Comparative molecular field analysis and synthetic validation of a hydroxyamide-propofol binding and functional block of neuronal voltage-dependent sodium channels

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 7056-7063

  Brown, Milton L ^a   Eidam, Hilary A ^b   Paige, Mikell ^a   Jones, Paulianda J ^b   Patel, Manoj K ^c  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Alcohols; Amides; Hippocampal neurons; Propofol; Sodium channels

Indexed keywords

1 ( 3,5 DIISOPROPYL 4 METHOXYMETHOXY PHENYL) 2,2,2 TRIFLUOROETHANONE; 2 ( 3,5 DIISOPROPYL 4 METHOXYMETHOXY PHENYL) 3,3,3 TRIFLUORO 2 HYDROXYPROPIONITRILE; 3,3,3 TRIFLUORO 2 HYDROXY 2 ( 4 HYDROXY 3,5 DIISOPROPYL PHENYL)PROPIONAMIDE; 4 ( 3,5 DIISOPROPYL 4 METHOXYMETHOXY PHENYL)BUTAN 1 OL; 4 BROMO 2,6 DIISOPROPHYL PHENOL; 5 ( 3,5 DIISOPROPYL 4 METHOXYMETHOXY PHENYL) 5 TRIFLUOROMETHYL IMIDAZOLIDINE 2,4 DIONE; 5 ( 4 HYDROXY 3,5 DIISOPROPYL PHENYL) 5 TRIFLUOROMETHYL IMIDAZOLIDINE 2,4 DIONE; 5 ( 4 IODOBUTYL) 1,3 DIISOPROPYL 2 METHOXYMETHOXY BENZENE; 5 ( 6 IODOHEXYL) 1,3 DIISOPROPYL 2 METHOXYMETHOXY BENZENE; 5 BROMO 1,3 DIISOPROPYL 2 METHOXYMETHOXYBENZENE; 6 ( 3,5 DIISOPROPYL 4 METHOXYMETHOXY PHENYL)HEXAN 1 OL; AMIDE; BATRACHOTOXININ A 20ALPHA BENZOATE; BENZENE DERIVATIVE; CYANOHYDRIN; HYDANTOIN; HYDROXYAMIDE; IMIDAZOLIDINE DERIVATIVE; LIGAND; PHENOL DERIVATIVE; PROPIONAMIDE DERIVATIVE; PROPOFOL; SILANE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; TERT BUTYL [ 4 ( 3,5 DIISOPROPYL 4 METHOXYMETHOXY PHENYL)BUTOXY]DIMETHYL SILANE; TERT BUTYL [ 6 ( 3,5 DIISOPROPYL 4 METHOXYMETHOXY PHENYL)HEXYLOXY]DIMETHYL SILANE; TERT BUTYL( 4 IODOBUTOXY)DIMETHYL SILANE; TERT BUTYL( 6 IODOHEXYLOXY)DIMETHYL SILANE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL CULTURE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG ANTAGONISM; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; ELECTRICITY; HIPPOCAMPUS; IC 50; NERVE CELL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SODIUM CURRENT; STEREOSPECIFICITY; SYNTHESIS; VALIDATION PROCESS;

AMIDES; ANESTHETICS, INTRAVENOUS; ANIMALS; CELLS, CULTURED; HIPPOCAMPUS; INHIBITORY CONCENTRATION 50; MICE; MODELS, MOLECULAR; NERVOUS SYSTEM DISEASES; NEURONS; PROPOFOL; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949163361     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.069     Document Type: Article

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