Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel

Journal of Medicinal Chemistry

Volumn 42, Issue 9, 1999, Pages 1537-1545

  Brown, Milton L ^a   Zha, Congxiang C ^a   Van Dyke, Christopher C ^c   Brown, George B ^b   Brouillette, Wayne J ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c TRIPOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HYDROXY ALPHA PHENYLAMIDE; ANILIDE; CARBAMAZEPINE; HYDANTOIN DERIVATIVE; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; ANTICONVULSANTS; CEREBRAL CORTEX; HYDANTOINS; ION CHANNEL GATING; LEAST-SQUARES ANALYSIS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEURONS; RATS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

EID: 0033529093     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980556l     Document Type: Article

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