Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations

Gene Therapy

Volumn 13, Issue 17, 2006, Pages 1253-1262

  Goodrich, L R ^a,d   Brower Toland, B D ^a   Warnick, L ^a   Robbins, P D ^b   Evans, C H ^c   Nixon, A J ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Adenovirus; Cartilage; Growth factor; IGF I; Repair

Indexed keywords

ADENOVIRUS VECTOR; GLYCOPROTEIN E; GLYCOPROTEIN E1; MESSENGER RNA; PROTEOGLYCAN; SOMATOMEDIN C; TOLONIUM CHLORIDE;

ADENOVIRUS 5; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL LAMENESS; ANIMAL TISSUE; ARTICLE; CARTILAGE BIOPSY; CARTILAGE CELL; CELL CLONING; CELL STRUCTURE; CELL TYPE; CHONDROPATHY; CONTROLLED STUDY; CYTOCHEMISTRY; CYTOMEGALOVIRUS; DOSE RESPONSE; EXPERIMENTAL MODEL; GENE DELETION; GENE SEQUENCE; GENE TRANSFER; GENETIC TRANSDUCTION; HISTOPATHOLOGY; HORSE; IN SITU HYBRIDIZATION; JOINT EFFUSION; METACARPOPHALANGEAL JOINT; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SYNOVIAL FLUID; SYNOVIUM; TISSUE REPAIR; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ACUTE DISEASE; ADENOVIRIDAE; ANIMALS; CARTILAGE, ARTICULAR; GENE THERAPY; GENETIC VECTORS; HORSES; IN SITU HYBRIDIZATION; INJECTIONS, INTRA-ARTICULAR; INSULIN-LIKE GROWTH FACTOR I; LIGANDS; METACARPOPHALANGEAL JOINT; MODELS, ANIMAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNOVIAL FLUID; TIME FACTORS; TRANSDUCTION, GENETIC; TREATMENT OUTCOME; WOUND HEALING;

ADENOVIRIDAE; ANIMALIA; CYTOMEGALOVIRUS; EQUIDAE; HUMAN ADENOVIRUS TYPE 5;

EID: 33747609579     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302757     Document Type: Article

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