Gold Sodium Thiomalate and Chloroquine Inhibit Cytokine Production in Monocytic THP-1 Cells Through Distinct Transcriptional and Posttranslational Mechanisms

Journal of Clinical Immunology

Volumn 23, Issue 6, 2003, Pages 477-484

  Seitz, Michael ^a   Valbracht, Jean ^b   Quach, Jacqueline ^b   Lotz, Martin ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Chloroquine; Gold; IL 1; MAP kinase; Monocytes; TNF

Indexed keywords

AUROTHIOMALATE; CHLOROQUINE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MONOCYTE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ANTIRHEUMATIC AGENTS; CASPASE 1; CELL LINE; CHLOROQUINE; CYTOKINES; GOLD SODIUM THIOMALATE; HUMANS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; METHOTREXATE; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0842287486     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOCI.0000010424.41475.17     Document Type: Article

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