Combinational chelation therapy abrogates lead-induced neurodegeneration in rats

Toxicology and Applied Pharmacology

Volumn 240, Issue 2, 2009, Pages 255-264

  Pachauri, Vidhu ^a   Saxena, Geetu ^a   Mehta, Ashish ^a   Mishra, Deepshikha ^a   Flora, Swaran J S ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Apoptosis; Biogenic amines; Lead; Neurobehavioral; Oxidative stress; Reactive oxygen species

Indexed keywords

CALCIUM; CAPTOPRIL; CYTOCHROME C; LEAD; MONOISOAMYL SUCCIMER; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SUCCIMER; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR CHANGE; BEHAVIOR DISORDER; CHELATION THERAPY; CHRONIC TOXICITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DRUG EFFICACY; ENZYME RELEASE; EXPLORATORY BEHAVIOR; LEAD POISONING; LEARNING; MALE; MEMORY; MONOTHERAPY; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; TOXICOKINETICS;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BEHAVIOR, ANIMAL; BIOGENIC AMINES; CALCIUM; CAPTOPRIL; CHELATING AGENTS; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DNA DAMAGE; DRUG THERAPY, COMBINATION; EXPLORATORY BEHAVIOR; LEAD POISONING, NERVOUS SYSTEM; LEARNING; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMORY; MITOCHONDRIA; MOTOR ACTIVITY; NERVE DEGENERATION; NEURONS; NITRIC OXIDE; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SUCCIMER;

RATTUS;

EID: 70349243096     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.07.001     Document Type: Article

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