Immune impairment in HIV infection: Existence of risky and immunodeficiency thresholds

Journal of Theoretical Biology

Volumn 260, Issue 4, 2009, Pages 490-501

  Iwami, Shingo ^a   Miura, Tomoyuki ^b   Nakaoka, Shinji ^c,d   Takeuchi, Yasuhiro ^a  

^a SHIZUOKA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bistability; Dendritic cell; HIV infection; Immune impairment; Immunodeficiency; Mathematical model; Saddle node bifurcation; Transcritical bifurcation

Indexed keywords

CELL ORGANELLE; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; IMMUNE SYSTEM; INFECTIVITY; NUMERICAL MODEL;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CLINICAL ARTICLE; DENDRITIC CELL; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOPATHOLOGY; INFECTION RISK; MATHEMATICAL MODEL; PATHOGENESIS; PRIORITY JOURNAL; VIRUS LOAD;

DENDRITIC CELLS; DISEASE PROGRESSION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNE TOLERANCE; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES, CYTOTOXIC;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 70049095281     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2009.06.023     Document Type: Article

References (42)

1. Altes H.K., Wodarz D., and Jansen V.A.A. The dual role of CD4 T helper cells in the infection dynamics of HIV and their importance for vaccination. J. Theor. Biol. 214 (2002) 633-646
2. Altes H.K., Ribeiro R.M., and de Boer R.J. The race between initial T-helper expansion and virus growth upon HIV infection influences polyclonality of the response and viral set-point. Proc. R. Soc. London B 270 (2003) 1349-1358
3. Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., Freeman G.J., and Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439 (2006) 682-687
4. Binley J.M., Clas B., Gettie A., Vesanen M., Montefiori D.C., Sawyer L., Booth J., Lewis M., Marx P.A., Bonhoeffer S., and Moore J.P. Passive infusion of immune serum into simian immunodeficiency virus-infected rhesus macaques undergoing a rapid disease course has minimal effect on plasma viremia. Virology 270 (2000) 237-249
5. Ciupe M.S., Bivort B.L., Bortz D.M., and Nelson P.W. Estimating kinetic parameters from HIV primary infection data through the eyes of three different mathematical models. Math. Biosci. 200 (2006) 1-27
6. Cecilia D., Kleeberger C., Munoz A., Giorgi J.V., and Zolla-Pazner S. A longitudinal study of neutralizing antibodies and disease progression in HIV-1-infected subjects. J. Infect. Dis. 179 (1999) 1365-1374
7. Connolly N.C., Whiteside T.L., Wilson C., Kondragunta V., Rinaldo C.R., and Riddler S.A. Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individuals. Clin. Vaccine Immunol. 15 (2008) 284-292
8. Davenport M.P., Ribeiro R.M., and Perelson A.S. Kinetics of virus-specific CD 8 + T cells and the control of human immunodeficiency virus infection. J. Virol. 78 (2004) 10096-100103
9. De Boer R.J., and Boerlijst M.C. Diversity and virulence thresholds in AIDS. Proc. Natl. Acad. Sci. USA 94 (1994) 544-548
10. Donaghy H., Pozniak A., Gazzard B., Qazi N., Gilmour J., Gotch F., and Patterson S. Loss of blood CD 11 c + myeloid and CD 11 c - plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 98 (2001) 2574-2576
11. Donaghy H., Gazzard B., Gotch F., and Patterson S. Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1. Blood 101 (2003) 4505-4511
12. Freeman G.J., Wherry E.J., Ahmed R., and Sharpe A.H. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J. Exp. Med. 203 (2006) 2223-2227
13. Galvani A.P. The role of mutation accumulation in HIV progression. Proc. R. Soc. London B 272 (2005) 1851-1858
14. Garcia F., Lejeune M., Climent N., Gil C., Alcami J., Morente V., Alos L., Ruiz A., Setoain J., Fumero E., Castro P., Lopez A., Cruceta A., Piera C., Florence E., Pereira A., Libois A., Gonzalez N., Guila M., Caballero M., Lomena F., Joseph J., Miro J.M., Pumarola T., Plana M., Gatell J.M., and Gallart T. Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infection. J. Infect. Dis. 191 (2005) 1680-1685
15. Hogue I.B., Bajaria S.H., Fallert B.A., Qin S., Reinhart T.A., and Kirschner D.E. The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection. J. Gen. Virol. 89 (2008) 2228-2239
16. Iwami S., Nakaoka S., and Takeuchi Y. Viral diversity limits immune diversity in asymptomatic phase of HIV infection. Theor. Popul. Biol. 73 (2008) 332-341
17. Iwami, S., Nakaoka, S., Takeuchi, Y., Immune impairment thresholds in HIV infection, in revision.
18. Iwasa Y., Michor F., and Nowak M.A. Virus evolution within patients increases pathogenicity. J. Theor. Biol. 232 (2005) 17-26
19. Janewa, C., Travers, P., Walport, M., Shlomchik, M.J., 2004. Immunobiology: The Immune System in Health and Disease. Garland Pub..
20. Kawamura T., Gatanaga H., Borris D.L., Connors M., Mitsuya H., and Blauvelt A. Decreased stimulation of CD 4 + T cell proliferation and IL-2 production by highly enriched populations of HIV-infected dendritic cells. J. Immunol. 170 (2003) 4260-4266
21. Kozyrev I.L., Ibuki K., Shimada T., Kuwata T., Takemura T., Hayami M., and Miura T. Characterization of less pathogenic infectious molecular clones derived from acute-pathogenic SHIV-89.6P stock virus. Virology 282 (2001) 6-13
22. Lore K., Sonnerborga A., Brostrom C., Goh L.-E., Perrin L., McDade H., Stellbrink H.-J., Gazzard B., Weber R., Napolitano L.A., vanKooyk Y., and Andersson J. Accumulation of DC - SIGN + CD 40 + dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection. AIDS 16 (2002) 683-692
23. Mandl J.N., Regoes R.R., Garber D.A., and Feinberg M.B. Estimating the effectiveness of simian immunodeficiency virus-specific CD 8 + T cells from the dynamics of viral immune escape. J. Virol. 81 (2007) 11982-11991
24. Macatonia S.E., Lau R., Patterson S., Pinching A.J., and Knight S.C. Dendritic cell infection, depletion and dysfunction in HIV-infected individuals. Immunology 71 (1990) 38-45
25. McKnight A., and Clapham P.R. Immune escape and tropism of HIV. Trends Microbiol. 3 (1995) 356-361
26. McMichael A.J., and Rowland-Jones S.L. Cellular immune responses to HIV. Nature 410 (2001) 980-987
27. Meissnera E.G., Duus K.M., Gao F., Yu X.-F., and Su L. Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope. Virology 328 (2004) 74-88
28. Nowak M.A., and May R.M. Virus Dynamics (2000), Oxford University Press, Oxford
29. Ogg G.S., Jin X., Bonhoeffer S., Moss P., Nowak M.A., Monard S., Segal J.P., Cao Y., Rowland-Jones S.L., Hurley A., Markowitz M., Ho D.D., McMichael A.J., and Nixon D.F. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy. J. Virol. 73 (1999) 797-800
30. Patterson S., English N.R., Longhurst H., Balfe P., Helbert M., Pinching A.J., and Knight S.C. Analysis of human immunodeficiency virus type 1 (HIV-1) variants and levels of infection in dendritic and T cells from symptomatic HIV-1-infected patients. J. Gen. Virol. 79 (1998) 247-257
31. Perelson A.S., Neumann A.U., Markowitz M., Leonard J.M., and Ho D.D. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271 (1996) 1582-1586
32. Regoes R.R., Wodarz D., and Nowak M.A. Virus dynamics: the effect of target cell limitation and immune responses on virus evolution. J. Theor. Biol. 191 (1998) 451-462
33. Richman D.D. HIV chemotherapy. Nature 410 (2001) 995-1001
34. Rinaldo C.R. Dendritic cell-based human immunodeficiency virus vaccine. J. Int. Med. 265 (2008) 138-158
35. Smed-Sorensen A., Lore K., Walther-Jallow L., Anderson J., and Spetz A. HIV-1 infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation. Blood 104 (2004) 2810-2817
36. Stafford M.A., Corey L., Cao Y., Daar E.S., Ho D.D., and Perelson A.S. Modeling plasma virus concentration during primary HIV infection. J. Theor. Biol. 203 (2000) 285-301
37. Thieme H.R. Mathematics in Population Biology (2003), Princeton University Press, Princeton
38. Tunetsugu-Yokota Y. How does HIV infection destroy the host immune system?. J. AIDS Res. 7 (2005) 171-179
39. Velu V., Titanji K., Zhu B., Husain S., Pladevega A., Lai L., Vanderford T.H., Chennareddi L., Silvestri G., Freeman G.J., Ahmed R., and Amara R.R. Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458 (2009) 206-210
40. Wu L., and Kewal-Ramani V.N. Dendritic-cell interactions with HIV: infection and viral dissemination. Nat. Rev. Immunol. 6 (2006) 859-868
41. Wodarz D., Klenerman P., and Nowak M.A. Dynamics of cytotoxic T-lymphocyte exhaustion. Proc. R. Soc. London B 265 (1998) 191-203
42. Wodarz D., and Nowak M.A. Specific therapy regimes could engender long-term immunological control of HIV. Proc. Natl. Acad. Sci. USA 96 (1999) 14464-14469