Immunological mimicry of PrPC-PrPSc interactions: Antibody-induced PrP misfolding

Protein Engineering, Design and Selection

Volumn 22, Issue 8, 2009, Pages 523-529

  Li, Li ^a   Guest, Will ^a   Huang, Alan ^a   Plotkin, Steven S ^a   Cashman, Neil R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Binding and conversion domains; Misfolding; Monoclonal antibody; Prion

Indexed keywords

BINDING AND CONVERSION DOMAINS; CELLULAR PRION PROTEINS; IMMUNOPRECIPITATIONS; ISOFORMS; MISFOLDING; MONOCLONAL ANTIBODIES (MABS); MOUSE BRAIN; PHYSICAL INTERACTIONS; PRION; PRION DISEASE; SPECIFIC SITES;

ALLERGIES; AMINES; BINDING SITES; COMPETITION; DISSOCIATION; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; SURFACE PLASMON RESONANCE;

SCANDIUM;

DITYROSINE; EPITOPE; MONOCLONAL ANTIBODY; PRION PROTEIN; UNCLASSIFIED DRUG; DRUG DERIVATIVE; ISOPROTEIN; TYROSINE;

ALPHA HELIX; ANIMAL TISSUE; ARTICLE; BETA SHEET; BRAIN; BRAIN HOMOGENATE; FLOW CYTOMETRY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN INTERACTION; ANIMAL; BRAIN LEVEL; CHEMISTRY; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN ANALYSIS; PROTEIN DOMAIN; THERMODYNAMICS;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN CHEMISTRY; FLOW CYTOMETRY; HUMANS; MICE; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN ISOFORMS; PRPC PROTEINS; PRPSC PROTEINS; THERMODYNAMICS; TYROSINE;

EID: 70349208589     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzp038     Document Type: Article

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