Radiation and chemotherapy bystander effects induce early genomic instability events: Telomere shortening and bridge formation coupled with mitochondrial dysfunction

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 669, Issue 1-2, 2009, Pages 131-138

  Gorman, Sheeona ^a   Tosetto, Miriam ^a   Lyng, Fiona ^b   Howe, Orla ^b   Sheahan, Kieran ^a   O'Donoghue, Diarmuid ^a   Hyland, John ^a   Mulcahy, Hugh ^a   O'Sullivan, Jacintha ^a  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b ST LUKE S HOSPITAL   (Ireland)

Author keywords

Mitochondria; Nuclear instability; Radiation bystander

Indexed keywords

FLUOROURACIL; FOLINIC ACID; MANGANESE SUPEROXIDE DISMUTASE; OXALIPLATIN; REACTIVE OXYGEN METABOLITE;

AGED; ARTICLE; BYSTANDER EFFECT; CANCER TISSUE; CELL JUNCTION; CHEMOTHERAPY; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; IRRADIATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; TELOMERE;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BYSTANDER EFFECT; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; FLUOROURACIL; GENOMIC INSTABILITY; HUMANS; LEUCOVORIN; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIAL DISEASES; ORGANOPLATINUM COMPOUNDS; OXIDATIVE STRESS; PROGNOSIS; RADIOTHERAPY DOSAGE; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TELOMERE; TISSUE CULTURE TECHNIQUES; TISSUE EXTRACTS; TREATMENT OUTCOME;

EID: 70349108775     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.06.003     Document Type: Article

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