The effects of inhaled KP-496, a novel dual antagonist for cysteinyl leukotriene receptor and thromboxane A2 receptor, on allergic asthmatic responses in Guinea Pigs

Pharmacology

Volumn 84, Issue 4, 2009, Pages 249-256

  Suda, Masahiro ^a   Okuda, Toshiaki ^a   Ishimura, Masakazu ^a   Kurokawa, Shigeo ^a   Tokuoka, Shota ^a   Nakamura, Tsutomu ^a   Takahashi, Yoshimasa ^b   Tanaka, Hiroyuki ^b   Nagai, Hiroichi ^b  

^a KAKEN PHARMACEUTICAL CO LTD   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Airway inflammation; Allergic asthmatic model, guinea pigs; Cysteinyl leukotriene; Dual antagonist; Thromboxane A2

Indexed keywords

ACETYLCHOLINE; ANTIASTHMATIC AGENT; KP 496; LEUKOTRIENE RECEPTOR BLOCKING AGENT; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AIRWAY; ALLERGIC ASTHMA; ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL INFILTRATION; CONTROLLED STUDY; DRUG MECHANISM; EOSINOPHIL; EPITHELIUM HYPERPLASIA; GUINEA PIG; HISTOPATHOLOGY; INFLAMMATORY CELL; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; SMOOTH MUSCLE;

ACETYLCHOLINE; ADMINISTRATION, INHALATION; ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; BENZOATES; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; GUINEA PIGS; LUNG; MALE; OVALBUMIN; PNEUMONIA; RECEPTORS, LEUKOTRIENE; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; THIAZOLES;

EID: 70349264329     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000241724     Document Type: Article

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