Variations of plasmatic concentrations of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions

Veterinary Research Communications

Volumn 33, Issue 7, 2009, Pages 701-709

  Verwilghen, Denis R ^a   Vanderheyden, L ^a,b   Franck, T ^a   Busoni, V ^a   Enzerink, E ^c   Gangl, M ^d   Lejeune, J P ^a,b   van Galen, G ^a   Grulke, S ^a   Serteyn, D ^a,b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b European Horse Centre   (Belgium)

^c Veterinair Centrum Someren   (Netherlands)

^d VETAGRO SUP   (France)

Author keywords

Cartilage; Growth factors; Horses; IGF I; Osteochondrosis

Indexed keywords

SOMATOMEDIN C;

ADULTHOOD; AGE; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CHONDROPATHY; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; HORSE DISEASE; NONHUMAN; OSTEOCHONDRAL LESION; OSTEOCHONDROSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

AGING; ANIMALS; CARTILAGE; HORSE DISEASES; HORSES; INSULIN-LIKE GROWTH FACTOR I; JOINT DISEASES; OSTEOCHONDROSIS; PREVALENCE; SPECIES SPECIFICITY; WOUNDS AND INJURIES;

EQUIDAE;

EID: 70349263948     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11259-009-9219-2     Document Type: Article

References (48)

1. Alarid ET, Schlechter NL, Russell SM, Nicoll CS (1992) Evidence suggesting that insulin-like growth factor-I is necessary for the trophic effects of insulin on cartilage growth in vivo. Endocrinology 130:2305-2309. doi: 10.1210/en.130.4.2305
2. Baxter GM, Turner AS (2002) Diseases of Bone and related structures. In: Stashak TS, Adams OR (Eds.), Adams' lameness in horses. Lippincott Williams & Wilkins, Baltimore, pp. 401-407.
3. Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, McIlwraith CW (2004) Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals. Am J Vet Res 65:143-150. doi: 10.2460/ ajvr.2004.65.143
4. Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB (2001) The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orthop Res 19:11-17. doi: 10.1016/S0736-0266(00)00004-8
5. Carlson CS, Cullins LD, Meuten DJ (1995) Osteochondrosis of the articular-epiphyseal cartilage complex in young horses: Evidence for a defect in cartilage canal blood supply. Vet Pathol 32:641-647.
6. Champion ZJ, Breier BH, Ewen WE, Tobin TT, Casey PJ (2002) Blood plasma concentrations of insulin-like growth factor-I (IGF-I) in resting standardbred horses. Vet J 163:45-50. doi: 10.1053/tvjl.2001.0619
7. Dik KJ, Enzerink E, van Weeren PR (1999) Radiographic development of osteochondral abnormalities, in the hock and stifle of Dutch Warmblood foals, from age 1 to 11 months. Equine Vet J Suppl 31:9-15.
8. Ekman S, Carlson CS (1998) The pathophysiology of osteochondrosis. Vet Clin North Am Small Anim Pract 28:17-32.
9. Fortier LA, Balkman CE, Sandell LJ, Ratcliffe A, Nixon AJ (2001) Insulin-like growth factor-I gene expression patterns during spontaneous repair of acute articular cartilage injury. J Orthop Res 19:720-728. doi: 10.1016/S0736-0266(00)00070-X
10. Fortier LA, Kornatowski MA, Mohammed HO, Jordan MT, O'Cain LC, Stevens WB (2005) Age-related changes in serum insulin-like growth factor-I, insulin-like growth factor-I binding protein-3 and articular cartilage structure in Thoroughbred horses. Equine Vet J 37:37-42. doi: 10.2746/ 0425164054406838
11. Gangl M, Serteyn D, Lejeun JP (2007) A type II-collagen derived peptide and its nitrated form as new markers of inflammation and cartilage degradation in equine osteochondral lesions. Res Vet Sci 82:68-75. doi: 10.1016/j.rvsc.2006.03.008
12. Glade MJ, Belling TH, Jr. (1984) Growth plate cartilage metabolism, morphology and biochemical composition in over- and underfed horses. Growth 48:473-482.
13. Goodrich LR, Brower-Toland BD, Warnick L, Robbins PD, Evans CH, Nixon AJ (2006) Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations. Gene Ther 13:1253-1262. doi: 10.1038/sj.gt.3302757
14. Goodrich LR, Hidaka C, Robbins PD, Evans CH, Nixon AJ (2007) Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br 89:672-685. doi: 10.1302/0301-620X.89B5.18343
15. Henson FMD, Davenport C, Butler L, Moran I, Shingleton WD, Jeffcott LB, Schofield PN (1997) Effects of insulin and insulin-like growth factors I and II on the growth of equine fetal and neonatal chondrocytes. Equine Vet J 29:441-447.
16. Hintz RL, Clemmons DR, Underwood LE, Van Wyk JJ (1972) Competitive binding of somatomedin to the insulin receptors of adipocytes, chondrocytes, and liver membranes. Proc Natl Acad Sci USA 69:2351-2353. doi: 10.1073/pnas.69.8.2351
17. Jeffcott LB (1991) Osteochondrosis in the Horse - Searching for the Key to Pathogenesis. Equine Vet J 23:331-338.
18. Jeffcott LB (1993) Problems and pointers in equine osteochondrosis. Equine Vet J Suppl 16:1-3.
19. Jeffcott LB (1996) Osteochondrosis - An international problem for the horse industry. Journal of Equine Veterinary Science 16:32-37. doi: 10.1016/S0737-0806(96)80063-3
20. Lejeune JP, Franck T, Gangl M, Schneider N, Michaux C, Deby-Dupont G, Serteyn D (2007) Plasma concentration of insulin-like growth factor I (IGF-I) in growing Ardenner horses suffering from juvenile digital degenerative osteoarthropathy. Vet Res Commun 31:185-195. doi: 10.1007/ s11259-006-3385-2
21. Madry H, Kaul G, Cucchiarini M, Stein U, Zurakowski D, Remberger K, Menger MD, Kohn D, Trippel SB (2005) Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther 12:1171-1179. doi: 10.1038/sj.gt.3302515
22. Malinowski K, Christensen RA, Hafs HD, Scanes CG (1996) Age and breed differences in thyroid hormones, insulin-like growth factor (IGF)-I and IGF binding proteins in female horses. J Anim Sci 74:1936-1942.
23. McDonald AR, Goldfine ID (1988) Glucocorticoid regulation of insulin receptor gene transcription in IM-9 cultured lymphocytes. J Clin Invest 81:499-504. doi: 10.1172/JCI113347
24. Morales TI (1994) Transforming growth factor-beta and insulin-like growth factor-1 restore proteoglycan metabolism of bovine articular cartilage after depletion by retinoic acid. Arch Biochem Biophys 315:190-198. doi: 10.1006/abbi.1994.1489
25. Morisset S, Frisbie DD, Robbins PD, Nixon AJ, McIlwraith CW (2007) IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects. Clin Orthop Relat Res 462:221-228. doi: 10.1097/ BLO.0b013e3180dca05f
26. Neidel J, Schulze M, Sova L (1994) Insulin-like growth factor I accelerates recovery of articular cartilage proteoglycan synthesis in culture after inhibition by interleukin 1. Arch Orthop Trauma Surg 114:43-48. doi: 10.1007/BF00454736
27. Nielsen FC (1992) The molecular and cellular biology of insulin-like growth factor II. Prog Growth Factor Res 4:257-290. doi: 10.1016/ 0955-2235(92)90023-B
28. Nixon AJ, Haupt JL, Frisbie DD, Morisset SS, McIlwraith CW, Robbins PD, Evans CH, Ghivizzani S (2005) Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther 12:177-186. doi: 10.1038/ sj.gt.3302396
29. Pavasant P, Shizari T, Underhill CB (1996) Hyaluronan synthesis by epiphysial chondrocytes is regulated by growth hormone, insulin-like growth factor-1, parathyroid hormone and transforming growth factor-beta 1. Matrix Biol 15:423-432. doi: 10.1016/S0945-053X(96)90161-4
30. Platt D, Bayliss MT (1995) Proteoglycan metabolism of equine articular cartilage and its modulation by insulin-like growth factors. J Vet Pharmacol Ther 18:141-149. doi: 10.1111/j.1365-2885.1995.tb00568.x
31. Pool RR (1993) Difficulties in definition of equine osteochondrosis; differentiation of developmental and acquired lesions. Equine Vet J Suppl 16:5-12.
32. Ralston SL (1996) Hyperglycemia/hyperinsulinemia after feeding a meal of grain to young horses with osteochondritis dissecans (OCD) lesions. Pferdeheilkunde 12:320-322.
33. Rogachefsky RA, Dean DD, Howell DS, Altman RD (1993) Treatment of canine osteoarthritis with insulin-like growth factor-1 (IGF-1) and sodium pentosan polysulfate. Osteoarthritis Cartilage 1:105-114. doi: 10.1016/ S1063-4584(05)80025-1
34. Schalwijk J, Joosten LA, Van de Berg WB, van Wijk JJ, van de Putte LB (1989) Insulin-like growth factor stimulation of chondrocyte proteoglycon synthesis in human synovial fluid. Arthritis Rheum 32:66-71. doi: 10.1002/anr.1780320111
35. Schramme MC (2000) The role of insulin-like growth factor-I in the physiological and pathological responses of equine articular cartilage. PhD thesis, The Royal Veterinary College, London. p. 311.
36. Semevolos SA, Nixon AJ, Brower-Toland BD (2001) Changes in molecular expression of aggrecan and collagen types I, II, and X, insulin-like growth factor-I, and transforming growth factor-beta 1 in articular cartilage obtained from horses with naturally acquired osteochondrosis. Am J Vet Res 62:1088-1094. doi: 10.2460/ajvr.2001.62.1088
37. Semevolos SA, Nixon AJ, Strassheim L (2004) Unlocking the key to equine articular osteochondrosis: The role of molecular regulators. In: AAEP Focus on Joints, Louisville, Kentucky, pp. 98-102.
38. Shingleton WD, Mackie EJ, Cawston TE, Jeffcott LB (1997) Cartilage canals in equine articular/epiphyseal growth cartilage and a possible association with dyschondroplasia. Equine Vet J 29:360-364.
39. Sloet van Oldenruitenborgh-Oosterbaan MM, Mol JA, Barneveld A (1999) Hormones, growth factors and other plasma variables in relation to osteochondrosis. Equine Vet J Suppl. 31:45-54.
40. Staniar WB, Kronfeld DS, Akers RM, Harris PA (2007) Insulin-like growth factor I in growing thoroughbreds. J Anim Physiol Anim Nutr (Berl) 91:390-399. doi: 10.1111/j.1439-0396.2006.00666.x
41. Thissen JP, Ketelslegers JM, Underwood LE (1994) Nutritional Regulation of the Insulin-Like Growth-Factors. Endocr Rev 15:80-101.
42. Treiber KH, Boston RC, Kronfeld DS, Staniar WB, Harris PA (2005) Insulin resistance and compensation in Thoroughbred weanlings adapted to high-glycemic meals. J Anim Sci 83:2357-2364.
43. Tuncel M, Halici M, Canoz O, Yildirim Turk C, Oner M, Ozturk F, Kabak S (2005) Role of insulin like growth factor-I in repair response in immature cartilage. Knee 12:113-119. doi: 10.1016/j.knee.2004.04.003
44. Verwilghen DR, Busoni V, Peters F, Grulke S, Serteyn D (2007). Radiological study on Developmental Orthopaedic Disorders in horses presented for sBs stallion admission (2003-2007). In: Schramme MC, Tremaine WH, et al. (Eds.), 16th Annual Scientific Meeting of the ECVS. Dublin.
45. Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D (1999) Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 96:7324-7329. doi: 10.1073/pnas.96.13.7324
46. Yakar S, Rosen CJ, Beamer WG (2002) Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110:771-781.
47. Ytrehus B, Carlson CS, Ekman S (2007) Etiology and pathogenesis of osteochondrosis. Vet Pathol 44:429-448. doi: 10.1354/vp.44-4-429
48. Zofkova I (2003) Pathophysiological and clinical importance of insulin-like growth factor-I with respect to bone metabolism. Physiol Res 52:657-679.