Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics

Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2003, Pages 2494-2501

  Choudhury Mukherjee, Indrani ^a   Schenck, Hilary A ^a   Cechova, Sylvia ^b   Pajewski, Thomas N ^b   Kapur, Jaideep ^b   Ellena, Jeffrey ^a   Cafiso, David S ^a   Brown, Milton L ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYL 3,3,3 TRIFLUORO 2 HYDROXYPROPIONAMIDE; 2 BENZYLOXY 3,3,3 TRIFLUORO 2 PHENYLPROPIONAMIDE; 3 AMINO 1,1,1 TRIFLUORO 2 PHENYLPROPAN 2 OL; 3 CHLORO 3,3 DIFLUORO 2 HYDROXY 2 PHENYLPROPIONAMIDE; 3 HYDROXY 1 METHYL 3 TRIFLUOROMETHYL 1,3 DIHYDROINDOL 2 ONE; 3 HYDROXY 3 TRIFLUOROMETHYL 1,3 DIHYDROINDOL 2 ONE; 3,3,3 TRIFLUORO 2 HYDROXY 2 PHENYLPROPIONAMIDE DERIVATIVE; 3,3,3 TRIFLUORO 2 HYDROXY 2 PHENYLPROPIONIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4,4,4 TRIFLUORO 2 HYDROXY 2 PHENYLBUTYRAMIDE; ANESTHETIC AGENT; AROMATIC COMPOUND; ATROLACTAMIDE; ISOFLURANE; KETAMINE; LIPID; LIPOSOME; PENTETRAZOLE; PROPOFOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD PRESSURE; BRAIN NERVE CELL; CHANNEL GATING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG FORMULATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC CURRENT; ELECTRIC POTENTIAL; ELECTRIC SHOCK; GENERAL ANESTHESIA; HEART ARRHYTHMIA; HEART RATE; HEMODYNAMICS; HIPPOCAMPUS; HUMAN; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NAUSEA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SIDE EFFECT; SINUS TACHYCARDIA; SOMNOLENCE; THOUGHT DISORDER; TREMOR; VOMITING;

ADMINISTRATION, ORAL; AMIDES; ANESTHETICS, GENERAL; ANIMALS; ANTICONVULSANTS; BLOOD PRESSURE; CELLS, CULTURED; DRUG DESIGN; HEART RATE; HIPPOCAMPUS; ION CHANNEL GATING; ION CHANNELS; ISOFLURANE; LIPOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PROPIONATES; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0037763705     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020546r     Document Type: Article

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