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Volumn 53, Issue 2, 2008, Pages 244-252

Type 1 and Type 2 5α-Reductase Expression in the Development and Progression of Prostate Cancer

Author keywords

5 Reductase; Benign prostatic hyperplasia; Dutasteride; Enlarged prostate; Finasteride; Prostate cancer

Indexed keywords

ANDROSTANOLONE; DUTASTERIDE; FINASTERIDE; ISOENZYME; PLACEBO; STEROID 5ALPHA REDUCTASE 1; STEROID 5ALPHA REDUCTASE 2; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE;

EID: 37349107226     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2007.10.052     Document Type: Review
Times cited : (103)

References (59)
  • 1
    • 0029910571 scopus 로고    scopus 로고
    • Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas
    • Bonkhoff H., Stein U., Aumuller G., and Remberger K. Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas. Prostate 29 (1996) 261-267
    • (1996) Prostate , vol.29 , pp. 261-267
    • Bonkhoff, H.1    Stein, U.2    Aumuller, G.3    Remberger, K.4
  • 2
    • 0024436129 scopus 로고
    • The effect of a 5 alpha-reductase inhibitor on androgen physiology in the immature male rat
    • George F.W., Johnson L., and Wilson J.D. The effect of a 5 alpha-reductase inhibitor on androgen physiology in the immature male rat. Endocrinology 125 (1989) 2434-2438
    • (1989) Endocrinology , vol.125 , pp. 2434-2438
    • George, F.W.1    Johnson, L.2    Wilson, J.D.3
  • 3
    • 0026756111 scopus 로고
    • Prostate visualization studies in males homozygous and heterozygous for 5 alpha-reductase deficiency
    • Imperato-McGinley J., Gautier T., Zirinsky K., et al. Prostate visualization studies in males homozygous and heterozygous for 5 alpha-reductase deficiency. J Clin Endocrinol Metab 75 (1992) 1022-1026
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 1022-1026
    • Imperato-McGinley, J.1    Gautier, T.2    Zirinsky, K.3
  • 4
    • 0026782628 scopus 로고
    • Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene
    • Deslypere J.P., Young M., Wilson J.D., and McPhaul M.J. Testosterone and 5 alpha-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene. Mol Cell Endocrinol 88 (1992) 15-22
    • (1992) Mol Cell Endocrinol , vol.88 , pp. 15-22
    • Deslypere, J.P.1    Young, M.2    Wilson, J.D.3    McPhaul, M.J.4
  • 5
    • 0033305674 scopus 로고    scopus 로고
    • Androgen-induced regrowth in the castrated rat ventral prostate: role of 5alpha-reductase
    • Wright A.S., Douglas R.C., Thomas L.N., Lazier C.B., and Rittmaster R.S. Androgen-induced regrowth in the castrated rat ventral prostate: role of 5alpha-reductase. Endocrinology 140 (1999) 4509-4515
    • (1999) Endocrinology , vol.140 , pp. 4509-4515
    • Wright, A.S.1    Douglas, R.C.2    Thomas, L.N.3    Lazier, C.B.4    Rittmaster, R.S.5
  • 6
    • 0026055914 scopus 로고
    • Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism
    • Andersson S., Berman D.M., Jenkins E.P., and Russell D.W. Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism. Nature 354 (1991) 159-161
    • (1991) Nature , vol.354 , pp. 159-161
    • Andersson, S.1    Berman, D.M.2    Jenkins, E.P.3    Russell, D.W.4
  • 7
    • 0022852328 scopus 로고
    • The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications
    • Petrow V. The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications. Prostate 9 (1986) 343-361
    • (1986) Prostate , vol.9 , pp. 343-361
    • Petrow, V.1
  • 9
    • 0020529324 scopus 로고
    • Changes in dihydrotestosterone metabolism and the development of benign prostatic hyperplasia in the aging beagle
    • Isaacs J.T. Changes in dihydrotestosterone metabolism and the development of benign prostatic hyperplasia in the aging beagle. J Steroid Biochem 18 (1983) 749-757
    • (1983) J Steroid Biochem , vol.18 , pp. 749-757
    • Isaacs, J.T.1
  • 10
    • 0036754256 scopus 로고    scopus 로고
    • Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia
    • Roehrborn C.G., Boyle P., Nickel J.C., Hoefner K., and Andriole G. Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia. Urology 60 (2002) 434-441
    • (2002) Urology , vol.60 , pp. 434-441
    • Roehrborn, C.G.1    Boyle, P.2    Nickel, J.C.3    Hoefner, K.4    Andriole, G.5
  • 11
    • 0006075228 scopus 로고    scopus 로고
    • The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efficacy and Safety Study Group
    • McConnell J.D., Bruskewitz R., Walsh P., et al. The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride Long-Term Efficacy and Safety Study Group. N Engl J Med 338 (1998) 557-563
    • (1998) N Engl J Med , vol.338 , pp. 557-563
    • McConnell, J.D.1    Bruskewitz, R.2    Walsh, P.3
  • 12
    • 33746047132 scopus 로고    scopus 로고
    • Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
    • Xu Y., Dalrymple S.L., Becker R.E., Denmeade S.R., and Isaacs J.T. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Clin Cancer Res 12 (2006) 4072-4079
    • (2006) Clin Cancer Res , vol.12 , pp. 4072-4079
    • Xu, Y.1    Dalrymple, S.L.2    Becker, R.E.3    Denmeade, S.R.4    Isaacs, J.T.5
  • 13
    • 0037812658 scopus 로고    scopus 로고
    • The influence of finasteride on the development of prostate cancer
    • Thompson I.M., Goodman P.J., Tangen C.M., et al. The influence of finasteride on the development of prostate cancer. N Engl J Med 349 (2003) 215-224
    • (2003) N Engl J Med , vol.349 , pp. 215-224
    • Thompson, I.M.1    Goodman, P.J.2    Tangen, C.M.3
  • 14
    • 33751422525 scopus 로고    scopus 로고
    • Looking back at PCPT: looking forward to new paradigms on prostate cancer screening and prevention
    • Canby-Hagino E., Hernandez J., Brand T.C., and Thompson I. Looking back at PCPT: looking forward to new paradigms on prostate cancer screening and prevention. Eur Urol 51 (2007) 27-33
    • (2007) Eur Urol , vol.51 , pp. 27-33
    • Canby-Hagino, E.1    Hernandez, J.2    Brand, T.C.3    Thompson, I.4
  • 15
    • 33751399718 scopus 로고    scopus 로고
    • The prostate cancer prevention trial and its messages
    • Hamdy F.C. The prostate cancer prevention trial and its messages. Eur Urol 51 (2007) 6-8
    • (2007) Eur Urol , vol.51 , pp. 6-8
    • Hamdy, F.C.1
  • 17
    • 0026326528 scopus 로고
    • Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue
    • Jenkins E.P., Hsieh C.L., Milatovich A., et al. Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. Genomics 11 (1991) 1102-1112
    • (1991) Genomics , vol.11 , pp. 1102-1112
    • Jenkins, E.P.1    Hsieh, C.L.2    Milatovich, A.3
  • 18
    • 0026723090 scopus 로고
    • Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions
    • Normington K., and Russell D.W. Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. J Biol Chem 267 (1992) 19548-19554
    • (1992) J Biol Chem , vol.267 , pp. 19548-19554
    • Normington, K.1    Russell, D.W.2
  • 19
    • 0027234897 scopus 로고
    • Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression
    • Thigpen A.E., Silver R.I., Guileyardo J.M., et al. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest 92 (1993) 903-910
    • (1993) J Clin Invest , vol.92 , pp. 903-910
    • Thigpen, A.E.1    Silver, R.I.2    Guileyardo, J.M.3
  • 21
    • 0028303201 scopus 로고
    • Expression and regulation of steroid 5 alpha-reductase 2 in prostate disease
    • Silver R.I., Wiley E.L., Davis D.L., et al. Expression and regulation of steroid 5 alpha-reductase 2 in prostate disease. J Urol 152 (1994) 433-437
    • (1994) J Urol , vol.152 , pp. 433-437
    • Silver, R.I.1    Wiley, E.L.2    Davis, D.L.3
  • 22
    • 0026612464 scopus 로고
    • Disposition and pharmacokinetics of [14C] finasteride after oral administration in humans
    • Carlin J.R., Höglund P., Eriksson L.O., et al. Disposition and pharmacokinetics of [14C] finasteride after oral administration in humans. Drug Metab Dispos 20 (1992) 148-155
    • (1992) Drug Metab Dispos , vol.20 , pp. 148-155
    • Carlin, J.R.1    Höglund, P.2    Eriksson, L.O.3
  • 23
    • 0025808821 scopus 로고
    • Pharmacokinetics and biochemical efficacy after single and multiple oral administration of N-(2-methyl-2-propyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17 beta-carboxamide, a new type of specific competitive inhibitor of testosterone 5 alpha-reductase, in volunteers
    • Ohtawa M., Morikawa H., and Shimazaki J. Pharmacokinetics and biochemical efficacy after single and multiple oral administration of N-(2-methyl-2-propyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17 beta-carboxamide, a new type of specific competitive inhibitor of testosterone 5 alpha-reductase, in volunteers. Eur J Drug Metab Pharmacokinet 16 (1991) 15-21
    • (1991) Eur J Drug Metab Pharmacokinet , vol.16 , pp. 15-21
    • Ohtawa, M.1    Morikawa, H.2    Shimazaki, J.3
  • 24
    • 0028807269 scopus 로고
    • Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: towards perfection of rates of time-dependent inhibition by using ligand-binding energies
    • Tian G., Mook Jr. R.A., Moss M.L., and Frye S.V. Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: towards perfection of rates of time-dependent inhibition by using ligand-binding energies. Biochemistry 34 (1995) 13453-13459
    • (1995) Biochemistry , vol.34 , pp. 13453-13459
    • Tian, G.1    Mook Jr., R.A.2    Moss, M.L.3    Frye, S.V.4
  • 26
    • 2442545242 scopus 로고    scopus 로고
    • Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor
    • Clark R.V., Hermann D.J., Cunningham G.R., et al. Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor. J Clin Endocrinol Metab 89 (2004) 2179-2184
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2179-2184
    • Clark, R.V.1    Hermann, D.J.2    Cunningham, G.R.3
  • 27
    • 34249989027 scopus 로고    scopus 로고
    • The effect of dutasteride on intraprostatic dihydrotestosterone concentration in men with benign prostatic hyperplasia
    • Wurzel R., Ray P., Major-Walker K., Shannon J., and Rittmaster R. The effect of dutasteride on intraprostatic dihydrotestosterone concentration in men with benign prostatic hyperplasia. Prostate Cancer Prostatic Dis 10 (2007) 149-154
    • (2007) Prostate Cancer Prostatic Dis , vol.10 , pp. 149-154
    • Wurzel, R.1    Ray, P.2    Major-Walker, K.3    Shannon, J.4    Rittmaster, R.5
  • 28
    • 0026503988 scopus 로고
    • Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia
    • McConnell J.D., Wilson J.D., George F.W., et al. Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J Clin Endocrinol Metab 74 (1992) 505-508
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 505-508
    • McConnell, J.D.1    Wilson, J.D.2    George, F.W.3
  • 29
    • 0345672747 scopus 로고    scopus 로고
    • Selectivity of finasteride as an in vivo inhibitor of 5alpha-reductase isozyme enzymatic activity in the human prostate
    • Span P.N., Voller M.C., Smals A.G., et al. Selectivity of finasteride as an in vivo inhibitor of 5alpha-reductase isozyme enzymatic activity in the human prostate. J Urol 161 (1999) 332-337
    • (1999) J Urol , vol.161 , pp. 332-337
    • Span, P.N.1    Voller, M.C.2    Smals, A.G.3
  • 30
    • 4143136459 scopus 로고    scopus 로고
    • Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor progression in prostate cancer
    • Andriole G.L., Humphrey P., Ray P., et al. Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor progression in prostate cancer. J Urol 172 (2004) 915-919
    • (2004) J Urol , vol.172 , pp. 915-919
    • Andriole, G.L.1    Humphrey, P.2    Ray, P.3
  • 31
    • 0032588595 scopus 로고    scopus 로고
    • Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue
    • Iehle C., Radvanyi F., Gil Diez de Medina S., et al. Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue. J Steroid Biochem Mol Biol 68 (1999) 189-195
    • (1999) J Steroid Biochem Mol Biol , vol.68 , pp. 189-195
    • Iehle, C.1    Radvanyi, F.2    Gil Diez de Medina, S.3
  • 32
    • 17644362707 scopus 로고    scopus 로고
    • Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer
    • Thomas L.N., Lazier C.B., Gupta R., et al. Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer. Prostate 63 (2005) 231-239
    • (2005) Prostate , vol.63 , pp. 231-239
    • Thomas, L.N.1    Lazier, C.B.2    Gupta, R.3
  • 33
    • 0141988845 scopus 로고    scopus 로고
    • 5alpha-reductase type 1 immunostaining is enhanced in some prostate cancers compared with benign prostatic hyperplasia epithelium
    • Thomas L.N., Douglas R.C., Vessey J.P., et al. 5alpha-reductase type 1 immunostaining is enhanced in some prostate cancers compared with benign prostatic hyperplasia epithelium. J Urol 170 (2003) 2019-2025
    • (2003) J Urol , vol.170 , pp. 2019-2025
    • Thomas, L.N.1    Douglas, R.C.2    Vessey, J.P.3
  • 34
    • 0035094483 scopus 로고    scopus 로고
    • Messenger ribonucleic acid levels of steroid 5 alpha-reductase 2 in human prostate predict the enzyme activity
    • Soderstrom T.G., Bjelfman C., Brekkan E., et al. Messenger ribonucleic acid levels of steroid 5 alpha-reductase 2 in human prostate predict the enzyme activity. J Clin Endocrinol Metab 86 (2001) 855-858
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 855-858
    • Soderstrom, T.G.1    Bjelfman, C.2    Brekkan, E.3
  • 35
    • 0141676080 scopus 로고    scopus 로고
    • Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma
    • Luo J., Dunn T.A., Ewing C.M., Walsh P.C., and Isaacs W.B. Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma. Prostate 57 (2003) 134-139
    • (2003) Prostate , vol.57 , pp. 134-139
    • Luo, J.1    Dunn, T.A.2    Ewing, C.M.3    Walsh, P.C.4    Isaacs, W.B.5
  • 36
    • 20444476601 scopus 로고    scopus 로고
    • Steroid 5alpha-reductase isozymes I and II in recurrent prostate cancer
    • Titus M.A., Gregory C.W., Ford III O.H., et al. Steroid 5alpha-reductase isozymes I and II in recurrent prostate cancer. Clin Cancer Res 11 (2005) 4365-4371
    • (2005) Clin Cancer Res , vol.11 , pp. 4365-4371
    • Titus, M.A.1    Gregory, C.W.2    Ford III, O.H.3
  • 37
    • 0030856520 scopus 로고    scopus 로고
    • Differential gene expression of steroid 5 alpha-reductase 2 in core needle biopsies from malignant and benign prostatic tissue
    • Bjelfman C., Soderstrom T.G., Brekkan E., et al. Differential gene expression of steroid 5 alpha-reductase 2 in core needle biopsies from malignant and benign prostatic tissue. J Clin Endocrinol Metab 82 (1997) 2210-2214
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2210-2214
    • Bjelfman, C.1    Soderstrom, T.G.2    Brekkan, E.3
  • 38
    • 4544248276 scopus 로고    scopus 로고
    • Chemoprevention of prostate cancer in men at high risk: rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trial
    • Andriole G., Bostwick D., Brawley O., et al. Chemoprevention of prostate cancer in men at high risk: rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trial. J Urol 172 (2004) 1314-1317
    • (2004) J Urol , vol.172 , pp. 1314-1317
    • Andriole, G.1    Bostwick, D.2    Brawley, O.3
  • 39
    • 0029888406 scopus 로고    scopus 로고
    • Histopathological effects of androgen deprivation in prostatic cancer
    • Civantos F., Soloway M.S., and Pinto J.E. Histopathological effects of androgen deprivation in prostatic cancer. Semin Urol Oncol 14 (1996) 22-31
    • (1996) Semin Urol Oncol , vol.14 , pp. 22-31
    • Civantos, F.1    Soloway, M.S.2    Pinto, J.E.3
  • 40
    • 0031814673 scopus 로고    scopus 로고
    • The effect of finasteride on the prostate gland in men with elevated serum prostate-specific antigen levels
    • Cote R.J., Skinner E.C., Salem C.E., et al. The effect of finasteride on the prostate gland in men with elevated serum prostate-specific antigen levels. Br J Cancer 78 (1998) 413-418
    • (1998) Br J Cancer , vol.78 , pp. 413-418
    • Cote, R.J.1    Skinner, E.C.2    Salem, C.E.3
  • 41
    • 34548217770 scopus 로고    scopus 로고
    • Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors
    • Cussenot O., Azzouzi A.R., Nicolaiew N., et al. Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors. Eur Urol 52 (2007) 1082-1089
    • (2007) Eur Urol , vol.52 , pp. 1082-1089
    • Cussenot, O.1    Azzouzi, A.R.2    Nicolaiew, N.3
  • 42
    • 33744790339 scopus 로고    scopus 로고
    • The PCPT: new findings, new insights and clinical implications for the prevention of prostate cancer
    • Akduman B., and Crawford E.D. The PCPT: new findings, new insights and clinical implications for the prevention of prostate cancer. Eur Urol Suppl 5 (2006) 634-639
    • (2006) Eur Urol Suppl , vol.5 , pp. 634-639
    • Akduman, B.1    Crawford, E.D.2
  • 43
    • 34248138901 scopus 로고    scopus 로고
    • Quantifying the impact of prostate volumes, numbers of biopsy cores, and 5alpha-reductase inhibitor therapy on the probability of prostate cancer detection using mathematical modeling
    • Serfling R., Schulman M.T., Thompson G.L., et al. Quantifying the impact of prostate volumes, numbers of biopsy cores, and 5alpha-reductase inhibitor therapy on the probability of prostate cancer detection using mathematical modeling. J Urol 153 (2007) 2352-2356
    • (2007) J Urol , vol.153 , pp. 2352-2356
    • Serfling, R.1    Schulman, M.T.2    Thompson, G.L.3
  • 45
    • 4444331484 scopus 로고    scopus 로고
    • Effect of dutasteride on the detection of prostate cancer in men with benign prostatic hyperplasia
    • Andriole G.L., Roehrborn C., Schulman C., et al. Effect of dutasteride on the detection of prostate cancer in men with benign prostatic hyperplasia. Urology 64 (2004) 537-541
    • (2004) Urology , vol.64 , pp. 537-541
    • Andriole, G.L.1    Roehrborn, C.2    Schulman, C.3
  • 46
    • 0036755404 scopus 로고    scopus 로고
    • Androgen receptor as a target in androgen-independent prostate cancer
    • Balk S.P. Androgen receptor as a target in androgen-independent prostate cancer. Urology 60 (2002) 132-138
    • (2002) Urology , vol.60 , pp. 132-138
    • Balk, S.P.1
  • 47
    • 84928580276 scopus 로고
    • Studies on prostatic cancer: the effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins C., and Hodges C.V. Studies on prostatic cancer: the effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1 (1941) 293-297
    • (1941) Cancer Res , vol.1 , pp. 293-297
    • Huggins, C.1    Hodges, C.V.2
  • 48
    • 42749106212 scopus 로고    scopus 로고
    • Mike S, Harrison C, Coles B, et al. Chemotherapy for hormone-refractory prostate cancer. Cochrane Database Syst Rev 2006:CD005247.
  • 49
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • Stanbrough M., Bubley G.J., Ross K., et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 66 (2006) 2815-2825
    • (2006) Cancer Res , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3
  • 50
    • 0036170838 scopus 로고    scopus 로고
    • Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells
    • Zegarra-Moro O.L., Schmidt L.J., Huang H., and Tindall D.J. Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res 62 (2002) 1008-1013
    • (2002) Cancer Res , vol.62 , pp. 1008-1013
    • Zegarra-Moro, O.L.1    Schmidt, L.J.2    Huang, H.3    Tindall, D.J.4
  • 51
    • 0029011116 scopus 로고
    • Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
    • Taplin M.E., Bubley G.J., Shuster T.D., et al. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 332 (1995) 1393-1398
    • (1995) N Engl J Med , vol.332 , pp. 1393-1398
    • Taplin, M.E.1    Bubley, G.J.2    Shuster, T.D.3
  • 52
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • Visakorpi T., Hyytinen E., Koivisto P., et al. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet 9 (1995) 401-406
    • (1995) Nat Genet , vol.9 , pp. 401-406
    • Visakorpi, T.1    Hyytinen, E.2    Koivisto, P.3
  • 53
    • 0033152164 scopus 로고    scopus 로고
    • Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
    • Taplin M.E., Bubley G.J., Ko Y.J., et al. Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. Cancer Res 59 (1999) 2511-2515
    • (1999) Cancer Res , vol.59 , pp. 2511-2515
    • Taplin, M.E.1    Bubley, G.J.2    Ko, Y.J.3
  • 54
    • 0042130389 scopus 로고    scopus 로고
    • Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663
    • Taplin M.E., Rajeshkumar B., Halabi S., et al. Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. J Clin Oncol 21 (2003) 2673-2678
    • (2003) J Clin Oncol , vol.21 , pp. 2673-2678
    • Taplin, M.E.1    Rajeshkumar, B.2    Halabi, S.3
  • 55
    • 0242439518 scopus 로고    scopus 로고
    • Role of the androgen receptor axis in prostate cancer
    • Culig Z. Role of the androgen receptor axis in prostate cancer. Urology 62 (2003) 21-26
    • (2003) Urology , vol.62 , pp. 21-26
    • Culig, Z.1
  • 56
    • 0035361340 scopus 로고    scopus 로고
    • A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    • Gregory C.W., He B., Johnson R.T., et al. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy. Cancer Res 61 (2001) 4315-4319
    • (2001) Cancer Res , vol.61 , pp. 4315-4319
    • Gregory, C.W.1    He, B.2    Johnson, R.T.3
  • 57
    • 3242756036 scopus 로고    scopus 로고
    • Ras signaling in prostate cancer progression
    • Weber M.J., and Gioeli D. Ras signaling in prostate cancer progression. J Cell Biochem 91 (2004) 13-25
    • (2004) J Cell Biochem , vol.91 , pp. 13-25
    • Weber, M.J.1    Gioeli, D.2
  • 58
    • 3442881953 scopus 로고    scopus 로고
    • Finasteride and bicalutamide as primary hormonal therapy in patients with advanced adenocarcinoma of the prostate
    • Tay M.H., Kaufman D.S., Regan M.M., et al. Finasteride and bicalutamide as primary hormonal therapy in patients with advanced adenocarcinoma of the prostate. Ann Oncol 15 (2004) 974-978
    • (2004) Ann Oncol , vol.15 , pp. 974-978
    • Tay, M.H.1    Kaufman, D.S.2    Regan, M.M.3
  • 59
    • 0031010962 scopus 로고    scopus 로고
    • Finasteride and flutamide as potency-sparing androgen-ablative therapy for advanced adenocarcinoma of the prostate
    • Brufsky A., Fontaine-Roth P., Berlane K., et al. Finasteride and flutamide as potency-sparing androgen-ablative therapy for advanced adenocarcinoma of the prostate. Urology 49 (1997) 913-920
    • (1997) Urology , vol.49 , pp. 913-920
    • Brufsky, A.1    Fontaine-Roth, P.2    Berlane, K.3


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