-
1
-
-
15044359236
-
Linking Rap to cell adhesion
-
Bos J.L. Linking Rap to cell adhesion. Curr Opin Cell Biol 17 (2005) 123-128
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 123-128
-
-
Bos, J.L.1
-
2
-
-
33846847701
-
Rap1: a key regulator in cell-cell junction formation
-
Kooistra M.R., Dube N., and Bos J.L. Rap1: a key regulator in cell-cell junction formation. J Cell Sci 120 (2007) 17-22
-
(2007)
J Cell Sci
, vol.120
, pp. 17-22
-
-
Kooistra, M.R.1
Dube, N.2
Bos, J.L.3
-
3
-
-
4444264392
-
Integrins: dynamic scaffolds for adhesion and signaling in platelets
-
Shattil S.J., and Newman P.J. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood 104 (2004) 1606-1615
-
(2004)
Blood
, vol.104
, pp. 1606-1615
-
-
Shattil, S.J.1
Newman, P.J.2
-
4
-
-
33748454742
-
Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3
-
This study reports the reconstitution of a platelet-specific Rap1-dependent signaling pathway in CHO cells and describes how Rap1 and its effector RIAM can effectively activate talin and integrin signaling. The epistatic relationships between Rap1, RIAM and talin are elegantly demonstrated.
-
Han J., Lim C.J., Watanabe N., Soriani A., Ratnikov B., Calderwood D.A., Puzon-McLaughlin W., Lafuente E.M., Boussiotis V.A., Shattil S.J., et al. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol 16 (2006) 1796-1806. This study reports the reconstitution of a platelet-specific Rap1-dependent signaling pathway in CHO cells and describes how Rap1 and its effector RIAM can effectively activate talin and integrin signaling. The epistatic relationships between Rap1, RIAM and talin are elegantly demonstrated.
-
(2006)
Curr Biol
, vol.16
, pp. 1796-1806
-
-
Han, J.1
Lim, C.J.2
Watanabe, N.3
Soriani, A.4
Ratnikov, B.5
Calderwood, D.A.6
Puzon-McLaughlin, W.7
Lafuente, E.M.8
Boussiotis, V.A.9
Shattil, S.J.10
-
5
-
-
8744300054
-
Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion
-
Critchley D.R. Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion. Biochem Soc Trans 32 (2004) 831-836
-
(2004)
Biochem Soc Trans
, vol.32
, pp. 831-836
-
-
Critchley, D.R.1
-
6
-
-
0032563558
-
Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells
-
Priddle H., Hemmings L., Monkley S., Woods A., Patel B., Sutton D., Dunn G.A., Zicha D., and Critchley D.R. Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells. J Cell Biol 142 (1998) 1121-1133
-
(1998)
J Cell Biol
, vol.142
, pp. 1121-1133
-
-
Priddle, H.1
Hemmings, L.2
Monkley, S.3
Woods, A.4
Patel, B.5
Sutton, D.6
Dunn, G.A.7
Zicha, D.8
Critchley, D.R.9
-
7
-
-
51049100594
-
Talin depletion reveals independence of initial cell spreading from integrin activation and traction
-
Zhang X., Jiang G., Cai Y., Monkley S.J., Critchley D.R., and Sheetz M.P. Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol 10 (2008) 1062-1068
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1062-1068
-
-
Zhang, X.1
Jiang, G.2
Cai, Y.3
Monkley, S.J.4
Critchley, D.R.5
Sheetz, M.P.6
-
8
-
-
37549064277
-
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
-
Petrich B.G., Marchese P., Ruggeri Z.M., Spiess S., Weichert R.A., Ye F., Tiedt R., Skoda R.C., Monkley S.J., Critchley D.R., et al. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med 204 (2007) 3103-3111
-
(2007)
J Exp Med
, vol.204
, pp. 3103-3111
-
-
Petrich, B.G.1
Marchese, P.2
Ruggeri, Z.M.3
Spiess, S.4
Weichert, R.A.5
Ye, F.6
Tiedt, R.7
Skoda, R.C.8
Monkley, S.J.9
Critchley, D.R.10
-
9
-
-
28844490120
-
Genetic, biochemical and structural approaches to talin function
-
Critchley D.R. Genetic, biochemical and structural approaches to talin function. Biochem Soc Trans 33 (2005) 1308-1312
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 1308-1312
-
-
Critchley, D.R.1
-
10
-
-
0027757072
-
Talin distribution and phosphorylation in thrombin-activated platelets
-
Bertagnolli M.E., Locke S.J., Hensler M.E., Bray P.F., and Beckerle M.C. Talin distribution and phosphorylation in thrombin-activated platelets. J Cell Sci 106 Pt 4 (1993) 1189-1199
-
(1993)
J Cell Sci
, vol.106
, Issue.PART 4
, pp. 1189-1199
-
-
Bertagnolli, M.E.1
Locke, S.J.2
Hensler, M.E.3
Bray, P.F.4
Beckerle, M.C.5
-
11
-
-
0031014969
-
Rapid Ca2+-mediated activation of Rap1 in human platelets
-
Franke B., Akkerman J.W., and Bos J.L. Rapid Ca2+-mediated activation of Rap1 in human platelets. EMBO J 16 (1997) 252-259
-
(1997)
EMBO J
, vol.16
, pp. 252-259
-
-
Franke, B.1
Akkerman, J.W.2
Bos, J.L.3
-
12
-
-
5044241734
-
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
-
Identification of RIAM as a Rap1 effector and first assessment of its potential to induce actin poymerization via Ena/VASP family proteins.
-
Lafuente E.M., van Puijenbroek A.A., Krause M., Carman C.V., Freeman G.J., Berezovskaya A., Constantine E., Springer T.A., Gertler F.B., and Boussiotis V.A. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell 7 (2004) 585-595. Identification of RIAM as a Rap1 effector and first assessment of its potential to induce actin poymerization via Ena/VASP family proteins.
-
(2004)
Dev Cell
, vol.7
, pp. 585-595
-
-
Lafuente, E.M.1
van Puijenbroek, A.A.2
Krause, M.3
Carman, C.V.4
Freeman, G.J.5
Berezovskaya, A.6
Constantine, E.7
Springer, T.A.8
Gertler, F.B.9
Boussiotis, V.A.10
-
13
-
-
46249121793
-
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3
-
A life cell study in which bimolecular fluorescence complementation with integrin subunits is achieved after activation of a thrombin pathway that signals via Rap1, RIAM and talin. The system by Han et al. is expanded herein by additional engineering of thrombin/PAR receptors into CHO cells.
-
Watanabe N., Bodin L., Pandey M., Krause M., Coughlin S., Boussiotis V.A., Ginsberg M.H., and Shattil S.J. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol 181 (2008) 1211-1222. A life cell study in which bimolecular fluorescence complementation with integrin subunits is achieved after activation of a thrombin pathway that signals via Rap1, RIAM and talin. The system by Han et al. is expanded herein by additional engineering of thrombin/PAR receptors into CHO cells.
-
(2008)
J Cell Biol
, vol.181
, pp. 1211-1222
-
-
Watanabe, N.1
Bodin, L.2
Pandey, M.3
Krause, M.4
Coughlin, S.5
Boussiotis, V.A.6
Ginsberg, M.H.7
Shattil, S.J.8
-
14
-
-
64149100431
-
RIAM activates integrins by linking talin to Ras GTPase membrane-targeting sequences
-
Lee H.S., Lim C.J., Puzon-McLaughlin W., Shattil S.J., and Ginsberg M.H. RIAM activates integrins by linking talin to Ras GTPase membrane-targeting sequences. J Biol Chem 284 (2009) 5119-5127
-
(2009)
J Biol Chem
, vol.284
, pp. 5119-5127
-
-
Lee, H.S.1
Lim, C.J.2
Puzon-McLaughlin, W.3
Shattil, S.J.4
Ginsberg, M.H.5
-
15
-
-
4644221351
-
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
-
Crittenden J.R., Bergmeier W., Zhang Y., Piffath C.L., Liang Y., Wagner D.D., Housman D.E., and Graybiel A.M. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med 10 (2004) 982-986
-
(2004)
Nat Med
, vol.10
, pp. 982-986
-
-
Crittenden, J.R.1
Bergmeier, W.2
Zhang, Y.3
Piffath, C.L.4
Liang, Y.5
Wagner, D.D.6
Housman, D.E.7
Graybiel, A.M.8
-
16
-
-
0036790996
-
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling
-
Eto K., Murphy R., Kerrigan S.W., Bertoni A., Stuhlmann H., Nakano T., Leavitt A.D., and Shattil S.J. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A 99 (2002) 12819-12824
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 12819-12824
-
-
Eto, K.1
Murphy, R.2
Kerrigan, S.W.3
Bertoni, A.4
Stuhlmann, H.5
Nakano, T.6
Leavitt, A.D.7
Shattil, S.J.8
-
17
-
-
5044244482
-
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics
-
Krause M., Leslie J.D., Stewart M., Lafuente E.M., Valderrama F., Jagannathan R., Strasser G.A., Rubinson D.A., Liu H., Way M., et al. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell 7 (2004) 571-583
-
(2004)
Dev Cell
, vol.7
, pp. 571-583
-
-
Krause, M.1
Leslie, J.D.2
Stewart, M.3
Lafuente, E.M.4
Valderrama, F.5
Jagannathan, R.6
Strasser, G.A.7
Rubinson, D.A.8
Liu, H.9
Way, M.10
-
18
-
-
33646198551
-
MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin
-
Chang C., Adler C.E., Krause M., Clark S.G., Gertler F.B., Tessier-Lavigne M., and Bargmann C.I. MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol 16 (2006) 854-862
-
(2006)
Curr Biol
, vol.16
, pp. 854-862
-
-
Chang, C.1
Adler, C.E.2
Krause, M.3
Clark, S.G.4
Gertler, F.B.5
Tessier-Lavigne, M.6
Bargmann, C.I.7
-
19
-
-
55349103811
-
Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation
-
Genetic analysis of Pico, a RIAM/Lpd homologue in Drosophila. The authors establish a genetic link between Pico and the SRF response, both probably being coupled by shifts in F-actin levels in various cells. This relationship has wider implementations for organismal growth control.
-
Lyulcheva E., Taylor E., Michael M., Vehlow A., Tan S., Fletcher A., Krause M., and Bennett D. Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Dev Cell 15 (2008) 680-690. Genetic analysis of Pico, a RIAM/Lpd homologue in Drosophila. The authors establish a genetic link between Pico and the SRF response, both probably being coupled by shifts in F-actin levels in various cells. This relationship has wider implementations for organismal growth control.
-
(2008)
Dev Cell
, vol.15
, pp. 680-690
-
-
Lyulcheva, E.1
Taylor, E.2
Michael, M.3
Vehlow, A.4
Tan, S.5
Fletcher, A.6
Krause, M.7
Bennett, D.8
-
20
-
-
0842266583
-
Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion
-
Bivona T.G., Wiener H.H., Ahearn I.M., Silletti J., Chiu V.K., and Philips M.R. Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol 164 (2004) 461-470
-
(2004)
J Cell Biol
, vol.164
, pp. 461-470
-
-
Bivona, T.G.1
Wiener, H.H.2
Ahearn, I.M.3
Silletti, J.4
Chiu, V.K.5
Philips, M.R.6
-
21
-
-
0042490495
-
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
-
Katagiri K., Maeda A., Shimonaka M., and Kinashi T. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol 4 (2003) 741-748
-
(2003)
Nat Immunol
, vol.4
, pp. 741-748
-
-
Katagiri, K.1
Maeda, A.2
Shimonaka, M.3
Kinashi, T.4
-
22
-
-
5444267347
-
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking
-
Katagiri K., Ohnishi N., Kabashima K., Iyoda T., Takeda N., Shinkai Y., Inaba K., and Kinashi T. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol 5 (2004) 1045-1051
-
(2004)
Nat Immunol
, vol.5
, pp. 1045-1051
-
-
Katagiri, K.1
Ohnishi, N.2
Kabashima, K.3
Iyoda, T.4
Takeda, N.5
Shinkai, Y.6
Inaba, K.7
Kinashi, T.8
-
23
-
-
17844363949
-
Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis
-
Ohba Y., Ikuta K., Ogura A., Matsuda J., Mochizuki N., Nagashima K., Kurokawa K., Mayer B.J., Maki K., Miyazaki J., et al. Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J 20 (2001) 3333-3341
-
(2001)
EMBO J
, vol.20
, pp. 3333-3341
-
-
Ohba, Y.1
Ikuta, K.2
Ogura, A.3
Matsuda, J.4
Mochizuki, N.5
Nagashima, K.6
Kurokawa, K.7
Mayer, B.J.8
Maki, K.9
Miyazaki, J.10
-
24
-
-
0034646610
-
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
-
Sakkab D., Lewitzky M., Posern G., Schaeper U., Sachs M., Birchmeier W., and Feller S.M. Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J Biol Chem 275 (2000) 10772-10778
-
(2000)
J Biol Chem
, vol.275
, pp. 10772-10778
-
-
Sakkab, D.1
Lewitzky, M.2
Posern, G.3
Schaeper, U.4
Sachs, M.5
Birchmeier, W.6
Feller, S.M.7
-
25
-
-
33748198795
-
The PDZ-GEF dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryo
-
Huelsmann S., Hepper C., Marchese D., Knoll C., and Reuter R. The PDZ-GEF dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryo. Development 133 (2006) 2915-2924
-
(2006)
Development
, vol.133
, pp. 2915-2924
-
-
Huelsmann, S.1
Hepper, C.2
Marchese, D.3
Knoll, C.4
Reuter, R.5
-
26
-
-
15744364621
-
Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function
-
Wittchen E.S., Worthylake R.A., Kelly P., Casey P.J., Quilliam L.A., and Burridge K. Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem 280 (2005) 11675-11682
-
(2005)
J Biol Chem
, vol.280
, pp. 11675-11682
-
-
Wittchen, E.S.1
Worthylake, R.A.2
Kelly, P.3
Casey, P.J.4
Quilliam, L.A.5
Burridge, K.6
-
27
-
-
59649092177
-
The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications
-
Dejana E., Tournier-Lasserve E., and Weinstein B.M. The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev Cell 16 (2009) 209-221
-
(2009)
Dev Cell
, vol.16
, pp. 209-221
-
-
Dejana, E.1
Tournier-Lasserve, E.2
Weinstein, B.M.3
-
28
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
29
-
-
14944377651
-
Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase
-
Cullere X., Shaw S.K., Andersson L., Hirahashi J., Luscinskas F.W., and Mayadas T.N. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 105 (2005) 1950-1955
-
(2005)
Blood
, vol.105
, pp. 1950-1955
-
-
Cullere, X.1
Shaw, S.K.2
Andersson, L.3
Hirahashi, J.4
Luscinskas, F.W.5
Mayadas, T.N.6
-
30
-
-
85006314494
-
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
-
Enserink J.M., Christensen A.E., de Rooij J., van Triest M., Schwede F., Genieser H.G., Doskeland S.O., Blank J.L., and Bos J.L. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol 4 (2002) 901-906
-
(2002)
Nat Cell Biol
, vol.4
, pp. 901-906
-
-
Enserink, J.M.1
Christensen, A.E.2
de Rooij, J.3
van Triest, M.4
Schwede, F.5
Genieser, H.G.6
Doskeland, S.O.7
Blank, J.L.8
Bos, J.L.9
-
31
-
-
11144305139
-
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway
-
Fukuhara S., Sakurai A., Sano H., Yamagishi A., Somekawa S., Takakura N., Saito Y., Kangawa K., and Mochizuki N. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 25 (2005) 136-146
-
(2005)
Mol Cell Biol
, vol.25
, pp. 136-146
-
-
Fukuhara, S.1
Sakurai, A.2
Sano, H.3
Yamagishi, A.4
Somekawa, S.5
Takakura, N.6
Saito, Y.7
Kangawa, K.8
Mochizuki, N.9
-
32
-
-
24144444059
-
Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
-
Kooistra M.R., Corada M., Dejana E., and Bos J.L. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett 579 (2005) 4966-4972
-
(2005)
FEBS Lett
, vol.579
, pp. 4966-4972
-
-
Kooistra, M.R.1
Corada, M.2
Dejana, E.3
Bos, J.L.4
-
33
-
-
66349090219
-
Direct spatial control of Epac1 by cAMP
-
Ponsioen B., Gloerich M., Ritsma L., Rehmann H., Bos J.L., and Jalink K. Direct spatial control of Epac1 by cAMP. Mol Cell Biol 29 (2009) 2521-2531
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2521-2531
-
-
Ponsioen, B.1
Gloerich, M.2
Ritsma, L.3
Rehmann, H.4
Bos, J.L.5
Jalink, K.6
-
34
-
-
51349150613
-
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
-
Rehmann H., Arias-Palomo E., Hadders M.A., Schwede F., Llorca O., and Bos J.L. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature 455 (2008) 124-127
-
(2008)
Nature
, vol.455
, pp. 124-127
-
-
Rehmann, H.1
Arias-Palomo, E.2
Hadders, M.A.3
Schwede, F.4
Llorca, O.5
Bos, J.L.6
-
35
-
-
31944446602
-
MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion
-
Sakurai A., Fukuhara S., Yamagishi A., Sako K., Kamioka Y., Masuda M., Nakaoka Y., and Mochizuki N. MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell 17 (2006) 966-976
-
(2006)
Mol Biol Cell
, vol.17
, pp. 966-976
-
-
Sakurai, A.1
Fukuhara, S.2
Yamagishi, A.3
Sako, K.4
Kamioka, Y.5
Masuda, M.6
Nakaoka, Y.7
Mochizuki, N.8
-
36
-
-
34548794724
-
Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1
-
Wei P., Satoh T., Edamatsu H., Aiba A., Setsu T., Terashima T., Kitazawa S., Nakao K., Yoshikawa Y., Tamada M., et al. Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Biochem Biophys Res Commun 363 (2007) 106-112
-
(2007)
Biochem Biophys Res Commun
, vol.363
, pp. 106-112
-
-
Wei, P.1
Satoh, T.2
Edamatsu, H.3
Aiba, A.4
Setsu, T.5
Terashima, T.6
Kitazawa, S.7
Nakao, K.8
Yoshikawa, Y.9
Tamada, M.10
-
37
-
-
0030761145
-
Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22
-
Serebriiskii I., Estojak J., Sonoda G., Testa J.R., and Golemis E.A. Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22. Oncogene 15 (1997) 1043-1049
-
(1997)
Oncogene
, vol.15
, pp. 1043-1049
-
-
Serebriiskii, I.1
Estojak, J.2
Sonoda, G.3
Testa, J.R.4
Golemis, E.A.5
-
39
-
-
7844247192
-
Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25, 2-27
-
Craig H.D., Gunel M., Cepeda O., Johnson E.W., Ptacek L., Steinberg G.K., Ogilvy C.S., Berg M.J., Crawford S.C., Scott R.M., et al. Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25, 2-27. Hum Mol Genet 7 (1998) 1851-1858
-
(1998)
Hum Mol Genet
, vol.7
, pp. 1851-1858
-
-
Craig, H.D.1
Gunel, M.2
Cepeda, O.3
Johnson, E.W.4
Ptacek, L.5
Steinberg, G.K.6
Ogilvy, C.S.7
Berg, M.J.8
Crawford, S.C.9
Scott, R.M.10
-
40
-
-
0028941797
-
A gene responsible for cavernous malformations of the brain maps to chromosome 7q
-
Dubovsky J., Zabramski J.M., Kurth J., Spetzler R.F., Rich S.S., Orr H.T., and Weber J.L. A gene responsible for cavernous malformations of the brain maps to chromosome 7q. Hum Mol Genet 4 (1995) 453-458
-
(1995)
Hum Mol Genet
, vol.4
, pp. 453-458
-
-
Dubovsky, J.1
Zabramski, J.M.2
Kurth, J.3
Spetzler, R.F.4
Rich, S.S.5
Orr, H.T.6
Weber, J.L.7
-
41
-
-
33845994436
-
Deletions in CCM2 are a common cause of cerebral cavernous malformations
-
Liquori C.L., Berg M.J., Squitieri F., Leedom T.P., Ptacek L., Johnson E.W., and Marchuk D.A. Deletions in CCM2 are a common cause of cerebral cavernous malformations. Am J Hum Genet 80 (2007) 69-75
-
(2007)
Am J Hum Genet
, vol.80
, pp. 69-75
-
-
Liquori, C.L.1
Berg, M.J.2
Squitieri, F.3
Leedom, T.P.4
Ptacek, L.5
Johnson, E.W.6
Marchuk, D.A.7
-
42
-
-
0034925464
-
Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations
-
Clatterbuck R.E., Eberhart C.G., Crain B.J., and Rigamonti D. Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations. J Neurol Neurosurg Psychiatry 71 (2001) 188-192
-
(2001)
J Neurol Neurosurg Psychiatry
, vol.71
, pp. 188-192
-
-
Clatterbuck, R.E.1
Eberhart, C.G.2
Crain, B.J.3
Rigamonti, D.4
-
43
-
-
0034517320
-
Ultrastructural pathological features of cerebrovascular malformations: a preliminary report
-
Wong J.H., Awad I.A., and Kim J.H. Ultrastructural pathological features of cerebrovascular malformations: a preliminary report. Neurosurgery 46 (2000) 1454-1459
-
(2000)
Neurosurgery
, vol.46
, pp. 1454-1459
-
-
Wong, J.H.1
Awad, I.A.2
Kim, J.H.3
-
44
-
-
0034702087
-
KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation
-
Eerola I., Plate K.H., Spiegel R., Boon L.M., Mulliken J.B., and Vikkula M. KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation. Hum Mol Genet 9 (2000) 1351-1355
-
(2000)
Hum Mol Genet
, vol.9
, pp. 1351-1355
-
-
Eerola, I.1
Plate, K.H.2
Spiegel, R.3
Boon, L.M.4
Mulliken, J.B.5
Vikkula, M.6
-
45
-
-
7244251522
-
Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations
-
Plummer N.W., Gallione C.J., Srinivasan S., Zawistowski J.S., Louis D.N., and Marchuk D.A. Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations. Am J Pathol 165 (2004) 1509-1518
-
(2004)
Am J Pathol
, vol.165
, pp. 1509-1518
-
-
Plummer, N.W.1
Gallione, C.J.2
Srinivasan, S.3
Zawistowski, J.S.4
Louis, D.N.5
Marchuk, D.A.6
-
46
-
-
12144290066
-
KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex
-
discussion 949
-
Guzeloglu-Kayisli O., Amankulor N.M., Voorhees J., Luleci G., Lifton R.P., and Gunel M. KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex. Neurosurgery 54 (2004) 943-949 discussion 949
-
(2004)
Neurosurgery
, vol.54
, pp. 943-949
-
-
Guzeloglu-Kayisli, O.1
Amankulor, N.M.2
Voorhees, J.3
Luleci, G.4
Lifton, R.P.5
Gunel, M.6
-
47
-
-
35548936992
-
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions
-
Using cultured endothelial cells the authors demonstrate a function for KRIT-1 as a Rap1 effector in VE-cadherin-based junctions. They show that KRIT-1's adaptor role relies on Rap1 activation levels and that KRIT-1 governs endothelial barrier function.
-
Glading A., Han J., Stockton R.A., and Ginsberg M.H. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol 179 (2007) 247-254. Using cultured endothelial cells the authors demonstrate a function for KRIT-1 as a Rap1 effector in VE-cadherin-based junctions. They show that KRIT-1's adaptor role relies on Rap1 activation levels and that KRIT-1 governs endothelial barrier function.
-
(2007)
J Cell Biol
, vol.179
, pp. 247-254
-
-
Glading, A.1
Han, J.2
Stockton, R.A.3
Ginsberg, M.H.4
-
48
-
-
28744459491
-
Effect of thrombin on permeability of human epithelial cell monolayers
-
Hayashi S., Takeuchi K., Suzuki S., Tsunoda T., Tanaka C., and Majima Y. Effect of thrombin on permeability of human epithelial cell monolayers. Pharmacology 76 (2006) 46-52
-
(2006)
Pharmacology
, vol.76
, pp. 46-52
-
-
Hayashi, S.1
Takeuchi, K.2
Suzuki, S.3
Tsunoda, T.4
Tanaka, C.5
Majima, Y.6
-
49
-
-
8744274131
-
p21-activated kinase regulates endothelial permeability through modulation of contractility
-
Stockton R.A., Schaefer E., and Schwartz M.A. p21-activated kinase regulates endothelial permeability through modulation of contractility. J Biol Chem 279 (2004) 46621-46630
-
(2004)
J Biol Chem
, vol.279
, pp. 46621-46630
-
-
Stockton, R.A.1
Schaefer, E.2
Schwartz, M.A.3
-
50
-
-
34948833449
-
CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations
-
Voss K., Stahl S., Schleider E., Ullrich S., Nickel J., Mueller T.D., and Felbor U. CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. Neurogenetics 8 (2007) 249-256
-
(2007)
Neurogenetics
, vol.8
, pp. 249-256
-
-
Voss, K.1
Stahl, S.2
Schleider, E.3
Ullrich, S.4
Nickel, J.5
Mueller, T.D.6
Felbor, U.7
-
51
-
-
24144454827
-
CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis
-
Zawistowski J.S., Stalheim L., Uhlik M.T., Abell A.N., Ancrile B.B., Johnson G.L., and Marchuk D.A. CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. Hum Mol Genet 14 (2005) 2521-2531
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2521-2531
-
-
Zawistowski, J.S.1
Stalheim, L.2
Uhlik, M.T.3
Abell, A.N.4
Ancrile, B.B.5
Johnson, G.L.6
Marchuk, D.A.7
-
52
-
-
33847001613
-
Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations
-
discussion 359
-
Zhang J., Rigamonti D., Dietz H.C., and Clatterbuck R.E. Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations. Neurosurgery 60 (2007) 353-359 discussion 359
-
(2007)
Neurosurgery
, vol.60
, pp. 353-359
-
-
Zhang, J.1
Rigamonti, D.2
Dietz, H.C.3
Clatterbuck, R.E.4
-
53
-
-
0035542933
-
Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation
-
Zhang J., Clatterbuck R.E., Rigamonti D., Chang D.D., and Dietz H.C. Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation. Hum Mol Genet 10 (2001) 2953-2960
-
(2001)
Hum Mol Genet
, vol.10
, pp. 2953-2960
-
-
Zhang, J.1
Clatterbuck, R.E.2
Rigamonti, D.3
Chang, D.D.4
Dietz, H.C.5
-
54
-
-
0030924021
-
ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin
-
Chang D.D., Wong C., Smith H., and Liu J. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. J Cell Biol 138 (1997) 1149-1157
-
(1997)
J Cell Biol
, vol.138
, pp. 1149-1157
-
-
Chang, D.D.1
Wong, C.2
Smith, H.3
Liu, J.4
-
55
-
-
0037084658
-
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis
-
Zawistowski J.S., Serebriiskii I.G., Lee M.F., Golemis E.A., and Marchuk D.A. KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. Hum Mol Genet 11 (2002) 389-396
-
(2002)
Hum Mol Genet
, vol.11
, pp. 389-396
-
-
Zawistowski, J.S.1
Serebriiskii, I.G.2
Lee, M.F.3
Golemis, E.A.4
Marchuk, D.A.5
-
56
-
-
59649084619
-
The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases
-
This work provides evidence for CCM2, a direct interaction partner of CCM1, in regulation of Rho signaling in endothelial cells.
-
Whitehead K.J., Chan A.C., Navankasattusas S., Koh W., London N.R., Ling J., Mayo A.H., Drakos S.G., Marchuk D.A., Davis G.E., et al. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 15 (2009) 177-184. This work provides evidence for CCM2, a direct interaction partner of CCM1, in regulation of Rho signaling in endothelial cells.
-
(2009)
Nat Med
, vol.15
, pp. 177-184
-
-
Whitehead, K.J.1
Chan, A.C.2
Navankasattusas, S.3
Koh, W.4
London, N.R.5
Ling, J.6
Mayo, A.H.7
Drakos, S.G.8
Marchuk, D.A.9
Davis, G.E.10
-
57
-
-
0346403347
-
Heart of glass regulates the concentric growth of the heart in zebrafish
-
Mably J.D., Mohideen M.A., Burns C.G., Chen J.N., and Fishman M.C. Heart of glass regulates the concentric growth of the heart in zebrafish. Curr Biol 13 (2003) 2138-2147
-
(2003)
Curr Biol
, vol.13
, pp. 2138-2147
-
-
Mably, J.D.1
Mohideen, M.A.2
Burns, C.G.3
Chen, J.N.4
Fishman, M.C.5
-
58
-
-
59649085331
-
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway
-
Genetics in mouse and zebrafish are combined to elegantly link the function of the heart of glass (Het1) transmembrane protein with the CCM complex. It also provides a first model of how CCM proteins are biochemically tethered to Het1.
-
Kleaveland B., Zheng X., Liu J.J., Blum Y., Tung J.J., Zou Z., Chen M., Guo L., Lu M.M., Zhou D., et al. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med 15 (2009) 169-176. Genetics in mouse and zebrafish are combined to elegantly link the function of the heart of glass (Het1) transmembrane protein with the CCM complex. It also provides a first model of how CCM proteins are biochemically tethered to Het1.
-
(2009)
Nat Med
, vol.15
, pp. 169-176
-
-
Kleaveland, B.1
Zheng, X.2
Liu, J.J.3
Blum, Y.4
Tung, J.J.5
Zou, Z.6
Chen, M.7
Guo, L.8
Lu, M.M.9
Zhou, D.10
-
59
-
-
11844273330
-
Adhesion remodeling underlying tissue morphogenesis
-
Lecuit T. Adhesion remodeling underlying tissue morphogenesis. Trends Cell Biol 15 (2005) 34-42
-
(2005)
Trends Cell Biol
, vol.15
, pp. 34-42
-
-
Lecuit, T.1
-
60
-
-
42649123661
-
Epithelial morphogenesis in embryos: asymmetries, motors and brakes
-
Quintin S., Gally C., and Labouesse M. Epithelial morphogenesis in embryos: asymmetries, motors and brakes. Trends Genet 24 (2008) 221-230
-
(2008)
Trends Genet
, vol.24
, pp. 221-230
-
-
Quintin, S.1
Gally, C.2
Labouesse, M.3
-
61
-
-
0033081407
-
The Rap1 GTPase functions as a regulator of morphogenesis in vivo
-
Asha H., de Ruiter N.D., Wang M.G., and Hariharan I.K. The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J 18 (1999) 605-615
-
(1999)
EMBO J
, vol.18
, pp. 605-615
-
-
Asha, H.1
de Ruiter, N.D.2
Wang, M.G.3
Hariharan, I.K.4
-
62
-
-
0037083415
-
Rap1 GTPase regulation of adherens junction positioning and cell adhesion
-
Investigating genetically mosaic Drosophila wing imaginal discs the authors demonstrate for the first time a vital function for Rap1 in reconstituting AJs during the late stages of cytokinesis. A failure in this process causes cells in mitotic clones to loose cohesion and to aberrantly disperse into wild-type tissue.
-
Knox A.L., and Brown N.H. Rap1 GTPase regulation of adherens junction positioning and cell adhesion. Science 295 (2002) 1285-1288. Investigating genetically mosaic Drosophila wing imaginal discs the authors demonstrate for the first time a vital function for Rap1 in reconstituting AJs during the late stages of cytokinesis. A failure in this process causes cells in mitotic clones to loose cohesion and to aberrantly disperse into wild-type tissue.
-
(2002)
Science
, vol.295
, pp. 1285-1288
-
-
Knox, A.L.1
Brown, N.H.2
-
63
-
-
0141566657
-
The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo
-
In vivo demonstration of a Rap1 effector function for Canoe (Cno) in ectodermal cells involved in cell migration and closure of the Drosophila embryo.
-
Boettner B., Harjes P., Ishimaru S., Heke M., Fan H.Q., Qin Y., Van Aelst L., and Gaul U. The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo. Genetics 165 (2003) 159-169. In vivo demonstration of a Rap1 effector function for Canoe (Cno) in ectodermal cells involved in cell migration and closure of the Drosophila embryo.
-
(2003)
Genetics
, vol.165
, pp. 159-169
-
-
Boettner, B.1
Harjes, P.2
Ishimaru, S.3
Heke, M.4
Fan, H.Q.5
Qin, Y.6
Van Aelst, L.7
Gaul, U.8
-
64
-
-
36048986349
-
The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis
-
Identification of PDZ-GEF as a relevant Rap1GEF in a morphogenetic process using genetic approaches in Drosophila. By linking PDZ-GEF function to Cno, this study also provides an example for specific Rap1 effector selection and MyosinII regulation by a GEF in an in vivo process.
-
Boettner B., and Van Aelst L. The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis. Mol Cell Biol 27 (2007) 7966-7980. Identification of PDZ-GEF as a relevant Rap1GEF in a morphogenetic process using genetic approaches in Drosophila. By linking PDZ-GEF function to Cno, this study also provides an example for specific Rap1 effector selection and MyosinII regulation by a GEF in an in vivo process.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7966-7980
-
-
Boettner, B.1
Van Aelst, L.2
-
65
-
-
2942587231
-
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
-
Bertet C., Sulak L., and Lecuit T. Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation. Nature 429 (2004) 667-671
-
(2004)
Nature
, vol.429
, pp. 667-671
-
-
Bertet, C.1
Sulak, L.2
Lecuit, T.3
-
66
-
-
46849095863
-
The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions
-
Description of a role for mammalian PDZ-GEF2 in adherens junctional maturation. The study, by employing RNAi and fluorescence microscopy concludes that not initial formation of AJs but rather their differentiation into a tightly sealed state is specifically affected by PDZ-GEF2.
-
Dube N., Kooistra M.R., Pannekoek W.J., Vliem M.J., Oorschot V., Klumperman J., Rehmann H., and Bos J.L. The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions. Cell Signal 20 (2008) 1608-1615. Description of a role for mammalian PDZ-GEF2 in adherens junctional maturation. The study, by employing RNAi and fluorescence microscopy concludes that not initial formation of AJs but rather their differentiation into a tightly sealed state is specifically affected by PDZ-GEF2.
-
(2008)
Cell Signal
, vol.20
, pp. 1608-1615
-
-
Dube, N.1
Kooistra, M.R.2
Pannekoek, W.J.3
Vliem, M.J.4
Oorschot, V.5
Klumperman, J.6
Rehmann, H.7
Bos, J.L.8
-
67
-
-
37149020570
-
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans
-
In this RNAi screen the authors uncover a link between Rap1 function and the exocyst complex in the C. elegans hypodermis. Synthetic loss of Rap1 and individual exocyst dosages compromises AJ levels and ventral closure of the hypodermis.
-
Frische E.W., Pellis-van Berkel W., van Haaften G., Cuppen E., Plasterk R.H., Tijsterman M., Bos J.L., and Zwartkruis F.J. RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J 26 (2007) 5083-5092. In this RNAi screen the authors uncover a link between Rap1 function and the exocyst complex in the C. elegans hypodermis. Synthetic loss of Rap1 and individual exocyst dosages compromises AJ levels and ventral closure of the hypodermis.
-
(2007)
EMBO J
, vol.26
, pp. 5083-5092
-
-
Frische, E.W.1
Pellis-van Berkel, W.2
van Haaften, G.3
Cuppen, E.4
Plasterk, R.H.5
Tijsterman, M.6
Bos, J.L.7
Zwartkruis, F.J.8
-
68
-
-
11144260994
-
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity
-
Pellis-van Berkel W., Verheijen M.H., Cuppen E., Asahina M., de Rooij J., Jansen G., Plasterk R.H., Bos J.L., and Zwartkruis F.J. Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. Mol Biol Cell 16 (2005) 106-116
-
(2005)
Mol Biol Cell
, vol.16
, pp. 106-116
-
-
Pellis-van Berkel, W.1
Verheijen, M.H.2
Cuppen, E.3
Asahina, M.4
de Rooij, J.5
Jansen, G.6
Plasterk, R.H.7
Bos, J.L.8
Zwartkruis, F.J.9
-
69
-
-
0036837880
-
Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway
-
Lee J.H., Cho K.S., Lee J., Kim D., Lee S.B., Yoo J., Cha G.H., and Chung J. Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway. Mol Cell Biol 22 (2002) 7658-7666
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7658-7666
-
-
Lee, J.H.1
Cho, K.S.2
Lee, J.3
Kim, D.4
Lee, S.B.5
Yoo, J.6
Cha, G.H.7
Chung, J.8
-
70
-
-
29744458622
-
Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis
-
The study provides the first example for a RapGEF mutation causing a stem cell defect. It shows that the loss of male stem cells in PDZ-GEF mutant testis is due to insufficient adhesion between stem and somatic cells at the stem cell/hub interface
-
Wang H., Singh S.R., Zheng Z., Oh S.W., Chen X., Edwards K., and Hou S.X. Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Dev Cell 10 (2006) 117-126. The study provides the first example for a RapGEF mutation causing a stem cell defect. It shows that the loss of male stem cells in PDZ-GEF mutant testis is due to insufficient adhesion between stem and somatic cells at the stem cell/hub interface
-
(2006)
Dev Cell
, vol.10
, pp. 117-126
-
-
Wang, H.1
Singh, S.R.2
Zheng, Z.3
Oh, S.W.4
Chen, X.5
Edwards, K.6
Hou, S.X.7
-
71
-
-
34247527731
-
Male and female Drosophila germline stem cells: two versions of immortality
-
Fuller M.T., and Spradling A.C. Male and female Drosophila germline stem cells: two versions of immortality. Science 316 (2007) 402-404
-
(2007)
Science
, vol.316
, pp. 402-404
-
-
Fuller, M.T.1
Spradling, A.C.2
-
72
-
-
0141483737
-
Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome
-
Yamashita Y.M., Jones D.L., and Fuller M.T. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 301 (2003) 1547-1550
-
(2003)
Science
, vol.301
, pp. 1547-1550
-
-
Yamashita, Y.M.1
Jones, D.L.2
Fuller, M.T.3
-
73
-
-
33645294955
-
Rap-GEF/Rap signaling restricts the formation of supernumerary spermathecae in Drosophila melanogaster
-
Singh S.R., Oh S.W., Liu W., Chen X., Zheng Z., and Hou S.X. Rap-GEF/Rap signaling restricts the formation of supernumerary spermathecae in Drosophila melanogaster. Dev Growth Differ 48 (2006) 169-175
-
(2006)
Dev Growth Differ
, vol.48
, pp. 169-175
-
-
Singh, S.R.1
Oh, S.W.2
Liu, W.3
Chen, X.4
Zheng, Z.5
Hou, S.X.6
-
74
-
-
0031648724
-
Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the jun N-terminal kinase pathway in Drosophila morphogenesis
-
Takahashi K., Matsuo T., Katsube T., Ueda R., and Yamamoto D. Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the jun N-terminal kinase pathway in Drosophila morphogenesis. Mech Dev 78 (1998) 97-111
-
(1998)
Mech Dev
, vol.78
, pp. 97-111
-
-
Takahashi, K.1
Matsuo, T.2
Katsube, T.3
Ueda, R.4
Yamamoto, D.5
-
75
-
-
0032822081
-
Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis
-
Ikeda W., Nakanishi H., Miyoshi J., Mandai K., Ishizaki H., Tanaka M., Togawa A., Takahashi K., Nishioka H., Yoshida H., et al. Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J Cell Biol 146 (1999) 1117-1132
-
(1999)
J Cell Biol
, vol.146
, pp. 1117-1132
-
-
Ikeda, W.1
Nakanishi, H.2
Miyoshi, J.3
Mandai, K.4
Ishizaki, H.5
Tanaka, M.6
Togawa, A.7
Takahashi, K.8
Nishioka, H.9
Yoshida, H.10
-
76
-
-
33645525311
-
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
-
Zhadanov A.B., Provance Jr. D.W., Speer C.A., Coffin J.D., Goss D., Blixt J.A., Reichert C.M., and Mercer J.A. Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development. Curr Biol 9 (1999) 880-888
-
(1999)
Curr Biol
, vol.9
, pp. 880-888
-
-
Zhadanov, A.B.1
Provance Jr., D.W.2
Speer, C.A.3
Coffin, J.D.4
Goss, D.5
Blixt, J.A.6
Reichert, C.M.7
Mercer, J.A.8
-
77
-
-
0033519211
-
Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein
-
Takahashi K., Nakanishi H., Miyahara M., Mandai K., Satoh K., Satoh A., Nishioka H., Aoki J., Nomoto A., Mizoguchi A., et al. Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. J Cell Biol 145 (1999) 539-549
-
(1999)
J Cell Biol
, vol.145
, pp. 539-549
-
-
Takahashi, K.1
Nakanishi, H.2
Miyahara, M.3
Mandai, K.4
Satoh, K.5
Satoh, A.6
Nishioka, H.7
Aoki, J.8
Nomoto, A.9
Mizoguchi, A.10
-
78
-
-
20144388403
-
Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion
-
Wei S.Y., Escudero L.M., Yu F., Chang L.H., Chen L.Y., Ho Y.H., Lin C.M., Chou C.S., Chia W., Modolell J., et al. Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion. Dev Cell 8 (2005) 493-504
-
(2005)
Dev Cell
, vol.8
, pp. 493-504
-
-
Wei, S.Y.1
Escudero, L.M.2
Yu, F.3
Chang, L.H.4
Chen, L.Y.5
Ho, Y.H.6
Lin, C.M.7
Chou, C.S.8
Chia, W.9
Modolell, J.10
-
79
-
-
0034254923
-
The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin
-
Boettner B., Govek E.E., Cross J., and Van Aelst L. The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Proc Natl Acad Sci U S A 97 (2000) 9064-9069
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 9064-9069
-
-
Boettner, B.1
Govek, E.E.2
Cross, J.3
Van Aelst, L.4
-
80
-
-
14444271574
-
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction
-
Mandai K., Nakanishi H., Satoh A., Obaishi H., Wada M., Nishioka H., Itoh M., Mizoguchi A., Aoki T., Fujimoto T., et al. Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol 139 (1997) 517-528
-
(1997)
J Cell Biol
, vol.139
, pp. 517-528
-
-
Mandai, K.1
Nakanishi, H.2
Satoh, A.3
Obaishi, H.4
Wada, M.5
Nishioka, H.6
Itoh, M.7
Mizoguchi, A.8
Aoki, T.9
Fujimoto, T.10
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