Use-dependent inhibition of Na+ currents by benzocaine homologs

Biophysical Journal

Volumn 70, Issue 1, 1996, Pages 194-201

  Quan, Catherine ^a   Mok, Wai Man ^a   Wang, Ging Kuo ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOCAINE;

ARTICLE; BINDING SITE; CELL CULTURE; DEPOLARIZATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; REGULATORY MECHANISM; SODIUM CURRENT; STEADY STATE; VOLTAGE CLAMP;

EID: 0344161262     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(96)79563-2     Document Type: Article

References (24)

1. Bean, B. P., C J. Cohen, and R. W. Tsien. 1983 Lidocaine block of cardiac sodium channels. J. Gen. Physiol. 81:613-542.
2. Butterworth, J. F., and G. R. Strichartz. 1990. Molecular mechanisms of local anesthetics: a review. Anesthesiology. 72:711-734.
3. Cahalan, M. D., and W. Almers. 1979. Interactions between quaternary lidocaine. the sodium channel gates and tetrodotoxin. Biophys. J. 27: 39-56.
4. Chernoff, D. M., and G. R. Strichartz. 1989. Tonic and phasic block of neuronal sodium currents by 5-hydroxyhexano-2′,6′-xylide, a neutral lidocaine homologue. J. Gen. Physiol. 93:1075-1090.
5. Cota, G., and C. M. Armstrong. 1989. Sodium channel gating in clonal pituitary cells: the inactivation step is not voltage dependent J. Gen. Physiol. 94:213-232.
6. Courtney, K. R. 1975. Mechanism of frequency-dependent inhibition of sodium currents in frog; myelinated nerve by the lidocaine derivative GEA-968. J. Pharmacol. Exp. Ther. 195:225-236.
7. Elliott, J. R., D. A. Haydon, and B. M. Hendry, 1987. Local anesthetic effects of benzene and structurally related molecules, including benzocaine. on the squid giant axon. Pflugers Arch. 409:589-595.
8. Hamill, O. P., E. Marty, M. E. Neher, B. Sakmann, and F. J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:85-100.
9. Hille, B. 1977. Local anesthetics: hydrophilic and hydrophobic pathways for the drug receptor reaction. J. Gen. Physiol. 69:497-515.
10. Hodgkin, A. L., and A. E. Huxley. 1952. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117:500-544.
11. Huang, L Y. M., and G. Ehrenstein. 1981. Local Anesthetics QX-572 and benzocaine act at separate sites on the batrachotoxin-activated sodium channel. J. Gen. Physiol. 77:137-153.
12. Koppenhofer, E., R.-G. Sommer, and U. Froese. 1987. Effects of benzocaine and its isomers on sodium permeability and steady-state sodium inactivation in the myelinated nerve, obtained by an improved dissection technique. Gen. Physiol. Biophys. 6:209-222.
13. Marquardt, D. W. 1963. An algorithm for least squares estimation of nonlinear parameters. J. Soc. Ind. Appl, Math. 11:431
14. Meeder, T., and W. Ulbricht. 1987. Action of benzocaine on sodium channels of frog nodes of Ranvier treated with chloramine-T. Pflugers Arch. 409:265-273.
15. + channels in the membrane of myelinated nerve by benzocaine. Pflugers Arch. 390:230-236.
16. Schneider, M. F., and J. M. Dubois. 1986. Effects of benzocaine on the kinetics of normal and batrachotoxin-modified Na channels in frog node of Ranvier. Biophys. J. 50:523-530.
17. Schwarz, W., P. T. Palade, and B. Hille. 1977. Local anesthetics: effect of pH on use-dependent block of sodium channels in frog muscle. Biophys. J. 20:343-368.
18. Starmer, C. F., A. O. Grant, and H. C. Strauss. 1984. Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. Biophys. J. 46:15-27.
19. Strichartz, G. R. 1973. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J. Gen. Physiol. 62:37-57.
20. + channels. J. Gen. Physiol 96: 1105-1127.
21. + channels Mol Pharmacol. 44:667-676.
22. + channels by batrachotoin. Pflugers Arch. 427:309-316.
23. + channels. State-dependent interactions. J. Gen. Physiol. 103:501-518.
24. + channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons. Biophys. J. 47:685-694.