메뉴 건너뛰기




Volumn 8, Issue 6, 2007, Pages 462-468

Current status of tissue kallikrein inhibitors: Importance in cancer

Author keywords

Cancer; Kallikrein; Kallistatin; Kinin; Protease inhibitor; Serpin

Indexed keywords

8 O [12 (LEUCINOYLAMINO)DODECANOYL] 8 O DEBUTANOYLTHAPSIGARIN; ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 1 ANTITRYPSIN; KALLIKREIN; KALLIKREIN INHIBITOR; KALLISTATIN; PLASMINOGEN ACTIVATOR INHIBITOR 3; PROSTATE SPECIFIC ANTIGEN; PROTEIN; PROTEIN INHIBITOR; SERIN PROTEASE INHIBITOR KAZAL TYPE 5; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; THAPSIGARGIN; TISSUE KALLIKREIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 34249863596     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (49)
  • 1
    • 34249864675 scopus 로고    scopus 로고
    • Frey EK, Kraut H, Werle E: Kallikrein (Padutin). Ferdinand Enke Verlag, Stuttgart, Germany (1950). •• This monograph was translated from German into English in 1977. The book provides a comprehensive review of the foundation of the kallikrein-kinin system.
    • Frey EK, Kraut H, Werle E: Kallikrein (Padutin). Ferdinand Enke Verlag, Stuttgart, Germany (1950). •• This monograph was translated from German into English in 1977. The book provides a comprehensive review of the foundation of the kallikrein-kinin system.
  • 2
    • 34249898245 scopus 로고    scopus 로고
    • Frey EK, Kraut H, Werle E, Vogel R, Zickgraf-Rüdel G, Trautschold I: Das Kallikrein-kinin-system und Seine Inhibitoren. Ferdinand Enke Verlag, Stuttgart, Germany (1968). • Soon after the discovery of tissue kallikrein a series of manuscripts were published in Biochemie Zeitschrift on the presence of kallikrein inhibitors in the circulation and organ tissues. This monograph collates this early research, from which inspiration has been drawn for the characterization of kallikrein inhibitors.
    • Frey EK, Kraut H, Werle E, Vogel R, Zickgraf-Rüdel G, Trautschold I: Das Kallikrein-kinin-system und Seine Inhibitoren. Ferdinand Enke Verlag, Stuttgart, Germany (1968). • Soon after the discovery of tissue kallikrein a series of manuscripts were published in Biochemie Zeitschrift on the presence of kallikrein inhibitors in the circulation and organ tissues. This monograph collates this early research, from which inspiration has been drawn for the characterization of kallikrein inhibitors.
  • 3
    • 10444240277 scopus 로고    scopus 로고
    • Inhibition of plasma kallikrein by C1-inhibitor: Role of endothelial cells and the amino-terminal domain of C1-inhibitor
    • Ravindran S, Grys TE, Welch RA, Schapira M, Patston PA: Inhibition of plasma kallikrein by C1-inhibitor: Role of endothelial cells and the amino-terminal domain of C1-inhibitor. Thromb Haemost (2004) 92(6):1277-1283.
    • (2004) Thromb Haemost , vol.92 , Issue.6 , pp. 1277-1283
    • Ravindran, S.1    Grys, T.E.2    Welch, R.A.3    Schapira, M.4    Patston, P.A.5
  • 4
    • 0035115852 scopus 로고    scopus 로고
    • Bhoola K, Ramsaroop R, Plendl J, Cassim B, Dlamini Z, Naicker S: Kallikrein and kinin receptor expression in inflammation and cancer. Biol Chem (2001) 382(1):77-89. • This is one of the first publications to report the upregulation of hK1 in cancer, and delineate the carcinogenesis role of kinin peptides. The finding of hK1 expression during the formation of new capillaries by cultured microvascular endothelial cells is described.
    • Bhoola K, Ramsaroop R, Plendl J, Cassim B, Dlamini Z, Naicker S: Kallikrein and kinin receptor expression in inflammation and cancer. Biol Chem (2001) 382(1):77-89. • This is one of the first publications to report the upregulation of hK1 in cancer, and delineate the carcinogenesis role of kinin peptides. The finding of hK1 expression during the formation of new capillaries by cultured microvascular endothelial cells is described.
  • 5
    • 0026556434 scopus 로고    scopus 로고
    • Bhoola KD, Figueroa CD, Worthy K: Bioregulation of kinins: Kallikreins, kininogens and kininases. Pharmacol Rev (1992) 44(1):1-80. •• A critical review of the literature on kinins published from the early 1900s to 1992.
    • Bhoola KD, Figueroa CD, Worthy K: Bioregulation of kinins: Kallikreins, kininogens and kininases. Pharmacol Rev (1992) 44(1):1-80. •• A critical review of the literature on kinins published from the early 1900s to 1992.
  • 6
    • 78650583245 scopus 로고    scopus 로고
    • Kallikrein-kinin cascade
    • Laurent G, Shapiro SD Eds, Elsevier Ltd, Oxford, UK
    • Bhoola KD, Fink E: Kallikrein-kinin cascade. In: Encyclopaedia of Respiratory Medicine. Laurent G, Shapiro SD (Eds), Elsevier Ltd, Oxford, UK (2006):483-493.
    • (2006) Encyclopaedia of Respiratory Medicine , pp. 483-493
    • Bhoola, K.D.1    Fink, E.2
  • 7
    • 0022480680 scopus 로고    scopus 로고
    • Chao J, Tillman DM, Wang MY, Margolius HS, Chao L: Identification of a new tissue-kallikrein-binding protein. Biochem J (1986) 239(2):325-331. •• A seminal article that reports the discovery of kallistatin. The biochemical properties of this serine protease inhibitor are described for the first time, which led to influential publications on the molecular mechanisms by which kallistatin interacts with hK1, resulting in the inhibition of hK1.
    • Chao J, Tillman DM, Wang MY, Margolius HS, Chao L: Identification of a new tissue-kallikrein-binding protein. Biochem J (1986) 239(2):325-331. •• A seminal article that reports the discovery of kallistatin. The biochemical properties of this serine protease inhibitor are described for the first time, which led to influential publications on the molecular mechanisms by which kallistatin interacts with hK1, resulting in the inhibition of hK1.
  • 8
    • 33745665581 scopus 로고    scopus 로고
    • Inhibition profiles of human tissue kallikreins by serine protease inhibitors
    • Luo LY, Jiang W: Inhibition profiles of human tissue kallikreins by serine protease inhibitors. Biol Chem (2006) 387(6):813-816.
    • (2006) Biol Chem , vol.387 , Issue.6 , pp. 813-816
    • Luo, L.Y.1    Jiang, W.2
  • 9
    • 1542719189 scopus 로고    scopus 로고
    • Recombinant production, purification and biochemical characterization of domain 6 of LEKTI: A temporary Kazal-type-related serine proteinase inhibitor
    • Kreutzmann P, Schulz A, Standker L, Forssmann WG, Magert HJ: Recombinant production, purification and biochemical characterization of domain 6 of LEKTI: A temporary Kazal-type-related serine proteinase inhibitor. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 803(1):75-81.
    • (2004) J Chromatogr B Analyt Technol Biomed Life Sci , vol.803 , Issue.1 , pp. 75-81
    • Kreutzmann, P.1    Schulz, A.2    Standker, L.3    Forssmann, W.G.4    Magert, H.J.5
  • 10
    • 28244435723 scopus 로고    scopus 로고
    • Schechter NM, Choi EJ, Wang ZM, Hanakawa Y, Stanley JR, Kang Y, Clayman GL, Jayakumar A: Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI). Biol Chem (2005) 386(11):1173-1184. •• This research paper describes the expression of hK5 and hK7 in the skin, and their inhibition by LEKTI. Mutations of LEKTI are considered to be implicated in the inherited skin disorder, the Netherton syndrome, typified by severe skin scaling.
    • Schechter NM, Choi EJ, Wang ZM, Hanakawa Y, Stanley JR, Kang Y, Clayman GL, Jayakumar A: Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI). Biol Chem (2005) 386(11):1173-1184. •• This research paper describes the expression of hK5 and hK7 in the skin, and their inhibition by LEKTI. Mutations of LEKTI are considered to be implicated in the inherited skin disorder, the Netherton syndrome, typified by severe skin scaling.
  • 11
    • 33744951683 scopus 로고    scopus 로고
    • Hekim C, Leinonen J, Narvanen A, Koistinen H, Zhu L, Koivunen E, Vaisanen V, Stenman UH: Novel peptide inhibitors of human kallikrein 2. J Biol Chem (2006) 281(18):12555-12560. •• This paper reports a novel concept that utilizes the enzymic activity of hK2 to deliver an anticancer drug.
    • Hekim C, Leinonen J, Narvanen A, Koistinen H, Zhu L, Koivunen E, Vaisanen V, Stenman UH: Novel peptide inhibitors of human kallikrein 2. J Biol Chem (2006) 281(18):12555-12560. •• This paper reports a novel concept that utilizes the enzymic activity of hK2 to deliver an anticancer drug.
  • 12
    • 9444268199 scopus 로고    scopus 로고
    • Janssen S, Jakobsen CM, Rosen DM, Ricklis RM, Reineke U, Christensen SB, Lilja H, Denmeade SR: Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer. Mol Cancer Ther (2004) 3(11):1439-1450. •• This paper describes the use of a combinatorial tetrapeptide library as an investigative tool for the identification of new peptide inhibitors. Prostate cancer cells secrete hK2, which can uniquely act as a target for proteolytic activation of cytotoxic drugs. This novel concept, if developed clinically, could have a major impact on cancer therapy, in particular in the treatment of prostate cancer.
    • Janssen S, Jakobsen CM, Rosen DM, Ricklis RM, Reineke U, Christensen SB, Lilja H, Denmeade SR: Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer. Mol Cancer Ther (2004) 3(11):1439-1450. •• This paper describes the use of a combinatorial tetrapeptide library as an investigative tool for the identification of new peptide inhibitors. Prostate cancer cells secrete hK2, which can uniquely act as a target for proteolytic activation of cytotoxic drugs. This novel concept, if developed clinically, could have a major impact on cancer therapy, in particular in the treatment of prostate cancer.
  • 13
    • 33644765198 scopus 로고    scopus 로고
    • Janssen S, Rosen DM, Ricklis RM, Dionne CA, Lilja H, Christensen SB, Isaacs JT, Denmeade SR: Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug. Prostate (2006) 66(4):358-368. •• A cutting edge study on the development of a drug delivery system based on the concept described in reference [35].
    • Janssen S, Rosen DM, Ricklis RM, Dionne CA, Lilja H, Christensen SB, Isaacs JT, Denmeade SR: Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug. Prostate (2006) 66(4):358-368. •• A cutting edge study on the development of a drug delivery system based on the concept described in reference [35].
  • 14
    • 0033802080 scopus 로고    scopus 로고
    • Kallikrein and kinin receptor genes
    • Mahabeer R, Bhoola KD: Kallikrein and kinin receptor genes. Pharmacol Ther (2000) 88(1):77-89.
    • (2000) Pharmacol Ther , vol.88 , Issue.1 , pp. 77-89
    • Mahabeer, R.1    Bhoola, K.D.2
  • 16
    • 0035115850 scopus 로고    scopus 로고
    • The expanded human kallikrein (KLK) gene family: Genomic organization, tissue-specific expression and potential functions
    • Clements J, Hooper J, Dong Y, Harvey T: The expanded human kallikrein (KLK) gene family: Genomic organization, tissue-specific expression and potential functions. Biol Chem (2001) 382(1):5-14.
    • (2001) Biol Chem , vol.382 , Issue.1 , pp. 5-14
    • Clements, J.1    Hooper, J.2    Dong, Y.3    Harvey, T.4
  • 17
    • 0035018273 scopus 로고    scopus 로고
    • The new human tissue kallikrein gene family: Structure, function and association to disease
    • Yousef GM, Diamandis EP: The new human tissue kallikrein gene family: Structure, function and association to disease. Endocr Rev (2001) 22(2):184-204.
    • (2001) Endocr Rev , vol.22 , Issue.2 , pp. 184-204
    • Yousef, G.M.1    Diamandis, E.P.2
  • 18
    • 8144222388 scopus 로고    scopus 로고
    • The emerging roles of human tissue kallikreins in cancer
    • Borgono CA, Diamandis EP: The emerging roles of human tissue kallikreins in cancer. Nat Rev Cancer (2004) 4(11):876-890.
    • (2004) Nat Rev Cancer , vol.4 , Issue.11 , pp. 876-890
    • Borgono, C.A.1    Diamandis, E.P.2
  • 19
    • 19344371357 scopus 로고    scopus 로고
    • Human tissue kallikrein gene family: Applications in cancer
    • Obiezu CV, Diamandis EP: Human tissue kallikrein gene family: Applications in cancer. Cancer Lett (2005) 224(1):1-22.
    • (2005) Cancer Lett , vol.224 , Issue.1 , pp. 1-22
    • Obiezu, C.V.1    Diamandis, E.P.2
  • 20
    • 3543150203 scopus 로고    scopus 로고
    • Human tissue kallikreins: Physiologic roles and applications in cancer
    • Borgono CA, Michael IP, Diamandis EP: Human tissue kallikreins: Physiologic roles and applications in cancer. Mol Cancer Res (2004) 2(5):257-280.
    • (2004) Mol Cancer Res , vol.2 , Issue.5 , pp. 257-280
    • Borgono, C.A.1    Michael, I.P.2    Diamandis, E.P.3
  • 21
    • 0032708778 scopus 로고    scopus 로고
    • Visualisation of tissue kallikrein and kinin receptors in oesophageal carcinoma
    • Dlamini Z, Raidoo D, Bhoola K: Visualisation of tissue kallikrein and kinin receptors in oesophageal carcinoma. Immunopharmacology (1999) 43(2-3):303-310.
    • (1999) Immunopharmacology , vol.43 , Issue.2-3 , pp. 303-310
    • Dlamini, Z.1    Raidoo, D.2    Bhoola, K.3
  • 22
    • 24644457254 scopus 로고    scopus 로고
    • 2 receptor in mast and giant cells infiltrating oesophageal squamous cell carcinoma
    • 2 receptor in mast and giant cells infiltrating oesophageal squamous cell carcinoma. J Clin Pathol (2005) 58(9):915-922.
    • (2005) J Clin Pathol , vol.58 , Issue.9 , pp. 915-922
    • Dlamini, Z.1    Bhoola, K.D.2
  • 23
    • 0034769317 scopus 로고    scopus 로고
    • Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms
    • Sawant S, Snyman C, Bhoola K: Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms. Int Immunopharmacol (2001) 1(12):2063-2080.
    • (2001) Int Immunopharmacol , vol.1 , Issue.12 , pp. 2063-2080
    • Sawant, S.1    Snyman, C.2    Bhoola, K.3
  • 24
    • 25144446869 scopus 로고    scopus 로고
    • Visualization of transforming growth factor-β1, tissue kallikrein, and kinin and transforming growth factor-β receptors on human clear-cell renal carcinoma cells
    • Moodley R, Snyman C, Odhav B, Bhoola KD: Visualization of transforming growth factor-β1, tissue kallikrein, and kinin and transforming growth factor-β receptors on human clear-cell renal carcinoma cells. Biol Chem (2005) 386(4):375-382.
    • (2005) Biol Chem , vol.386 , Issue.4 , pp. 375-382
    • Moodley, R.1    Snyman, C.2    Odhav, B.3    Bhoola, K.D.4
  • 25
    • 0032706204 scopus 로고    scopus 로고
    • Kinin receptors are expressed in human astrocytic tumour cells
    • Raidoo DM, Sawant S, Mahabeer R, Bhoola KD: Kinin receptors are expressed in human astrocytic tumour cells. Immunopharmacology (1999) 43(2-3):255-263.
    • (1999) Immunopharmacology , vol.43 , Issue.2-3 , pp. 255-263
    • Raidoo, D.M.1    Sawant, S.2    Mahabeer, R.3    Bhoola, K.D.4
  • 26
    • 3042750282 scopus 로고    scopus 로고
    • The tissue kallikrein family of serine proteases: Functional roles in human disease and potential as clinical biomarkers
    • Clements JA, Willemsen NM, Myers SA, Dong Y: The tissue kallikrein family of serine proteases: Functional roles in human disease and potential as clinical biomarkers. Crit Rev Clin Lab Sci (2004) 41(3):265-312.
    • (2004) Crit Rev Clin Lab Sci , vol.41 , Issue.3 , pp. 265-312
    • Clements, J.A.1    Willemsen, N.M.2    Myers, S.A.3    Dong, Y.4
  • 28
    • 33745655393 scopus 로고    scopus 로고
    • Cellular distribution of human tissue kallikreins: Immunohistochemical localization
    • Petraki CD, Papanastasiou PA, Karavana VN, Diamandis EP: Cellular distribution of human tissue kallikreins: Immunohistochemical localization. Biol Chem (2006) 387(6):653-663.
    • (2006) Biol Chem , vol.387 , Issue.6 , pp. 653-663
    • Petraki, C.D.1    Papanastasiou, P.A.2    Karavana, V.N.3    Diamandis, E.P.4
  • 29
    • 0024374351 scopus 로고
    • Bradykinin receptor number and sensitivity to ligand stimulation of mitogenesis is increased by expression of a mutant ras oncogene
    • Roberts RA, Gullick WJ: Bradykinin receptor number and sensitivity to ligand stimulation of mitogenesis is increased by expression of a mutant ras oncogene. J Cell Science (1989) 94(3):527-535.
    • (1989) J Cell Science , vol.94 , Issue.3 , pp. 527-535
    • Roberts, R.A.1    Gullick, W.J.2
  • 30
    • 0024151625 scopus 로고
    • Involvement of the kinin-generating cascade in enhanced vascular permeability in tumor tissue
    • Matsumura Y, Kimura M, Yamamoto T, Maeda H: Involvement of the kinin-generating cascade in enhanced vascular permeability in tumor tissue. Jpn J Cancer Res (1988) 79(12):1327-1334.
    • (1988) Jpn J Cancer Res , vol.79 , Issue.12 , pp. 1327-1334
    • Matsumura, Y.1    Kimura, M.2    Yamamoto, T.3    Maeda, H.4
  • 31
    • 0034531685 scopus 로고    scopus 로고
    • Expression of tissue kallikrein and kinin receptors in angiogenic microvascular endothelial cells
    • Plendl J, Snyman C, Naidoo S, Sawant S, Mahabeer R, Bhoola KD: Expression of tissue kallikrein and kinin receptors in angiogenic microvascular endothelial cells. Biol Chem (2000) 381(11):1103-1115.
    • (2000) Biol Chem , vol.381 , Issue.11 , pp. 1103-1115
    • Plendl, J.1    Snyman, C.2    Naidoo, S.3    Sawant, S.4    Mahabeer, R.5    Bhoola, K.D.6
  • 32
    • 0035153591 scopus 로고    scopus 로고
    • A synthetic tissue kallikrein inhibitor suppresses cancer cell invasiveness
    • Wolf WC, Evans MD, Chao L, Chao J: A synthetic tissue kallikrein inhibitor suppresses cancer cell invasiveness. Am J Pathol (2001) 159(5):1797-1805.
    • (2001) Am J Pathol , vol.159 , Issue.5 , pp. 1797-1805
    • Wolf, W.C.1    Evans, M.D.2    Chao, L.3    Chao, J.4
  • 33
    • 0034824499 scopus 로고    scopus 로고
    • Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3
    • Rehault S, Monget P, Mazerbourg S, Tremblay R, Gutman N, Gauthier F, Moreau T: Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3. Eur J Biochem (2001) 268(10):2960-2968.
    • (2001) Eur J Biochem , vol.268 , Issue.10 , pp. 2960-2968
    • Rehault, S.1    Monget, P.2    Mazerbourg, S.3    Tremblay, R.4    Gutman, N.5    Gauthier, F.6    Moreau, T.7
  • 35
    • 32344435145 scopus 로고    scopus 로고
    • Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: HK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)
    • Beaufort N, Debela M, Creutzburg S, Kellermann J, Bode W, Schmitt M, Pidard D, Magdolen V: Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR). Biol Chem (2006) 387(2):217-222.
    • (2006) Biol Chem , vol.387 , Issue.2 , pp. 217-222
    • Beaufort, N.1    Debela, M.2    Creutzburg, S.3    Kellermann, J.4    Bode, W.5    Schmitt, M.6    Pidard, D.7    Magdolen, V.8
  • 36
    • 33745645866 scopus 로고    scopus 로고
    • Human kallikrein 4: Enzymatic activity, inhibition, and degradation of extracellular matrix proteins
    • Obiezu CV, Michael IP, Levesque MA, Diamandis EP: Human kallikrein 4: Enzymatic activity, inhibition, and degradation of extracellular matrix proteins. Biol Chem (2006) 387(6):749-759.
    • (2006) Biol Chem , vol.387 , Issue.6 , pp. 749-759
    • Obiezu, C.V.1    Michael, I.P.2    Levesque, M.A.3    Diamandis, E.P.4
  • 37
    • 0027048724 scopus 로고
    • Kallistatin: A novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence
    • Zhou GX, Chao L, Chao J: Kallistatin: A novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence. J Biol Chem (1992) 267(36):25873-25880.
    • (1992) J Biol Chem , vol.267 , Issue.36 , pp. 25873-25880
    • Zhou, G.X.1    Chao, L.2    Chao, J.3
  • 38
    • 0029556746 scopus 로고
    • Biochemistry, regulation and potential function of kallistatin
    • Chao J, Chao L: Biochemistry, regulation and potential function of kallistatin. Biol Chem Hoppe Seyler (1995) 376(12):705-713.
    • (1995) Biol Chem Hoppe Seyler , vol.376 , Issue.12 , pp. 705-713
    • Chao, J.1    Chao, L.2
  • 39
    • 0034704148 scopus 로고    scopus 로고
    • Chen VC, Chao L, Chao J: A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein. J Biol Chem (2000) 275(51):40371-40377. •• An outstanding paper describing experiments that delineated the molecular interactions between hK1 and kallistatin.
    • Chen VC, Chao L, Chao J: A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein. J Biol Chem (2000) 275(51):40371-40377. •• An outstanding paper describing experiments that delineated the molecular interactions between hK1 and kallistatin.
  • 40
    • 0034624099 scopus 로고    scopus 로고
    • Roles of the P1, P2, and P3 residues in determining inhibitory specificity of kallistatin toward human tissue kallikrein
    • Chen VC, Chao L, Chao J: Roles of the P1, P2, and P3 residues in determining inhibitory specificity of kallistatin toward human tissue kallikrein. J Biol Chem (2000) 275(49):38457-38466.
    • (2000) J Biol Chem , vol.275 , Issue.49 , pp. 38457-38466
    • Chen, V.C.1    Chao, L.2    Chao, J.3
  • 41
    • 0034660418 scopus 로고    scopus 로고
    • Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis
    • Chen VC, Chao L, Chao J: Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis. Biochim Biophys Acta (2000) 1479(1-2):237-246.
    • (2000) Biochim Biophys Acta , vol.1479 , Issue.1-2 , pp. 237-246
    • Chen, V.C.1    Chao, L.2    Chao, J.3
  • 44
    • 33748646005 scopus 로고    scopus 로고
    • Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, Goettig P: Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences. J Biol Chem (2006) 281(35):25678-25688. •• An excellent paper that provides a rational basis for using specific molecular substrate features to design new inhibitors for tissue kallikreins.
    • Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, Goettig P: Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences. J Biol Chem (2006) 281(35):25678-25688. •• An excellent paper that provides a rational basis for using specific molecular substrate features to design new inhibitors for tissue kallikreins.
  • 45
    • 0030958118 scopus 로고    scopus 로고
    • Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites
    • Portaro FC, Cezari MH, Juliano MA, Juliano L, Walmsley AR, Prado ES: Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites. Biochem J (1997) 323(1):167-171.
    • (1997) Biochem J , vol.323 , Issue.1 , pp. 167-171
    • Portaro, F.C.1    Cezari, M.H.2    Juliano, M.A.3    Juliano, L.4    Walmsley, A.R.5    Prado, E.S.6
  • 46
    • 27644557524 scopus 로고    scopus 로고
    • Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents
    • Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N: Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents. Br J Pharmacol (2005) 146(5):670-678.
    • (2005) Br J Pharmacol , vol.146 , Issue.5 , pp. 670-678
    • Houle, S.1    Papez, M.D.2    Ferazzini, M.3    Hollenberg, M.D.4    Vergnolle, N.5
  • 47
    • 0036848045 scopus 로고    scopus 로고
    • Involvement of tissue kallikrein but not plasma kallikrein in the development of symptoms mediated by endogenous kinins in acute pancreatitis in rats
    • Griesbacher T, Rainer I, Tiran B, Evans DM: Involvement of tissue kallikrein but not plasma kallikrein in the development of symptoms mediated by endogenous kinins in acute pancreatitis in rats. Br J Pharmacol (2002) 137(5):692-700.
    • (2002) Br J Pharmacol , vol.137 , Issue.5 , pp. 692-700
    • Griesbacher, T.1    Rainer, I.2    Tiran, B.3    Evans, D.M.4
  • 49
    • 0035227870 scopus 로고    scopus 로고
    • Linear competitive inhibition of human tissue kallikrein by 4-aminobenzamidine and benzamidine and linear mixed inhibition by 4-nitroaniline and aniline
    • Sousa MO, Miranda TL, Costa EB, Bittar ER, Santoro MM, Figueiredo AF: Linear competitive inhibition of human tissue kallikrein by 4-aminobenzamidine and benzamidine and linear mixed inhibition by 4-nitroaniline and aniline. Braz J Med Biol Res (2001) 34(1):35-44.
    • (2001) Braz J Med Biol Res , vol.34 , Issue.1 , pp. 35-44
    • Sousa, M.O.1    Miranda, T.L.2    Costa, E.B.3    Bittar, E.R.4    Santoro, M.M.5    Figueiredo, A.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.