Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes

Toxicology and Applied Pharmacology

Volumn 231, Issue 3, 2008, Pages 393-400

  Ji, Lili ^a,b   Chen, Ying ^a,c   Liu, Tianyu ^a   Wang, Zhengtao ^a,b,c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl xL; Caspase; Cytochrome c; Hepatocytes; Protein degradation; Pyrrolizidine alkaloid

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALPASTATIN; CASPASE 3; CASPASE 9; CASPASE INHIBITOR; CLIVORINE; CYTOCHROME C; ISOLINE; MONOCROTALINE; POLYUBIQUITIN; PROTEASOME INHIBITOR; PROTEIN BCL XL; PYRROLIZIDINE ALKALOID; SENECIONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; LIVER CELL; LIVER TOXICITY; MALE; MEDICINAL PLANT; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; TEA; UBIQUITINATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CASPASES; CELL LINE; CELL SURVIVAL; HEPATOCYTES; HUMANS; MALE; MICE; MICE, INBRED ICR; MITOCHONDRIA; PYRROLIZIDINE ALKALOIDS; SIGNAL TRANSDUCTION;

LIGULARIA HODGSONII; SENECIO VULGARIS;

EID: 50849121064     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.05.015     Document Type: Article

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