Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 8, 2009, Pages 595-601

  Disli, Olcay Murat ^a   Ozdemir, Ercan ^a   Berkan, Ocal ^a   Bagcivan, Ihsan ^a   Durmus, Nedim ^a   Parlak, Ahmet ^a  

^a CUMHURIYET UNIVERSITY   (Turkey)

Author keywords

Fasudil; Nitric oxide; Radial artery; Rho kinase; Vasospasm; Y 27632

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FASUDIL; N(G) NITROARGININE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

ADULT; ARTERY GRAFT; ARTICLE; CLINICAL ARTICLE; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY SURGERY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RADIAL ARTERY; RISK FACTOR; VASCULAR RING; VASODILATATION; VASOSPASM;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AGED; AMIDES; CONSTRICTION, PATHOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; NITROARGININE; NITROPRUSSIDE; OXADIAZOLES; PROTEIN KINASE INHIBITORS; PYRIDINES; QUINOXALINES; RADIAL ARTERY; RECEPTORS, CALCIUM-SENSING; RHO-ASSOCIATED KINASES; VASOCONSTRICTION; VASODILATION;

EID: 70349091068     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-043     Document Type: Article

References (46)

1. Amano, M., Fukata, Y., and Kaibuchi, K. 2000. Regulation and functions of Rho-associated kinase. Exp. Cell Res. 261(1): 44-51. doi:10.1006/excr.2000. 5046. PMID:11082274.
2. 2+ signalling requirements. Biochem. J. 337(Pt 2): 153-169. doi:10.1042/0264-6021:3370153. PMID:9882611.
3. Bolz, S.S., Vogel, L., Sollinger, D., Derwand, R., de Wit, C., Loirand, G., and Pohl, U. 2003. Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. Circulation, 107(24): 3081-3087. doi:10.1161/01.CIR.0000074202.19612.8C. PMID:12796138.
4. Budzyn, K., Marley, P.D., and Sobey, C.G. 2006. Targeting Rho and Rho-kinase in the treatment of cardiovascular disease. Trends Pharmacol. Sci. 27(2): 97-104. doi:10.1016/j.tips.2005.12.002. PMID:16376997.
5. Büssemaker, E., Pistrosch, F., Förster, S., Herbrig, K., Gross, P., Passauer, J., and Brandes, R.P. 2007. Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide. Am. J. Physiol. Heart Circ. Physiol. 293(1): H541-H547. doi:10.1152/ajpheart.00770. 2006. PMID:17384125.
6. Cable, D.G., Caccitolo, J.A., Pearson, P.J., O'Brien, T., Mullany, C.J., Daly, R.C., et al. 1998. New approaches to prevention and treatment of radial artery graft vasospasm. Circulation, 98(19 Suppl): II15-II21, discussion II21-II22. PMID:9852874. (Pubitemid 28512159)
7. Cai, H., and Harrison, D.G. 2000. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 87(10): 840-844. PMID:11073878.
8. Chitaley, K., and Webb, R.C. 2002. Nitric oxide induces dilation of rat aorta via inhibition of Rho-kinase signaling. Hypertension, 39(2 Pt 2): 438-442. doi:10.1161/hy02t2.102960. PMID:11882586. (Pubitemid 34165162)
9. Chitaley, K., Weber, D.S., and Webb, R.C. 2001. RhoA/Rho-kinase, vascular changes, and hypertension. Curr. Hypertens. Rep. 3(2): 139-144. doi:10.1007/s11906-001-0028-4. PMID:11276396.
10. Demiryürek, S., Kara, A.F., Celik, A., Tarakçioǧlu, M., Baǧci, C., and Demiryürek, A.T. 2005. Effects of Y-27632, a selective Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats. Biochem. Pharmacol. 69(1): 49-58. doi:10.1016/j.bcp.2004.09.016. PMID:15588713.
11. Faymonville, M.E., Deby-Dupont, G., Larbuisson, R., Deby, C., Bodson, L., Limet, R., and Lamy, M. 1986. Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmonary bypass in humans. J. Thorac. Cardiovasc. Surg. 91(6): 858-866. PMID:3520158.
12. 2+ sensitization of smooth muscle. FEBS Lett. 440(1-2): 183-187. doi:10.1016/S0014-5793(98)01455-0. PMID:9862451. (Pubitemid 28558761)
13. Fujihara, H., Walker, L.A., Gong, M.C., Lemichez, E., Boquet, P., Somlyo, A.V., and Somlyo, A.P. 1997. Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B. Mol. Biol. Cell, 8(12): 2437-2447. PMID:9398666.
14. He, G.W. 1999. Arterial grafts for coronary artery bypass grafting: biological characteristics, functional classification, and clinical choice. Ann. Thorac. Surg. 67(1): 277-284. doi:10.1016/S0003-4975(98)01207-7. PMID:10086578.
15. He, G.W., and Yang, C.Q. 1995. Comparison among arterial grafts and coronary artery: an attempt at functional classification. J. Thorac. Cardiovasc. Surg. 109(4): 707-715. doi:10.1016/S0022-5223(95)70352-7. PMID:7715218.
16. He, G.W., and Yang, C.G. 2000. Comparative study on calcium channel antagonists in the human radial artery: clinical implications. J. Cardiovasc. Surg. (Torino), 119(1): 94-100. doi:10.1016/S0022-5223(00)70222-4
17. He, G.W., Rosenfeldt, F.L., Buxton, B.F., and Angus, J.A. 1989. Reactivity of human isolated internal mammary artery to constrictor and dilator agents: Implications for treatment of internal mammary artery spasm. Circulation, 80: I-141-I-150.
18. He, G.W., Yang, C.Q., and Starr, A. 1995. Overview of the nature of vasoconstriction in arterial grafts for coronary operations. Ann. Thorac. Surg. 59(3): 676-683. doi:10.1016/0003-4975(94)01011-0. PMID:7887711.
19. 2+ sensitivity in rabbit pulmonary artery smooth muscle. Pflugers Arch. 417(1): 21-28. doi:10.1007/BF00370764. PMID:2127310.
20. Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., and Narumiya, S. 2000. Pharmacological properties of Y-27632, a specific inhibitor of Rho-associated kinases. Mol. Pharmacol. 57(5): 976-983. PMID:10779382.
21. Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Kawano, Y., Fukata, Y., et al. 2000. Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β. Circulation, 101(11): 1319-1323. PMID:10725293. (Pubitemid 30158621)
22. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., et al. 1996. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science, 273(5272): 245-248. doi:10.1126/science.273.5272.245. PMID:8662509.
23. Kulik, A., Rubens, F.D., Gunning, D., Bourke, M.E., Mesana, T.G., and Ruel, M. 2007. Radial artery graft treatment with phenoxybenzamine is clinically safe and may reduce perioperative myocardial injury. Ann. Thorac. Surg. 83(2): 502-509. doi:10.1016/j.athoracsur.2006.09.089. PMID:17257977.
24. Lewis, R.S. 1999. Store-operated calcium channels. Adv. Second Messenger Phosphoprotein Res. 33: 279-307. PMID:10218123.
25. Manabe, S., and Sunamori, M. 2006. Radial artery graft for coronary artery bypass surgery: biological characteristics and clinical outcome. J. Card. Surg. 21(1): 102-114, 115. doi:10.1111/j.1540-8191.2006.00182.x. PMID:16426364.
26. Mombouli, J.V., and Vanhoutte, P.M. 1999. Endothelial dysfunction: from physiology to therapy. J. Mol. Cell. Cardiol. 31(1): 61-74. doi:10.1006/jmcc. 1998.0844. PMID:10072709.
27. Morel, N., and Godfraind, T. 1993. Regulation of calcium channels in vascular smooth muscle. In Calcium antagonists. Edited by T. Godfraind, S. Govoni, R. Paoletti, and P.M. Vanhoutte. Kluwer Academic Publishers, Dordrecht, The Netherlands. pp. 25-30.
28. 2+ indicator aequorin. Cardiovasc. Drugs Ther. 4(5): 1355-1362. doi:10.1007/BF02018263. PMID:2278871.
29. 2+ release, and RhoA activation. J. Thorac. Cardiovasc. Surg. 135(1): 135-138.
30. Murphy, E. 2004. Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection. Circ. Res. 94(1): 7-16. doi:10.1161/01.RES.0000108082.76667.F4. PMID:14715531.
31. Noma, K., Oyama, N., and Liao, J.K. 2006. Physiological role of ROCKs in the cardiovascular system. Am. J. Physiol. Cell Physiol. 290(3): C661-C668. doi:10.1152/ajpcell.00459.2005.
32. Olson, M.F. 2008. Applications for ROCK kinase inhibition. Curr. Opin. Cell Biol. 20(2): 242-248. doi:10.1016/j.ceb.2008.01.002. PMID:18282695.
33. Rikitake, Y., Kim, H.H., Huang, Z., Seto, M., Yano, K., Asano, T., et al. 2005. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke, 36(10): 2251-2257. doi:10.1161/01.STR.0000181077. 84981.11. PMID:16141422.
34. Sadaba, J.R., Mathew, K., Munsch, C.M., and Beech, D.J. 2000. Vasorelaxant properties of nicorandil on human radial artery. Eur. J. Cardiothorac. Surg. 17(3): 319-324. doi:10.1016/S1010-7940(00)00325-0. PMID:10758394.
35. Salmenperä, M., and Levy, J.H. 1996. The in vitro effects of phosphodiesterase inhibitors on the human internal mammary artery. Anesth. Analg. 82(5): 954-957. doi:10.1097/00000539-199605000-199700011. PMID:8610905.
36. 2+ sensitization of contraction in vascular smooth muscle. J. Biol. Chem. 275(28): 21722-21729. doi:10.1074/jbc.M000753200. PMID:10783386.
37. Sawada, N., Itoh, H., Ueyama, K., Yamashita, J., Doi, K., Chun, T.-H., et al. 2000. Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries. Circulation, 101(17): 2030-2033. PMID:10790342. (Pubitemid 30233164)
38. Sawada, N., Itoh, H., Yamashita, J., Doi, K., Inoue, M., Masatsugu, K., et al. 2001. cGMP-dependent protein kinase phosphorylates and inactivates RhoA. Biochem. Biophys. Res. Commun. 280(3): 798-805. doi:10.1006/bbrc.2000.4194. PMID:11162591.
39. Shackcloth, M.J., Conant, A.R., Thekkudan, J., Ghotkar, S., Simpson, A.W.M., and Dihmis, W.C. 2008. Attenuation of receptor-dependent and -independent vasoconstriction in the human radial artery. Eur. J. Cardiothorac. Surg. 34(4): 839-844. doi:10.1016/j.ejcts.2008.06.016. PMID:18678507.
40. Shimokawa, H., Seto, M., Katsumata, N., Amano, M., Kozai, T., Yamawaki, T., et al. 1999. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc. Res. 43(4): 1029-1039. doi:10.1016/S0008-6363(99)00144-3. PMID:10615430.
41. Somlyo, A.P., and Somlyo, A.V. 1998. From pharmacomechanical coupling to G-proteins and myosin phosphatase. Acta Physiol. Scand. 164(4): 437-448. doi:10.1046/j.1365-201X.1998.00454.x. PMID:9887967.
42. Somlyo, A.P., and Somlyo, A.V. 2000. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J. Physiol. 522(Pt 2): 177-185. doi:10.1111/j.1469-7793.2000.t01-2-00177.x. PMID:10639096.
43. Tachibana, E., Harada, T., Shibuya, M., Saito, K., Takayasu, M., Suzuki, Y., and Yoshida, J. 1999. Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage. Acta Neurochir. (Wien), 141(1): 13-19. doi:10.1007/s007010050260. PMID:10071681.
44. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., et al. 1997. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature, 389(6654): 990-994. doi:10.1038/40187. PMID:9353125.
45. Watkins, W.D., Peterson, M.B., Kong, D.L., Kono, K., Buckley, M.J., Levine, F.H., and Philbin, D.M. 1982. Thromboxane and prostacyclin changes during cardiopulmonary bypass with and without pulsatile flow. J. Thorac. Cardiovasc. Surg. 84(2): 250-256. PMID:6980332.
46. Weber, D.S., and Webb, R.C. 2001. Enhanced relaxation to the Rho-kinase inhibitor Y-27632 in mesenteric arteries from mineralocorticoid hypertensive rats. Pharmacology, 63(3): 129-133. doi:10.1159/000056123. PMID:11598417.