The discovery of novel, potent and selective PDE5 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 18, 2001, Pages 2461-2464

  Bi, Yingzhi ^a   Stoy, Patrick ^a   Adam, Leonard ^a   He, Bin ^a   Krupinski, John ^a   Normandin, Diane ^a   Pongrac, Ron ^a   Seliger, Laurie ^a   Watson, Andrew ^a   Macor, John E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PYRAZOLOPYRIDOPYRIMIDINE DERIVATIVE; PYRAZOLOPYRIMIDINE DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG;

ARTICLE; CATTLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FLUSHING; HEADACHE; HEART; HUMAN; IC 50; KIDNEY; NAUSEA; NONHUMAN; RAT; THROMBOCYTE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0035903884     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00466-8     Document Type: Article

References (15)