Organic anion transporting polypeptide 2-mediated uptake of paclitaxel and 2′ethylcarbonate-linked paclitaxel in freshly isolated rat hepatocytes

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 8, 2009, Pages 1029-1035

  Tanino, Tadatoshi ^a   Nawa, Akihiro ^b   Nakao, Mao ^a   Noda, Manabu ^a   Fujiwara, Sawako ^b   Iwaki, Masahiro ^a  

^a KINKI UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Organic anion transporting polypeptide 2; P glycoprotein insensitive prodrug; Paclitaxel; Rat hepatocytes

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 2 ETHYLCARBONATE; INDOMETACIN; LIVER PROTEIN; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; PACLITAXEL; PRODRUG; RIFAMPICIN; UNCLASSIFIED DRUG; VERAPAMIL; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; PACLITAXEL 2' ETHYLCARBONATE; PACLITAXEL 2'-ETHYLCARBONATE; SLC21A1 PROTEIN, RAT; SLC22A7 PROTEIN, RAT; SLCO1C1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SUSPENSION; DRUG ANTAGONISM; DRUG INHIBITION; DRUG METABOLISM; DRUG UPTAKE; LIVER CELL; MALE; NONHUMAN; PROTEIN TRANSPORT; RAT; ANIMAL; DOSE RESPONSE; METABOLISM; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANIC CATION TRANSPORT PROTEINS; PACLITAXEL; PREGNENOLONE CARBONITRILE; PRODRUGS; RATS; RATS, WISTAR;

EID: 70249111175     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.08.0006     Document Type: Article

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