C/EBPα and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genes

Leukemia

Volumn 15, Issue 5, 2001, Pages 779-786

  Wang, W ^a   Wang, X ^a   Ward, A C ^b   Touw, I P ^b   Friedman, A D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

C EBP ; Cytokines; G CSF receptor; Granulopoiesis; Hematopoiesis

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; ELASTASE; ESTROGEN RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; HYBRID PROTEIN; INTERLEUKIN 3; MESSENGER RNA; MYELOPEROXIDASE; RNA; TYROSINE; CCAAT ENHANCER BINDING PROTEIN ALPHA; GRANULOCYTE COLONY STIMULATING FACTOR; LEUKOCYTE ELASTASE; PEROXIDASE;

ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOPLASM; GENE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MUTANT; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CELL DIVISION; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; MOUSE; PHYSIOLOGY; TRANSGENE;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIVISION; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; LEUKOCYTE ELASTASE; MICE; PEROXIDASE; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; TRANSGENES;

EID: 0034744101     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402094     Document Type: Article

References (40)

1. A novel temporal pattern of three C/EBP family members in differentiating myelomonocytic cells
2. NF-M (chicken C/EBPβ) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line
3. CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic differentiation from bipotential myeloid cells
4. Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
5. PU.1 (Spi-1) and C/EBPα regulate expression of the granulocyte-macrophage colony-stimulating factor receptor α gene
6. Absence of G-CSF signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
7. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6
8. PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
9. GADD153/CHOP, a DNA damage-inducible protein, reduced CCAAT/enhancer binding protein activities and increased apoptosis in 32D cl3 myeloid cells
10. Lymphoproliferative disorder and imbalanced T-helper response in C/EBPβ-deficient mice
11. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
12. Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene
13. A novel human CCAAT/enhancer binding protein gene, C/EBP epsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T cell receptor alpha/delta locus
14. Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor
15. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice
16. C/EBPα by-passes G-CSF signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
17. IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes
18. Mutations in the gene for granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
19. Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration
20. Advanced mammalian gene transfer: High titre retroviral receptors with multiple drug selection markers and a complementary helper-free packaging cell line
21. Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D cl3
22. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
23. Regulation of proliferative and differentiative responses in a murine progenitor cell line
24. Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation
25. Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor
26. C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
27. Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter
28. Suppression of apoptosis during cytokine deprivation of 32D cells is not sufficient to induce complete granulocytic differentiation
29. Enforced expression of bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice
30. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
31. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor deficiency, and impaired neutrophil mobilization
32. Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice
33. Mice lacking both granulocyte colony stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival
34. Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes
35. Thrombopoietin, the Mpl ligand, is essential for full megakaryocyte development
36. Interleukin 5 regulates the isoform expression of its own receptor α-subunit
37. Receptors that induce erythroid differentiation of Ba/F3 cells: Structural requirements and effect on STAT5 binding
38. Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells
39. Regulation of granulopoiesis by transcription factors and cytokines (review)
40. Binding of NF-Y transcription factor to one of the cis-elements in the myeloperoxidase gene promoter that responds to granulocyte colony-stimulating factor