Rho kinase contributes to basal vascular tone in humans: Role of endothelium-derived nitric oxide

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 1, 2007, Pages

  Bussemaker E ^a,c   Pistrosch, Frank ^a   Förster, Sarah ^a   Herbrig, Kay ^a   Gross, Peter ^a   Passauer, Jens ^a   Brandes, Ralf P ^b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Forearm blood flow

Indexed keywords

FASUDIL; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN PHOSPHATASE; NITRIC OXIDE; PROTEIN KINASE B; RHO KINASE;

ADULT; ARTERIAL PRESSURE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SYSTOLE; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADULT; BLOOD FLOW VELOCITY; DOSE-RESPONSE RELATIONSHIP, DRUG; FOREARM; HUMANS; MALE; NITRIC OXIDE; RHO GTP-BINDING PROTEINS; VASOCONSTRICTION;

EID: 34547103521     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00770.2006     Document Type: Article

References (35)

1. Andresen BT, Romero GG, Jackson EK. The Rho/Rho kinase/phospholipase D pathway mediates the enhanced interaction between alpha(2)-adrenoceptors and angiotensin II receptors in the renal vasculature of spontaneously hypertensive rats (Abstract). Hypertension 38: 487, 2001.
2. Batchelor TJP, Sadaba JR, Ishola A, Pacaud P, Munsch CM, Beech DJ. Rho-kinase inhibitors prevent agonist-induced vasospasm in human internal mammary artery. Br J Pharmacol 132: 302-308, 2001.
3. Bolz SS, Vogel L, Sollinger D, Derwand R, de Wit C, Loirand G, Pohl U. Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. Circulation 107: 3081-3087, 2003.
4. Bumpus FM, Sen S, Smeby RR, Sweet C, Ferrario CM, Khosla MC. Use of angiotensin-II-antagonists in experimental hypertension. Circ Res 32: 150-158, 1973.
5. Bussemaker E, Passauer J, Reimann D, Schulze B, Reichel W, Gross P. The vascular endothelin system is not overactive in normotensive hemodialysis patients. Kidney Int 62: 940-948, 2002.
6. Cardillo C, Kilcoyne CM, Waclawiw M, Cannon RO, Panza JA. Role of endothelin in the increased vascular tone of patients with essential hypertension. Hypertension 33: 753-758, 1999.
7. Cavarape A, Bauer J, Bartoli E, Endlich K, Parekh N. Effects of angiotensin II, arginine vasopressin and tromboxane A2 in renal vascular bed: role of rho-kinase. Nephrol Dial Transplant 18: 1764-1769, 2003.
8. Cavarape A, Endlich N, Assaloni R, Bartoli E, Steinhausen M, Parekh N, Endlich K. Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo. J Am Soc Nephrol 14: 37-45, 2003.
9. Cifkova R, Erdine S, Fagard R, Farsang C, Heagerty AM, Kiowski W, Kjeldsen S, Luscher T, Mallion JM, Mancia G, Poulter N, Rahn KH, Rodicio JL, Ruilope LM, van Zwieten P, Waeber B, Williams B, Zanchetti A. Practice guidelines for primary care physicians: 2003 ESH/ESC hypertension guidelines. J Hypertens 21: 1779-1786, 2003.
10. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105, 2000.
11. Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79: 387-423, 1999.
12. G-monomethyl-L-arginine of responses to endotheliumdependent vasodilators in human forearm vasculature. Br J Pharmacol 134: 939-944, 2001.
13. Dibona GF. Neural control of renal-function - cardiovascular implications. Hypertension 13: 539-548, 1989.
14. Goddard J, Johnston NR, Hand MF, Cumming AD, Rabelink TJ, Rankin AJ, Webb DJ. Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade. Circulation 109: 1186-1193, 2004.
15. Haynes WG, Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet 344: 852-854, 1994.
16. Horowitz A, Menice CB, Laporte R, Morgan KG. Mechanisms of smooth muscle contraction. Physiol Rev 76: 967-1003, 1996.
17. Kishi T, Hirooka Y, Masumoto A, Ito K, Kimura Y, Inokuchi K, Tagawa T, Shimokawa H, Takeshita A, Sunagawa K. Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure. Circulation 111: 2741-2747, 2005.
18. Krum H, Viskoper RJ, Lacourciere Y, Budde M, Charlon V. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. N Engl J Med 338: 784-790, 1998.
19. Masumoto A, Hirooka Y, Shimokawa H, Hironaga K, Setoguchi S, Takeshita A. Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans. Hypertension 38: 1307-1310, 2001.
20. Miao LY, Dai Y, Zhang J. Mechanism of RhoA/Rho kinase activation in endothelin-1-induced contraction in rabbit basilar artery. Am J Physiol Heart Circ Physiol 283: H983-H989, 2002.
21. Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, Yang ZH. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol 22: 8467-8477, 2002.
22. Nohria A, Grunert ME, Rikitake Y, Noma K, Prsic A, Ganz P, Liao JK, Creager MA. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res 99: 1426-1432, 2006.
23. Noma K, Goto C, Nishioka K, Hara K, Kimura M, Umemura T, Jitsuiki D, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Higashi Y. Smoking, endothelial function, and Rho-kinase in humans. Arterioscler Thromb Vasc Biol 25: 2630-2635, 2005.
24. Passauer J, Bussemaker E, Range U, Plug M, Gross P. Evidence in vivo showing increase of baseline nitric oxide generation and impairment of endothelium-dependent vasodilation in normotensive patients on chronic hemodialysis. J Am Soc Nephrol 11: 1726-1734, 2000.
25. Passauer J, Pistrosch F, Bussemaker E, Lassig G, Herbrig K, Gross P. Reduced agonist-induced endothelium-dependent vasodilation in uremia is attributable to an impairment of vascular nitric oxide. J Am Soc Nephrol 16: 959-965, 2005.
26. Randriamboavonjy V, Busse R, Fleming I. 20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. Hypertension 41: 801-806, 2003.
27. 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res 93: 548-556, 2003.
28. Saris JJ, van Dijk MA, Kroon I, Schalekamp MADH, Danser AHJ. Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm. Hypertension 35: 764-768, 2000.
29. Schubert R, Kalentchuk VU, Krien U. Rho kinase inhibition partly weakens myogenic reactivity in rat small arteries by changing calcium sensitivity. Am J Physiol Heart Circ Physiol 283: H2288-H2295, 2002.
30. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522: 177-185, 2000.
31. Stroes ESG, Luscher TF, deGroot FG, Koomans HA, Rabelink TJ. Cyclosporin A increases nitric oxide activity in vivo. Hypertension 29: 570-575, 1997.
32. Taddei S, Virdis A, Ghiadoni L, Sudano I, Notari M, Salvetti A. Vasoconstriction to endogenous endothelin-1 is increased in the peripheral circulation of patients with essential hypertension. Circulation 100: 1680-1683, 1999.
33. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389: 990-994, 1997.
34. VanBavel E, Mulvany MJ. Role of wall tension in the vasoconstrictor response of cannulated rat mesenteric small arteries. J Physiol 477: 103-115, 1994.
35. Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P, Liao JK. Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol 24: 1842-1847, 2004.