The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity

European Journal of Immunology

Volumn 39, Issue 8, 2009, Pages 2259-2269

  Riquelme, Erick ^a   Carreño, Leandro J ^a   González, Pablo A ^a   Kalergis, Alexis M ^a,b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Anti tumoral immune response; Cytotoxic CD8+ T cells half life of TCR pMHC interaction

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; LAMP1 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL INTERACTION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL DESTRUCTION; TUMOR IMMUNITY; ADOPTIVE IMMUNOTHERAPY; ANIMAL; C57BL MOUSE; CD4+ T LYMPHOCYTE; COCULTURE; CYTOLOGY; CYTOTOXICITY; EXPERIMENTAL MELANOMA; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; PROTEIN BINDING; TIME; TRANSGENIC MOUSE; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; COCULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOTHERAPY, ADOPTIVE; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; TUMOR BURDEN;

EID: 70249131174     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939341     Document Type: Article

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