Prophylactic effect of melatonin in reducing lead-induced neurotoxicity in the rat

Cellular and Molecular Biology Letters

Volumn 8, Issue 2, 2003, Pages 461-470

  El Sokkary, Gamal H ^a   Kamel, Esam S ^b   Reiter, Russel J ^c  

^a Assiut University   (Egypt)

^b SOUTH VALLEY UNIVERSITY   (Egypt)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Corpus Striatum; Glutathione; Hippocampus; Lead Acetate; Lipid Peroxidation; Melatonin; Superoxide Dismutase

Indexed keywords

GLUTATHIONE; LEAD; MELATONIN; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; HISTOPATHOLOGY; LEAD POISONING; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROPHYLAXIS; PUTAMEN; PYRAMIDAL NERVE CELL; RAT;

ANIMALIA;

EID: 0038266630     PISSN: 14258153     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Finkelstein, Y., Markowitz, M.E. and Rosen, J.F. Low-level lead-induced neurotoxicity in children: an update on central nervous system effects. Brain Res. Rev. 27 (1998) 168-176.
2. Gabr, M.A., El-Badry, M. and Wahdaan, M.H. A study on the effects of inorganic lead on postnatal development of the motor cerebral cortex in albino rat. Assiut Med. J. 26 (2002) 133-145.
3. Villeda-Hernandez, J., Barroso-Moguel, R., Mendez-Armenta, M., Nava-Ruiz, C., Huerta-Romero, R. and Riso, C. Enhanced brain regional lipid peroxidation in developing rats exposed to low level lead acetate. Brain Res. Bull. 55 (2001) 247-251.
4. Ito, Y., Niiya, Y., Kurita, H., Shima, S. and Sarai, S. Serum lipid peroxide level and blood superoxide dismutase activity in workers with occupational exposure to lead. Int. Arch.Occup. Environ. Health 56 (1985) 119-127.
5. El-Sokkary, G.H., Reiter, R.J., Cuzzocrea, S., Caputi, A.P., Hassanein, A.M.M. and Tan, D.X. Role of melatonin in reduction of lipid peroxidation and peroxynitrite formation in nonseptic shock induced by zymosan. Shock 12 (1999) 402-408.
6. 3. Neuroendocrinol. Lett. 21 (2000) 461-468.
7. Lee, Y.M., Chen, H.R., Hsiao, G., Sheu, J.R., Wang, J.J. and Yen, N.H. Protection effects of melatonin on myocardial ischemia/reperfusion injury in vivo. J. Pineal Res. 33 (2002) 72-80.
8. Parlakpinar, H., Sahna, E., Ozer, M.K., Ozugurlu, F., Vardi, N. and Acet, A. Physiological and pharmacological concentrations of melatonin protect against cisplatin-induced acute renal toxicity. J. Pineal Res. 33 (2002) 161-167.
9. Reiter, R.J., Tan, D.X., Cabrera, J., D'Arpa, D., Sainz, R.M., Mayo, J.C. and Ramos, S. The oxidant/antioxidant network: role of melatonin. Biol. Signals Recept. 8 (1999) 56-63.
10. Tan, D.X., Reiter, R.J., Manchester, L.C., Yan, M.T., El-Sawi, M., Sainz, R.M., Mayo, J.C., Kohen, R, Allegra, M. and Hardeland, R. Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger. Curr. Topics Med. Chem. 2 (2002) 181-192.
11. Allegra, M., Reiter, R.J., Tan, D.X., Gentile, C., Tesoriere, L., Livrea, M.A. The chemistry of melatonin's interaction's interaction with reactive species. J. Pineal Res. 34 (2003) 1-10.
12. Tan, D. X., Chen, I. D., Poeggeler, B., Manchester, L. C., Reiter, R. J. Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocr. J. 1 (1993) 57-60.
13. Zang L.Y., Cosma, G., Gardner, H. and Vallynathan, V. Scavenging of reactive oxygen species by melatonin. Biochem. Biophys. Acta 1452 (1998) 469-477.
14. Turjanski, A.G., Sanez, D.A., Doctorovich, F., Estrin, D.A. and Rosenstein, E. Nitrosation of melatonin by nitric oxide: A computational study. J. Pineal Res. 31 (2001) 97-101.
15. Blanchard, B., Pompon, D. and Ducroq, C. Nitrosation of melatonin by nitric oxide and peroxynitrite. J. Pineal Res. 29 (2000) 184-192.
16. Tan, D.X., Manchester, L C., Reiter, R.J., Plummer, B.F., Limson, J., Weintraub, S.T. and Qi, W. Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation. Free Radic. Biol. Med. 29 (2000) 1177-1185.
17. Reiter, R.J., Tan, D.X., Osuna, C. and Gitto, E. Actions of melatonin in the reduction of oxidative stress: a review. J. Biomed. Sci. 7 (2000) 444-448.
18. Garcia, J.J., Reiter, R.J., Ortiz, G.G., Oh, C.S., Tang, L., Yu, B.P. and Escames, G. Melatonin enhances tamoxifin's ability to prevent the reduction in microsomal membrane fluidity induced by lipid peroxidation. J. Membr. Biol. 162 (1998) 59-65.
19. Acuña-Castroviejo, D., Martin, M., Macias, M., Escames, G., Loen, J., Khaldy, H. and Reiter, R.J. Melatonin, mitochondria, and cellular bioenergetics. J. Pineal Res. 30 (2001) 65-74.
20. Misra, H.P. and Fridovich, I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247 (1972) 3170-3175.
21. Beutler, E., Duron, O. and Kelly, B.M. Improved method for the involved in lead determination of blood glutathione. J. Lab. Clin. Med. 61 (1963) 882-888.
22. Moore, M.R., McIntosh, M.J. and Bushnell, W.R. The neurotoxicity of lead. Neurotoxicology 7 (1986) 541-556.
23. Jett, D.A. and Guilarte, T.R. Developmental lead exposure alters N-methyl-D-aspartate and muscarinic receptors in the rat hippocampus: An autoradiographic study. Neurotoxicology 16 (1995) 7-18.
24. Stoltenburg-Didinger, G. Neuropathology of the hippocampus and its susceptibility to neurotoxic insult. Neurotoxicology 15 (1994) 445-450.
25. Nehru, B. and Sidhu, P. Behavior and neurotoxic consequences of lead on rat brain followed by recovery. Biol. Trace Elem. Res. 84 (2001) 113-121.
26. Hermes-Lima, M., Pereira, B. and Bechara, E.J.H. Are free radicals poisoning? Xenobiotica 21 (1991) 1085-1090.
27. Sandhir, R., Julka, D. and Gill, K.D. Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes. Pharmacol. Toxicol. 74 (1994) 66-71.
28. +) neurotoxicity in rats. Neurosci. Lett. 245 (1998) 61-64.
29. Tan, D.X., Manchester, L.C., Reiter, R.J., Qi, W., Kim, S.J., El-Sokkary, G.H. Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice. J. Neurosci. Res. 54 (1998) 282-289.
30. Lezoualc'h, F., Skutella, T., Widmann, M. and Behl, C. Melatonin prevents oxidative stress-induced cell death in hippocampal cells. NeuroReport 7 (1996) 2071-2077.
31. Skaper, S.D., Ancona, B., Facci, L., Franceschini, D. and Giusti, P. Melatonin prevents the delayed death of hippocampal neurons induced by enhanced excitatory neurotransmission and the nitridergic pathway. FASEB J. 12 (1998) 725-731.
32. Pappolla, M.A., Chyan, Y.J., Poeggeler, B., Frangione, B., Wilson, G., Ghiso, J. and Reiter, R.J. An assessment of the antioxidant and antiamyloidogenic properties of melatonin: Implications for Alzheimer's disease. J. Neurol Transm. 107 (2000) 203-231.
33. Benitez-King, G. and Anton-Tay, F. Calmodulin mediates melatonin cytoskeletal effects. Experientia 49 (1993) 635-641.
34. Huerto-Delgadillo, L., Anton-Tay, F. and Benitez-King, G. Effects of melatonin in microtubule assembly dependent on hormone concentration: role of melatonin as a calmodulin antagonist. J. Pineal Res. 17 (1994) 55-62.
35. Floreani, M., Skaper, S.D., Facci, L., Lipartiti, M. and Giusti, P. Melatonin maintains glutathione homeostasis in kainic acid-exposed rat brain tissues. FASEB J. 11 (1997) 1309-1315.
36. Mohan, N., Sadeghi, K., Reiter, R.J., Meltz and M.L. The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-κB. Biochem. Mol. Biol. Int. 37 (1995) 1063-1070.
37. Pozo, D.J., Reiter, R.J., Calvo, J.R. and Guerrero, J.M. Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. J. Cell. Biochem. 65 (1997) 430-442.
38. Antolin, I., Rodriguez, C., Sainz, R.M., Mayo J.C., Uria, H., Kotler, M.L., Rodriguez-Colunga, M.J., Tolivia, D. and Menendez-Pelaez, A. Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes. FASEB J. 10 (1996) 882-890.