Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats

Environmental Toxicology and Pharmacology

Volumn 9, Issue 4, 2001, Pages 173-184

  Pande, Manisha ^a   Mehta, Ashish ^a   Pant, Bhagwat P ^a   Flora, Swaran J S ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Acute lead toxicity; Biochemical variables; Combined administration; n Acetylcysteine; Prevention and treatment; Rats; Thiol chelator

Indexed keywords

ACETYLCYSTEINE; LEAD; MONOISOAMYL MESO 2,3 DIMERCAPTOSUCCINIC ACID; SUCCIMER; SUCCIMER DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CHELATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; LEAD BLOOD LEVEL; LEAD POISONING; LIVER TOXICITY; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; REDUCTION;

EID: 0035066086     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(01)00064-3     Document Type: Article

References (43)

1. The antioxidant action of n-acetylcysteine in reaction with hydrogen peroxide, hydroxy radical, superoxide and hypochlorous acid
2. European standardized method for the determination of delta aminolevulinic acid dehydratase activity in blood
3. Comparison of dimercaptosuccinic acid and calcium disodium ethylenediametetraacetic acid versus dimercaptoprpanol and ethylenediaminetetraacetic acid in children with lead poisoning
4. Molecular mechanism of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions
5. Microsomal lipid peroxidation
6. Estimation of the hemoglobin by the alkaline haematin method
7. Changes in glutathione and cellular energy as potential mechanisms of papverine induced hepatotoxicity in vitro
8. Free radical pathology genome
9. In vivo indices of oxidative stress in lead exposed c57bl/6 mice are reduced by treatment with meso 2,3-dimercaptosuccinic acid or n-acetylcysteine
10. Arsenic induced oxidative stress and its reversibility following combined administration of n-acetylcysteine and meso 2,3-diemercaptosuccinic acid in rats
11. Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats
12. Adjuvants for therapeutic chelating drugs in lead intoxication
13. Combined therapeutic potential of meso 2,3-dimeracptosuccinic acid and calcium disodium edentate on the mobilization and distribution of lead in experimental lead intoxication in rats
14. Dimercaptosuccinic acid in the treatment of depression following lead exposure
15. Meso 2,3-dimercaptosuccinic acid monoalkyl esters of meso 2,3-dimercaptosuccinic acid
16. The current role of 2,3-dimercaptosuccinic acid (DMSA) in the management of childhood lead poisoning
17. Role of chelating agents for prevention, intervention and treatment of exposure to toxic metals
18. Occupational lead exposure in Denmark: Screening with a haematofluorimeter
19. Can antioxidant be beneficial in the treatment of lead poisoning?
20. Antioxidant role of α-lipoic acid in lead toxicity
21. A fluorometeric method for the determination of oxidized and reduced glutathione in tissue
22. Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso 2,3-dimercaptosuccinic acid in the mouse
23. Effect of chelate treatment on kidney, bone and brain lead levels of lead intoxicated mice
24. Decreasing 203Hg retention by intraperitoneal treatment with monoalkyl esters of meso 2,3-dimeracaptosuccinic acid in rats
25. Monoisoamyl meso 2,3-dimercaptosuccinate as a delayed treatment for mercury removal in rats
26. Lead induced tissue fatty acid alterations and lipid peroxidation
27. Free radicals involvement in neurological porphyrias and lead poisoning
28. Oxygen toxicity related to exposure to lead
29. Effect of N-acetylcysteine and 2,3-dimercaptosuccinic acid on lead induced oxidative stress in rat lenses
30. Pro-oxidant effects of δ-aminolevulinic acid on Chinese Hamster Ovary cells
31. Oral dimercaptosuccinic acid and ongoing exposure to lead: Effects on heme synthesis and lead distribution in a rat model
32. Determination of copper and zinc in biological materials
33. A calorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase
34. Lead-hemoglobin interaction as a possible source of reactive oxygen species - A Chemiluminescent Study
35. The effects of Succimer on the absorption of lead in adults determined by using the stable isotope pb204
36. Lead induced lipid peroxidation and antioxidant defense components of developing chick embryos
37. Chelation in metal intoxication xxiv: Influence of various components of vitamin b complex on therapeutic efficacy of disodium calcium versenate in lead intoxication
38. Monoisoamyl meso 2,3-dimercaptosuccinate: Interaction with metallothionein bound cadmium in vitro and evidence of active transport into renal and hepatic cells in vivo
39. Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it
40. Mobilization of lead in mice by administration of monoalkyl esters of meso 2,3-dimercaptosuccinic acid
41. Enzymes in rat urine: Alkaline phosphatase
42. Determination of lead in biological and related materials by atomic absorption spectrophotometry