Up-regulation of inhibitory natural killer receptors CD94/NKG2A with suppressed intracellular perforin expression of tumor-infiltrating CD8 + T lymphocytes in human cervical carcinoma

Cancer Research

Volumn 65, Issue 7, 2005, Pages 2921-2929

  Sheu, Bor Ching ^a   Chiou, Shin Heng ^a,b   Lin, Ho Hsiung ^a   Chow, Song Nan ^a   Huang, Su Cheng ^a   Ho, Hong Nerng ^a,b   Hsu, Su Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CD94 ANTIGEN; INTERLEUKIN 15; LECTIN; MEMBRANE RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG 2 A; PERFORIN; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 15 RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CANCER INFILTRATION; CELL ASSAY; COCULTURE; CONTROLLED STUDY; CYTOLYSIS; CYTOPATHOGENIC EFFECT; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE CULTURE; MIXED LYMPHOCYTE CULTURE; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR ASSOCIATED LEUKOCYTE; UPREGULATION; UTERINE CERVIX CARCINOMA;

ANTIGENS, CD; ANTIGENS, CD94; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HUMANS; INTERLEUKIN-15; LECTINS, C-TYPE; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTES, TUMOR-INFILTRATING; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; RECEPTORS, IMMUNOLOGIC; RECOMBINANT PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; UTERINE CERVICAL NEOPLASMS;

EID: 16844368435     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2108     Document Type: Article

References (54)

1. Ferrini S, Cambiaggi A, Meazza R, et al. T cell clones expressing the NK-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol 1994;24:2294-8.
2. Mingari MC, Vitale C, Cambiaggi A, et al. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int Immunol 1995;7:697-703.
3. + NK cells by the expression of clonally distributed functional surface molecules. Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J Exp Med 1990;172:1589-98.
4. Moretta A, Vitale M, Bottino C, et al. P58 molecules as putative receptors for MHC class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J Exp Med 1993;178:597-604.
5. Moretta A, Biassoni R, Bottino C, et al. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev 1997;155:105-17.
6. Doherty DG, O'Farrelly C. Innate and adaptive lymphoid cells in the human liver. Immunol Rev 2000;174:5-20.
7. Schmidt RE, Murray C, Daley JF, Schlossman SF, Ritz J. A subset of natural killer cells in peripheral blood displays a mature T cell phenotype. J Exp Med 1986;164:351-6.
8. Speiser D, Valmori D, Rimoldi D, et al. CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients. Eur J Immunol 1999;29:1990-9.
9. Vilches C, Parham P. KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu Rev Immunol 2002;20:217-51.
10. Colonna M, Samaridis J. Cloning of immunoglobulin superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995;268:405-8.
11. Litwin V, Gumperz JE, Parham P, Phillips JH, Lanier LL. NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules. J Exp Med 1994;180:537-43.
12. Pende D, Biassoni R, Cantoni C, et al. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. J Exp Med 1996;184:505-18.
13. Dohring C, Scheidegger D, Samaridis J, Cella M, Colonna M. A human killer inhibitory receptor specific for HLA-A. J Immunol 1996;156:3098-101.
14. + T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody. J Immunol 1990;144:3238-47.
15. Perez-Villar JJ, Melero I, Rodriguez A, et al. Functional ambivalence of the kp43 (CD94) NK cell-associated surface antigen. J Immunol 1995;154:5779-88.
16. Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J Immunol 1996;157:4741-5.
17. Chang CW, Rodriguez A, Carretero M, et al. Molecular characterization of human CD94: a type II membrane glycoprotein related to C type lectin superfamily. Eur J Immunol 1995;25:2433-7.
18. + T cells. J Exp Med 1997;186:109-20.
19. Bauer S, Groh V, Wu J, et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999;285:727-9.
20. Cosman D, Mullberg J, Sutherland CL, et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 2001;14:123-33.
21. Lopez-Botet M, Llano M, Navarro F, Bellon T. NK cell recognition of non-classical HLA class I molecules. Semin Immunol 2000;12:109-19.
22. Braud VM, Allan DS, O'Callaghan CA, et al. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 1998;391:795-9.
23. Lee N, Llano M, Carretero M, et al. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci U S A 1998;95:5199-204.
24. Sheu BC, Lin RH, Lien HC, Ho HN, Hsu SM, Huang SC. Predominant Th2/Tc2 polarity of tumor-infiltrating lymphocytes in human cervical cancer. J Immunol 2001;167:2972-8.
25. Sheu BC, Hsu SM, Ho HN, Lien HC, Huang SC, Lin RH. A novel role of metalloproteinase in cancer-mediated immunosuppression. Cancer Res 2001;61:237-42.
26. Sheu BC, Lin RH, Ho HN, Huang SC. Down-regulation of CD25 expression on activated tumor-infiltrating lymphocytes derived from human cervical carcinoma. Hum Immunol 1997;56:39-48.
27. Sheu BC, Hsu SM, Ho HN, Lin RH, Torng PL, Huang SC. Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes correlate with disease progression in human cervical cancer. Cancer 1999;86:1537-43.
28. Ruchatz H, Leung BP, Wei XQ, McInnes IB, Liew FY. Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: a role for 1L-15 in development of antigen-induced immunopathology. J Immunol 1998;160:5654-60.
29. Liu L, Chahroudi A, Silvestri G, et al. Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates. Nat Med 2002;8:185-9.
30. Hazelbag S, Fleuren GJ, Baelde JJ, Schuuring E, Kenter GG, Gorter A. Cytokine profile of cervical cancer cells. Gynecol Oncol 2001;83:235-43.
31. + cells. J Immunol 1998;160:1158-65.
32. Ikeda H, Lethe B, Lehmann F, et al. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity 1997;6:199-208.
33. Le Drean E, Vely F, Olcese L, et al. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Eur J Immunol 1998;28:264-76.
34. Mingari MC, Moretta A, Moretta L. Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses. Immunol Today 1998;19:153-7.
35. Tanaka J, Toubai T, Tsutsumi Y, et al. Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells. Blood 2004;104:768-74.
36. Huard B, Karlsson L. A subpopulation of CD8+ T cells specific for melanocyte differentiation antigens expresses killer inhibitory receptors (KIR) in healthy donors: evidence for a role of KIR in the control of peripheral tolerance. Eur J Immunol 2000;30:1665-75.
37. + T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell population. Proc Natl Acad Sci U S A 1996;93:12433-8.
38. + T cells is controlled by T-cell receptor engagement. Nature 2000;403:325-8.
39. + T cell responses. Nat Immunol 2002;3:189-95.
40. Exley M, Porcelli S, Furman M, Garcia J, Balk S. CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant Vα24JαQ T cell receptor α chains. J Exp Med 1998;188:867-76.
41. Norris S, Doherty DG, Collins C, et al. Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogeneous and include Vα24-JαQ and γδ T cell receptor bearing cells. Hum Immunol 1999;60:20-31.
42. + natural T cells with distinct cytotoxic activities and Th1, Th2 and Th0 cytokine secretion patterns. J Immunol 1999;163:2314-21.
43. + T cells closely correlates with CD56 surface expression. J Immunol 2000;164:1148-52.
44. Dunne J, Lynch S, O'Farrelly C, et al. Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15. J Immunol 2001;167:3129-38.
45. Mingari MC, Ponte M, Vitale C, Bellomo R, Moretta L. Expression of HLA class I-specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function. Hum Immunol 2000;61:44-50.
46. Lanier LL. Face off: the interplay between activating and inhibitory immune receptors. Curr Opin Immunol 2001;13:326-31.
47. Speiser DE, Pittet MJ, Valmori D, et al. In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J Exp Med 1999;190:775-82.
48. Guerra N, Guillard M, Angevin E, et al. Caignard. Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas. Blood 2000;95:2883-9.
49. + T cells. Trends Immunol 2003;24:162-4.
50. Derre L, Corvaisier M, Pandolfino MC, Diez E, Jotereau F, Gervois N. Expression of CD94/NKG2-A on human T lymphocytes is induced by IL-12: implications for adoptive immunotherapy. J Immunol 2002;168:4864-70.
51. + T cells. Proc Natl Acad Sci U S A 1998;95:1172-7.
52. Bertone S, Schiavetti F, Bellomo R, et al. Transforming growth factor-β-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes. Eur J Immunol 1999;29:23-9.
53. + T lymphocytes. Eur Cytokine Network 1999;10:357-63.
54. Castle PE, Hildesheim A, Bowman FP, et al. Cervical concentrations of interleukin-10 and interleukin-12 do not correlate with plasma levels. J Clin Immunol 2002;22:23-7.