Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a "paraptosis"-induced pathway that promotes systemic immunity against intracranial T9 gliomas

Blood

Volumn 100, Issue 4, 2002, Pages 1373-1380

  Chen, Yijun ^a,b,c   Douglass, Thomas ^a,b,c   Jeffes, Edward W B ^a,b,c   Xu, Qingcheng ^a,b,c   Williams, Christopher C ^a,b,c   Arpajirakul, Neary ^a,b,c   Delgado, Christina ^a,b,c   Kleinman, Michael ^a,b,c   Sanchez, Ramon ^a,b,c   Dan, Qinghong ^a,b,c   Kim, Ronald C ^a,b,c   Terry Wepsic, H ^a,b,c   Jadus, Martin R ^a,b,c  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; GANGLIOSIDE GM1; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL ISOLATION; CELL KILLING; CELL LINE; FEMALE; GLIOMA CELL; IMMUNOHISTOLOGY; MACROPHAGE; NEUTROPHIL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL; TUMOR GROWTH; TUMOR IMMUNITY;

EID: 0037103386     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-01-0174     Document Type: Article

References (42)

1. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/ paracrine mechanisms involving TGF-beta, PGE2, and PAF
2. Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages
3. Immunosuppressive effects of apoptotic cells
4. Natural adjuvants: Endogenous activators of dendritic cells
5. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression
6. The induction of tolerance by dendritic cells that have captured apoptotic cells
7. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
8. Differential effect of apoptotic versus necrotic tumor cells on macrophage antitumor activities
9. An alternative, nonapoptotic form of programmed cell death
10. Macrophages can recognize and kill tumor cells bearing the membrane isoform of macrophage colony stimulating factor
11. Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway
12. The biology and potential anti-cancer uses of membrane macrophage colony stimulating factor
13. Development of systemic immunity to glioblastoma multiforme using tumor cells genetically engineered to express the membrane-associated isoform of macrophage colony-stimulating factor
14. Rat brain tumor models in experimental neuro-oncology: The 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas
15. Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection
16. Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors
17. Membrane expression of macrophage colonystimulating factor on MADB106 breast cancer cells is not associated with in vitro cytotoxicity by macrophages but is associated with the induction lasting tumor immunity against syngeneic breast cancer cells in vivo
18. Non-immunogenic murine hepatocellular carcinoma Hepal-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor
19. Cytokine-induced neutrophil chemoattractant release from hepatocytes is modulated by Kupffer cells
20. T9 glioma cancer cells expressing membrane macrophage colony stimulating factor produce CD4+ associated protective immunization against different syngeneic glioma cells
21. Inhalation of resuspended road dust, but not ammonium nitrate, decreases the expression of the pulmonary macrophage Fc receptor
22. 77)
23. Induction of cytokine-induced neutrophil chemoattractant in response to various stresses in rat C6 glioma cells
24. Appearance of asialo GM1 glycosphingolipid on the cell surface during lymphokine-induced differentiation of M1 cells
25. Characterization of glycosphinolipids from cells of various types of human leukemia: Occurrence of two glycosphingolipids, one reacting with antiasialo GM1 antibody and one with anti-Forssman antibody
26. Mechanism of anti- asialo GM1 prevention of graft versus host disease identification of allo-antigen activation of T cells
27. Immunoelectron microscopic identification of asialo GM1-positive cells in adult rat liver
28. Inhibition of IL-8-induced W3/25+ (CD4+) T lymphocyte recruitment into subcutanoeus tissues of rats by selective depletion of in vivo neutrophils with a monoclonal antibody
29. Interleukin-8 has antitumor effects in the rat which are not associated with polymorphonuclear leukocyte cytotoxicity
30. The intriguing role of polymorphonuclear neutrophils in antitumor reactions
31. Neutrophil infiltration into human gliomas
32. IL-6 secretion by a rat T9 glioma clone induces a neutrophil-dependent antitumor response with resultant cellular, antiglioma immunity
33. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells
34. Polymorphonuclear neutrophils as accessory cells for T-cell activation: Major histocompatibility complex class II restricted antigen-dependent induction of T-cell proliferation
35. Tumor rejection and immune memory elicited by locally released LEC chemokine are associated with an impressive recruitment of APCs, lymphocytes and granulocytes
36. Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of legionella pneumophila pneumonia
37. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
38. Nitric oxide, superoxide and peroxynitrite: The good, the bad, the ugly
39. Induction of megamitochondria by some chemicals inducing oxidative strees in primary cultured rat hepatocytes
40. Free radical-induced megamitochondria formation and apoptosis
41. Protease-elicited TUNEL positivity of nonapoptotic fixed cells
42. Detection of apoptosis in tissue sections