Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway

Molecular and Cellular Biology

Volumn 22, Issue 21, 2002, Pages 7658-7666

  Lee, Jun Hee ^a   Cho, Kyoung Sang ^a   Lee, Jihyun ^a   Kim, Dohoon ^a   Lee, Sung Bae ^a   Yoo, Jungsik ^a   Cha, Guang Ho ^a   Chung, Jongkyeong ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN PDZ GEF; RAP PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME REGULATION; MORPHOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY DEVELOPMENT; PHENOTYPE; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; CELL LINEAGE; CELL SURVIVAL; DROSOPHILA MELANOGASTER; FEMALE; GENES, REPORTER; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HOMOZYGOTE; IN SITU NICK-END LABELING; MALE; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, ELECTRON, SCANNING; MODELS, GENETIC; NERVE TISSUE PROTEINS; OVARY; PHENOTYPE; PHOTORECEPTORS, INVERTEBRATE; PROTEIN BINDING; RAP1 GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSGENES;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0036837880     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.21.7658-7666.2002     Document Type: Article

References (39)

1. Adams, M. D., S. E. Celniker, R. A. Holt, C. A. Evans, J. D. Gocayne, P. G. Amanatides, S. E. Scherer, P. W. Li, R. A. Hoskins, R. F. Galle, et al. 2000. The genome sequence of Drosophila melanogaster. Science 287:2185-2195.
2. Ambrosio, L., A. P. Mahowald, and N. Perrimon. 1989. 1(1)pole hole is required maternally for pattern formation in the terminal regions of the embryo. Development 106:145-158.
3. Asha, H., N. D. de Ruiter, M. G. Wang, and I. K. Hariharan. 1999. The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J, 18:605-615.
4. Biggs, W. H., III, K. H. Zavitz, B. Dickson, A. van der Straten, D. Brunner, E. Hafen, and S. L. Zipursky. 1994. The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J. 13:1628-1635.
5. Bonfini, L., C. A. Karlovich, C. Dasgupta, and U. Banerjee. 1992. The Son of sevenless gene product: a putative activator of Ras. Science 255:603-606.
6. Bos, J. L. 1998. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral. EMBO J. 17:6776-6782.
7. Bos, J. L., J. de Rooij, and K. A. Reedquist. 2001. Rap1 signaling: adhering to new models. Nat. Rev. Mol. Cell. Biol. 2:369-377.
8. Cho, K. S., J. H. Lee, S. Kim, D. Kim, H. Koh, J. Lee, C. Kim, J. Kim, and J. Chung. 2001. Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. Proc. Natl. Acad. Sci. USA 98:6144-6149.
9. Cook, S. J., B. Rubinfeld, I. Albert, and F. McCormick. 1993. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 12:3475-3485.
10. de Rooij, J., N. M. Boenink, M. van Triest, R. H. Cool, A. Wittinghofer, and J. L. Bos. 1999. PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2. J. Biol. Chem. 274:38125-38130.
11. de Rooij, J., F. J. Zwartkruis, M. H. Verheijen, R. H. Cool, S. M. Nijman, A. Wittinghofer, and J. L. Bos. 1998. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396:474-477.
12. Gotoh, T., S. Hattori, S. Nakamura, H. Kitayama, M. Noda, Y. Takai, K. Kaibuchi, H. Matsui, O. Hatase, H. Takahashi, et al. 1995. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol. Cell. Biol. 15:6746-6753.
13. Hariharan, I. K., R. W. Carthew, and G. M. Rubin. Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination. Cell 67:717-722.
14. Hu, C. D., K. Kariya, G. Kotani, M. Shirouzu, S. Yokoyama, and T. Kataoka. 1997. Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1. J. Biol. Chem. 272:11702-11705.
15. Ishimaru, S., R. Williams, E. Clark, H. Hanafusa, and U. Gaul. 1999. Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. EMBO J. 18:145-155.
16. Kawasaki, H., G. M. Springett, N. Mochizuki, S. Toki, M. Nakaya, M. Matsuda, D. E. Housman, and A. M. Graybiel. 1998. A family of cAMP-binding proteins that directly activate Rap1. Science 282:2275-2279.
17. Kawasaki, H., G. M. Springett, S. Toki, J. J. Canales, P. Harlan, J. P. Blumenstiel, E. J. Chen, I. A. Bany, N. Mochizuki, A. Ashbacher, M. Matsuda, D. E. Housman, and A. M. Graybiel. 1998. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc. Natl. Acad. Sci. USA 95:13278-13283.
18. Kitayama, H., Y. Sugimoto, T. Matsuzaki, Y. Ikawa, and M. Noda. 1989. A ras-related gene with transformation suppressor activity. Cell 56:77-84.
19. Li, Q., I. K. Hariharan, F. Chen, Y. Huang, and J. A. Fischer. 1997. Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development. Proc. Natl. Acad. Sci. USA 94:12515-12520.
20. Liao, Y., K. Kariya, C. D. Hu, M. Shibatohge, M. Goshima, T. Okada, Y. Watari, X. Gao, T. G. Jin, Y. Yamawaki-Kataoka, and T. Kataoka. 1999. RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. J. Biol. Chem. 274:37815-37820.
21. Liao, Y., T. Satoh, X. Gao, T. G. Jin, C. D. Hu, and T. Kataoka. 2001. RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1-GTP and enhances Rap1-dependent B-Raf activation. J. Biol. Chem. 276:28478-28483.
22. Martin-Blanco, E., F. Roch, E. Noll, A. Baonza, J. B. Duffy, and N. Perrimon. 1999. A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing. Development 126:5739-5747.
23. Mizuno, T., K. Kaibuchi, T. Yamamoto, M. Kawamura, T. Sakoda, H. Fujioka, Y. Matsuura, and Y. Takai. 1991. A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc. Natl. Acad. Sci. USA 88:6442-6446.
24. Nambu, J. R., R. G. Franks, S. Hu, and S. T. Crews. 1990. The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells. Cell 63:63-75.
25. Newsome, T. P., B. Asling, and B. J. Dickson. 2000. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 127:851-860.
26. Ohtsuka, T., Y. Hata, N. Ide, T. Yasuda, E. Inoue, T. Inoue, A. Mizoguchi, and Y. Takai. 1999. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Biochem. Biophys. Res. Commun. 265:38-44.
27. Ohtsuka, T., K. Shimizu, B. Yamamori, S. Kuroda, and Y. Takai. 1996, Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein. J. Biol. Chem. 271:1258-1261.
28. Pham, N., I. Cheglakov, C. A. Koch, C. L. de Hoog, M. F. Moran, and D. Rotin. 2000. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Curr. Biol. 10:555-558.
29. Prober, D. A., and B. A. Edgar. 2000. Ras1 promotes cellular growth in the Drosophila wing. Cell 100:435-446.
30. Rebhun, J. F., A. F. Castro, and L. A. Quilliam. 2000. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. J. Biol. Chem. 275:34901-34908.
31. Stowers, R. S., and T. L. Sehwarz. 1999. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics 152:1631-1639.
32. Taguchi, A., K. Sawamoto, and H. Okano. 2000. Mutations modulating the argos-regulated signaling pathway in Drosophila eye development. Genetics 154:1639-1648.
33. Toba, G., T. Ohsako, N. Miyata, T. Ohtsuka, K. H. Seong, and T. Aigaki. 1999. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster. Genetics 151:725-737.
34. Tsuda, L., Y. H. Inoue, M. A. Yoo, M. Mizuno, M. Hata, Y. M. Lim, T. Adachi-Yamada, H. Ryo, Y. Masamune, and Y. Nishida. 1993. A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell 72:407-414.
35. Vossler, M. R., H. Yao, R. D. York, M. G. Pan, C. S. Rim, and P. J. Stork-1997. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73-82.
36. York, R. D., H. Yao, T. Dillon, C. L. Ellig, S. P. Eckert, E. W. McCleskey, and P. J. Stork. 1998. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622-626.
37. Yoshida, Y., M. Kawata, Y. Miura, T. Musha, T. Sasaki, A. Kikuchi, and Y. Takai. 1992. Microinjection of smg/rapl/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Mol. Cell. Biol. 12:3407-3414.
38. Zwartkruis, F. J., and J. L. Bos. 1999. Ras and Rap1: two highly related small GTPases with distinct function. Exp. Cell Res. 253:157-165.
39. Zwartkruis, F. J., R. M. Wolthuis, N. M. Nabben, B. Franke, and J. L. Bos. 1998. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling. EMBO J. 17:5905-5912.