The activation of MEK-ERK1/2 by glutamate receptor-stimulation is involved in the regulation of RPE proliferation and morphologic transformation

Experimental Eye Research

Volumn 86, Issue 2, 2008, Pages 207-219

  Pacheco Domínguez, Reyna Lizette ^a   Palma Nicolas, J Prisco ^a   López, Edith ^a   López Colomé, Ana María ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

actin cytoskeleton; glutamate; MAP kinases; proliferation, epithelio mesenchymal transition

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; IMMUNOFLUORESCENCE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VITREORETINOPATHY; WESTERN BLOTTING;

ACTINS; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYTOSKELETON; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLUTAMIC ACID; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, CONFOCAL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PIGMENT EPITHELIUM OF EYE; RATS; RATS, LONG-EVANS; RECEPTORS, GLUTAMATE; VITREORETINOPATHY, PROLIFERATIVE;

EID: 38949179153     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2007.10.011     Document Type: Article

References (62)

1. Abe T., Durlu Y.K., and Tamai M. The properties of retinal pigment epithelial cells in proliferative vitreoretinopathy compared with cultured retinal pigment epithelial cells. Exp. Eye Res. 63 (1996) 201-210
2. Barnstable C.J. Glutamate and GABA in retinal circuitry. Curr. Opin. Neurobiol. 3 (1993) 520-525
3. Bochaton-Piallat M.L., Kapetanios A., Donati G., Redard M., Gabián G., and Pournaras C. TGF-b1, TGFb receptor II and DE-A fibronectin expression in myofibroblast of vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2336-2342
4. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem 72 (1976) 248-254
5. Bradley J., Carter S.R., Rao V.R., Wang J., and Finkbeiner S. Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression. J. Neurosci. 26 (2006) 1065-1076
6. Calipel A., Mouriaux F., Glotin A.-L., Melecaze F., Faussat A.-M., and Mascarelli F. Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells. J. Biol. Chem. 28 (2006) 9238-9250
7. Castillo J., Davalos A., and Noya M. Progression of ischemic stroke and excitotoxic amino acids. Lancet 349 (1997) 79-83
8. Chang L., and Karin M. Mammalian MAP kinase signaling cascades. Nature 401 (2001) 37-40
9. Chang C.W., Roque R.S., Defoe D.M., and Caldwell R.B. An improved method for isolation and culture of pigment epithelial cells from rat retina. Curr. Eye Res. 10 (1991) 1081-1086
10. Chang F., Steelman L.S., Shelton J.G., Lee J.T., Navolanic P.M., Blalock W.L., Franklin R., and McCubrey J.A. Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway. Int. J. Oncol 22 (2003) 469-480
11. Choe E.S., and Wang J.Q. Group I metabotropic glutamate receptors control phosphorylation of CREB, Elk-1 and ERK via a CaMKII-dependent pathway in rat striatum. Neurosci. Lett. 313 (2001) 129-132
12. Diederen R.M., La Heij E.C., Deutz N.E., Kijlstra A., Kessels A.G., van Eijk H.M., Liem A.T., Dieudonne S., and Hendrikse F. Increased glutamate levels in the vitreous of patients with retinal detachment. Exp. Eye Res. 83 (2006) 45-50
13. Fragoso G., and López-Colomé A.M. Excitatory amino acid-induced inositol phosphate formation in cultured retinal pigment epithelium. Vis. Neurosci. 16 (1999) 263-269
14. Fricke V. A new scintillation cocktail based on Triton-X-100. Anal. Biochem 63 (1975) 555-558
15. Gadea A., Lopez E., and López-Colomé A.M. Glutamate-induced inhibition of D-aspartate uptake in Müller glia from the retina. Neurochem. Res. 29 (2004) 295-304
16. Grisanti S., and Guidry C. Transdifferentiation of retinal pigment epithelial cells from epithelial to mesenchymal phenotype. Invest. Ophthalmol. Vis. Sci. 36 (1995) 391-405
17. Haddad J.J. N-methyl-D-aspartate (NMDA) and the regulation of mitogen-activated protein kinase (MAPK) signaling pathways: a revolving neurochemical axis for therapeutic intervention?. Prog. Neurobiol. 77 (2005) 252-282
18. Hazzalin C.A., and Mahadevan L.C. MAPK-regulated transcription: a continuously variable gene switch?. Nat. Rev. Mol. Cell Biol. 3 (2002) 30-40
19. Hecquet C., Lefevre G., Valtink M., Engelmann K., and Mascarelli F. Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3091-3098
20. Ivanov A., Pellegrino C., Rama S., Dumalska I., Salyha Y., Ben-Ari Y., and Medina I. Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons. J. Physiol 572 (2006) 789-798
21. Iwano M., Plieth D., Danoff T.M., Xue C., Okada H., and Neilson E.G. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest 110 (2002) 341-350
22. Kase S., Yoshida K., Harada T., Harada C., Namekata K., Suzuki Y., Ohgami K., Shiratori K., Nakayama K.I., and Ohno S. Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment. Graefes Arch. Clin. Exp. Ophthalmol. 244 (2006) 352-358
23. Kew J.N.C., and Kemp J.A. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology 179 (2005) 4-29
24. Kiemer A.K., Takeuchi K., and Quinlan M.P. Identification of genes involved in epithelial-mesenchymal transition and tumor progression. Oncogene 20 (2001) 6679-6688
25. Kim I.K., and Arroyo J.G. Mechanisms in proliferative vitreoretinopathy. Ophthalmol. Clin. North Am. 15 (2002) 81-86
26. Kim M.J., Dunah A.W., Wang Y.T., and Sheng M. Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking. Neuron 46 (2005) 745-760
27. Krapivinsky G., Krapivinsky L., Manasian Y., Ivanov A., Tyzio R., Pellegrino C., Ben-Ari Y., Clapham D.E., and Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron 40 (2003) 775-784
28. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
29. Lee S.-C., Kwon O.-W., Seong G.-J., Kim S.-H., Ahn J.-E., and Kay E.-D.P. Epitheliomesenchymal transdifferentiation of cultured RPE cells. Ophthalmic Res. 33 (2001) 80-86
30. Li Q., and Puro D.G. Diabetes-induced dysfunction of the glutamate transporter in retinal Müller cells. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3109-3116
31. 2+-permeable AMPA receptors in synaptic plasticity and neuronal death. Trends Neurosci 30 (2007) 126-134
32. Liu Y., Wong T.P., Aarts M., Rooyakkers A., Liu L., Lai T.W., Wu D.C., Lu J., Tymianski M., Craig A.M., and Wang Y.T. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J. Neurosci 27 (2007) 2846-2857
33. López-Colomé A.M., Salceda R., and Fragoso G. Specific interaction of glutamate with membranes from cultured retinal pigment epithelium. J. Neurosci. Res. 34 (1993) 454-461
34. López-Colomé A.M., Fragoso G., Wright C.E., and Sturman J.A. Excitatory amino acid receptors in membranes from cultured human retinal pigment epithelium. Curr. Eye Res. 13 (1994) 553-560
35. Louzada-Junior P., Dias J.J., Santos W.F., Lachat J.J., Bradford H.F., and Coutinho-Netto J. Glutamate release in experimental ischaemia of the retina: an approach using microdialysis. J. Neurochem 59 (1992) 358-363
36. Mayer M.L. Glutamate receptor ion channels. Curr. Opin. Neurobiol. 15 (2005) 282-288
37. Michaelis E.K. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog. Neurobiol. 54 (1998) 369-415
38. Neal M.J., Cunningham J.R., Hutson P.H., and Hogg J. Effects of ischaemia on neurotransmitter release from the isolated retina. J. Neurochem 62 (1994) 1025-1033
39. mapk are required for fibroblast proliferation. Proc. Natl. Acad. Sci. USA 90 (1993) 8319-8323
40. Parsons J.T., Martin K.H., Slack J.K., Taylor J.M., and Weed S.A. Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19 (2000) 5606-5613
41. Pastor J.C., de la Rua E.R., and Martin F. Proliferative vitreoretinopathy: risk factors and pathobiology. Prog. Retin. Eye Res. 21 (2002) 127-144
42. Pawlak G., and Helfman D.M. Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts. Mol. Biol. Cell 13 (2002) 336-347
43. Pearson G., Robinson F., Gibson T.B., Xu B.-E., Karandikar M., Berman K., and Cobb M.H. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22 (2001) 153-183
44. Perkinton M.S., Sihra T.S., and Williams R.J. Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. J. Neurosci 19 (1999) 5861-5874
45. Pulido J.E., Pulido J.S., Erie J.C., Arroyo J., Bertram K., Lu M.-J., and Shippy S.A. A role for excitatory amino acids in diabetic eye disease. Exp. Diabetes Res. 2007, ID 36150 (2007)
46. Reuveni H., Geiger T., Geiger B., and Levitzki A. Reversal of the ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway. J. Cell Biol. 151 (2000) 1179-1192
47. Sahai E., Olson M.F., and Marshall C.J. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J 20 (2001) 755-766
48. Schinkmann K.A., Kim T.A., and Avraham S. Glutamate-stimulated activation of DNA synthesis via mitogen-activated protein kinase in primary astrocytes: involvement of protein kinase C and related adhesion focal tyrosine kinase. J. Neurochem 74 (2000) 1931-1940
49. Schramek H., Feifel E., Marschitz I., Golochtchapova N., Gstraunthaler G., and Montesano R. Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells. Am. J. Physiol. Cell Physiol 285 (2003) C652-C661
50. Shinohara Y., Nakajima Y., and Nakanishi S. Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling. J. Neurochem 78 (2001) 365-373
51. Stepulak A., Sifringer M., Rzeski W., Endesfelder S., Gratopp A., Pohl E.E., Bittigau P., Felderhoff-Mueser U., Kaindl A.M., Buhrer C., Hansen H.H., Stryjecka-Zimmer M., Turski L., and Ikonomidou C. NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proc. Natl. Acad. Sci. USA 102 (2005) 15605-15610
52. Strauss O. The retinal pigment epithelium in visual function. Physiol. Rev. 85 (2005) 845-881
53. Takano T., Kang J., Jaiswal J.K., Simon S.M., Lin J.H., Yu Y., Li Y., Yang J., Dienel G., Zielke H.R., and Nedergaard M. Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proc. Natl. Acad. Sci. USA 102 (2005) 16466-16471
54. Thandi S., Blank J.L., and Challiss R.A. Group-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal-regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways. J. Neurochem 83 (2002) 1139-1153
55. Thomas G.M., and Huganir R.L. MAPK cascade signalling and synaptic plasticity. Nat. Rev. Neurosci 5 (2004) 173-183
56. Tian X., and Feig L.A. Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons. J. Biol. Chem. 281 (2006) 7578-7582
57. Uchida N., Kiuchi Y., Miyamoto K., Uchida J., Tobe T., Tomita M., Shioda S., Nakai Y., Koide R., and Oguchi K. Glutamate-stimulated proliferation of rat retinal pigment epithelial cells. Eur. J. Pharmacol 343 (1998) 265-273
58. Wakabayashi Y., Yagihashi T., Kezuka J., Muramatsu D., Usui M., and Iwasaki T. Glutamate levels in aqueous humor of patients with retinal artery occlusion. Retina 26 (2006) 432-436
59. Wang J.Q., Fibuch E.E., and Mao L. Regulation of mitogen-activated protein kinases by glutamate receptors. J. Neurochem 100 (2007) 1-11
60. Weiland G.A., and Molinoff P.B. Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties. Life Sci. 29 (1981) 313-330
61. Xue C., Plieth D., Venkov C., Xu C., and Neilson E.G. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastases. Cancer Res. 63 (2003) 3386-3394
62. Yoon S., and Seger R. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24 (2006) 21-44