Complexity in transcription control at the activation domain-Mediator interface

Science Signaling

Volumn 2, Issue 69, 2009, Pages

  Balamotis, Michael A ^a   Pennella, Mario A ^a   Stevens, Jennitte L ^b   Wasylyk, Bohdan ^c   Belmont, Andrew S ^d   Berk, Arnold J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AMGEN INC   (United States)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SUBUNIT; TERNARY COMPLEX FACTOR; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTOME; EGR1 PROTEIN, MOUSE; HYBRID PROTEIN; MED23 PROTEIN, MOUSE; MESSENGER RNA; PHOTOPROTEIN; RNA POLYMERASE II; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL TYPE; CHROMATIN IMMUNOPRECIPITATION; EMBRYO; EMBRYONIC STEM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CELL LINE; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PROMOTER REGION; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; EARLY GROWTH RESPONSE PROTEIN 1; EMBRYONIC STEM CELLS; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LUMINESCENT PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA POLYMERASE II; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TERNARY COMPLEX FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 70349325994     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.1164302     Document Type: Article

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56. This study was supported by U.S. Public Health Service grant R37CA025235 and American Cancer Society postdoctoral fellowship grant PF0804801GMC to M.A.P. FRAP experiments were performed at the California NanoSystems Institute Advanced Light Microscopy/Spectroscopy Shared Facility at University of California, Los Angeles, directed by S. Weiss, Department of Chemistry and Biochemistry. We thank D. Bachiller for performing the analysis of the mutant embryo phenotype and the whole-mount embryo microscopy shown in fig. S1 while an Assistant Professor in the Department of Surgery, University of California, Los Angeles; S. Gallaher and J. Woo for their input; and C. Eng for technical assistance.