Synthesis, characterization, and antimicrobial evaluation of novel 4-pyrrol-1-yl-5,6,7,8-tetrahydro-pyrido[4′,3′:4,5] thieno[2,3-d]pyrimidine derivatives

Journal of Heterocyclic Chemistry

Volumn 46, Issue 5, 2009, Pages 975-979

  Parmar, Kokila ^a   Suthar, Bharat ^a   Suthar, Arun ^a   Maheta, Abhay ^b  

^a HEMCHANDRACHARYA NORTH GUJARAT UNIVERSITY   (India)

^b Enum Nostrum Remedis   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 PYRROL 1 YL 7 (TOLUENE 4 SULFONYL) 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 (4 FLUOROBENZENESULFONYL) 4 PYRROL 1 YL 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 (4 METHOXYBENZENESULFONYL) 4 PYRROL 1 YL 5,6,7,8 TETRAHYDRO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 (4 NITROBENZENESULFONYL) 4 PYRROL 1 YL 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 (BUTANE 1 SULFONYL) 4 PYRROL 1 YL 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 (PROPANE 1 SULFONYL) 4 PYRROL 1 YL 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 (PROPANE 2 SULFONYL) 4 PYRROL 1 YL 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 BENZENESULFONYL 4 PYRROL 1 YL 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 ETHANESULFONYL 4 PYRROL 1 YL 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; 7 METHANESULFONYL 4 PYRROL 1 YL 5,6,7,8 TETRAHYDROPYRIDO[4',3':4,5]THIENO[2,3 D]PYRIMIDINE; AMPICILLIN; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; CIPROFLOXACIN; NYSTATIN; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACTERIAL STRAIN; BROTH DILUTION; CANDIDA ALBICANS; CONTROLLED STUDY; CYCLIZATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; FUNGAL STRAIN; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES;

EID: 70349229918     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.190     Document Type: Article

References (31)

1. Rosemeyer, H. Chem Biodivers 2004, 1, 361.
2. Brown, D. J. The Chemistry of Heterocyclic Compounds; Wiley: New York, 1988; Vol.24, p 730.
3. Sinha, S.; Srivastava, M. Prog Drug Res 1994, 43, 143.
4. Guo, Z. Z.; Chin, H. L.; Jhon, K. P.; Richard, J. P.; Mei, Q. J.; Arthur, G.; Mark, A. M.; Yui, M. Bioorg Med Chem Lett 2001, 11, 2071.
5. Aleem, G.; Ani, V.; Sherry, F. Q.; Roy, L. K. J Med Chem 1996, 39, 3228.
6. Hermecz, I. Adv Heterocycl Chem 1995, 63, 103.
7. Hermecz, I. Adv Heterocycl Chem 1999, 73, 178.
8. Mohammed, A. E.; Shaban, E. A.; Morgaan, A. E. Adv Heterocycl Chem 2000, 77, 345.
9. Elnagdi, M. H.; Elgemeie, G. H.; Elmoghayar, M. R. Adv Heterocycl Chem 1987, 41, 319.
10. Hermecz, I. Adv Heterocycl Chem 1987, 42, 83.
11. Varvounis, G.; Giannopoulos, T. Adv Heterocycl Chem 1996, 66, 193.
12. Litvinov, V. P. Russ Chem Bull 2004, 53, 487.
13. Waterson, A. G.; Petrova, K. G.; Hornbergera, K. R.; Hubbarda, R. D.; Sammonda, D. M.; Smitha, S. C.; Dicksona, H. D. Bioorg Med Chem Lett 2009, 19, 1332.
14. Tu, S.; Zhang, J.; Jia, R.; Jiang, B.; Zhang, Y.; Jiang, H. Org Biomol Chem 2007, 5, 1450.
15. Hafez, H. N.; El-Gazzara, A. B. A. Bioorg Med Chem Lett 2008, 18, 5222.
16. Alagarsamy, V.; Meena, S.; Ramseshu, K. V.; Solomon, V. R.; Thirumurugan, K.; Dhanabal, K.; Murugan, M. Eur J Med Chem 2006, 41, 1293.
17. Chambharea, R. V.; Khadseb, B. G.; Bobdeb, A. S.; Bahekar, R. H. Eur J Med Chem 2003, 38, 89.
18. Rashad, A. E.; Ali, M. A.; Nucleosides Nucleotides Nucleic Acids 2006, 25, 17.
19. Kidwai, M.; Venkataramanan, R.; Garg, R. K.; Bhushan, K. R. J Chem Res 2000, 12, 586.
20. Dai, Y.; Guo, Y.; Frey, R. R.; Ji, Z.; Curtin, M. L.; Ahmed, A. A.; Albert, D. H.; Arnold, L.; Arries, S. S.; Barlozzari, T.; Bauch, J. L.; Bouska, J. J.; Bousquet, P. F.; Cunha, G. A.; Glaser, K. B.; Guo, J.; Li, J.; Marcotte, P. A.; Marsh, K. C.; Moskey, M. D.; Pease, L. J.; Stewart, K. D.; Stoll, V. S.; Tapang, P.; Wishart, N.; Davidsen, S. K.; Michaelides, M. R. J Med Chem 2005, 48, 6066.
21. Schroeder, M. C.; Hamby, J. M.; Connolly, C. J.; Grohar, P. J.; Winters, R. T.; Barvian, M. R.; Moore, C. W.; Boushelle, S. L.; Crean, S. M.; Kraker, A. J.; Driscoll, D. L.; Vincent, P. W.; Elliott, W. L.; Lu, G. H.; Batley, B. L.; Dahring, T. K.; Major, T. C.; Panek, R. L.; Doherty, A. M.; Showalter, H. D. J Med Chem 2001, 44, 1915.
22. Wardakhan, W. W.; Abdel-Salam, O. M.; Elmegeed, G. A. Acta Pharm 2008, 58, 1.
23. Kikuchi, H.; Yamamoto, K.; Horoiwa, S.; Hirai, S.; Kasahara, R.; Hariguchi, N.; Matsumoto, M.; Oshima, Y. J Med Chem 2006, 49, 4698.
24. Grunewald, G. L.; Seim, M. R.; Bhat, S. R.; Wilson, M. E.; Criscione, K. R. Bioorg Med Chem 2008, 16, 542.
25. Litvinov, V. P. In Advances in Heterocyclic Chemistry; Katritzky, A. R., Ed.; Academic Press: New York, 2006; Vol.92, p 83.
26. Ivachtchenko, A.; Kovalenko, S.; Tkachenko, O. V.; Parkhomenko, O. J Comb Chem 2004, 6, 573.
27. Mailavaram, R. P.; Deb, P. K. Chem Pharm Bull 2007, 55, 776.
28. Gewald, K.; Schinke, E.; Bottcher, H. Chem Ber 1966, 99, 94.
29. National Committee for Clinical Laboratory Standards. Methods for Dilution, Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Approved Standard, (M7A5), 5th ed.; National Committee for Clinical Laboratory Standards: Wayne, PA, 2000.
30. Shadomy, S. In Manual of Clinical Microbiology; Albert, B., Ed.; ASM Press: Washington, DC, 1991; p 1173.
31. Rattan, A. Antimicrobials in Laboratory Medicine; BI Churchill Livingstone: India, 2000; p 85.