Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700

Journal of Pharmaceutical Sciences

Volumn 95, Issue 2, 2006, Pages 336-347

  Sai, Yoshimichi ^a   Kato, Yukio ^a   Nakamura, Keiko ^a   Kato, Sayaka ^a   Nishimura, Tomohiro ^a   Kubo, Yoshiyuki ^a   Tamai, Ikumi ^b   Yang, Shu ^c   Hu, Zhuhan ^c   Yamada, Ichimaro ^d   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c Research Institute for Liver Diseases Shanghai Co Ltd   (China)

^d MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Active transport; Cellular uptake; Distribution; Excretion; Hepatocytes; Membrane transport; Organic anion transporter; Transporters

Indexed keywords

1 (3 CYANO 4 NEOPENTYLOXYPHENYL)PYRAZOLE 4 CARBOXYLIC ACID; ADENOSINE TRIPHOSPHATE; ANION; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CARRIER PROTEIN; CIMETIDINE; DRUG CARRIER; ESTRADIOL 17 GLUCURONIDE; FOLIC ACID; INDOMETACIN; INOSINE; LACTIC ACID; NUCLEOSIDE DERIVATIVE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 8; ORGANIC ANION TRANSPORTING POLYPEPTIDE B; ORGANIC CATION TRANSPORTER 2; PROBENECID; ROTENONE; SALICYLIC ACID; SODIUM ION; SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; TAUROCHOLIC ACID; THYMIDINE; UNCLASSIFIED DRUG; URIC ACID; URIDINE; XANTHINE OXIDASE INHIBITOR; Y 700;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG ELIMINATION; DRUG EXCRETION; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG UPTAKE; GOUT; HUMAN; HUMAN CELL; HYPERURICEMIA; IN VIVO STUDY; MALE; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; RAT;

EID: 32644452742     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20540     Document Type: Article

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