Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases

Biochemical Journal

Volumn 422, Issue 2, 2009, Pages 383-392

  Sexton, Daniel J ^a   Chen, Ting ^a   Martik, Diana ^a   Kuzmic, Petr ^b   Kuang, Guannan ^a   Chen, Jie ^a   Nixon, Andrew E ^a   Zuraw, Bruce L ^c   Forteza, Rosanna M ^d   Abraham, William M ^e   Wood, Clive R ^a  

^a Dyax Corp   (United States)

^b BioKin Ltd   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Antibody inhibition of protease; Asthma; Bradykinin; Chronic obstructive pulmonary disease; Kallikrein; Kinin

Indexed keywords

ASTHMA; BRADYKININ; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; KALLIKREIN; KININ;

AMINO ACIDS; BINDING SITES; BIOASSAY; BIOSENSORS; CELL MEMBRANES; CELL PROLIFERATION; MONOCLONAL ANTIBODIES; PHASE INTERFACES; SULFUR COMPOUNDS;

BODY FLUIDS;

ALLERGEN; CARBACHOL; EPIDERMAL GROWTH FACTOR RECEPTOR; KALLIKREIN INHIBITOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY DX 2300; SERINE PROTEINASE; TISSUE KALLIKREIN; TISSUE KALLIKREIN 1; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSENSOR; BRONCHOSPASM; BRONCHUS MUCOSA; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG FUNCTION; LUNG LAVAGE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RESPIRATORY TRACT DISEASE; SALIVA ANALYSIS; SHEEP; SURFACE PLASMON RESONANCE; TRACHEA MUCOSA; TRACHEOBRONCHIAL TREE; URINALYSIS; VALIDATION PROCESS; ANIMAL; ANTIBODY COMBINING SITE; ASTHMA; BINDING COMPETITION; CELL CULTURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; MOUSE; PHYSIOLOGY;

OVIS ARIES;

ANIMALS; ANTIBODIES, MONOCLONAL; ASTHMA; BINDING SITES, ANTIBODY; BINDING, COMPETITIVE; CELLS, CULTURED; HUMANS; MICE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SHEEP; TISSUE KALLIKREINS;

EID: 70149116329     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090010     Document Type: Article

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