A generalized numerical approach to rapid-equilibrium enzyme kinetics: Application to 17β-HSD

Molecular and Cellular Endocrinology

Volumn 248, Issue 1-2, 2006, Pages 172-181

  Kuzmič, Petr ^a  

^a BioKin Ltd   (United States)

Author keywords

Data analysis; DYNAFIT; Enzyme kinetics; Mathematics; Mechanism; Multiple simultaneous equilibria; Statistics; Steady state; Theory

Indexed keywords

NATURAL PRODUCT; TESTOSTERONE 17BETA DEHYDROGENASE;

COMPUTER AIDED DESIGN; COMPUTER PROGRAM; CONFERENCE PAPER; ENZYME KINETICS; INHIBITION KINETICS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PRIORITY JOURNAL; REACTION ANALYSIS; SIMULATION;

17-HYDROXYSTEROID DEHYDROGENASES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; PHYTOESTROGENS; SOFTWARE;

EID: 33644907149     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2005.10.012     Document Type: Conference Paper

References (13)

1. M.T. Beck, and I. Nagypál Chemistry of Complex Equilibria 1990 Ellis Horwood Chichester
2. K.B. Burnham, and D.R. Anderson Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach second ed 2002 Springer-Verlag New York
3. J.J. Dongarra, J.R. Bunch, C.B. Moler, and G.W. Stewart LINPACK User's Guide 1979 Society for Industrial and Applied Mathematics Philadelphia
4. A. Krazeisen, R. Breitling, G. Moeller, and J. Adamski Phytoestrogens inhibit human 17 β -hydroxysteroid dehydrogenase type 5 Mol. Cell. Endocrinol. 171 2001 151 162
5. E. Kreyszig Advanced Engineering Mathematics seventh ed 1993 John Wiley New York
6. P. Kuzmič Program DYNAFIT for the analysis of enzyme kinetic data: Application to HIV proteinase Anal. Biochem. 237 1996 260 273
7. P. Kuzmič Fixed-point methods for computing the equilibrium composition of complex biochemical mixtures Biochem. J. 331 1998 571 575
8. P. Kuzmič, K.Y. Ng, and T.D. Heath Mixtures of tight-binding enzyme-inhibitors: kinetic-analysis by a recursive rate-equation Anal. Biochem. 200 1992 68 73
9. W.H. Press, S.A. Teukolsky, W.T. Vetterling, and B.P. Flannery Numerical Recipes in C 1992 Cambridge University Press Cambridge
10. I.H. Segel Enzyme Kinetics 1975 Wiley New York
11. W.R. Smith, and R.W. Missen Chemical Reaction Equilibrium Analysis: Theory and Algorithms 1982 Wiley-Interscience New York
12. J. Stoer, and R. Bulirsch Introduction to Numerical Analysis 1991 Springer-Verlag New York
13. J.W. Williams, and J.F. Morrison The kinetics of reversible tight-binding inhibition Meth. Enzymol. 63 1979 437 467