch A, Bagnoli F, Covacci A, Stein M. 2007. Analysis of detergent-resistant membranes of Helicobacter pylori-infected cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity. Cell Microbiol 10:781-794.
    • (2007) Cell Microbiol , vol.10 , pp. 781-794
    • Zeaiter, Z.1    Cohen, D.2    Müsch, A.3    Bagnoli, F.4    Covacci, A.5    Stein, M.6


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