M-CSF elevates c-Fos and phospho-C/EBPα(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification

Blood

Volumn 114, Issue 10, 2009, Pages 2172-2180

  Jack, Graham D ^a   Zhang, Li ^a   Friedman, Alan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; HOMODIMER; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL ESTER; PHOSPHOLIPASE C GAMMA2; PROTEIN C FOS; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA; STAT3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CELL SPECIFICITY; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GRANULOCYTE; GRANULOPOIESIS; HEMATOPOIETIC STEM CELL; INHIBITION KINETICS; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CYTOLOGY; DIMERIZATION; DRUG EFFECT; GRANULOCYTE PRECURSOR; HUMAN; METABOLISM; MONOCYTE MACROPHAGE PRECURSOR CELL; MYELOPOIESIS; ONCOGENE; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL LINE; DIMERIZATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENES, FOS; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE PRECURSOR CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGE COLONY-STIMULATING FACTOR; MAP KINASE SIGNALING SYSTEM; MICE; MONOCYTE-MACROPHAGE PRECURSOR CELLS; MYELOPOIESIS; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; STAT3 TRANSCRIPTION FACTOR;

EID: 70349246857     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-11-191536     Document Type: Article

References (49)

1. Iwasaki H, Akashi K. Hematopoietic developmental pathways: on cellular basis. Oncogene. 2007; 26:6687-6696. (Pubitemid 47585095)
2. Friedman AD. Transcriptional control of granulocyte and monocyte development. Oncogene. 2007;26:6816-6828. (Pubitemid 47585105)
3. Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994;265:1573-1577. (Pubitemid 24308970)
4. McKercher SR, Torbett BE, Anderson KL, et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996;15:5647-5658. (Pubitemid 26385624)
5. Zhang P, Iwasaki-Arai J, Iwasaki H, et al. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα. Immunity. 2004; 21:853-863. (Pubitemid 39642186)
6. Dahl R, Walsh JC, Lancki D, et al. Regulation of macrophage and neutrophil cell fates by the PU.1:C/ EBPα ratio and granulocyte colony-stimulating factor. Nat Immunol. 2003;4:1029-1036. (Pubitemid 37265925)
7. Wang D, D'Costa J, Civin CI, Friedman AD. C/EBPα directs monocytic commitment of primary myeloid progenitors. Blood. 2006;108:1223-1229. (Pubitemid 44232018)
8. Cai DH, Wang D, Keefer J, Yeamans C, Hensley K, Friedman AD. C/EBPα:AP-1 leucine zipper heterodimers bind novel DNAelement, activate the PU.1 promoter, and direct monocyte lineage commitment more potently than C/EBPα homodimers or AP-1. Oncogene. 2008;27:2772-2779. (Pubitemid 351581472)
9. Laslo P, Spooner CJ, Warmflash A, et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 2006;126: 755-766. (Pubitemid 44233633)
10. Dahl R, Iyer SR, Owens KS, Cuylear DD, Simon MC. The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction. J Biol Chem. 2007;282:6473-6483. (Pubitemid 47100818)
11. Ward AC, Loeb DM, Soede-Bobok AA, Touw IP, Friedman AD. Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia. 2000;14:973-990. (Pubitemid 30389501)
12. Bourette RP, Rohrschneider LR. Early events in M-CSF receptor signaling. Growth Factors. 2000; 17:155-166.
13. Lee C, Raz R, Gimeno R, et al. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Cell. 2002; 17:63-72. (Pubitemid 34874619)
14. Panopoulos AD, Zhang L, Snow JW, et al. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood. 2006;108: 3682-3690. (Pubitemid 44864545)
15. Mermel CH, McLemore ML, Liu F, et al. Src family kinases are important negative regulators of G-CSFdependent granulopoiesis. Blood. 2006;108:2562-2568. (Pubitemid 44776989)
16. Junttila I, Bourette RP, Rohrschneider LR, Silvennoinen O. M-CSF induced differentiation of myeloid precursor cells involves activation of PKC- and expression of Pkare. J Leukocyte Biol. 2003;73:281-288. (Pubitemid 36158303)
17. Gobert-Gosse S, Bourgin C, Liu WQ, Garbay C, Mouchiroud G. M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2-Sos association and phosphatidylinositol 3-kinase activity. Cell Signal. 2005;17:1352-1362. (Pubitemid 41206645)
18. Bourette RP, Grasset MF, Mouchiroud G. E2a/ Pbx1 oncogene inhibits terminal differentiation but not myeloid potential of pro-T cells. Oncogene. 2007;26:234-247. (Pubitemid 46095734)
19. Bourgin-Hierle C, Gobert-Gosse S, Therier J, Grasset MF, Mouchiroud G. Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-γ2 and MAP kinases ERK1 and ERK2. Leukemia. 2008;22:161-169.
20. Miranda MB, Xu H, Torchia JA, Johnson DE. Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway. Leuk Res. 2005;29:1293-1306. (Pubitemid 41297642)
21. Palacios R, Steinmetz M. IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell. 1985;41:727-734. (Pubitemid 15225429)
22. Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 1990;18:3587-3596. (Pubitemid 20191808)
23. Finer MH, Dull TJ, Qin L, Farson D, Roberts MR. Kat: a high-efficiency retroviral transduction system for primary human T lymphocytes. Blood. 1994;83:43-50. (Pubitemid 24016514)
24. Wang W, Wang X, Ward AC, Touw IP, Friedman AD. C/EBPα and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genes. Leukemia. 2001;15:779-786. (Pubitemid 32492701)
25. Okazaki K, Sagata N. The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. EMBO J. 1995;14:5048-5059.
26. Dance M, Montagner A, Salles JP, Yart A, Raynal P. The molecular functions of Shp2 in the Ras/ mitogen-activated protein kinase (ERK1/2) pathway. Cell Signal. 2008;20:453-459.
27. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404: 193-197. (Pubitemid 30154488)
28. Ross SE, Radomska HS, Wu B, et al. Phosphorylation of C/EBPα inhibits granulopoiesis. Mol Cell Biol. 2004;24:675-686.
29. Chen L, Sung SS, Yip LR, et al. Discovery of a novel Shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006;70:562-570. (Pubitemid 44092317)
30. Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF. Phorbol esterinduced myeloid differentiation is mediated by protein kinase C-α and δ and not by protein kinase C-βII, -ε, -ζ, and -η. J Biol Chem. 1993;268: 20110-20115. (Pubitemid 23278909)
31. Lotem J, Sachs L. Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion. Proc Natl Acad Sci U S A. 1979; 76:5158-5162. (Pubitemid 10231836)
32. Koeffler HP, Bar-Eli M, Territo M. Phorbol diesterinduced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia. J Clin Invest. 1980;66:1101-1108.
33. Hsu CL, Kikuchi K, Kondo M. 2007. Activation of mitogen-activated protein kinase kinase (MEK)/ extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment. Blood. 2007;110:1420-1428. (Pubitemid 47443956)
34. Robb L. Cytokine receptors and hematopoietic differentiation. Oncogene. 2007;26:6715-6723.
35. Lau LF, Nathans D. Expression of a set of growthrelated immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci U S A. 1987;84:1182-1186. (Pubitemid 17027316)
36. Buchwalter G, Gross C, Wasylyk B. Ets ternary complex transcription factors. Gene. 2004;324:1-14. (Pubitemid 38030321)
37. Krishnaraju K, Hoffman B, Liebermann DA. Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages. Blood. 2001;97: 1298-1305. (Pubitemid 32183752)
38. Radomska HS, Basseres DS, Zheng R, et al. Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med. 2006;203:371-381. (Pubitemid 43290846)
39. Lu W, Gong D, Bar-Sagi D, Cole PA. Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. Mol Cell. 2001;8:759-769. (Pubitemid 33030210)
40. Araki T, Nawa H, Neel BG. 2003. Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. J Biol Chem. 2003;278:41677-41684. (Pubitemid 37310425)
41. Sharf R, Meraro D, Azriel A, Thornton AM, Ozato K, Petricoin EF. Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA. J Biol Chem. 1997;272: 9785-9792. (Pubitemid 27171643)
42. Huang W, Horvath E, Eklund EA. PU.1, interferon regulatory factor 2 (IRF2) and the interferon consensus sequence binding protein (ICSBP/IRF8) cooperate to activate NF-1 transcription in differentiating myeloid cells. J Biol Chem. 2007;282: 6629-6643. (Pubitemid 47100819)
43. Holtschke T, Lohler J, Kanno Y, et al. Immunodefi- ciency and chronic myelogenous leukemia-like syndrome in mice with a targeted deletion of the ICSBP gene. Cell. 1996;87:307-317. (Pubitemid 26359008)
44. Tsujimura H, Nagamura-Inoue T, Tamura T, Ozato K. IFN consensus sequence binding protein/IFN regulatory factor-8 guides bone marrow progenitor cells towards the macrophage lineage. J Immunol. 2002;169:1261-1269. (Pubitemid 34809167)
45. Rosenbauer F, Wagner K, Kutok JL, et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU. 1. Nat Genet. 2004;36:624-630. (Pubitemid 38715991)
46. Dakic A, Metcalf D, Di Rago L, Mifsud S, Wu L, Nutt SL. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med. 2005;201:1487-1502. (Pubitemid 40664092)
47. Yeamans C, Wang D, Paz-Priel I, Torbett BE, Tenen DG, Friedman AD. C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. Blood. 2007;110:3136-3142. (Pubitemid 350106304)
48. Bollag G, Clapp DW, Shih S, et al. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in hematopoietic cells. Nat Genet. 1996;12:144-148. (Pubitemid 26051293)
49. Kieslinger M, Woldman I, Moriggl R, et al. Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev. 2000;14:232-244. (Pubitemid 30070988)