Doxycycline accelerates renal cyst growth and fibrosis in the pcy/pcy mouse model of type 3 nephronophthisis, a form of recessive polycystic kidney disease

Histochemistry and Cell Biology

Volumn 132, Issue 2, 2009, Pages 199-210

  Osten, Larissa ^a   Kubitza, Marion ^a   Gallagher, Anna Rachel ^b   Kastner, Jürgen ^a   Olbrich, Heike ^c   De Vries, Uwe ^a   Kees, Frieder ^a   Lelongt, Brigitte ^d   Somlo, Stefan ^b   Omran, Heymut ^c   Witzgall, Ralph ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d INSERM   (France)

Author keywords

Doxycycline; Intracellular calcium; Nephronophthisis; Polycystic kidney disease; Primary cilia

Indexed keywords

CALCIUM; DOXYCYCLINE; MATRIX METALLOPROTEINASE; PROTEINASE K; TISSUE INHIBITOR OF METALLOPROTEINASE 2; CELL SURFACE RECEPTOR; PKHD1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CALCIUM CELL LEVEL; CELL STRAIN; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; KIDNEY CYST; KIDNEY FIBROSIS; KIDNEY POLYCYSTIC DISEASE; KIDNEY SIZE; METABOLISM; MOUSE; NEPHRONOPHTHISIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSGENIC MOUSE; TUMOR GROWTH; URINE; ANIMAL; CHEMICALLY INDUCED DISORDER; CYST; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FIBROSIS; GENETICS; HELA CELL; KIDNEY; MOUSE MUTANT; PATHOLOGY;

ANIMALIA; MUS; MUS MUSCULUS;

ANIMALS; CYSTS; DISEASE MODELS, ANIMAL; DOXYCYCLINE; FIBROSIS; HELA CELLS; HUMANS; KIDNEY; MATRIX METALLOPROTEINASES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; POLYCYSTIC KIDNEY DISEASES; RECEPTORS, CELL SURFACE; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 70349261185     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-009-0588-y     Document Type: Article

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