-
1
-
-
0038529679
-
Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease
-
Adessi C., Frossard M.J., Boissard C., Fraga S., Bieler S., Ruckle T., Vilbois F., Robinson S.M., Mutter M., Banks W.A., and Soto C. Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease. Journal of Biological chemistry 278 (2003) 13905-13911
-
(2003)
Journal of Biological chemistry
, vol.278
, pp. 13905-13911
-
-
Adessi, C.1
Frossard, M.J.2
Boissard, C.3
Fraga, S.4
Bieler, S.5
Ruckle, T.6
Vilbois, F.7
Robinson, S.M.8
Mutter, M.9
Banks, W.A.10
Soto, C.11
-
2
-
-
0021318441
-
Catalase in vitro
-
Aebi H. Catalase in vitro. Methods in Enzymology 105 (1984) 121-126
-
(1984)
Methods in Enzymology
, vol.105
, pp. 121-126
-
-
Aebi, H.1
-
3
-
-
58149374037
-
Antioxidant therapy in Alzheimer's disease: theory and practice
-
Aliev G., Obrenovich M.E., Reddy V.P., Shenk J.C., Moreira P.I., Nunomura A., Zhu X., Smith M.A., and Perry G. Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Reviews in Medicinal Chemistry 8 (2008) 1395-1406
-
(2008)
Mini Reviews in Medicinal Chemistry
, vol.8
, pp. 1395-1406
-
-
Aliev, G.1
Obrenovich, M.E.2
Reddy, V.P.3
Shenk, J.C.4
Moreira, P.I.5
Nunomura, A.6
Zhu, X.7
Smith, M.A.8
Perry, G.9
-
4
-
-
0037107177
-
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
-
Bacskai B.J., Kajdasz S.T., McLellan M.E., Games D., Seubert P., Schenk D., and Hyman B.T. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. Journal of Neuroscience 22 (2002) 7873-7878
-
(2002)
Journal of Neuroscience
, vol.22
, pp. 7873-7878
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
McLellan, M.E.3
Games, D.4
Seubert, P.5
Schenk, D.6
Hyman, B.T.7
-
5
-
-
0032575687
-
Is apoptosis key in Alzheimer's disease?
-
Barinaga M. Is apoptosis key in Alzheimer's disease?. Science 281 (1998) 1303-1304
-
(1998)
Science
, vol.281
, pp. 1303-1304
-
-
Barinaga, M.1
-
6
-
-
0030728765
-
Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease
-
Behl C. Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease. Cell and Tissue Research 290 (1997) 471-480
-
(1997)
Cell and Tissue Research
, vol.290
, pp. 471-480
-
-
Behl, C.1
-
7
-
-
0031882236
-
Oxidative stress in the pathogenesis of Alzheimer's disease and antioxidant neuroprotection
-
Behl C., and Holsboer F. Oxidative stress in the pathogenesis of Alzheimer's disease and antioxidant neuroprotection. Fortschritte der Neurologie-Psychiatrie 66 (1998) 113-121
-
(1998)
Fortschritte der Neurologie-Psychiatrie
, vol.66
, pp. 113-121
-
-
Behl, C.1
Holsboer, F.2
-
8
-
-
0028233494
-
Hydrogen peroxide mediates amyloid beta protein toxicity
-
Behl C., Davis J.B., Lesley R., and Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77 (1994) 817-827
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
10
-
-
32644475566
-
Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35
-
Clementi M.E., Pezzotti M., Orsini F., Sampaolese B., Mezzogori D., Grassi C., Giardina B., and Misiti F. Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35. Biochemical and Biophysical Research Communications 342 (2006) 206-213
-
(2006)
Biochemical and Biophysical Research Communications
, vol.342
, pp. 206-213
-
-
Clementi, M.E.1
Pezzotti, M.2
Orsini, F.3
Sampaolese, B.4
Mezzogori, D.5
Grassi, C.6
Giardina, B.7
Misiti, F.8
-
11
-
-
0036975682
-
Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease
-
De Felice F.G., and Ferreira S.T. Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease. Cellular and Molecular Neurobiology 22 (2002) 545-563
-
(2002)
Cellular and Molecular Neurobiology
, vol.22
, pp. 545-563
-
-
De Felice, F.G.1
Ferreira, S.T.2
-
12
-
-
0035349804
-
Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy
-
De Felice F.G., Houzel J.C., Garcia-Abreu J., Louzada Jr. P.R., Afonso R.C., Meirelles M.N., Lent R., Neto V.M., and Ferreira S.T. Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy. FASEB Journal 15 (2001) 1297-1299
-
(2001)
FASEB Journal
, vol.15
, pp. 1297-1299
-
-
De Felice, F.G.1
Houzel, J.C.2
Garcia-Abreu, J.3
Louzada Jr., P.R.4
Afonso, R.C.5
Meirelles, M.N.6
Lent, R.7
Neto, V.M.8
Ferreira, S.T.9
-
13
-
-
49649116929
-
Designed amyloid beta peptide fibril - a tool for high-throughput screening of fibril inhibitors
-
Dolphin G.T., Ouberai M., Dumy P., and Garcia J. Designed amyloid beta peptide fibril - a tool for high-throughput screening of fibril inhibitors. ChemMedChem 2 (2007) 1613-1623
-
(2007)
ChemMedChem
, vol.2
, pp. 1613-1623
-
-
Dolphin, G.T.1
Ouberai, M.2
Dumy, P.3
Garcia, J.4
-
14
-
-
12244281810
-
Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model
-
Drake J., Link C.D., and Butterfield D.A. Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model. Neurobiology of Aging 24 (2003) 415-420
-
(2003)
Neurobiology of Aging
, vol.24
, pp. 415-420
-
-
Drake, J.1
Link, C.D.2
Butterfield, D.A.3
-
15
-
-
34548812551
-
The role of amyloid beta peptide 42 in Alzheimer's disease
-
Findeis M.A. The role of amyloid beta peptide 42 in Alzheimer's disease. Pharmacology and Therapeutics 116 (2007) 266-286
-
(2007)
Pharmacology and Therapeutics
, vol.116
, pp. 266-286
-
-
Findeis, M.A.1
-
16
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer's disease
-
Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends in Neuroscience 20 (1997) 154-159
-
(1997)
Trends in Neuroscience
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
17
-
-
84880187014
-
Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal
-
Hardy J. Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. Journal of Alzheimer's Disease 9 (2006) 151-153
-
(2006)
Journal of Alzheimer's Disease
, vol.9
, pp. 151-153
-
-
Hardy, J.1
-
18
-
-
0026597063
-
Alzheimer's disease: the amyloid cascade hypothesis
-
Hardy J.A., and Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 256 (1992) 184-185
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
20
-
-
33750449952
-
A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide
-
Kim W., Kim Y., Min J., Kim D.J., Chang Y.T., and Hecht M.H. A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide. ACS Chemical Biology 1 (2006) 461-469
-
(2006)
ACS Chemical Biology
, vol.1
, pp. 461-469
-
-
Kim, W.1
Kim, Y.2
Min, J.3
Kim, D.J.4
Chang, Y.T.5
Hecht, M.H.6
-
21
-
-
0025732677
-
Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly (ADP-ribose) polymerase
-
Kirkland J.B. Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly (ADP-ribose) polymerase. Biochimica et Biophysica Acta 1092 (1991) 319-325
-
(1991)
Biochimica et Biophysica Acta
, vol.1092
, pp. 319-325
-
-
Kirkland, J.B.1
-
22
-
-
33747484171
-
N-methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure
-
Kokkoni N., Stott K., Amijee H., Mason J.M., and Doig A.J. N-methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure. Biochemistry 45 (2006) 9906-9918
-
(2006)
Biochemistry
, vol.45
, pp. 9906-9918
-
-
Kokkoni, N.1
Stott, K.2
Amijee, H.3
Mason, J.M.4
Doig, A.J.5
-
23
-
-
0026554428
-
Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
-
LeBel C.P., Ischiropoulos H., and Bondy S.C. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chemical Research in Toxicology 5 (1992) 227-231
-
(1992)
Chemical Research in Toxicology
, vol.5
, pp. 227-231
-
-
LeBel, C.P.1
Ischiropoulos, H.2
Bondy, S.C.3
-
24
-
-
33947719234
-
Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway
-
Lee S., Fernandez E.J., and Good T.A. Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway. Protein Science 16 (2007) 723-732
-
(2007)
Protein Science
, vol.16
, pp. 723-732
-
-
Lee, S.1
Fernandez, E.J.2
Good, T.A.3
-
25
-
-
0028172886
-
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red
-
Lorenzo A., and Yankner B.A. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proceedings of Natural Academy of Science USA 91 (1994) 12243-12247
-
(1994)
Proceedings of Natural Academy of Science USA
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.A.2
-
27
-
-
0032031780
-
Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease
-
Marcus D.L., Thomas C., Rodriguez C., Simberkoff K., Tsai J.S., Strafaci J.A., and Freedman M.L. Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease. Experimental Neurology 150 (1998) 40-44
-
(1998)
Experimental Neurology
, vol.150
, pp. 40-44
-
-
Marcus, D.L.1
Thomas, C.2
Rodriguez, C.3
Simberkoff, K.4
Tsai, J.S.5
Strafaci, J.A.6
Freedman, M.L.7
-
28
-
-
0026032039
-
Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease
-
Masliah E., Terry R.D., Alford M., DeTeresa R., and Hansen L.A. Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. American Journal of Pathology 138 (1991) 235-246
-
(1991)
American Journal of Pathology
, vol.138
, pp. 235-246
-
-
Masliah, E.1
Terry, R.D.2
Alford, M.3
DeTeresa, R.4
Hansen, L.A.5
-
29
-
-
0014691242
-
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
-
McCord J.M., and Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). The Journal of Biological Chemistry 244 (1969) 6049-6055
-
(1969)
The Journal of Biological Chemistry
, vol.244
, pp. 6049-6055
-
-
McCord, J.M.1
Fridovich, I.2
-
30
-
-
0033430085
-
Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown
-
Milton N.G. Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown. The Biochemical Journal 344 Pt 2 (1999) 293-296
-
(1999)
The Biochemical Journal
, vol.344
, Issue.PART 2
, pp. 293-296
-
-
Milton, N.G.1
-
31
-
-
0034643895
-
Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells
-
Misonou H., Morishima-Kawashima M., and Ihara Y. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry 39 (2000) 6951-6959
-
(2000)
Biochemistry
, vol.39
, pp. 6951-6959
-
-
Misonou, H.1
Morishima-Kawashima, M.2
Ihara, Y.3
-
32
-
-
33646828380
-
Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of l-carnitine and dl-alpha-lipoic acid
-
Muthuswamy A.D., Vedagiri K., Ganesan M., and Chinnakannu P. Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of l-carnitine and dl-alpha-lipoic acid. Clinica Chimica Acta; International Journal of Clinical Chemistry 368 (2006) 84-92
-
(2006)
Clinica Chimica Acta; International Journal of Clinical Chemistry
, vol.368
, pp. 84-92
-
-
Muthuswamy, A.D.1
Vedagiri, K.2
Ganesan, M.3
Chinnakannu, P.4
-
33
-
-
0037099243
-
Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis
-
Peng Q.L., Buz'Zard A.R., and Lau B.H. Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis. Brain Research 104 (2002) 55-65
-
(2002)
Brain Research
, vol.104
, pp. 55-65
-
-
Peng, Q.L.1
Buz'Zard, A.R.2
Lau, B.H.3
-
34
-
-
0032845739
-
The nonfibrillar amyloid beta-peptide induces apoptotic neuronal cell death: involvement of its C-terminal fusogenic domain
-
Pillot T., Drouet B., Queille S., Labeur C., Vandekerchkhove J., Rosseneu M., Pincon-Raymond M., and Chambaz J. The nonfibrillar amyloid beta-peptide induces apoptotic neuronal cell death: involvement of its C-terminal fusogenic domain. Journal of Neurochemistry 73 (1999) 1626-1634
-
(1999)
Journal of Neurochemistry
, vol.73
, pp. 1626-1634
-
-
Pillot, T.1
Drouet, B.2
Queille, S.3
Labeur, C.4
Vandekerchkhove, J.5
Rosseneu, M.6
Pincon-Raymond, M.7
Chambaz, J.8
-
36
-
-
0037528769
-
Involvement of protein phosphatase 2A in interferon-alpha-2b-induced apoptosis in K562 human chronic myelogenous leukaemia cells
-
Saydam G., Aydin H.H., Sahin F., Selvi N., Oktem G., Terzioglu E., Buyukkececi F., and Omay S.B. Involvement of protein phosphatase 2A in interferon-alpha-2b-induced apoptosis in K562 human chronic myelogenous leukaemia cells. Leukemia Research 27 (2003) 709-717
-
(2003)
Leukemia Research
, vol.27
, pp. 709-717
-
-
Saydam, G.1
Aydin, H.H.2
Sahin, F.3
Selvi, N.4
Oktem, G.5
Terzioglu, E.6
Buyukkececi, F.7
Omay, S.B.8
-
38
-
-
0034018813
-
Apoptosis in Alzheimer's disease
-
Shimohama S. Apoptosis in Alzheimer's disease. Apoptosis 5 (2000) 9-16
-
(2000)
Apoptosis
, vol.5
, pp. 9-16
-
-
Shimohama, S.1
-
39
-
-
3343017533
-
Oxidative stress: a theoretical model or a biological reality?
-
Sorg O. Oxidative stress: a theoretical model or a biological reality?. Comptes Rendus Biologies 327 (2004) 649-662
-
(2004)
Comptes Rendus Biologies
, vol.327
, pp. 649-662
-
-
Sorg, O.1
-
40
-
-
0032839878
-
Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease
-
Soto C. Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease. Molecular Medicine Today 5 (1999) 343-350
-
(1999)
Molecular Medicine Today
, vol.5
, pp. 343-350
-
-
Soto, C.1
-
42
-
-
13644265462
-
Ferulic acid ethyl ester protects neurons against amyloid beta- peptide (1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity
-
Sultana R., Ravagna A., Mohmmad-Abdul H., Calabrese V., and Butterfield D.A. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide (1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. Journal of Neurochemistry 92 (2005) 749-758
-
(2005)
Journal of Neurochemistry
, vol.92
, pp. 749-758
-
-
Sultana, R.1
Ravagna, A.2
Mohmmad-Abdul, H.3
Calabrese, V.4
Butterfield, D.A.5
-
43
-
-
0028322017
-
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
-
Suzuki N., Cheung T.T., Cai X.D., Odaka A., Otvos Jr. L., Eckman C., Golde T.E., and Younkin S.G. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 264 (1994) 1336-1340
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
Odaka, A.4
Otvos Jr., L.5
Eckman, C.6
Golde, T.E.7
Younkin, S.G.8
-
44
-
-
0037524251
-
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis
-
Tamagno E., Parola M., Guglielmotto M., Santoro G., Bardini P., Marra L., Tabaton M., and Danni O. Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis. Free Radical Biology and Medicine 35 (2003) 45-58
-
(2003)
Free Radical Biology and Medicine
, vol.35
, pp. 45-58
-
-
Tamagno, E.1
Parola, M.2
Guglielmotto, M.3
Santoro, G.4
Bardini, P.5
Marra, L.6
Tabaton, M.7
Danni, O.8
-
45
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
-
Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., and Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Annals of Neurology 30 (1991) 572-580
-
(1991)
Annals of Neurology
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
46
-
-
0025738516
-
Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production
-
Vistica D.T., Skehan P., Scudiero D., Monks A., Pittman A., and Boyd M.R. Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Research 51 (1991) 2515-2520
-
(1991)
Cancer Research
, vol.51
, pp. 2515-2520
-
-
Vistica, D.T.1
Skehan, P.2
Scudiero, D.3
Monks, A.4
Pittman, A.5
Boyd, M.R.6
-
47
-
-
0036141139
-
Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation
-
Xiao X.Q., Zhang H.Y., and Tang X.C. Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. Journal of Neuroscience Research 67 (2002) 30-36
-
(2002)
Journal of Neuroscience Research
, vol.67
, pp. 30-36
-
-
Xiao, X.Q.1
Zhang, H.Y.2
Tang, X.C.3
-
48
-
-
58149173970
-
Oxidative stress induces macroautophagy of amyloid beta-protein and ensuing apoptosis
-
Zheng L., Kagedal K., Dehvari N., Benedikz E., Cowburn R., Marcusson J., and Terman A. Oxidative stress induces macroautophagy of amyloid beta-protein and ensuing apoptosis. Free Radical Biology and Medicine 246 (2009) 422-429
-
(2009)
Free Radical Biology and Medicine
, vol.246
, pp. 422-429
-
-
Zheng, L.1
Kagedal, K.2
Dehvari, N.3
Benedikz, E.4
Cowburn, R.5
Marcusson, J.6
Terman, A.7
|