Non-hybridization saturable mechanisms play a role in the uptake of 68Ga-labeled LNA-DNA mixmer antisense oligonucleotides in rats

Oligonucleotides

Volumn 19, Issue 3, 2009, Pages 223-231

  Lendvai, Gabor ^a,b   Monazzam, Azita ^a,b   Velikyan, Irina ^a   Eriksson, Barbro ^b   Josephsson, Raymond ^c   Lngström, Bengt ^a,d   Bergström, Mats ^d   Estrada, Sergio ^a,e  

^a BIACORE AB   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c NOVARTIS PHARMA AG   (Switzerland)

^d UPPSALA UNIVERSITY   (Sweden)

^e Uppsala Imanet   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHROMOGRANIN A; DNA; GALLIUM 68; LOCKED NUCLEIC ACID; MESSENGER RNA; POLYADENYLIC ACID; POLYINOSINIC ACID; SCAVENGER RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG UPTAKE; HUMAN; HUMAN CELL; HYBRIDIZATION; IN VIVO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALS; CELL LINE, TUMOR; CHROMOGRANIN A; GALLIUM RADIOISOTOPES; HUMANS; MALE; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; POLY A; POLY I; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SCAVENGER; RNA, MESSENGER;

RATTUS;

EID: 70349288035     PISSN: 15454576     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.2009.0192     Document Type: Article

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